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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Sari Pediatri Paediatrica Indonesiana Belitung Nursing Journal Jurnal Gizi Klinik Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer
Sri Mulatsih
Department Of Child Health, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Central Java
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Prognostic factor of heart failure in children with left-to-right shunt acyanotic congenital heart disease Weny Inrianto; Indah K. Murni; Sri Mulatsih; Sasmito Nugroho
Paediatrica Indonesiana Vol 59 No 2 (2019): March 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.152 KB) | DOI: 10.14238/pi59.2.2019.63-6

Abstract

Background Anemia is highly prevalent and affects morbidity and mortality in adults with acquired heart disease. However, its role in children with acyanotic congenital heart disease (CHD) is unclear. Objective To assess anemia and other potential prognostic factors of congestive failure in children with left-to-right shunt acyanotic CHD. Methods We conducted a case-control study in the Pediatric Cardiology Clinic, Dr. Sardjito Hospital from January to December 2017 in children with left-to-right shunt acyanotic CHD. The case and control groups consisted of subjects with and without heart failure, respectively. Anemia was defined as hemoglobin concentration <11 g/dL. Measured outcome was the prevalence of congestive heart failure, as determined by the Ross criteria. Anemia, defect type, defect size, age at diagnosis, and gender were analyzed by logistic regression analysis as potential predictive factors of heart failure. Results Of 100 children with left-to-right shunt acyanotic CHD, 50 had heart failure (the case group) and 50 did not (the control group). The prevalence of anemia was 45%. Multivariable logistic regression revealed that defect size was the most significant factor for predicting heart failure, with adjusted OR 7.6 (95%CI 2.5 to 22.8) for moderate shunts and 21.1 (95%CI 6.8 to 65.4) for large shunts. Anemia, type of defect, age of diagnosis, and gender were not statistically significant factors for predicting outcomes. Conclusion Anemia is not a significant, prognostic factor for heart failure in children with left-to-right shunt acyanotic CHD. However, moderate and large shunts in children with left-to-right shunt acyanotic CHD are predictive of the occurrence of congestive heart failure.
Implementing Yogyakarta Pediatric Cancer Registry for 16 years Sri Mulatsih; Adnina Hariningrum; Ignatius Purwanto; Rizki Oktasari
Paediatrica Indonesiana Vol 59 No 4 (2019): July 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.945 KB) | DOI: 10.14238/pi59.4.2019.188-94

Abstract

Background A hospital-based cancer registry can be used as a guide to decision-making. Considering the limited cancer registry data in the population, the Yogyakarta Pediatric Cancer Registry (YPCR) is one of the pioneers of hospital-based pediatric cancer registries in Indonesia. The YPCR was started in 2000 in Dr. Sardjito Hospital. Objective To describe the characteristics of childhood cancer and the outcomes by analyzing overall survival (OS) and event-free survival (EFS) based on data from Yogyakarta Pediatric Cancer Registry. Methods Data were collected from the YPCR for the period of 2000 to 2016. Childhood cancers were classified into 12 groups based on the 3rd edition International Classification for Childhood Cancer (ICCC). Incidence, frequency, and distribution of cases were grouped by sex, age, and patients’ place of residence. Incidence was further analyzed using SPSS software. Kaplan-Meier test was used to analyze OS and EFS. Results Within the study period, 2,441 children aged 0-18 years were diagnosed with cancer. The highest incidence was found in the 1-5-year age group. The most common diagnoses found were leukemia, myeloproliferative disorders, and myelodysplastic disease (58%); lymphoma and reticuloendothelial neoplasm (8%); retinoblastoma (6%); soft tissue and other extra-osseous sarcomas (5%); as well as neuroblastoma and other peripheral nervous cell tumors (5%). The OSs of acute lymphoblastic leukemia (ALL), high risk ALL (HR-ALL), and standard risk (SR-ALL) were 31.8%, 18.5%, and 43.9%, respectively. The EFSs of ALL, HR-ALL, and SR-ALL were 23.9%, 14.7%, and 32.4%, respectively. For solid tumors, the OS was 13.7% and EFS was 6.4%. Conclusion The number of new cases of childhood cancer has increased in the last few years. The Yogyakarta Pediatric Cancer Registry (YPCR), which serves as a hospital-based pediatric cancer registry, has an important role to evaluate clinical and non-clinical aspects of childhood cancer.
PATIENT SATISFACTION AND ITS RELATIONSHIP WITH THE QUALITY OF COMPREHENSIVE EMERGENCY OBSTETRIC AND NEONATAL CARE (CEmONC) IN THE GENERAL HOSPITAL OF PANEMBAHAN SENOPATI BANTUL Fitri Dian Kurniati; Lely Lusmilasari; Sri Mulatsih
Belitung Nursing Journal Vol. 3 No. 4 (2017): July - August
Publisher : Belitung Raya Foundation, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.492 KB) | DOI: 10.33546/bnj.106

Abstract

Background: Patient satisfaction has emerged as an increasingly important health outcome and is currently used to evaluate the quality of care. Objective: To describe the level of satisfaction of mothers after caesarean section and examine its relationship with the quality of Comprehensive Emergency Obstetric and Neonatal Care (CEmONC). Methods: This was an analytic descriptive study using cross-sectional design. The study was conducted in Alamanda ward in the General Hospital (RSUD) of Panembahan Senopati Bantul Indonesia during September until November 2016. There were 55 respondents selected using purposive sampling. The instruments included The Scale for Measuring Maternal Satisfaction (SMMS) – caesarean birth and the Quality of CEmONC questionnaires. Spearman’s rho and logistic regression were performed for data analysis. Result: Results showed that 47.3% respondents rated the quality of CEmONC in high category and 56.4% were satisfied. The correlation value between quality of CEmONC and patient satisfaction was 0.285 (p = 0.035; OR = 1.96). Conclusion: Level of satisfaction of mothers after caesarean section was associated with the quality of CEmONC in the General Hospital of Panembahan Senopati Bantul Indonesia.
Identifikasi risiko malnutrisi dan evaluasi status nutrisi pasien kanker anak dengan pengobatan kemoterapi Agus Santosa; Sri Mulatsih; Susetyowati Susetyowati
Jurnal Gizi Klinik Indonesia Vol 15, No 4 (2019): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.37015

Abstract

Identification of malnutritional risk and nutrition status evaluation of pediatric cancer patients with chemotherapy treatmentBackground: Hospitalized childhood cancer patients had a high risk for malnutrition, either caused by the disease or effects of cancer treatment. Malnutrition in cancer patients gives negative impacts on treatment outcomes in the form of increasing morbidity and mortality rates. Nutrition screening for identifying malnutrition risks could prevent malnutrition in hospitals.Objectives: Investigating the influence of malnutrition risk during hospitalization on the changes in the nutritional status of childhood cancer patients with chemotherapy treatment. Methods: This research was observational research with the nested case-control design. The research subjects were childhood cancer patients aged 2-18 years old meeting the inclusion criteria. They were 64 in number consisting of the case group involving 32 patients and a control group involving the rest. During hospitalization, analyses of nutritional intake, change in body weight, nutritional status, and hospitalization period. Furthermore, the analyses of the influence of malnutrition risk on the outcome between those two groups were then compared. Results: There was a significant influence of malnutrition risk on less energy intake (p<0.001), less protein intake (p=0.002), weight loss >2% (p<0.001), poor nutritional status based on the BMI/U (p=0.011), and longer hospitalization (p=0.034). The group of patients with malnutrition risks had risks of 15.5 (CI 95%: 3.991-63.359) times higher for less energy intake, 6.12 (CI 95%: 1.675-24.906) times higher for less protein intake, and 45.3 (CI 95%: 5.666-1940.768) times higher for weight loss > 2% than the group of patients without malnutrition risks.Conclusions: Patients with a significant risk of malnutrition had less energy and protein intake, weight loss > 2%, poor nutritional status based on BMI/U, and longer hospitalization.
Faktor yang Memengaruhi Episode Transfusi Packed Red Cell (PRC) pada Anak dengan Keganasan DIAN A.P PURWANTO; SRI MULATSIH; TEGUH TRIYONO
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.562 KB) | DOI: 10.33371/ijoc.v11i2.501

Abstract

ABSTRACTPRC transfusion is an adjuvant therapy frequently used in children with malignancy. There are some factors affecting transfusion episodes. For rational use of PRC must consider these factors. Objective: To find factors affecting transfusion episodes in children with malignancy. This retrospective cohort study evaluated children with malignancy between January 1 and December 31, 2015 who were admitted to Sardjito hospital. Patients were receiving therapy dan PRC transfusion during the four months following cancer diagnosis. Those with incomplete data or renal failure were excluded. The influence of these factors were analyzed with Chi-square or Fisher’s exact and Kolmogorov-Smirnov when iligible, and the most influential factor were analyzed by logistic regression. Out of 123 subjects receiving a PRC transfusion, 56 (45,5%) subjects received a PRC transfusion more than one times episodes. Higher episodes of transfusion were observed for patients whose bleeding (RR 6.940 (95%CI 2.563 to 18.790). Lower episodes of transfusion were observed for patients receiving transfusion previously and hematological malignancies, but the result were not significant (RR 0,524 (IK95% 0,057 – 4,852) and 0,464 (IK 95% 0,140 – 1,540) respectively). Bleeding is factor affecting transfusion episodes of PRC in children with malignancy.ABSTRAKTransfusi PRC merupakan terapi adjuvant yang sering digunakan pada anak dengan keganasan. Terdapat beberapa faktor yang memengaruhi episode transfusi sehingga penggunaan PRC rasional harus mempertimbangkan faktor tersebut. Penelitian ini bertujuan mengetahui faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. Penelitian kohort retrospektif pada anak (0 –18 tahun) yang dirawat di RSUP Dr. Sardjito dengan penyakit keganasan yang telah terdiagnosis selama empat bulan dan mendapat terapi serta transfusi PRC sejak 1 Januari – 31 Desember 2015. Register tidak lengkap atau dengan gagal ginjal dieksklusi. Pengaruh faktor– faktor tersebut dianalisis dengan uji Chi-square atau uji Fisher serta Kolmogorov-Smirnov bila tidak memenuhi syarat, dan faktor yang paling berpengaruh dianalisis dengan uji logistic regression. Dari 123 subjek, 56 subjek dengan episode transfusi PRC > 1 kali. Keganasan hematologi, riwayat transfusi, dan perdarahan memengaruhi episode transfusi PRC > 1 kali. Analisis multivariat didapatkan perdarahan memengaruhi episode transfusi PRC > 1 kali (RR 6,940 (IK95% 2,563 – 18,790), namun riwayat transfusi dan keganasan hematologi tidak bermakna dengan nilai RR secara berturut-turut 0,524 (IK95% 0,057 – 4,852) dan 0,464 (IK 95% 0,140 – 1,540). Penelitian ini menyimpulkan bahwa perdarahan merupakan faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. 
A male Covid-19 convalescent plasma donor with long existence of SARS-Cov-2 antibodies: a case report Teguh Triyono; Usi Sukorini; Andri Christianalusi; Sri Mulatsih; Hans Vrielink
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art12

Abstract

Covid-19 Convalescent Plasma (CCP) was one of alternative therapy for Covid-19 patients. The use of convalescent plasma as an adjunct therapy must consider its efficacy, benefits, and risk, both for the patient and the donor. Convalescent Plasma was produced from purified human plasma. Convalescent Plasma was a passive immunity which provide active antibodies. CCP give immunity to the patient through the transfusion of a survivor’s antibodies. We were reporting a case of male CCP donor with long existence of SARS-Cov-2. This donor performed up to 16 donations, which was an unusual case in CCP donor. The SARS-CoV-2 antibody titer was analyzed using Elecsys® Anti-SARS-CoV-2 (Roche Diagnostics). The SARS-CoV-2 antibody showed high level of total SARS-CoV-2 antibodies, with the Cut off Indexes (COI) anti SARS-Cov-2 antibody were still quite high (132 U/mL). The highest donor antibody COI (204.6 U/mL) was seen in 11th donation at 6 months after recovery, while the lowest antibody COI (130.8 U/mL) was in 15th donation at 7 months after recovering. Evaluation of donor health status were performed after the 16th donation and analyzed as well. In conclusion, 16 CCP donations of 600 mL resulting in 48 units of 200 mL plasma in 8 months was safe for the donor, with the SARS-Cov-2 antibody titer remained high in the whole period.
Co-Authors Adnina Hariningrum Agus Santosa Allen Yeoh Andri Christianalusi Dessy Shinta Murty DIAN A.P PURWANTO Eggi Arguni Fitri Dian Kurniati Hans Vrielink Hasriza Eka Putra Ida S. Laksanawati Ignatius Purwanto Indah K. Murni Iwan Dwiprahasto Jonliberti Purba Julie Christine Krisnanto Wibowo Lely Lusmilasari, Lely Mohammad Juffrie, Mohammad Muhammad Riza Neti Nurani Rina Triasih Rizki Oktasari Samalalita Rahmatina Sasmito Nugroho Sasmito Nugroho Sofia Mubarika Sri Astuti Sudadi Sunarto Sunarto Susetyowati Sutaryo Sutaryo Teguh Triyono Tunjung Wibowo Usi Sukorini Wahyu Budiyanto Weny Inrianto Yeow Liang Yuliani Purwantika