This study aims to analyze the influence of industrial work practice experience and social media utilization on the entrepreneurial interest of Grade XII Marketing students at SMK Negeri 1 Medan. A quantitative approach with an ex post facto method was employed. The sample consisted of 64 students selected through a census technique. Data were collected using a questionnaire and analyzed using multiple linear regression with SPSS version 27. The results show that industrial work practice experience has a positive and significant effect on entrepreneurial interest (tcount = 5.751; sig. = 0.000), as does social media utilization (tcount = 3.171; sig. = 0.002). Simultaneously, both variables significantly influence entrepreneurial interest (Fcount = 36.285; sig. = 0.000). The coefficient of determination (R²) is 0.543, indicating that both independent variables contribute 54.3% to the variation in students’ entrepreneurial interest. These findings underscore the importance of hands-on experience and the strategic use of digital technology in fostering entrepreneurial spirit among vocational school students.