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All Journal Smart Medical Journal Alami Journal (Alauddin Islamic Medical) Journal GHIDZA: Jurnal Gizi dan Kesehatan Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Jurnal Komunitas Kesehatan Masyarakat Jurnal Abmas Negeri (JAGRI) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Cermin Dunia Kedokteran
Andi Weri Sompa
UNIVERSITAS MUHAMMADIYAH MAKASSAR
Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Efektivitas Citicoline sebagai Agen Neuroprotektif dalam Tata Laksana Traumatic Brain Injury Wilaksono, Bhirau; Sompa, Andi Weri
Cermin Dunia Kedokteran Vol 50 No 12 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i12.1015

Abstract

Background: Traumatic brain injury (TBI) is a condition resulting from physical trauma to the head which can cause structural damage to the brain and interfere with cognitive, motor and emotional functions. Citicoline is a natural compound that plays an important role in phospholipid metabolism and neurotransmitter synthesis in the brain. This evidence-based case report (EBCR) study aims to provide scientific evidence of the potential benefits of citicoline in improving clinical outcomes in TBI patients. Method: Literature search using the PICO format. The formulation of clinical questions was arranged by case. Search for articles on March 6–7th 2023 using the Publish or Perish (PoP) software with the target of searching articles for the last 10 years (2013-2023) on the Scopus, Pubmed, Google Scholar databases, and manual searches on the Cochrane database, using the keyword 'traumatic brain' injury' AND 'therapy' AND 'citicoline' AND 'neuroprotective' AND 'treatment' AND 'outcome' along with synonyms and related terms. Results: Four studies were obtained, with the level of evidence 1a which resulted from a meta-analysis or systematic review of various randomized controlled trials, which were then critically reviewed. Two studies reported no significance of clinical assessment and the Glasgow Coma Scale (GCS); two other studies showed significant results at the level of independence. Conclusion: This study shows that citicoline is beneficial in the independence of TBI patients but does not produce a significant difference in the Glasgow Coma Scale assessment.
Co-Authors Abdul Muis Abdul Rahman Rahim Ahmad Zaki Ami Febriza Anastasia Juliana Andi Dian Diarfah Andi Kurnia Bintang Andi Makbul Aman Andi Riska Gunawati Bhirau Wilaksono Dito Anurogo Emy Andira Maricar, Nadra Muhammad Akbar Nirwana Fitriani Walena Nurmayasari.H.Abd.Rauf Rauly Rahmadhani Rauly Rahmadhani Rina Masadah Rina Masadah Suarni, Agusdiwana Susi Aulina Umar, Husaini Wilaksono, Bhirau Wulaa, Nurwapina Langga Yudy Goysal Yushusna Yusbar