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All Journal E-Jurnal Medika Udayana JURNAL BIOMEDIK Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) Journal of Global Pharma Technology Bali Dermatology Venereology and Aesthetic Journal
Anak Agung Gde Putra Wiraguna
Department Of Dermatology Faculty Of Medicine, Udayana University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peran sirkumsisi sebagai pencegahan infeksi herpes genetalis: suatu studi kohort retrospektif Made Wardhana; Martina Windari; Marrietta Sugiarti Sadeli; Anak Agung Gde Putra Wiraguna; Ni Made Dwi Puspawati; I Gusti Ayu Agung Elis Indira; Pande Agung Mahariski
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.07 KB) | DOI: 10.15562/ism.v12i2.1069

Abstract

Background: Recurrent genital herpes (RGH) is a sexually transmitted infection that is a serious public health problem and is quite prominent in most countries worldwide. Management for this infection is antiviral and circumcision. Male circumcision significantly reduces human immunodeficiency virus (HIV) infection and other sexually transmitted infections. This research aims to evaluate circumcision efficacy as the prevention for herpes simplex virus type 2 (HSV-2) infection compared with oral acyclovir.Methods: This research is an experimental study with a retrospective cohort approach. We included 45 males, 24 subjects circumcised and 21 subjects without circumcision and took oral acyclovir as standard treatment. RGH was diagnosed based on typical clinical manifestation. Follow up treatment every two weeks and continued to 2 months after circumcised and given with oral acyclovir. Successful treatment was stated without recurrent genital herpes.Results: Of 24 circumcised subjects, 19 were cured, and five non-circumcised subjects suffered recurrent genital herpes (not cured). Among 21 subjects without circumcision was cured, and 12 subjects were not cured. Based on these results, the value of NNT= 2.7.Conclusion: Circumcision can be considered effective in reducing the incidence of HGR and prevent recurrence of HGR with the NNT value of 2.7.  Latar Belakang: Herpes genetalis rekuren (HGR) merupakan infeksi menular seksual menjadi masalah kesehatan masyarakat yang serius dan cukup menonjol pada sebagian besar negara di dunia. Penanganannya adalah oral dengan antivirus dan tindakan sirkumsisi. Sirkumsisi pada pria secara signifikan mengurangi insiden infeksi human immunodeficiency virus (HIV) dan penyakit infeksi menular lainnya. Penelitian ini mengevaluasi efikasi sirkumsisi sebagai pencegahan infeksi virus herpes simpleks tipe 2 (HSV-2) dibandingkan dengan pemberian obat asiklovir.Metode: Studi ekperimental dengan pendekatan retrospektif kohort dengan mengikutsertakan 45 subjek pria dewasa, 24 subjek disirkumsisi dan 21 tanpa sirkumsisi dan hanya diberikan asiklovir sebagai obat standar. Diagnosis HGR dilakukan secara klinis dengan yang manifestasi klinis yang khas da pemeriksaan Tzanck. Setelah pemberian terapi dilakukan kontrol setiap 2 minggu sampai 2 bulan. Terapi dinyatakan berhasil bila tidak ada kekambuhan.Hasil: Dari 24 subjek disirkumsisi, 19 subjek dinyatakan sembuh dan 5 subjek mengalami kekambuhan (tidak sembuh). Dari 21 subjek tanpa sirkumsisi, 9 subjek dinyatakan sembuh dan 12 subjek dinyatakan tidak sembuh. Berdasarkan hasil ini didapatkan nilai NNT=2,7.Simpulan: Sirkumsisi dapat dinilai cukup efektif mengurangi angka kejadian HGR dan dapat mencegah kekambuhan HGR dengan nilai NNT 2.7.
Administration of Topical Passion Fruit Extract Cream (Passiflora edulis) inhibits the Increase of MMP-1 Levels and Decreases the Amount of Collagen in Wistar Rats (Rattus norvegicus) Exposed to UV-B Rays Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Aging skin is most prevalent due to exposure to sunlight, especially UV-B rays. UV-B rays which stimulate the formation of free radicals are highly reactive molecules with unpaired electrons that can cause elevated levels of MMP-1, causing a decrease in the amount of skin collagen. This study was an experimental animal study with a post-test only control group design.  Method: A total of 36 Wistar rat were divided into 2 groups, each consisting of 18 Wistar rat, the control group was smeared with placebo cream and the treatment intervention group was smeared with passion fruit seed extract cream 100%, all groups were exposed to UV-B with a total dose of 840 mJ / cm ² for 4 weeks, then an excision was carried out for the examination of dermis collagen amount and level of MMP-1.  Result: The results of the comparative analysis of the two groups using independent t-test showed that there were significant differences between the two groups, the mean level of MMP-1 and the mean amount of collagen with p <0.05. The mean level of MMP-1 and the mean amount of collagen treatment in intervention group were 2.32% and 70.32%, and control group showed the mean level of MMP-1 and the average amount of collagen at 2.99% and 63.63% respectively.  Conclusion: the administration of passion fruit seed extract cream inhibited the increase of level of MMP-1 and the decrease of total collagen level in Wistar rat skin was exposed to UV-B.Keywords: Passion fruit, MMP-1, collagen, Skin.
Topical Applications of Caulerpa spp. Extract Preventing Skin Aging through Improving Skin Moisture, Pigmentation and Decrease Laxity Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Caulerpa spp. extract contains neoxanthin, free astaxanthin, antheraxanthin, canthaxanthin, astaxanthin monoester, fucoxanthin, astaxanthin diester, and beta carotene, vitamins A, C, and E, minerals, amino acids and polyphenols which are photocemoprotective as to protect skin from damage caused by exposure to UV-B rays. This study aims to determine the effectiveness of topical 0.2% Caulerpa spp. extract in preventing premature skin aging in research subjects assessed by the parameters of skin moisture, pigmentation, and laxity of the skin. Method: This study was purely experimental research, using the randomized double-blind pretest-posttest control group design. A total of 40 research subjects participated in this study and were divided into two groups, namely the treatment group of 20 subjects, who were given interventions in the form of topical 0.2% Caulerpa spp. extract gel on the face, and the control group of 20 subjects who were given intervention in the form of application topical base cream on the face. All groups performed a pretest with a simple A-one scanner to assess skin aging with moisture, pigmentation, and laxity parameters on the skin. The two study groups were then treated for one month and post-tested. The research data was then collected for statistical analysis of using independent t-test and paired sample t-test. Results: Differences in skin assessments were analysed before and after therapy. Differences in assessment before therapy obtained p<0.05 on laxity and pore variables. Differences in assessment after treatment were found to be p<0.05 also in laxity and pores. Test differences in skin assessment in the two groups with Mann-Whitney using the difference in values after and before therapy obtained p<0.05 in pigmentation, laxity, humidity, pores, sebum U zone, and sebum T zone. Conclusion: Topical administration of topical Caulerpa spp. gel on the face has a photo protective effect by reducing pigmentation and laxity and increasing skin moisture.Keywords: Caulerpa spp., Skin aging, Pigmentation, Laxity.
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Stefani Nurhadi
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 1 No. 2 (December 2018)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ya8fq451

Abstract

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state. Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris. Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method. Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% CI 2.765-8.332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
Bacterial vaginosis as a risk factor of preterm premature rupture of membrane (PPROM) Anak Agung Gde Putra Wiraguna; Luh Made Mas Rusyati; I Dewa Ayu Vanessa Vijayamurthy
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 1 No. 2 (December 2018)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/0g76d102

Abstract

Introduction: The pathogenesis of PPROM is complex and not fully understood. Recent studies showed that such role of genital tract infection as bacterial vaginosis in the pathogenesis of PPROM turned out to be present. They produce lipase enzymes in which they can form compounds with the fibrous tissue of the amniotic membrane resulting in an increased risk of rupture of the membrane. Objective: This study aims to prove that bacterial vaginosis is a risk factor for preterm premature rupture of membrane. Material and methods: This research used the case-control method. Sampling was using the consecutive sampling method and had fulfilled inclusion and exclusion criteria with age-based matching, then vaginal swab sampling was conducted, painted with gram staining in the Dermatology and Venereology Laboratory of Sanglah Hospital, and Nugent score. Result: Total of 76 pregnant women with 24-36 weeks of gestation were investigated, 38 mothers with PPROM and 38 mothers with normal pregnancy. The average score of Nugent at preterm PROM was 7.18 and in normal pregnancy was 2.37. Bacterial vaginosis risking for PPROM 7 times (OR= 7.0, 95% CI= 1.21-17.68, p= 0.001). Conclusion: Bacterial vaginosis as a risk factor for the occurrence of PPROM.
High plasma H2O2 level and low plasma catalase level as risk factors for acne vulgaris Anak Agung Gde Putra Wiraguna; Made Wardhana; Made Kusuma Dewi Maharani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 2 No. 1 (June 2019)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/vacekd89

Abstract

Background: In this recent time, ROS and oxidative stress have been said to play an important role in the pathogenesis of inflamed acne lesions. One example of ROS produced by neutrophil through phagocytosis is H2O2. Nevertheless, there is an enzymatic antioxidant which catalyses H2O2 called catalase. Imbalance of free radicals and antioxidants due to excessive ROS formation promotes the state of oxidative stress and inflammation of the acne lesion. Objective: This study aimed to determine plasma H2O2 and catalase level as a risk factor for acne. Methods: This matched-pair case-control observational analytic study involving 38 patients with acne and 38 patients without acne. Sampling was done using consecutive sampling which fulfils the inclusion and exclusion criteria and followed by matching with age and gender. H2O2 and catalase level measured on both groups. The analysis was done using SPSS. Results: H2O2 mean level in the case and control group, respectively 0.68 ± 0.03 and 0.42 ± 0.04 µmol/ml. High H2O2 level was determined from cut-off point >0.62 µmol/ml. High H2O2 was a statistically significant risk factor for acne vulgaris (p<0.001; 95% CI: 4.59-40.62; OR: 13.67). The mean level of catalase in the case and control group respectively 0.48 ± 0.06 and 0.74 ± 0.07 U/ml. Low catalase level was determined from the cut-off point <0.58 U/ml. Catalase was significant risk factor for acne vulgaris (p<0.001; 95% CI: 5.18-77.21; OR: 20.00). Conclusion: High levels of H2O2 plasma and low levels of catalase plasma is a risk factor of acne vulgaris.
The positive correlation between serum malondialdehyde levels with vitiligo severity and activity I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Putu Nila Wardhani Batan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 2 No. 1 (June 2019)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/y650jm10

Abstract

Background: There are several theories that suggest melanocyte death in vitiligo, one example is oxidative stress theory. Oxidative stress primarily manifested by lipid peroxidation ultimately produce malondialdehyde. Malondialdehyde is a stable marker to assess an oxidative stress event. The correlation between serum malondialdehyde levels and vitiligo severity and activity remained controversial in previous studies. Objective: This study aimed to verify whether or not the serum MDA levels are positively correlated with vitiligo severity and activity. Methods: This study was an analytical cross-sectional study. which involved 64 subjects with vitiligo and 20 subjects without vitiligo. Serum MDA levels were measured to mark an oxidative stress event, whereas the severity and activity of vitiligo were clinically assessed with vitiligo area severity index (VASI) and vitiligo disease activity (VIDA) scoring system. Results: Total 64 subjects with vitiligo and 20 subjects without vitiligo participated in this study. Serum MDA mean levels of vitiligo subjects were significantly higher compared to subjects without vitiligo (p<0.05). Serum MDA levels had a strong positive correlation with VASI score (r=0.761; p<0.01). The strong positive correlation found between serum MDA levels with vitiligo activity assessed by VASI score in vitiligo subjects (r=0.609; p<0.01), and high serum MDA levels increased the risk for developing vitiligo (PR=7.62; 95% CI: 2.49-23.30; p<0.01). Serum MDA levels influenced vitiligo as much as 10.1%, meanwhile the remaining 89.9% were influenced by other variables apart from high serum MDA levels out of this study (R2=0.101; p<0.05). Conclusion: Serum MDA levels were positively correlated with vitiligo severity and activity, and high serum MDA levels increased the risk of developing vitiligo.
Co-Authors Angela Sandi Tagaroi Rahasia Anne Carolina Kencanawati Astried Haryanto Balqis Wasliati Batan, Putu Nila Wardhani Bunge Dianmentari Chynthia Friama Diana Niti Santoso Dwindi Saptania Erwin Sugito Fatri Idana Fiter, Joni Gde Ngurah Idraguna Pinatih Golda Bernadet Lemewu I Dewa Ayu Vanessa Vijayamurthy I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Made Aman I Ketut Agus Somia Ida Bagus Gede Jayadharma Ida Sri Iswari Junivan Lindra Komang Aditya Yudistira Komang Saputra Yadnya Luh Made Mas Rusyati Made Kusuma Dewi Maharani Made Wardhana Maharani, Made Kusuma Dewi Marrietta Sugiarti Sadeli Martina Windari Maya Cesarya Simangunsong Meiny Linda Setiawan Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Wayan Winarti Olivia Julita Pande Agung Mahariski Phery Candres Prima Saraswati Sanjiwani Sudarsa Priskila Ariana Putu Nila Wardhani Batan Rahel Lisana Debora Hutagalung Somia Sri Subramaniam Stefani Nurhadi Vanessa Vijayamurthy Vijayamurthy, I Dewa Ayu Vanessa Wimpie I Pangkahila Yuziana Yuziana