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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Borneo Journal of Pharmacy
Sylvia Utami Tunjung Pratiwi
Faculty Of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potential of Indonesian Plants as Polymicrobial Anti-Biofilm Rafika Sari; Sylvia Utami Tunjung Pratiwi; Yosi Bayu Murti; Ema Damayanti
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5645

Abstract

Biofilm infection occurs in 80% of chronic infections caused by 60% of biofilms from plankton cells and polymicrobial biofilms. Due to synergistic interactions between species, infections caused by polymicrobial biofilms are more virulent than monospecies biofilm infections. New anti-biofilm candidates are constantly being developed by tracing the content of active compounds from medicinal plants native to Indonesia. The need to find new plant sources that have the potential as anti-biofilms is increasingly needed along with increasing microbial resistance. Various studies show that active compounds that have anti-biofilm potential are polyphenols, quercetin, curcumin, gallic acid, and ferulic acid. The mechanism of action of anti-biofilms is through the prevention of attachment and formation of biofilms, inhibition of quorum sensing, and inhibition of gene expression in microbes.
Antibacterial and Antibiofilm Activity Testing of Black Betel Leaves (Piper betle L. var. nigra) Ethanol Extract on Staphylococcus aureus and Pseudomonas aeruginosa Using Microdilution Method Adha, Tasya Hardina; Ikawati, Zullies; Pratiwi, Sylvia Utami Tunjung
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 1 (2025): February 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i1.59

Abstract

The use of antibiotics is key to treating infected wounds. However, its effectiveness has begun to decrease due to the high bacterial resistance, which is caused by the phenomenon of biofilm. Therefore, it’s necessary to discover new antibacterial and antibiofilm activity agents that can be used as alternative therapies. This study aims to test the antibacterial and antibiofilm activity of black betel leaves (Piper betle L. var. nigra) ethanol extract. Antibacterial and antibiofilm activity test was conducted using the microdilution method against Staphylococcus aureus and Pseudomonas aeruginosa with concentration variations 4; 2; 1; 0.5; 0.25; and 0.125 mg/mL, also used positive control kanamycin 10 mg/mL and negative control DMSO 1%. The results showed that the black betel leaves ethanol extract had low antibacterial activity with MIC50 > 4 mg/mL for both bacteria and vigorous antibiofilm activity with MBIC50 < 0.125 mg/mL for S. aureus and MBIC = 0.491 mg/mL for P. aeruginosa. The antibacterial activity of the black betel leaves ethanol extract was lower than it’s antibiofilm activity, the antibacterial and antibiofilm activities of the black betel leaves ethanol extract were higher against S. aureus than P. aeruginosa.Keywords: Antibacterial, Antibiofilm, Piper betle L. var. nigra
Nanoemulsion Mouthwash Formulation of Bajakah Tampala (Spatholobus littoralis Hassk.) Skin Extract Against Candida albicans Hamzah, Hasyrul; Gunawan, Dede Reza; Pratiwi, Sylvia Utami Tunjung; Bakhtiar, Muh. Irham; Pratama, Virgiawan Yoga; Subhan, Muhammad; Maulana, Riza
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5548

Abstract

Candida albicans can cause two infections in humans: superficial and systemic. The ability of C. albicans to infect the host is influenced by virulence factors and character changes so that it can fool the immune system. From the character change factor, C. albicans can form a biofilm. This study aims to determine the good concentration in inhibiting and determine the antifungal and antibiofilm activity of nanoemulsion mouthwash formulation of bajakah tampala (Spatholobus littoralis Hassk) skin extract against C. albicans. This research was conducted with an experimental method. The formulation used a spontaneous magnetic stirrer technique to make nanoemulsion preparations. Antifungal and antibiofilm tests were carried out by dilution method using a 96-well plate and a microplate reader with a wavelength of 620 nm to determine the percentage inhibition against C. albicans and determine MIC50 and MBIC50. The results showed that the nanoemulsion mouthwash formulation of S. littoralis inhibited the planktonic and biofilm of C. albicans. The concentration of 1% is expressed as MIC50 and MBIC50. Therefore, the nanoemulsion formulation of S. littoralis extract could inhibit the growth of C. albicans in the oral cavity.
Co-Authors Adha, Tasya Hardina Aini Febriana Ardani, Marisya Bakhtiar, Muh. Irham Dian Mayasari Ema Damayanti FERRY RAHMA PUSPITA Fita Rahmawati Fransisca Priskaningtyas Wulandari Gunawan, Dede Reza Hamzah, Hasyrul Iramie Duma Kencana Irianto Joselin Ekaputri Khoirunnissa Hida MAULANA, RIZA Meiliana Meiliana Meta Juniatik Muhammad Subhan Ni&#039;matul Munawaroh NURI IRIYANI Nurul Pangestuti Pratama, Virgiawan Yoga Rafika Sari Rina Kuswahyuning Ronny Martien Shinta Sari Dewi SINTAYU PUTRI WANDAN SARI Sudarsono Sudarsono Titik Nuryastuti Triana Hertiani Yosi Bayu Murti