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All Journal Jurnal Psikologi Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Insight: Jurnal Ilmiah Psikologi Jurnal Ekonomi dan Bisnis Dharma Andalas Al-Qalb : Jurnal Psikologi Islam Jurnal Al Azhar Indonesia Seri Ilmu Sosial Jurnal Simki Economic Edu Cendikia: Jurnal Ilmiah Kependidikan Jurnal Ekonomika Dan Bisnis
Fitria Rahmi
prodi psikologi unand
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.642 KB) | DOI: 10.14499/indonesianjpharm0iss0pp12-19

Abstract

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay – to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) – was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 µg/m) for 48 h caused 13-84% growth inhibition (IC 5077 µg/mL) of the cells, while arecoline (ARE) treatment (10-500 µg/mL) showed 8-73% inhibition (IC50 180 µg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferative 
Co-Authors Bagus Riyono Boer, Novrizal Riady Dahar , Reni Dian Handayani Edy Meiyanto Herdiansyah, Rido lala septiyani sembiring, lala septiyani Liliyana Sari Natalia, Gita Nofriyanti , Lola Pratiwi, Nabila Ratna Asmah Susidarti Reni Dahar Rifedi, Satrifa Rustini Rustini Sarry, Septi Mayang Sri Handayani Yanti, Nino Sri Purnama Zarkasi, Irwa R. Zulkarnaini Zulkarnaini