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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Komunikasi dan Organisasi (J-KO) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh The Journal of Society Medicine (JSOCMED)
Rajuddin Rajuddin
Division of Reproductive Endocrinology Fertility Departement of Obsterics and Gynecology
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar Rajuddin, Rajuddin; Tahir, Muh.
Jurnal Komunikasi dan Organisasi (J-KO) Vol 4, No 1 (2022): FEBRUARI
Publisher : Program Studi Ilmu Komunikasi, FISIP Unismuh Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26644/jko.v4i1.15830

Abstract

Komunikasi merupakan salah satu faktor yang menentukan pencapaian tujuan dalam menyampaikan pesan. Komunikasi dinilai memiliki pengaruh dalam prosesnya dengan berbagai media yang di gunakan termasuk dalam komunikasi dakwah sebagai media dalam menyampaikan pesan agama secara media digital. Berdasarkan hal tersebut, kajian penelitian ini bertujuan mendeskripsikan dan menjelaskan Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar. Penelitian ini menggunakan metode kualitatif untuk mendeskripsikan dan menjelaskan Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar. Data penelitian dikumpul dengan menggunakan instrumen berupa wawanacara dan dokumentasi. Adapun beberapa faktor dari hasil penelitian ini 1. Gerakan Komunikasi Dakwah Digital di jadikan sebagai subjek utama yang harus mampu berperan besar tentu konsep yang kekinian, dakwah para pemuda medsos justru lebih menargetkan dakwahnya pada kalangan muda-mudi tentunya dalam berbagai hal keagamaan termasuk pola perubahan tingkah laku, sikap moral dan mental. 2. Hubungan sosial pesan dakwah digital harus mampu di arahkan oleh pemuda adalah untuk mempengaruhi tiga aspek perubahan diri, yaitu perubahan aspek pengetahuan, Aspek sikap dan aspek prilaku. 3. Strategi dakwah segi sarana dan prasarana dalam hal ini adalah media dakwah yang digunakan harus mengatasnamakan suatu lembaga yang resmi, memperjelas sumber referensi dan membuat konten atau di masukkan dalam media yang di gunakan sehingga dapat di lihat kapan dan di mana saja.
Efektivitas dan Keamanan Elektroakupunktur pada Manajemen Nyeri Persalinan indirayani, Ima Indirayani; Meuratana, Putri Ade Meuratana; Aditya, Rizka Aditya; Rajuddin, Rajuddin
Journal of Medical Science Vol 3 No 1 (2022): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.181 KB) | DOI: 10.55572/jms.v3i1.64

Abstract

Nyeri persalinan menjadi suatu kendala yang menghambat suksesnya persalinan pervaginam dan tidak tahan terhadap nyeri saat persalinan menjadi penyebab meningkatnya permintaan Seksio Caesaria (SC) dimana tindakan SC sendiri meningkatkan risiko morbiditas dan mortalitas terhadap ibu. Manajemen nyeri di Kamar Bersalin terutama di kota Banda Aceh saat ini belum berjalan sebagaimana mestinya, pasien bersalin belum mendapatkan pelayanan manajemen nyeri saat persalinan. Elektroakupunktur merupakan salah satu metode manajemen nyeri non-farmakologi yang terbukti efektif menurunkan nyeri dengan efek samping yang hampir tidak ada serta terjangkau. Tujuan penelitian ini adalah untuk mengetahui efektifitas Elektroakupunktur dalam menurunkan derajat nyeri persalinan serta menilai keamanan elektroakupunktur. Penelitian ini merupakan studi prospektif, experimental randomized contolled trial dengan double blind. Ibu dengan kehamilan tanpa komplikasi yang menjalankan proses persalinan dan sudah memasuki kala 1 aktif diacak untuk mendapatkan baik intervensi Elektroakupunktur atau intervensi Sham Akupunktur (Plasebo) sebagai manajemen nyeri persalinan. Luaran primer efektitivitas yang dinilai adalah penurunan nyeri rata-rata yang diukur dengan Numerical Rating Scale (NRS) dari sebelum intervensi, dan setelah 30 menit, 60 menit, 90 menit hingga 120 menit pasca intervensi. Luaran primer keamanan yaitu efek samping yang terjadi dalam 15 menit pasca Tindakan. Luaran sekunder lainnya yang dinilai yaitu durasi persalinan, penggunaan oksitosin, derajat ruptur perineum, jumlah perdarahan serta skor APGAR. Terdapat 12 pasien yang berhasil direkrut. Terdapat penurunan skala nyeri pada kelompok elektroakupunktur yang lebih besar dibandingakan dengan kelompok sham baik pada 30, 60, 90, 120 menit pasca intervensi meskipun tidak mencapai nilai signifikan masing-masing 1.14, 1.33, 1.8, dan 1.3 versus -0.2, 0.25, 0.67, dan 0. Tidak dijumpai efek samping dari intervensi yang diberikan dari kedua kelompok. Tidak ada perbedaan luaran yang signifikan dari durasi persalinan, jumlah perdarahan, penggunaan oksitosin, derajat ruptur dan skor APGAR bayi dari kedua kelompok. Penerapan Elektroakupunktur pada titik EX-B2, BL 32, BL 33 dan BL 34 dapat digunakan sebagai terapi non farmakologi untuk mengurangi nyeri dan durasi persalinan serta aman dan mudah digunakan dengan tidak ada efek samping. Penelitian ini diharapkan menjadi salah satu pertimbangan untuk manajemen nyeri saat persalinan pada layanan di kamar bersalin RSUD dr. Zainoel Abidin ke depan, sehingga meningkatkan kualitas layanan bersalin dan memberi kepuasan pasien dalam menjalani proses persalinan.  
Prenatal Diagnosis, Neonatal Outcomes, and Management of Pregnancies Complicated by Gastroschisis Rajuddin, Rajuddin; Meutia, Inong Indira
Journal of Society Medicine Vol. 4 No. 9 (2025): September
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i9.244

Abstract

Introduction: Gastroschisis, a congenital abdominal wall defect, causes external protrusion of intestines and organs due to incomplete wall closure near the umbilicus. Accurate prenatal diagnosis through ultrasonography requires skilled operators to detect the defect and guide management. Early identification enables perinatal care planning to minimize complications, such as organ perforation, and optimize neonatal outcomes. This case report examines the prenatal diagnosis and management of gastroschisis in a primigravida, highlighting ultrasonography's role in clinical decision-making. Case Description: A 26-year-old primigravida at 34–35 weeks gestation was referred from Zubir Mahmud Regional Hospital with a prenatal diagnosis of gastroschisis. She reported severe abdominal pain and vaginal spotting for three weeks. Physical examination indicated stable hemodynamics, with obstetric findings including a fundal height of 26 cm, estimated fetal weight of 2015 g, left-sided fetal back, fetal heart rate of 142 beats/min, breech presentation, and no contractions. Speculum examination revealed a closed external cervical os, no dilation, negative fluxus, positive flour, protruding amniotic membranes, and a positive nitrazine test. Vaginal examination showed a posterior, soft cervix with no dilation or palpable fetal parts. The pregnancy was diagnosed with congenital gastroschisis, and a cesarean section was planned to prevent abdominal organ perforation. Conclusion: Gastroschisis, identified at 34–35 weeks gestation, necessitates early prenatal diagnosis to prepare for appropriate perinatal care. Cesarean delivery is a preferred strategy to reduce risks of organ damage, supporting improved neonatal outcomes in affected pregnancies.
The Role of Reproduction for the Future of Women's Health rajuddin, rajuddin; Maulida, Nurul Fadliati
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.2325

Abstract

Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar Rajuddin, Rajuddin; Tahir, Muh.
Jurnal Komunikasi dan Organisasi (J-KO) Vol. 4 No. 1 (2022): FEBRUARI
Publisher : Program Studi Ilmu Komunikasi, FISIP Unismuh Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/jko.v4i1.15830

Abstract

Komunikasi merupakan salah satu faktor yang menentukan pencapaian tujuan dalam menyampaikan pesan. Komunikasi dinilai memiliki pengaruh dalam prosesnya dengan berbagai media yang di gunakan termasuk dalam komunikasi dakwah sebagai media dalam menyampaikan pesan agama secara media digital. Berdasarkan hal tersebut, kajian penelitian ini bertujuan mendeskripsikan dan menjelaskan Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar. Penelitian ini menggunakan metode kualitatif untuk mendeskripsikan dan menjelaskan Gerakan Komunikasi Dakwah Digital Muhammadiyah di Kalangan Pemuda Milenial di Kelurahan Salaka Kecamatan Pattalassang Kabupaten Takalar. Data penelitian dikumpul dengan menggunakan instrumen berupa wawanacara dan dokumentasi. Adapun beberapa faktor dari hasil penelitian ini 1. Gerakan Komunikasi Dakwah Digital di jadikan sebagai subjek utama yang harus mampu berperan besar tentu konsep yang kekinian, dakwah para pemuda medsos justru lebih menargetkan dakwahnya pada kalangan muda-mudi tentunya dalam berbagai hal keagamaan termasuk pola perubahan tingkah laku, sikap moral dan mental. 2. Hubungan sosial pesan dakwah digital harus mampu di arahkan oleh pemuda adalah untuk mempengaruhi tiga aspek perubahan diri, yaitu perubahan aspek pengetahuan, Aspek sikap dan aspek prilaku. 3. Strategi dakwah segi sarana dan prasarana dalam hal ini adalah media dakwah yang digunakan harus mengatasnamakan suatu lembaga yang resmi, memperjelas sumber referensi dan membuat konten atau di masukkan dalam media yang di gunakan sehingga dapat di lihat kapan dan di mana saja.
Cortisol and pregnancy-related anxiety in relation to preeclampsia among third-trimester pregnant women: A case–control study from Aceh, Indonesia Hezron, Teuku M.; Dewi, Tgk. Puspa; Septivera, Yusra; Rajuddin, Rajuddin; Utami, Niken A.
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2985

Abstract

Despite extensive research, the interplay between hormonal stress markers and pregnancy-specific anxiety in the pathogenesis of preeclampsia remains insufficiently understood. This study aimed to analyze the simultaneous relationships between serum cortisol levels, pregnancy-related anxiety, and the occurrence of preeclampsia among third-trimester pregnant women. A case–control study was conducted at three hospitals in Banda Aceh, Indonesia, involving third-trimester pregnant women. Serum cortisol concentrations were measured using an immunoassay, and anxiety levels were assessed with the validated Pregnancy Related Anxiety Questionnaire (PRAQ). Preeclampsia diagnosis followed standard clinical and laboratory criteria. Associations between cortisol levels (categorized into high and normal) and PRAQ scores (classified as high and low–moderate) with preeclampsia were evaluated using the Chi-squared test, and crude odds ratios (OR) with 95% confidence intervals (95%CI). The Spearman’s correlation was used to determine the correlation between cortisol levels and PRAG scores. A total of 66 pregnant women were included in the final analysis (33 with preeclampsia and 33 with normal pregnancy). Women with high serum cortisol levels had a markedly greater likelihood of developing preeclampsia compared with those with normal cortisol levels (odds ratio (OR)=34.00; 95% confidence interval (95%CI): 4.93–234.46). Similarly, women with high pregnancy-related anxiety exhibited a significantly elevated risk of preeclampsia (OR=16.71; 95%CI: 4.95–56.39). No significant correlation was observed between cortisol levels and PRAQ scores in both groups (preeclampsia: r=-0.041, p=0.821; normal pregnancy: r=0.278, p=0.117). In conclusion, elevated serum cortisol and high pregnancy-related anxiety are independently associated with preeclampsia, although not directly correlated with each other. These findings highlight the potential of dual screening for cortisol and pregnancy-specific anxiety as an innovative approach for early identification of women at high risk of preeclampsia.
Evaluating serum cyclooxygenase-2 and vascular endothelial growth factor as biomarkers for endometriosis severity in reproductive-age women Aslam, Aga; Rajuddin, Rajuddin; Munizar, Munizar; Rusnaidi, Rusnaidi; Hasanuddin, Hasanuddin
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.2984

Abstract

Endometriosis affects approximately 10–15% of reproductive-age women and up to 70% of those with chronic pelvic pain, with diagnosis typically relying on invasive laparoscopy with histopathological confirmation. Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are central mediators of the inflammatory and angiogenic pathways underpinning endometriosis pathogenesis, making them promising candidates for non-invasive biomarkers. This study aimed to analyze the correlation between serum COX-2 and VEGF concentrations and endometriosis severity to evaluate their potential utility as non-invasive biomarkers. A cross-sectional study was conducted among women with confirmed endometriosis at Dr. Zainoel Abidin General Hospital in Banda Aceh, Indonesia, in 2025. Peripheral blood samples were collected preoperatively, and serum COX-2 and VEGF concentrations were quantified using ELISA. Endometriosis severity was classified according to the American Society for Reproductive Medicine staging system. Correlation analyses were performed to assess associations between biomarker levels and disease stage, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis to determine the area under the curve (AUC) values, optimal cut-off points, sensitivity, and specificity. Twenty-eight patients were included, with the mean COX-2 and VEGF levels being 1.16±1.28 ng/mL and 266.50±72.91 pg/mL, respectively. VEGF demonstrated a strong and statistically significant correlation with endometriosis staging (r=0.744, p<0.001), while COX-2 showed a limited correlation that did not reach statistical significance (r=0.367, p=0.055). The ROC analysis further highlighted VEGF’s superior diagnostic performance, with an AUC of 0.975 (95%CI: 0.926–1.000, p<0.001) compared with COX-2 (AUC 0.734; 95%CI: 0.518–0.950, p=0.057). The optimal VEGF threshold of 221 pg/mL yielded 90% sensitivity and 100% specificity, whereas the COX-2 threshold of 0.675 ng/mL provided 80% sensitivity and 62.5% specificity. These findings indicate that VEGF is a highly promising non-invasive biomarker for assessing endometriosis severity and may support the development of improved diagnostic approaches for endometriosis management.
Associations of VEGF and CA125 with disease stage and pain among women with endometriosis: A cross-sectional study in Indonesia Sujudi, Akmal; Rusnaidi, Rusnaidi; Dewi, Tgk. Puspa; Rajuddin, Rajuddin; Septivera, Yusra
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3013

Abstract

Endometriosis is a chronic gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity, affecting approximately 10% of women of reproductive age. Vascular endothelial growth factor (VEGF) and cancer antigen 125 (CA125) have been proposed as potential biomarkers in endometriosis; however, evidence regarding their association with disease stage and pain severity remains limited, particularly in the Indonesian population. The aim of this study was to evaluate the relationship between peritoneal fluid VEGF and serum CA125 levels with endometriosis stage and pain severity. A cross-sectional study was conducted involving patients with surgically and histopathologically confirmed endometriosis who underwent laparoscopy or laparotomy at Dr. Zainoel Abidin Hospital, Banda Aceh, between February and July 2025. Peritoneal fluid VEGF and serum CA125 levels were measured using enzyme-linked immunosorbent assay and chemiluminescence immunoassay, respectively. Endometriosis stage was classified according to the revised American Society for Reproductive Medicine (rASRM) criteria, and pain severity was assessed using the Numeric Rating Scale. Statistical analyses included Spearman’s correlation and receiver operating characteristic (ROC) curve analysis. Our data suggested no significant correlation between VEGF levels and endometriosis stage (r=0.042; p=0.813). Peritoneal fluid VEGF levels showed a moderate positive correlation with pain severity (r=0.505; p<0.05), and ROC analysis identified an optimal cut-off value of 39.45 pg/mL, with a sensitivity of 73.68% and specificity of 73.33% for distinguishing severe pain from mild-to-moderate pain. Serum CA125 levels demonstrated a significant positive correlation with endometriosis stage (r=0.422; p=0.013), and ROC analysis yielded an optimal cut-off value of 32.45 U/mL, with a sensitivity of 86.95% and a specificity of 63.64% for distinguishing stage IV endometriosis from lower stages. No significant correlation was observed between CA125 levels and pain severity (r=0.186; p=0.292). This study represents the first report from Indonesia to simultaneously evaluate peritoneal fluid VEGF and serum CA125 in relation to endometriosis stage and pain severity. This study highlights that CA125 is primarily associated with endometriosis stage, whereas VEGF is more closely related to pain severity, supporting their complementary roles in endometriosis assessment.
Relationship between serum CA125, prolactin and cortisol levels with disease stage and pain level in endometriosis patients Fasha, Teuku A.; Rajuddin, Rajuddin; Dewi, Tgk. Puspa; Rusnaidi, Rusnaidi; Munizar, Munizar
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.2988

Abstract

Endometriosis affects approximately 10% of women of reproductive age and is characterized by the presence of endometrial tissue outside the uterine cavity. Diagnostic delays are common due to nonspecific symptoms and the absence of reliable biomarkers. Serum CA125, prolactin, and cortisol have been implicated in the pathophysiology of endometriosis through inflammatory, neuroendocrine, and stress-response mechanisms. However, their role as biomarkers in endometriosis remains poorly studied. This study aimed to investigate the relationships between serum CA125, prolactin, and cortisol levels with endometriosis staging and pain severity in endometriosis patients. A cross-sectional study was conducted at Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia, involving women with laparoscopically confirmed endometriosis. Serum CA125, prolactin, and cortisol levels were measured using electrochemiluminescence immunoassay (ECLIA). Disease staging followed the American Society for Reproductive Medicine (ASRM) classification, and pain severity was assessed using the Numeric Rating Scale (NRS). Statistical analyses were performed using the Spearman correlation test. A total of 30 women with confirmed endometriosis were included in this study, with a mean age of 37.2 years. Endometriosis stages were distributed as stage II (20.0%), stage III (16.7%), and stage IV (63.3%), and the mean pain score was 5.60±1.48. Elevated serum biomarker levels were observed with CA125 of 72.65±55.39 U/mL, prolactin of 1456.77±1799.79 μIU/mL, and cortisol of 341.92±189.02 nmol/L. The serum CA125 level was positively correlated with endometriosis staging (r=0.580, p=0.001) but not with pain severity. Prolactin and cortisol had no significant correlations with disease stage or pain severity (all p>0.05). This study shows that serum CA125 levels are significantly correlated with endometriosis staging, supporting its potential as a biomarker of disease progression. Although prolactin and cortisol levels were elevated, their lack of association with clinical parameters suggests broader neuroendocrine dysregulation rather than direct markers of disease severity.
Co-Authors Aditya, Rizka Aditya Ali Baziad Aslam, Aga Dasrul Dasrul Dewi, Tgk. Puspa Donny, Donny Fasha, Teuku A. Fauzan . Gani, Azhari Hasanuddin Hasanuddin Hezron, Teuku M. indirayani, Ima Indirayani Komalasari Komalasari Mamfalutfi, Teuku Maulida, Nurul Fadliati Meuratana, Putri Ade Meuratana Meutia, Inong Indira Muh. Tahir Mukhamad Najib Munawar Munawar Munizar Munizar, Munizar Rini, Riska Firda Rusnaidi Septivera, Yusra Suciana, Suciana Sujudi, Akmal T. Z. Jacoeb Utami, Niken A. Wulandari, Firstia Ritri