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All Journal Majalah Obstetri dan Ginekologi Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JKM (Jurnal Kebidanan Malahayati) Journal of Health, Education, And Literacy (J-Healt) Biomolecular and Health Science Journal Pediomaternal Nursing Journal Majalah Biomorfologi (Biomorphology Journal) JIK (Jurnal Ilmu Kebidanan) Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL

Sri Ratna Dwiningsih

Departemen Obstetri Dan Ginekologi Fakultas Kedokteran Universitas Airlangga Surabaya

Author-ID : 2650021

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Relationship of Antral Follicle Count (AFC) with Levels of Estradiol Serum and Mature Ovarian Follicles in Women Undergoing the IVF Program at the Graha Amerta Fertility Clinic of General Hospital of Dr. Soetomo in the Period 2018 Anak Agung Renjani Kanya Kumari; RenyI’tishom; Hendy Hendarto; Sri Ratna Dwiningsih
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15608

Background: In the last two decades, one of the critical factors of assisted reproductive technology (ART)has been identified as ovarian capacity. Consequently, ovarian capacity markers have evolved to be part ofdiagnostic testing conducted regularly before IVF. Several predictor factors, such as antral follicle count(AFC), is one of several factors to predict ovarian capacity. These diagnostic procedures and tests have thepurpose of identifying women at high-risk patient who respond poorly toward controlled ovarian stimulationthroughout the IVF cycle. The ovarian response toward ovulation stimulation within this research was assessedby peak estradiol (E2) serum levels and the total number of mature follicles. There is no clear relationshipbetween AFC and levels of estradiol serum and the number of mature ovarian follicles to identify womenwho respond poorly. Methods: This study is an analytical study with a cross-sectional design. Samples weretaken from secondary data of medical records using the total sampling method on women undergoing the IVFprogram at the Graha Amerta fertility clinic of General Hospital of Dr. Soetomo from January 1 to December31 2018 according to the inclusion and exclusion criteria. The AFC variables, estradiol serum levels, and thenumber of mature ovarian follicles in the study were analyzed using Spearman’s correlation. Conclusion:There is a significant relationship between antral follicle count (AFC) with the levels of estradiol serum andthe number of mature follicles in women undergoing the IVF program.

Correlation between obesity and successful ovulation induction with Clomiphene citrate Rida Eka Setiani; Sri Ratna Dwiningsih; Gadis Meinar Sari
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.8309

ABSTRACTOvulation induction with clomiphene citrate is a hormonal therapy for infertile women with impaired ovarian function caused by dysregulation of the hypothalamus and pituitary, affecting egg development and ovulation. Several factors, such as obesity, influence the success rate of treatment with clomiphene citrate. According to the Asia-Pacific classification, obesity was classified into two categories, obesity type I (25-29,9 kg/m2) and obesity type II (≥30 kg/m2). The success rate of ovulation induction with clomiphene citrate in obese infertile women at Graha Amerta Fertility Clinic in Dr. Soetomo General Hospital on July 2019 – July 2020 was about 22.8%. The research aimed to analyze the correlation between obesity with successful ovulation induction with clomiphene citrate. This research method was observational analytic research with a cross-sectional approach. The data were collected from medical records of infertile obese women who undergo ovulation induction with clomiphene citrate. According to inclusion criteria, the number of samples is 79 cycles of infertile obese women who undergo ovulation induction with clomiphene citrate. Data analysis using Chi-square test. The result showed that successful ovulation induction in obese type I was 17.7% and in obese type II was 5.1%. There was a correlation between obesity with successful ovulation induction with clomiphene citrate (p=0.009). In conclusion, there was a correlation between obesity with successful ovulation induction.Keyword : ovulation induction, clomiphene citrate, obeseCorrespondence : sri-r-d@fk.unair.ac.idation induction.

Pengaruh Monoklonal Antibodi Bovine Zona Pelusida 3 (bZP3) terhadap Diameter dan Atresia Folikel Ovarium Mencit (Mus musculus) Annisa Trissatharra; Sri Ratna Dwiningsih; Ratna Sofaria Munir
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Objectives: To identify the effect of monoclonal antibody bZP3 at ovarian follicles that undergo atresia and diameter of various ovarian follicles.Materials and Methods: This is a true experimental research with post only control group design. Samples were 36 female mices (Mus musculus) which is divided into 6 groups, there are 3 control groups (group 1, 2, and 3) injected by Phospatase Buffer Saline (PBS) 50µl and 3 treatment groups (group 4, 5, and 6) injected by Mab bZP3 50µl. Group 1 and 4 terminated at 5th day, group 2 and 5 terminated at 10th day, and group 3 and 6 terminated at 20th day. Evaluation of atretic ovarian follicles and diameter of ovarian follicles performed by hematoxylin eosin (HE) and the data processed by parametric statistic.Results: There are no significant in different among groups in the aspect of atretic follicles and diameter of folicles (p>0.05), but descriptively, number of follicles undergo atresia of the follicle primary, secondary, and tertiary treatment group was higher than the control group, except on the 20th day of observation time.Conclusion: administration of Mab bZP3 had no effect to amount of atretic follicles and diameter of folicles during observation time.

Effect of bone marrow mesenchymal stem cells transplantation on BMP-15 expression and Graafian follicle count in mice model of endometriosis Ratriana Via Parasti; Widjiati Widjiati; Sri Ratna Dwiningsih
Majalah Obstetri dan Ginekologi Vol. 26 No. 3 (2018): December
Publisher : Universitas Airlangga

Objectives: To determine the effect of bone marrow mesenchy-mal stem cells (BMSCs) on BMP-15 expression and Graafian follicle count in endometriosis mice.Material and Methods: This study was a laboratory randomized clinical trial on Mus musculus. The object of the study was 42 mice which were divided into 3 groups, the control, endome-triosis, and endometriosis + BMSCs groups. Comparison of BMP-15 expression and Graafian follicle count between groups was evaluated.Results: Immunohistochemical analysis showed that BMP-15 expression in control, endometriosis, and endometriosis + BMSCs groups had p=0.551, p=0.446 and p=0.917 with ANOVA test p=0.273, indicating no statistically significant differences between groups . Graafian follicular count in the three groups had p=0.31, p=0.001, and p=0.006, with the Kruskal-Wallis test p=0.001. Graafian follicles in the endometriosis + BMSCs group were higher than those in control and endometriosis groups.Conclusion:In the endometriosis mouse model with bone mar-row stem cell transplantation the BMP-15 expression in each group did not show a difference, but a significant difference was found in the number of Graafian follicles.

The Comparison of Total Cholesterol Level in DMPA and Combination Injection Contraception Users Rara Yumna Elfrida; Gadis Meinar Sari; Sri Ratna Dwiningsih; Pudji Lestari
Pediomaternal Nursing Journal Vol. 6 No. 2 (2020): VOLUME 6 NO 2 SEPTEMBER 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/pmnj.v6i2.20352

Introduction: Hormonal injection contraception is the most widely used method of contraception in Indonesia. In long-term use, one of the side effects of injection contraception is changes in lipid metabolism in the body caused by the accumulation of hormones in the body. Two types of injectional contraception are widely used in Indonesia, namely combined injection and DMPA injection; different hormonal content has various side effects on the lipid profile. This study aimed to compare the total cholesterol level between acceptors of DMPA injection and combined injection.Methods: This study used an observational analytic method with a cross-sectional approach. The sample size is 60 respondents, including 30 DMPA injection acceptors and 30 combination injection acceptors. The sampling method uses a purposive sampling technique The independent variable in this study was the total cholesterol level of the acceptor, and the dependent variable was the acceptor of DMPA injection and the combination injection acceptor. Analysis of research data used the Independent T-test with α=0.05.Results: The results of the bivariate analysis found significant differences in total cholesterol levels in the DMPA injection contraception acceptor and combination injection with p= 0.037. It was found that overall cholesterol levels of DMPA injection acceptors were higher.Conclusion: There is a difference in total cholesterol levels in the DMPA injection contraception acceptor with a combination injection contraception acceptor.

Night Shift Work Accelerates Menopausal Age in Health Workers Sri Ratna Dwiningsih; Samsulhadi Samsulhadi; Arif Tunjungseto; Monika Lijuwardi; Arsana Wiyasa
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.25361

Introduction: Earlier menopause has been associated with increased risk of cardiovascular disease, osteoporosis, shorter life expectancy and even cognitive decline. There are many factors that cause differences in the age of menopause in women, one of these environmental factors is a history of night shift work as a consequence of a job. It is not yet known whether female medical workers, with a history of night shifts, get earlier menopause.Methods: This case control study was conducted among 57 female night workers of the Dr. Soetomo General Academic Hospital. Data collection was conducted from December 2019 - March 2020. The study sample was postmenopausal health workers (nurse and midwife) and administrators. The instrument used in this study was a list of interview questions. The data was processed using SPSS software release 23.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA Anindya Marcha Angelina Djianto; Tri Hartini Yuliawati; Sri Ratna Dwiningsih; Widjiati Widjiati
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Background: Ibuprofen is one of the most used non-steroidal anti-inflammatory drugs (NSAID) due to its ease of access without the need of prescription. However, ibuprofen may cause side effects associated with gastrointestinal mucosal injury. The discomfort caused when eating may cause nausea and loss of appetite which leads to weight loss. Objective: This study was done to prove changes in body weight after treatment of oral ibuprofen using mice as test subjects. Material and method: This study used pre-test post-test control group design. 33 female BALB/c mice were grouped into 3 groups (P1, P2, P3). P1 is a control group which was given aquadest as placebo, P2 was given 52 mg/kg body weight of oral ibuprofen and P3 was given 104 mg/kg body weight of oral ibuprofen. Treatment lasted for 15 days. Results were analyzed using Kruskal-Wallis test and Mann-Whitney U test in IBM SPSS Statistics 22. Result: 80% of the mice had their body weights decreased with an average decrease of 0.91 g (±2.26) in group P1, average decrease of 2.2 g (±2.15) in P2, and average decreased of 4.11 g (±2.62) in P3. Statistical analysis showed that body weight changes of group P3 has significant difference (p = 0.009) compared to P1 and P2. Conclusion: It can be concluded that 104 mg/kg dose of oral ibuprofen caused a decrease in body weight of female mice.

GANGGUAN MENSTRUASI PADA AKSEPTOR DMPA TIDAK TERKAIT IMT Cicilia Valentine Simamora; Sri Ratna Dwiningsih; Ninik Darsini
Indonesian Midwifery and Health Sciences Journal Vol. 3 No. 3 (2019): Indonesian Midwifery and Health Sciences Journal, July 2019
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v3i3.2019.196-203

Abstrak Latar Belakang: Kejadian akseptor drop out tertinggi karena efek samping yaitu pada metode suntikan. KB injeksi DMPA memiliki efek samping gangguan menstruasi. Untuk menjamin lancarnya menstruasi, wanita harus mempunyai kadar lemak sebanyak 22% dari berat badannya. Kadar lemak dapat ditentukan dengan menilai berat badan seseorang melalui pengukuran Indeks Massa Tubuh (IMT). Penelitian ini bertujuan untuk mempelajari hubungan IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA di Puskesmas Jagir. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Jumlah sampel sebanyak 67 orang meliputi akseptor KB injeksi DMPA di Puskesmas Jagir sesuai dengan kriteria inklusi. Sampling dilakukan dengan total sampling. Variabel bebas dalam penelitian ini adalah IMT pada akseptor KB injeksi DMPA, sedangkan variabel tergantung adalah gangguan menstruasi pada akseptor KB injeksi DMPA. Untuk mengetahui tingkat signifikan, data yang terkumpul akan diuji dengan uji statistik Pearson pada tingkat kemaknaan α=0,05. Hasil: Hasil penelitian didapatkan bahwa sebagian besar responden memiliki IMT normal (55,2%), IMT kurus (3,0%) dan IMT overweight (41,8%). Hampir seluruhnya mengalami gangguan menstruasi (88,1%) dan yang tidak mengalami gangguan menstruasi (11,4%). Setelah uji Pearson diperoleh nilai p=0,140 (p>0,05) yang berarti bahwa tidak ada hubungan antara IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA. Kesimpulan: Tidak ada hubungan antara IMT dengan gangguan menstruasi pada akseptor KB injeksi DMPA di Puskesmas Jagir. Abstract Background: The incidence of drop out acceptors mostly due to side effects, is found on the injection method. DMPA injection has side effects of menstrual disorders. To ensure a fluent menstruation, women should have fat mass at least 22% of their body weight. Fat mass can be determined by measuring the Body Mass Index (BMI). This research aims to study the relationship of BMI with menstrual disorders in DMPA injection receiver at Puskesmas Jagir. Methods: This research is an observational analytic research with a cross sectional approach. A total sample of 67 people included DMPA injection receiver at Puskesmas Jagir corresponding for inclusion criteria. Sampling is done by total sampling. The independent variable in this study was BMI in DMPA injection receiver, while the dependent variable was menstrual disorders in DMPA injection receiver. To determine a significant level, the collected data will be tested by Pearson at the significance level of α = 0.05. Results: The results of the study showed that most of respondents had normal BMI (55.2%), thin BMI (3,0%) and overweight BMI (44.8%). Most of them experienced menstrual disorders (88.1%) and others did not experience menstrual disorders (11.4%). After the Pearson test, the value of p = 0.140 (p > 0.05) which means that there is no relationship between BMI and menstrual disorders in DMPA injection receiver. Conclusion: There is no relationship of BMI with menstrual disorders in DMPA injection receiver at Puskesmas Jagir.

OMEGA 3 SUPPLEMENTATION DECREASE A BLOOD CHOLESTROL LEVEL IN TRAINED WOMEN Diana Rahima; Bambang Purwanto; Sri Ratna Dwiningsih
Indonesian Midwifery and Health Sciences Journal Vol. 5 No. 1 (2021): Indonesian Midwifery and Health Sciences Journal, January 2021
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v5i1.2021.13-17

AbstractBackground : Trained woean who experiencing menstrual disoders are found with high blood cholesterol level. This situation is contrary to who don’t experience menstrual disorder. Mentrual disorder condition has a low estrogen level. The low estrogen level is associated with endothelial disfunction which causes blood cholesterol increase. The benefit of omega 3 supplementation have been clinically proven to prevent atherosclerosis, decrease blood cholesterol levels, and playong an important role in modulating inflamation. Omega 3 supplementation is expected to decrease blood cholesterol levels in trained women. Method: This research is using field experimental with case control method. The samples are 30 trained womens contained by 15 are controlled and 15 are given treatment. The sampling technique is randomized allocation. The independent variabel is omega 3 300mg supplementation and the dependent variabel is blood cholesterol levels. Data are analized using parametric statistic paired T-test. Result: The bivariate analysis showed there is a meaningful difference on blood cholesterol levels in the treatment group p=0,0027 and no change in control group p=0,191 during treatment for 8 weeks. Conclusion: Omega 3 supplementation decrease a blood cholesterol levels in trained women.

THE BODY MASS INDEX (BMI) RELATED TO MENOPAUSE SYMPTOMS Olvinda Eka Zulfi; Sri Ratna Dwiningsih; Ilya Krisnana
Indonesian Midwifery and Health Sciences Journal Vol. 5 No. 1 (2021): Indonesian Midwifery and Health Sciences Journal, January 2021
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v5i1.2021.73-87

AbstractBackground : Menopause is a natural period in a woman's life related to hormonal changes and is marked by the cessation of menstruation in the last 12 months and can cause a wide range of sometimes bothersome menopause symptoms. That menopause symptoms associated with several risk factors such as Body Mass Index (BMI) and knowledge. The study aims to identify the relationship of BMI and knowledge with menopause symptoms in the Shafa group Padang Petok Nagari Panti Selatan. Method : This research is analitic observational research with cross sectional approach. The sampling technique was carried out by total sampling consisting of 55 respondents with inclusion criteria menopause women aged 45-65 years who have not experienced dementia, have good awareness and willing to be respondents. Data were obtained by weighing, measuring height and filling out The Menopause Rating Scale to evaluate the severity of menopause-related symptoms by respondents. Afterwards the data was analyzed by the Spearman rho test to see the association between BMI and knowledge with menopause symptoms. Result : The research shows 65,4% respondents with high BMI, 72,7% with lacking of knowledge and 60% with severe menopause symptoms. The results of the Spearman rho test showed a relationship between BMI and menopause symptoms (p value = 0.000), but there is no relationship between knowledge of menopause and menopause symptoms (p= 0,450). Conclusion : BMI related to menopause symptoms. Menopause women must monitor their weight in an effort to prevent these complaints.

Co-Authors -, Nur Mulyani Amalia Ramadhani Anak Agung Renjani Kanya Kumari Anindya Marcha Angelina Djianto Annisa Trissatharra Arsana Wiyasa Bambang Purwanto Cicilia Valentine Simamora Dhea Hesty Purwaningrum Diana Rahima Hendy Hendarto HERAWATI, LILIK I'tishom, Reny Ilya Krisnana, Ilya Monika Lijuwardi Ninik Darsini Noor Syafaatin Udhma Oktavianti, Anisa Dwi Olvinda Eka Zulfi Pratiwi Dwi Trisnanti Pudji Lestari Putri Lisdiana Rahmawati Rara Yumna Elfrida Ratna Sofaria Munir Ratriana Via Parasti Rida Eka Setiani Samsulhadi Samsulhadi Sari, Gadis Meinar Siti Khaerunnisa Sofia Al Farizi Sudaryanti, Lestari Sulistiawati Sulistiawati Thengkano, Irwanto Tri Hartini Yuliawati Tunjungseto, Arif Vienda Leony Agustina Widjiati Widjiati Yanuari Primariawan, Relly Yetti Hernaningsih Zafirah Delia

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