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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Urology Berkala Kedokteran Science and Technology Indonesia Health and Medical Journal Community Empowerment Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Eka Yudha Rahman
Department of Urology, Faculty of Medicine/Indonesia University, Cipto Mangunkusumo Hospital. Jl. Diponegoro No. 71 Jakarta 13420
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Aktivitas Antibiofilm Ekstrak Air Akar Pasak Bumi (Eurycoma Longifolia) Terhadap Biofilm Candida Albicans Atcc 10231 Tinjauan Parameter Minimal Biofilm Inhibitory Concentration (Mbic) Dan Mean Gray Value (Mgv) Azzahra, Jasmine Tarisha; Rahman, Eka Yudha; Khatimah, Husnul Khatimah
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1735

Abstract

Pendahuluan: Kandidiasis adalah infeksi jamur yang bisa diobati dengan obat seperti flukonazol dan ketokonazol. Namun, jamur bisa menjadi resisten dan bisa membentuk biofilm yang sulit diobati. Tanaman Eurycoma longifolia, atau pasak bumi yang berasal dari Kalimantan, mengandung zat bioaktif yang berpotensi sebagai antibiofilm. Tujuan: Tujuan penelitian ini adalah untuk menguji aktivitas antibiofilm ekstrak air akar Eurycoma longifolia terhadap biofilm yang dibentuk jamur C. albicans, berdasarkan parameter Minimum Biofilm Inhibitory Concentration (MBIC) dan nilai Mean Gray Value (MGV). Metode: Metode Penelitian ini eksperimental dengan rancangan true experimental post-test-only control-group design. Parameter yang diamati adalah Minimum Biofilm Inhibitory Concentration (MBIC) dan Mean Gray Value biofilm yang dihasilkan pada Candida albican dengan konsentrasi 5%, 10%, 20%, 40%, 80%, dan 100%, serta flukonazol 5% sebagai kontrol positif dan aquades steril sebagai kontrol negatif. Analisis data menggunakan Uji One-way Anova dan Post Hoc Duncan. Hasil: Hasil penelitian menunjukkan MBIC terdapat pada konsentrasi 10% dengan kejernihan sedang (+2). MGV pada konsentrasi 100% merupakan rerata tertinggi dengan nilai 162. Hasil analisis one-way-Anova (p<0.05), menunjukkan efek yang dihasilkan tiap kelompok perlakuan adalah berbeda bermakna. Uji Duncan (α 0,05), menghasilkan perbedaan bermakna rata-rata MGV dari setiap konsentrasi tidak berbeda bermakna dengan kontrol positif flukonazol 5%. Kesimpulan: Simpulan penelitian adalas ekstrak air akar E.longifolia menunjukkan aktivitas antibiofilm terhadap Candida albicans.
AKTIVITAS ANTIBAKTERI EKSTRAK AIR DAUN TALAS (Colacasia esculenta) TERHADAP Staphylococcus aureus ATCC.25923 IN VITRO Maulida, Maulida; Budiarti, Lia Yulia; Edyson, Edyson; Khatimah, Husnul; Rahman, Eka Yudha
Homeostasis Vol 8, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v8i2.18433

Abstract

Abstract: Staphylococcus aureus is a bacteria that causes infections transmitted through hand contact. The leaves of Colocasia esculenta L. Schott contain antibacterial compounds. This study aimed to analyze the antibacterial activity of water extracts from C. esculenta leaves against S. aureus, based on phenol coefficient values and inhibition zone diameters. The study used a posttest-only control group design with treatments at various concentrations (6.25%, 12.5%, 25%, 50%, 75%, and 100%) and controls of 70% alcohol and 5% phenol. The results showed a phenol coefficient value of >1 against S. aureus. Data analysis using One-way ANOVA and Post-hoc Duncan tests revealed significant differences with p<0.05. The inhibition zone at 100% concentration was 23.16 mm, classified as very strong. At 75% concentration, the inhibition zone was 19.5 mm, similar to the 19.56 mm zone produced by 70% alcohol. In conclusion, the extract shows strong antibacterial activity against S. aureus. Abstrak: Staphylococcus aureus (S.aureus) merupakan bakteri penyebab infeksi yang ditularkan melalui tangan. Daun Colocasia esculenta L. Schott mengandung senyawa antibakteri. Penelitian ini bertujuan menganalisis aktivitas antibakteri ekstrak air daun Colacasia esculenta terhadap Staphylococcus aureus berdasarkan nilai koefisien fenol dan diameter zona hambat. Penelitian menggunakan rancangan posttest-only with control group design. Perlakuan uji ekstrak air daun Colacasia esculenta (6,25%, 12,5%, 25%, 50%, 75%, dan 100%), kontrol alkohol 70%, fenol 5% sebagai pembanding. Hasil penelitian diperoleh nilai koefisien fenol >1 terhadap S.aureus. Data hasil penelitian di uji One-way ANOVA dan Post-hoc Duncan ditemukan perbedaan pada tiap perlakuan uji dengan p<0,05. Zona hambat Colacasia esculenta 100% yaitu 23,16 mm tergolong sangat kuat. Pada konsentrasi 75% diameter zona hambatnya 19,5 mm menghasilkan efek tidak jauh dari alkohol 70% yaitu 19,56 mm. Kesimpulan, ekstrak air daun Colacasia esculenta memiliki aktivitas antibakteri terhadap Staphylococcus aureus, berdasarkan nilai koefisien fenol dan diameter zona hambat.
Comparative Assessment of the Safety between Pazopanib and Sunitinib for Metastatic Renal Cell Carcinoma Rahman, Eka Yudha; Nur, Choirin; Yulizar, Deddy Rasyidan
Jurnal Kedokteran Brawijaya Vol. 32 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.02.4

Abstract

Renal cell carcinoma (RCC) is the most common kidney lesion with approximately 90% of all kidney malignancies and 30% of people with RCC have developed metastasis at the time of diagnosis. Based on European Association of Urology (EAU) guideline, therapy for metastatic RCC (mRCC) patient who cannot tolerate immune checkpoint inhibitor is pazopanib or sunitinib. However, these drugs cause several uncomfortable side effects for the patient. Therefore, this meta-analysis was made, based on the available evidence base, to compare the safety of pazopanib and sunitinib as the treatment of mRCC. Systematic reviews were made in accordance with the PRISMA guideline requirements, a literature review was conducted in January 2022 used PubMed, ScienceDirect, Cochrane Library, publishing year of at least 10 years with an adult population. And the data is analyzed using RevMan V.5.4. In total 1.665 participants, there were 431 patients taking pazopanib and 1.234 patients taking sunitinib from 8 studies. The result shows that sunitinib has more frequent result of side effects than pazopanib in several occasion like hand-foot syndrome, nausea/vomiting, skin rash, stomatitis & mucosal inflammation, leucopenia and thrombocytopenia. Meanwhile, there are no significant differences between pazopanib and sunitinib in causing other side effect such as fatigue, diarrhea, hypertension, anemia, and increased liver enzymes. The conclusion is that pazopanib is better and has less frequent side effects than sunitinib.
Emphysematous Cystitis with Bladder Mass caused by Colovesical Fistula: A Rare Case Report Rizal, Yosi; Rahman, Eka Yudha
Jurnal Kedokteran Brawijaya Vol. 32 No. 4 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.032.04.10

Abstract

Emphysematous cystitis (EC) is a rare manifestation of a complicated urinary tract infection, and its pathognomonic feature is a gas appearance inside the bladder wall and lumen. Emphysematous cystitis with bladder mass is an extremely rare finding. In this case study, a 59-year-old female presented with dysuria and pneumaturia for two months before admission. Following history taking and physical examination, a CT scan was performed to establish the diagnosis, which revealed thickening bladder wall with free gas appearance, impressing emphysematous cystitis. Urine culture showed no bacterial growth, cystoscopy revealed posterosuperior bladder mass, a biopsy was done followed by fulguration of the bladder and showed no malignancy, and MRI implied emphysematous cystitis with bladder dome adhesions of colon mass with colovesical fistula. After resection of colon anastomosis, colitis was found as the etiology of the colovesical fistula. An accurate diagnosis of the disease and correct treatment would result in a good prognosis and outcome.
Co-Authors Al-fath, Muhammad Fauzan Alexandro, Garry Annaba, Aziz Azzahra, Jasmine Tarisha Budiwinata, Winardi Didik Priyandoko Edyson Edyson, Edyson Fahdyanoor, Fahdyanoor Fatharoni, Gusti Dicky Hadiprasetyo, Dhanar Septyawan Husnul Khatimah Ika Kustiyah Oktaviyanti Istiana Istiana Khatimah, Husnul Khatimah Lena Rosida Lia Yulia Budiarti Maulida, Maulida Muhammad Halim Fathoni, Muhammad Halim Nafiah Syella, Nafiah Nafilah Syella, Nafilah Nia Kania Nur, Choirin Prawito Singodimedjo Rachman, M. Fathur Rizal Azis rizal, yosi Roselina Panghiyangani Sabrina, Adilah Hafizha Nur Skripsiana, Nika Sterina Sri Hayati Nufaliana, Sri Hayati Strata Pertiwi, Strata Sungsang Rochadi Sutapa, Hendra Trisula Utomo Umam, Akmal Fauzi Yusri WAHYU WIDOWATI Yulizar, Deddy Rasyidan Zakia, Sukma Dina