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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Universa Medicina Jurnal Abdi Insani Jurnal Integrasi Kesehatan dan Sains Bandung Conference Series : Medical Science
Samsudin Surialaga
Fakultas Kedokteran Universitas Islam Bandung
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Journal : Althea Medical Journal

 1 
Effect of Cucumis sativus L on Glucose Absorption through Intestinal Mucosal Membrane of Wistar Rat Models Amalia, Fitri; Surialaga, Samsudin; Rachmayati, Sylvia
Althea Medical Journa Vol 1, No 1 (2014)
Publisher : Althea Medical Journa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.91 KB)

Abstract

Background: The Cucumis sativus L has been used in traditional medicine for several conditions, with one of them being diabetes mellitus. The purpose of this experiment is to observe the anti-hyperglycemic effect of Cucumis sativus L on glucose absorption through the intestinal mucosal membrane of Wistar rats.Methods: The research was conducted on September–November 2012 at Biochemistry Laboratory, Faculty of Medicine, Universitas Padjadjaran. Using in situ perfusion method, the rat’s epithelial mucosa in the intestine was bathed in a simple glucose solution in control, and bathed in glucose and Cucumis sativus L infusion in treatment. After admission, a sample was taken from the digestive tract and the glucose level was measured through a spectrophotometer.Result: There is no significant difference in the absorption of control and treatment solution.Conclusion: The Cucumis sativus L does not have any significant effect on the glucose absorption through the intestinal mucosal membrane. Further studies are still needed to reveal the antihyperglycemic mechanism of Cucumis sativus L.[AMJ.2014;1(1):30–4]Keywords: Antihyperglycemic effect, Cucumis sativus L (Cucumber), Diabetes mellitus, Glucose absorption Pengaruh Cucumis sativus L pada Penyerapan Glukosa melalui usus mukosa Membran Tikus WistarLatar Belakang: Buah timun (Cucumis sativus Linn.) telah dipercaya sebagai obat tradisional beberapa penyakit, salah satunya adalah diabetes melitus. Penelitian ini ditujukan untuk mengetahui efek antihiperglikemi buah timun terhadap transpor glukosa melalui sel epitel mukosa usus halus tikus wistar.Metode: Dengan menggunakan metode perfusi in situ, usus halus tikus dialiri larutan glukosa selama 60 menit untuk kontrol dan larutan glukosa yang telah diberi infusa timun selama 60 menit untuk perlakuan. Sampel yang diambil berupa cairan yang dialirkan ke usus pengambilan dilakukan pada menit ke 0, 15, 30, 45, 60, kemudian dilakukan pengukuran kadar glukosa dengan menggunakan spektofotometri. Penelitian ini dilakukan pada September–November 2012 di Laboratorium Biokimia, Fakultas Kedokteran, Universitas PadjadjaranHasil: Tidak terdapat perbedaan bermakna antara penyerapan glukosa pada larutan kontrol dengan larutan perlakuan.Simpulan: Cucumis sativus L tidak memiliki pengaruh yang signifikan terhadap penyerapan glukosa melalui membran mukosa usus. Penelitian lebih lanjut masih diperlukan untuk mengetahui mekanisme anti hyperglycemic Cucumis sativus L.Kata kunci: Cucumis sativus L (Cucumber), diabetes mellitus, efek antihyperglycemic, penyerapan glukosa
Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion Zartiana, Rizda Nurul; Surialaga, Samsudin; Permana, Hikmat
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease. This study aimed to analyse the effect of Psidium guajava leaf to inhibit glucose absorption in intestine epithelial membrane of wistar rats.Methods: This laboratory experimental study used 5 wistar rats as subjects in the Laboratory of Biochemistry at Padjadjaran University from 10−26 October 2012. All rats were given three solutions by in situ perfusionmethod. The first was 25 ml 3.0 X 10-3 M glucose solution, the second was 25 ml 3.0 X 10-3 M glucose solution with 1 ml Psidium guajava infusion added, and the third was 25 ml 3.0 X 10-3 M glucose solution.The sample from each solution was taken five times at 0, 15, 30, 45, and 60 minutes after the solutions were given. The spectrophotometer was to quantify the concentration of glucose from the samples. Data were analyzed using Friedman and Wilcoxon test.Results:The means of glucose concentration for each solution from the first solution to the third were 6.126 mg/dl, 2.447 mg/dl, and 5.345 mg/dl. The probability value showed significant difference between the first and second solutions (p ≤ 0.05).Conclusions: Psidium guajava leaf infusion can inhibit glucose absorption in wistar rat intestine and the effect is reversible. [AMJ.2015;2(4):546–9] DOI: 10.15850/amj.v2n4.508
Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion Rizda Nurul Zartiana; Samsudin Surialaga; Hikmat Permana
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.213 KB)

Abstract

Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease. This study aimed to analyse the effect of Psidium guajava leaf to inhibit glucose absorption in intestine epithelial membrane of wistar rats.Methods: This laboratory experimental study used 5 wistar rats as subjects in the Laboratory of Biochemistry at Padjadjaran University from 10−26 October 2012. All rats were given three solutions by in situ perfusionmethod. The first was 25 ml 3.0 X 10-3 M glucose solution, the second was 25 ml 3.0 X 10-3 M glucose solution with 1 ml Psidium guajava infusion added, and the third was 25 ml 3.0 X 10-3 M glucose solution.The sample from each solution was taken five times at 0, 15, 30, 45, and 60 minutes after the solutions were given. The spectrophotometer was to quantify the concentration of glucose from the samples. Data were analyzed using Friedman and Wilcoxon test.Results:The means of glucose concentration for each solution from the first solution to the third were 6.126 mg/dl, 2.447 mg/dl, and 5.345 mg/dl. The probability value showed significant difference between the first and second solutions (p ≤ 0.05).Conclusions: Psidium guajava leaf infusion can inhibit glucose absorption in wistar rat intestine and the effect is reversible. [AMJ.2015;2(4):546–9] DOI: 10.15850/amj.v2n4.508
Effect of Cucumis sativus L on Glucose Absorption through Intestinal Mucosal Membrane of Wistar Rat Models Fitri Amalia; Samsudin Surialaga; Sylvia Rachmayati
Althea Medical Journal Vol 1, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.91 KB)

Abstract

Background: The Cucumis sativus L has been used in traditional medicine for several conditions, with one of them being diabetes mellitus. The purpose of this experiment is to observe the anti-hyperglycemic effect of Cucumis sativus L on glucose absorption through the intestinal mucosal membrane of Wistar rats.Methods: The research was conducted on September–November 2012 at Biochemistry Laboratory, Faculty of Medicine, Universitas Padjadjaran. Using in situ perfusion method, the rat’s epithelial mucosa in the intestine was bathed in a simple glucose solution in control, and bathed in glucose and Cucumis sativus L infusion in treatment. After admission, a sample was taken from the digestive tract and the glucose level was measured through a spectrophotometer.Result: There is no significant difference in the absorption of control and treatment solution.Conclusion: The Cucumis sativus L does not have any significant effect on the glucose absorption through the intestinal mucosal membrane. Further studies are still needed to reveal the antihyperglycemic mechanism of Cucumis sativus L.[AMJ.2014;1(1):30–4]Keywords: Antihyperglycemic effect, Cucumis sativus L (Cucumber), Diabetes mellitus, Glucose absorption Pengaruh Cucumis sativus L pada Penyerapan Glukosa melalui usus mukosa Membran Tikus WistarLatar Belakang: Buah timun (Cucumis sativus Linn.) telah dipercaya sebagai obat tradisional beberapa penyakit, salah satunya adalah diabetes melitus. Penelitian ini ditujukan untuk mengetahui efek antihiperglikemi buah timun terhadap transpor glukosa melalui sel epitel mukosa usus halus tikus wistar.Metode: Dengan menggunakan metode perfusi in situ, usus halus tikus dialiri larutan glukosa selama 60 menit untuk kontrol dan larutan glukosa yang telah diberi infusa timun selama 60 menit untuk perlakuan. Sampel yang diambil berupa cairan yang dialirkan ke usus pengambilan dilakukan pada menit ke 0, 15, 30, 45, 60, kemudian dilakukan pengukuran kadar glukosa dengan menggunakan spektofotometri. Penelitian ini dilakukan pada September–November 2012 di Laboratorium Biokimia, Fakultas Kedokteran, Universitas PadjadjaranHasil: Tidak terdapat perbedaan bermakna antara penyerapan glukosa pada larutan kontrol dengan larutan perlakuan.Simpulan: Cucumis sativus L tidak memiliki pengaruh yang signifikan terhadap penyerapan glukosa melalui membran mukosa usus. Penelitian lebih lanjut masih diperlukan untuk mengetahui mekanisme anti hyperglycemic Cucumis sativus L.Kata kunci: Cucumis sativus L (Cucumber), diabetes mellitus, efek antihyperglycemic, penyerapan glukosa DOI: 10.15850/amj.v1n1.294
Co-Authors Ahmad Rizki Akbar Dwiputra Andreanus A. S Ani Melani Maskoen Anna Martiana Annisa Rahmah Furqaani Arief Guntara Deandra Chitraenrieta Ramdhanoviella Diah Dhianawaty Dika Rifky Fernanda Edhyana Sahiratmadja Eka Hendryanny Fildza Khadijah Fitri Amalia Fitri Amalia Franseda Franseda Gibran Bramasta Dirgavansya Haura Maulidayanthi Heni Muflihah Herman Susanto Herry Garna Heru Haerudin Hikmat Permana Lelly Yuniarti Mas Rizky A. A. Syamsunarno Maulina Isnaini Sugiantoro Maulina Isnaini Sugiantoro Miska Amani Nabilla Azmi Hermawan Nurul Romadhona Pricilla Purushothman Puspita, Sara Putra Zam Zam Rachmatullah R. Ayu Wulandari Sekarini Ramdan Panigoro Rd.Tiara Indah Persariningrat Rizda Nurul Zartiana Rizda Nurul Zartiana, Rizda Nurul Rizki Suganda Prawiradilaga Rizky Suganda Prawiradilaga Siti Annisa Devi Trusda, Siti Annisa Devi Sylvia Rachmayati Uci Ary Lantika Vira Yuliana Suprayitno Wiwin Winarti Yani Triyani Yuniarti Zahra Shafa Qamilla Zulmansyah , Zulmansyah