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Combination of Doxorubicin and Areca Ethanolic Extract Induces Apoptosis by Increasing Caspase-3 Level on Breast Cancer (T47D) Cells Rahmi, Fitria; Meiyanto, Edy; Susidarti, Ratna Asmah
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Despite causing many side effects, doxorubicin (Dox) is still one of breast cancer drug of choice. Thus, combination of chemotherapy is developed in order to decrease doxorubicin regimen dose. The aim of this research is to examine the combination effect of doxorubicin (dox) and areca extract (AE) on T47D human breast cancer cells. The cytotoxic activity was determined using MTT assay. The combination index (Cl) of the combination treatment was calculated to determine the effects (synergistic, additive or antagonistic). The combination application of dox (6-22nM) and AE (8-30μg/ml) on T47D cells showed synergistic (Cl<0.9) or addictive effect )Cl =0.9-I.I). The effective combincation of dox-AE was 6nM-8μg/ml on Cl<0.5. Apoptosis induction of AE solely and its combination with dox was the observed using double staining method. Moreover, expression of Bax and caspase-3 protein which mediated apoptosis, were observed using immunocytochemistry. Combination of AE and Dox increased expression of Caspase-3 but did not increase expression of Bax. This result showed AE increase the effectiveness of doxorubicin against T47D cells.Keyword : Breast cancer, doxorubicin, areca extract, T47D cells
Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.642 KB) | DOI: 10.14499/indonesianjpharm0iss0pp12-19

Abstract

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay – to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) – was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 µg/m) for 48 h caused 13-84% growth inhibition (IC 5077 µg/mL) of the cells, while arecoline (ARE) treatment (10-500 µg/mL) showed 8-73% inhibition (IC50 180 µg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferative 
PENGAWASAN CAMAT DALAM PENATAAN PEMUKIMAN KUMUH DI KECAMATAN RUMBAI PESISIR KOTA PEKANBARU Rahmi, Fitria; ", Zulkarnaini
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 2: WISUDA OKTOBER 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Growth and development of an area of town is not always a positive affect. High population growth resulted in increased population density and an increased in the density of buildings for residential as well as an increased need of infrastructure to carry out activities in an effort to make ends meet. The increase in space requirements is almost always coupled with the growth and development of slums and squatter settlements in a region.Tassel coastal districts is one district that has slums, the residential area is located in one of the villages Meranti Pandak subdistrict coastal fringe. Villages that cannot escape the problem of untidiness. If it is left without treatment improvements will expand the existing slums. Efforts taken by the government to address this is through the implementation of the restructuring program of slums that have been implemented since the first approach taken by various coastal fringe districts, including mutual cooperation program of activities that include physical, environmental, and infrastructure there.One of the government programs in addressing the slum is a slum arrange evenly and thorough quality improvement in a very seedy area.This study aims to determine how much oversight arrangement slum districts on the fringe of society in the coastal city of Pekanbaru. The method used to achieve the purpose of the research is qualitative method.Keywords : Seedy, Structuring, Regulation, Supervision, Slums.
THE RELATIONSHIP BETWEEN CONSUMER INVOLVEMENT WITH BRAND AWARENESS IN THE PROCUREMENT OF SAMSUNG SMARTPHONE Rahmi, Fitria; Sarry, Septi Mayang; Boer, Novrizal Riady
Al-Qalb : Jurnal Psikologi Islam Vol 7, No 2 (2016)
Publisher : Universitas Islam Negeri Imam Bonjol Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15548/alqalb.v7i2.846

Abstract

A brand must be remembered by consumers for helping them when deciding to buy a product. This is related to brand awarenness which is owned by the consumer. Brand awareness is the ability for consumers to recognize and remember enough details of a brand in a given category to make it easier to buy. In this case the role of the process of storing information into the memory becomes important and one of the aspects associated with information processing is consumer involvement.This study describe the relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City. The subject of this research were 150 teenagers in Padang City, the data obtained by using non-probability sampling with accidental sampling technique. Data was obtained using brand awareness scale with reliability coefficient on 0,904 and consumer involvement scale with reliability coefficient on 0,901. The data analyzed using correlationproduct moment pearson test.Data obtained by correlation analysis the result of this research showed the correlation coefficient (r) of 0.609 and a significant number which was 0.000 (p <0.05). The results of this analysis indicated that thereis a positive relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City, it is means higher consumer involvement of a person, the higher brand awareness that one has,and when consumer involvement of a person is low, then the brand awareness of a person will be low.A brand must be remembered by consumers for helping them when deciding to buy a product. This is related to brand awarenness which is owned by the consumer. Brand awareness is the ability for consumers to recognize and remember enough details of a brand in a given category to make it easier to buy. In this case the role of the process of storing information into the memory becomes important and one of the aspects associated with information processing is consumer involvement.This study describe the relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City. The subject of this research were 150 teenagers in Padang City, the data obtained by using non-probability sampling with accidental sampling technique. Data was obtained using brand awareness scale with reliability coefficient on 0,904 and consumer involvement scale with reliability coefficient on 0,901. The data analyzed using correlationproduct moment pearson test.Data obtained by correlation analysis the result of this research showed the correlation coefficient (r) of 0.609 and a significant number which was 0.000 (p <0.05). The results of this analysis indicated that thereis a positive relationship between consumer involvement with the brand awareness in the purchase of Samsung Smartphone among teenagers in Padang City, it is means higher consumer involvement of a person, the higher brand awareness that one has,and when consumer involvement of a person is low, then the brand awareness of a person will be low.
PENGARUH KARAKTERISTIK PEKERJAAN TERHADAP PERILAKU KEWARGAAN ORGANISASI DENGAN MEDIATOR NILAI-NILAI KUALITAS KEHIDUPAN KERJA Rahmi, Fitria; Riyono, Bagus
Jurnal Psikologi Vol 15, No 1 (2016): April 2016
Publisher : Faculty of Psychology, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.29 KB) | DOI: 10.14710/jpu.15.1.64-76

Abstract

Organizational Citizenship Behavior (OCB) can be formally defined as a discretionary work behaviour of the employees that is not recognized by the formal reward or the sanction system of their organization. OCB can be seen as a voluntary behavior of the employees, which is out of the job description of their obligation, it is not directly related to the formal reward, but useful in improving the efficiency and effectiveness of the organization.Previous research found four aspects of the job characteristic (variety skill, task identity, task significance and autonomy) positively effected on OCB of employee. The objective of this study was to look effect of job characteristic to OCB which mediated by values of Quality of Work Life (QWL). This values as a foundation to display OCB. The subjects of this research were 65 employees from PT. X. Regression analysis showed that job characteristic significant toward OCB through the mediating of QWL values. In another word QWL had a mediator role between job characteristic and OCB. This finding were usefull to improve the OCB in company, with more attention to job characteristic that promote employees’ QWL. The results and benefits of the research were further discussed in the discussion.
Gambaran College Adjustment Pada Mahasiswa Angkatan 2020 Herdiansyah, Rido; Rahmi, Fitria; Sari, Liliyana
Edu Cendikia: Jurnal Ilmiah Kependidikan Vol. 1 No. 03 (2021): Artikel Riset Edisi Desember 2021
Publisher : ITScience (Information Technology and Science)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47709/educendikia.v1i3.1229

Abstract

University students are required to adjust to a different learning system from schools. The differences would made students experience difficulties, and this situation have been worsen with the COVID-19 pandemic that demanded a shift to full online learning. The purpose of this study was to describe college adjustment among university students, specifically class of 2020 which became the first class to experience full online learning when entering the college. The study used the descriptive quantitative method. A total of 380 Andalas University students in the class of 2020 was recruited through convenience sampling. The research instrument was the Student Adaptation to College Questionnaire (SACQ) developed by Baker & Syrik (1984) modified from Rohmah (2017). The results showed that college adjustment of university students was classified as high (68,42%). It shows that students generally have had effective behaviors in dealing with demands in the academic and social aspects, feel satisfied in college life, and have an attachment to the campus.
Analisis Fenomena Quarter–Life Crisis pada Usia Muda: Studi pada Pengguna Aktif Instagram Rahmi, Fitria; Zarkasi, Irwa R.
Jurnal Al Azhar Indonesia Seri Ilmu Sosial Vol 6, No 1 (2025): Februari 2025
Publisher : Universitas Al Azhar Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36722/jaiss.v6i1.3908

Abstract

Mengacu pada teori context collapse yang diperkenalkan oleh Boyd dan Marwick, penelitian ini mengidentifikasi bahwa media sosial berperan dalam menyatukan berbagai audiens dari konteks sosial yang berbeda ke dalam satu platform, sehingga menciptakan tekanan bagi individu untuk menyesuaikan identitas mereka sesuai dengan beragam ekspektasi audiens tersebut. Tekanan ini berkontribusi terhadap munculnya QLC yang ditandai dengan krisis identitas, kecemasan, serta ketidakstabilan emosional, yang diperburuk oleh perbandingan sosial dan standar pencapaian yang didorong oleh media sosial. Penelitian ini bertujuan mengeksplorasi fenomena Quarter-Life Crisis (QLC) yang dialami oleh generasi usia muda produktif, dengan menitikberatkan pada pengaruh media sosial terhadap pembentukan persepsi diri, pencapaian, dan interaksi sosial. Penelitian ini menggunakan pendekatan deskriptif kualitatif melalui wawancara semi-terstruktur terhadap 3 orang individu berusia 20-30 tahun yang berdomisili di Jakarta, untuk menggali lebih jauh bagaimana media sosial membentuk persepsi mereka mengenai diri, pencapaian, dan hubungan sosial. Hasil penelitian menunjukkan bahwa kesulitan dalam mengelola identitas di media sosial menimbulkan tekanan sosial yang signifikan, terutama bagi mereka yang merasa terjebak dalam standar pencapaian ideal yang diproyeksikan melalui platform digital. Studi ini menekankan pentingnya peningkatan kesadaran diri, pengelolaan audiens di media sosial, serta dukungan sosial yang konstruktif sebagai langkah mitigasi terhadap dampak negatif QLC dan fenomena context collapse.  Kata kunci: Context Collapse, Media Sosial, Quarter Life Crisis
Impelementasi Sak Emkm Dalam Penyusunan Laporan Keuangan Menggunakan Accurate Accounting Pada UMKM Hakuna Matata Pratiwi, Nabila; Rahmi, Fitria; Dahar , Reni
Jurnal Ekonomika Dan Bisnis (JEBS) Vol. 4 No. 1 (2024): Januari - Februari
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jebs.v4i1.1510

Abstract

The number of small, micro and medium enterprises (MSMEs) in Indonesia has increased significantly, but only a few MSMEs have implemented an accounting system in their financial records. Hakuna Matata MSMEs still carry out accounting records manually through recording expenses and receipts so that the owner does not know the exact amount of inventory and profit or loss earned. Manual recording can cause recording errors and the risk of losing data. The method used by the author in this research is descriptive qualitative with the type of case study. The data obtained is processed and then implemented into accurate software. From this research it can be concluded that the application of accurate software in Hakuna Matata MSMEs will ensure the preparation of financial reports more quickly and accurately, MSMEs can also find out the company's profit or loss. Computerized sales and purchase transactions also make it easy to find out inventory stock. The application of financial statements in accordance with SAK EMKM presents financial statements consisting of three components, namely the Statement of financial position, Income Statement and notes to financial statements prepared based on financial reports from accurate software.
Dari Manual ke Strategis: Penerapan Analisis CVP dalam Pengambilan Keputusan Laba UMKM Tempe Big Family Yanti, Nino Sri Purnama; Natalia, Gita; Dahar, Reni; Rahmi, Fitria
Jurnal Ekonomi dan Bisnis Dharma Andalas Vol 27 No 2 (2025): Jurnal Ekonomi dan Bisnis Dharma Andalas
Publisher : Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jebd.v27i2.2214

Abstract

UMKM Pabrik Tempe Big Family is one of the micro enterprises that plays an important role in driving the local economy in Padang City. Throughout its business operations, profit calculations have been carried out manually without the use of a structured analytical approach. This study aims to apply Cost-Volume-Profit (CVP) analysis as a tool to support better and more strategic profit planning. The analysis methods include the break-even point (BEP), margin of safety, and the calculation of required sales to achieve the targeted profit. Based on operational data from January to May 2025, the break-even sales point was found to be IDR 86.927.766, with a margin of safety of IDR 87.384.734 or 50,13%. To achieve a 35% profit target over the next five months, the business must generate sales of IDR 199.906.799, which would result in a profit of IDR63.890.750. These results demonstrate that the use of CVP analysis can serve as an effective foundation for financial planning and help business owners set measurable and achievable profit goals. Abstrak UMKM Pabrik Tempe Big family merupakan salah Usaha Mikro, Kecil dan Menengah yang turut berperan sebagai penggerak ekonomi di Kota Padang. selama menjalankan usahanya, perhitungan laba masih dilakukan secara manual tanpa menggunakan pendekatan analisis yang sistematis. Penelitian ini bertujuan untuk menerapkan analisis Cost Volume Profit (CVP) sebagai alat bantu dalam perencanaan laba yang lebih terarah dan strategis. Metode yang digunakan meliputi analisis Break Even Point (BEP), Margin of Safety, dan juga perhitungan penjualan yang dibutuhkan untuk mencapai target laba. Berdasarkan data operasional bulan Januari hingga Mei 2025, diperoleh hasil bahwa titik impas penjualan berada pada angka Rp86.927.766, dengan margin of safety sebesar Rp87.384.734 atau 50,13%. Untuk mencapai target laba sebesar 35% dalam lima bulan ke depan, UMKM ini harus memperoleh penjualan sebesar Rp199.906.799,- yang akan menghasilkan laba sebesar Rp63.890.750,-. Hasil ini menunjukkan bahwa penerapan analisis CVP dapat menjadi dasar perencanaan keuangan yang lebih efisien dan membantu pemilik usaha dalam menetapkan strategi pencapaian laba secara terukur.