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All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Jurnal Sehat Indonesia (JUSINDO) Cakradonya Dental Journal The Journal of Society Medicine (JSOCMED) Jurnal of Syiah Kuala Dentistry Society
Gani, Azhari
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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HUBUNGAN LAMA PENGGUNAAN KONTRASEPSI DEPO MEDROKSIPROGESTERON ASETAT (DMPA) DENGAN OBESITAS Suciana, Suciana; Rajuddin, Rajuddin; Gani, Azhari
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 3: No. 1 (Mei, 2017)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.006 KB) | DOI: 10.29103/averrous.v3i1.448

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan lama penggunaan kontrasepsi DMPA dengan obesitas. Penelitian dilakukan dengan menggunakan metode analitik cross sectional  terhadap 78 responden. Untuk mengukur lamanya penggunaan kontrasepsi DMPA digunakan kuesioner dan untuk mengukur obesitas dilakukan pengukuran BMI. Analisis data menggunakan uji Chi-Square dengan CI 95% dan ? = 0,05. Sebanyak 20,5% akseptor kontrasepsi DMPA dengan lama penggunaan DMPA 3-18 bulan mengalami obesitas, sedangkan akseptor yang menggunakan kontrasepsi DMPA >18 bulan sebanyak 59% mengalami obesitas dengan p value 0,001. Terdapat hubungan antara lama penggunaan kontrasepsi DMPA dengan obesitas.
Thyroid Heart Disease in Young Male, a Case Report Sihite, Perdana Liansyah; Hambali, Abdullah; Kamil, Muhammad Firdaus; Muhsin, Muhsin; Gani, Azhari; Diah, Muhammad
Journal of Society Medicine Vol. 2 No. 1 (2023): January
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.182 KB) | DOI: 10.47353/jsocmed.v2i1.20

Abstract

Introduction: The thyroid gland produces thyroid hormones that affect all tissue's metabolic processes, including the heart. Disorders of thyroid hormones, both increasing and decreasing thyroid hormones, can cause similar symptoms to primary heart disease. Thyroid heart disease (THD) is a heart disease that occurs due to increasing (hyperthyroid) or decreasing (hypothyroid) thyroid hormones in the circulation. Hyperthyroidism can cause several types of heart disease, including mitral regurgitation, tricuspid regurgitation, cardiomyopathy, heart failure, mitral valve prolapses, atrial fibrillation or sinus tachycardia. Method: This was a retrospective case report, after analysis of patient clinical data. The patient provided written informed consent to publish their case details and any accompanying images. Results: Almost all cases of THD occur in middle-aged women. Here we presented a 32-year-old male patient diagnosed with THD caused by graves' disease. Patient was admitted to emergency department due to shortness of breath. Medical and non-medical treatments were administered to the patients, and patients experienced improvement after several days of hospitalization. Conclusion: In fact, the progression of hyperthyroidism is characterized by remission and long-term exacerbations. Although some patients can remain euthyroid for a long time after therapy, many eventually get into hypothyroidism. Therefore, lifetime follow-up is an indication for all patients with hyperthyroidism.
Antibacterial and anti-inflammatory activities of Nothopanax scutellarium, Moringa oleifera and Piper betle extracts on staphylococcal mastitis animal model Sriyanti, Cut; Siregar, Tongku N.; Mudatsir, Mudatsir; Gani, Azhari; Hasan, Denny I.; Sutriana, Amalia
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.176

Abstract

Inappropriate and prolonged administration of antibiotics in mastitis could cause antibiotic resistance and herbal treatment might could be one alternative treatment. Nothopanax scutellarium, Moringa oleifera, and Piper betle are medicinal plants that contain various active compounds, including antibacterial and anti-inflammatory agents, but their potentials in treating mastitis are not well understood. The aim of this study was to assess the effectiveness of those plants against mastitis in rabbit model induced by Staphylococcus aureus. A total of 25 lactating rabbits (Oryctolagus cuniculus) weighing 3.0±0.4 kg were grouped into five groups: healthy control; mastitis control, and three treatment groups (Nothopanax scutellarium, Moringa oleifera, and Piper betle). Except the healthy control group, all animals were inoculated with 0.15 mL of Staphylococcus aureus containing 1.5x107colony forming unit (CFU)/mL on eight days after giving birth. The extract was administered orally after four hours Staphylococcus aureus inoculation at a dose of 50 mg/kg body weight, twice a day for five consecutive days. The number of bacteria in the milk and the level of serum interleukin 6 (IL-6) were measured and histopathological examination of mammary gland tissues were analyzed. The log number of total plate count of Staphylococcus aureus indicated that all extract groups had significant lower of bacterial logs compared to mastitis control (all comparisons had p<0.05) with the lowest was found in Piper betle group, followed by Nothopanax scutellarium and Moringa oleifera. The enzyme-linked immunosorbent assay (ELISA) results showed that all ethanolic extract groups had significantly lower levels of IL-6 compared to the mastitis control (all comparisons had p<0.05). The histopathologyassessment suggested that extract groups had lower infiltration of inflammatory cells such as lymphocytes and macrophages in alveoli compared to the mastitis control group. In conclusion, all three extracts contained antibacterial and anti-inflammatory activities and Piper betle had the most effective in reducing bacterial growth and IL-6 level compared to others.
SINDROMA BRUGADA DAN PENATALAKSANAANYA PADA LANSIA (Laporan Kasus) Gani, Azhari; Abdat, Munifah
Cakradonya Dental Journal Vol 12, No 2 (2020): Agustus 2020
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v12i2.17833

Abstract

Sindroma Brugada ditandai dengan elevasi segmen ST di sadapan prekordial kanan EKG, yangdikaitkan dengan resiko tinggi sudden cardiac death. Sindroma ini lebih banyak dialami oleh laki-lakiusia muda atau dewasa yang sehat. Penderita dapat mengalami gejala seperti pingsan, palpitasi,kematian mendadak akibat jantung, dan dapat pula tanpa gejala sebelumnya (spontan). Jika pasienmengalami masalah gigi maka perawatan gigi pada pasien dengan penyakit saluran jantung sulit karenaadanya potensi risiko kejadian yang mengancam jiwa. Dilaporkan satu kasus seorang laki-laki 75tahun dengan keluhan pingsan 2 jam sebelum masuk rumah sakit. Sebelumnya pasien merasa tidakenak badan, jantung berdebar-debar dan tidak sadarkan diri. Berdasarkan pemeriksaan fisik tidakditemukan kelainan. Sedangkan hasil pemeriksaan EKG ditemukan gambaran coved pada sadapanprekordial kanan ( V1,V2 dan V3 ). Hasil laboratorium dalam batas normal. Pasien tidak mempunyairiwayat sinkop, jantung berdebar dan nyeri dada sebelumnya. Pasien didiagnosa dengan SindromaBrugada tipe 1 dan diterapi dengan Bisoprolol 1 x 2,5 mg dan Aspilet 1 x 80 mg. Pasien kemudiandirujuk ke RSCM Jakarta untuk dilakukan Electrophisiology Study dan direncanakan untukpemasangan ICD.
Hubungan Pendidikan Dengan Tingkat Depresi Pada Pasien Hipertensi di Kecamatan Syiah Kuala Banda Aceh Alifa, Tasha; Gani, Azhari; Saragih, Juwita
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.128

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan pendidikan dengan tingkat depresi pada pasien hipertensi di Kecamatan Syiah Kuala Banda Aceh. Penelitian ini bersifat analitik dengan desain cross sectional dan teknik pengambilan sampel adalah simple random sampling dengan jumlah responden sebanyak 137 orang. Penelitian dilakukan dengan wawancara untuk menilai tingkat pendidikan dan menggunakan kuisioner Beck Depression Inventory-II (BDI-II) untuk menilai tingkat depresi. Pada pasien hipertensi yang berpendidikan rendah lebih tinggi mengalami gangguan depresi (24,5%) dibandingkan dengan pasien yang mempunyai pendidikan tinggi (7,1%). Hasil uji Chi-square pada penelitian ini didapatkan value = 0,004 dan α = 0,05. Kesimpulan dari penelitian ini adalah terdapat hubungan antara pendidikan dengan tingkat depresi pada pasien hipertensi di Kecamatan Syiah Kuala, Banda Aceh.
Complications and Management of Myocardial Infarction in Hypertensive Patients: A Review Gani, Azhari; Hayati, Kemala
Journal of Syiah Kuala Dentistry Society Vol 9, No 1 (2024): June 2024
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v9i1.40338

Abstract

Background: Myocardial infarction (MI) and hypertension are cardiovascular conditions that frequently coexist and influence each other. Hypertension not only increases the risk of MI but also complicates its clinical management. Therefore, it is crucial to understand the complications arising from this condition and the effective management strategies. Objectives: This systematic review aims to identify and analyze common complications in hypertensive patients experiencing MI and evaluate the optimal management approaches based on the latest literature. Methods: A literature search was conducted in electronic databases such as PubMed, Scopus, and Google Scholar using relevant keywords like "myocardial infarction," "hypertension," "complications," and "management." Articles published in the last five years were selected to ensure the most current information. Inclusion criteria included observational studies, clinical trials, and systematic reviews relevant to the topic. Data were extracted and analyzed descriptively. Results: Of the 1500 articles identified, 45 studies met the inclusion criteria. Major complications found in hypertensive patients with MI included heart failure, arrhythmias, stroke, and left ventricular dysfunction. The most effective management approaches included appropriate use of antihypertensive medications, early reperfusion interventions, and a multidisciplinary approach to controlling cardiovascular risk factors. The use of ACE inhibitors, beta-blockers, and aldosterone antagonists proved to have significant benefits in reducing morbidity and mortality. Conclusions: Complications of myocardial infarction in hypertensive patients require comprehensive and coordinated management. Effective management involves a combination of pharmacological and non-pharmacological therapies focusing on optimal blood pressure control and prevention of further complications. Further research is needed to explore more specific and personalized management strategies in this population.
Association Between Oral Pathogens in Infectious Endocarditis and Myocardial Infarction Risk Gani, Azhari
Journal of Syiah Kuala Dentistry Society Vol 8, No 2 (2023): December 2023
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v8i2.37118

Abstract

Background: This study investigated the association between infectious endocarditis caused by oral pathogens and an increased risk of myocardial infarction. The primary focus is on how oral pathogens, such as Streptococcus viridans and Staphylococcus aureus, commonly found in the oral flora, can enter the bloodstream and contribute to the development of infective endocarditis. Objective: This study aims to highlight the importance of oral health as an important aspect in preventing cardiovascular disease, especially for individuals with a history of heart valve disease or other cardiovascular risk factors. Methods: This study investigates how this pathogen attaches to damaged or abnormal heart valves, causing inflammation and further damage, which can lead to embolism formation. These emboli have the potential to block blood flow to the heart, causing ischemia and triggering myocardial infarction. The study also explored the role of inflammation and the immune response to infection in increasing the risk of arterial plaque formation and thrombosis. Results: The study found that these oral pathogens can enter the bloodstream through dental procedures or poor oral health conditions and attach to damaged or abnormal heart valves. This attachment causes inflammation and damage to the valve and the formation of emboli, which can move to the heart and block the coronary arteries. The result is an increased risk of ischemia and myocardial infarction, highlighting the importance of good oral health and effective cardiovascular risk management to prevent these heart health complications. Conclusion: Streptococcus viridans can enter the bloodstream and attach to damaged heart valves, causing inflammation and embolism formation that has the potential to block blood flow to the heart, causing ischemia and increasing the risk of heart attack and related cardiovascular complications.
Co-Authors Abdat, Munifah Alifa, Tasha Amalia Sutriana Diah, Muhammad Hambali, Abdullah Hasan, Denny I. Hayati, Kemala Kamil, Muhammad Firdaus Mudatsir Mudatsir Muhsin Muhsin Rajuddin Rajuddin Saragih, Juwita Sihite, Perdana Liansyah Siregar, Tongku N. Sriyanti, Cut Suciana, Suciana