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SKRINING KESEHATAN JIWA, RELIGIUSITAS, DAN KUALITAS HIDUP MAHASISWA FARMASI DAN KEDOKTERAN PADA PANDEMI COVID-19: SCREENING OF MENTAL HEALTH, RELIGIUSITY, AND QUALITY OF LIFE OF PHARMACEUTICAL AND MEDICAL STUDENTS IN THE COVID-19 PANDEMIC Widea Rossi Desvita; Wiwara Awisarita; Muhammad Fikri; Akrom; Laela Hayu Nurani; Isabella Meliawati Sikumbang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.342

Kesehatan mental mahasiswa Farmasi dan Kedokteran perlu diskrining terhadap keberadaan COVID-19. Faktor internal yang perlu diperhatikan adalah aspek religiusitas dan kualitas hidup. Instrumen yang dikembangkan untuk pemeriksaan kesehatan mental adalah SRQ29 serta religiusitas dan kualitas hidup dengan EQ5D. Tujuan dari penelitian ini adalah untuk mengetahui kesehatan mental dan kualitas hidup mahasiswa Farmasi dan Kedokteran pada masa pandemi COVID-19. Penelitian ini merupakan penelitian cross sectional diskriptif dengan metode survey terhadap 44 responden yang meliputi 36 mahasiswa Fakultas Farmasi dan 8 mahasiswa Fakultas Kedokteran. Metode yang digunakan untuk skrining kesehatan jiwa adalah instrumen kuesioner yaitu SRQ-29 untuk skrining kesehatan jiwa dan religiusitas yang berisi 29 pertanyaan terkait kesehatan jiwa responden, dan skrining kualitas hidup dengan instrumen EQ5D. Hasil penelitian menunjukkan bahwa dari skrining SRQ29 mahasiswa farmasi dan FK perguruan tinggi di Yogyakarta mengalami gejala PTSD (75%), cemas dan depresi (61,36%), gangguan psikotik (50%), penggunaan zat psikoaktif/ narkoba (2,27%). Berdasarkan hasil skrining religiusitas menunjukkan nilai yang tinggi terhadap keyakinan dan iman kepada Allah SWT (96,8%). Hasil EQ5D menunjukkan bahwa pandemi tidak berdampak besar pada aspek fisik, namun berdampak pada mental/ psikologis. Kesimpulan penelitian terkait kesehatan jiwa pada hasil skrining dengan instrumen SRQ29 menunjukkan bahwa mahasiswa farmasi dan FK perguruan tinggi di Yogyakarta mengalami masalah psikososial. Hal ini saat dikaitkan dengan religiusitas dan kualitas hidup menunjukkan adanya pengaruh faktor internal tersebut pada kesehatan jiwa.

Peningkatan Pengetahuan Ibu dalam Pengolahan Tanaman Obat Keluarga (TOGA) sebagai Relaksan dan Skrining Kesehatan Jiwa Widea Rossi Desvita; Tri Ani Marwati; Fikri Achmad Arif; Isabella Meliawati Sikumbang; Laela Hayu Nurani
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No Special-1 (2022): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v7iSpecial-1.2514

The COVID-19 pandemic impacts maternal psychological problems with an increasing prevalence of symptoms of depression and anxiety. In Branch Aisyiyah Demangan and Sapen DIY, activities were stopped during the pandemic, considering that many of the members were elderly and were in the red zone in June 2021. On this basis, it is necessary to carry out stimulus activities that can be carried out during a pandemic. This activity aims to know mental health conditions by screening mental health, promoting mental health, and using and managing traditional medicines for relaxants. The methods used in this activity are mental health screening, mental health counseling and training, presentation of herbal medicines with the right dose, and making herbal medicine that meets the standards of the Health Office. Activities are carried out online, starting with pretest, delivery of material, mental health screening, management of traditional medicinal plants, post-test. The analysis of the results was carried out by performing a paired t-test statistical test. The pretest and post-test results showed an increase from 82±0.55 to 93±0.84. Psychologically and emotionally, most respondents experienced complaints of fatigue (73.1%), followed by complaints of difficulty understanding feelings (46.2%), then complaints of anxiety, tension, or worry (42.3%). Screening results show that one respondent has a mild mental problem.

SKRINING KESEHATAN JIWA, RELIGIUSITAS, DAN KUALITAS HIDUP MAHASISWA FARMASI DAN KEDOKTERAN PADA PANDEMI COVID-19: SCREENING OF MENTAL HEALTH, RELIGIUSITY, AND QUALITY OF LIFE OF PHARMACEUTICAL AND MEDICAL STUDENTS IN THE COVID-19 PANDEMIC Widea Rossi Desvita; Wiwara Awisarita; Muhammad Fikri; Akrom; Laela Hayu Nurani; Isabella Meliawati Sikumbang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.342

Kesehatan mental mahasiswa Farmasi dan Kedokteran perlu diskrining terhadap keberadaan COVID-19. Faktor internal yang perlu diperhatikan adalah aspek religiusitas dan kualitas hidup. Instrumen yang dikembangkan untuk pemeriksaan kesehatan mental adalah SRQ29 serta religiusitas dan kualitas hidup dengan EQ5D. Tujuan dari penelitian ini adalah untuk mengetahui kesehatan mental dan kualitas hidup mahasiswa Farmasi dan Kedokteran pada masa pandemi COVID-19. Penelitian ini merupakan penelitian cross sectional diskriptif dengan metode survey terhadap 44 responden yang meliputi 36 mahasiswa Fakultas Farmasi dan 8 mahasiswa Fakultas Kedokteran. Metode yang digunakan untuk skrining kesehatan jiwa adalah instrumen kuesioner yaitu SRQ-29 untuk skrining kesehatan jiwa dan religiusitas yang berisi 29 pertanyaan terkait kesehatan jiwa responden, dan skrining kualitas hidup dengan instrumen EQ5D. Hasil penelitian menunjukkan bahwa dari skrining SRQ29 mahasiswa farmasi dan FK perguruan tinggi di Yogyakarta mengalami gejala PTSD (75%), cemas dan depresi (61,36%), gangguan psikotik (50%), penggunaan zat psikoaktif/ narkoba (2,27%). Berdasarkan hasil skrining religiusitas menunjukkan nilai yang tinggi terhadap keyakinan dan iman kepada Allah SWT (96,8%). Hasil EQ5D menunjukkan bahwa pandemi tidak berdampak besar pada aspek fisik, namun berdampak pada mental/ psikologis. Kesimpulan penelitian terkait kesehatan jiwa pada hasil skrining dengan instrumen SRQ29 menunjukkan bahwa mahasiswa farmasi dan FK perguruan tinggi di Yogyakarta mengalami masalah psikososial. Hal ini saat dikaitkan dengan religiusitas dan kualitas hidup menunjukkan adanya pengaruh faktor internal tersebut pada kesehatan jiwa.

Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro Aristiani, Windy; Desvita, Widea Rossi; Khayatulisma, Dika; Edityaningrum, Citra Ariani; Guntarti, Any; Nurani, Laela Hayu
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10887

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.

Factors Affecting the Anxiety Levels of Health Workers at Budi Kemuliaan Hospital in Managing Covid-19 Patients Astiti, Chairunnisa; Yuniasih, Dewi; Desvita, Widea Rossi; Safaria, Triantoro
Ahmad Dahlan Medical Journal Vol. 4 No. 2 (2023): November 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

This study aims to determine the factors that influence the level of anxiety of health workers in handling COVID-19 patients at Budi Kemuliaan Hospital, Batam City. This study uses an observational analytic method and a cross-sectional design with data collection through primary data. The study was conducted in December 2021 – January 2022 at Budi Kemuliaan Hospital Batam City with a research population of 99 health workers who were directly involved in handling COVID-19 patients with a total sample of 91 health workers who met the inclusion criteria and the sampling technique used was total sampling. The research data was taken using a questionnaire and then processed using SPSS. Of 91 respondents, 43 respondents (47.3%) did not experience anxiety, 41 respondents (45.1%) experienced mild anxiety, and 7 respondents (7.7%) experienced moderate anxiety. Based on the results of Kendall's Tau-b analysis, there was no relationship between age, gender, family status, level of knowledge, and availability of PPE on the anxiety level of health workers at Budi Kemuliaan Hospital Batam City (p>0.05). The conclusion is no factors that affect the anxiety level of workers' health. Further research is needed to analyze other factors that influence anxiety with different methods and measuring instruments.

Mental Health of Medical Students: A Bibliometric Analysis with Scopus Indexation Desvita, Widea Rossi; Aristiani, Windy; Yuniasih, Dewi; Sumarno, Andhira Setya Yudha
Ahmad Dahlan Medical Journal Vol. 6 No. 1 (2025): May 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/admj.v6i1.13050

Medical students are particularly susceptible to mental health challenges arising from academic pressure, clinical demands, and social expectations, which contribute to high rates of anxiety, depression, and burnout that jeopardize both well-being and professional performance; consequently, this study aimed to map the global research landscape on medical student mental health by conducting a bibliometric analysis of Scopus-indexed publications from 2013 to 2023 using a systematic search with keywords such as “medical student,” “mental health,” “depression,” “anxiety,” and “burnout,” followed by the extraction of metadata including titles, abstracts, authors, keywords, journals, and institutions, and subsequent analysis with VOS viewer software to visualize publication trends, collaboration networks, and research hotspots; the analysis of 7,126 publications revealed that “depression,” “anxiety,” and “burnout” were the most frequent keywords, identified key global collaborators, and indicated a surge in research activity during the COVID-19 pandemic, ultimately underscoring the increasing attention to mental health issues among medical students and highlighting the need for targeted interventions such as curriculum reform, enhanced mental health support programs, and resilience training to inform future research and guide policylevel strategies.

Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro Aristiani, Windy; Desvita, Widea Rossi; Khayatulisma, Dika; Edityaningrum, Citra Ariani; Guntarti, Any; Nurani, Laela Hayu
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10887

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.

Cytotoxicity of quercetin and curcumin combination against HeLa cells line Agitohutomo, Muhammad; Edityaningrum, Citra Ariani; Utari, Dina; Desvita, Widea Rossi; Aristiani, Windi; Nurani, Laela Hayu
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11488

Curcumin and quercetin combination are potential candidates for anticancer. Previous studies reported this combination active against several cancer cells including breast cancer, myeloid leukemia, and melanoma. However, the activity of this combination against cervical cancer has not been reported, yet. This study aimed to evaluate the cytotoxicity of the combination of curcumin and quercetin against HeLa and Vero cells. MTT assay was applied to evaluate cell growth inhibition. The inhibitory 50% concentration (IC50) of curcumin and quercetin on HeLa and Vero cells was determined and the selectivity index (SI) was then calculated. Combination index (CI) was calculated after evaluation of the cytotoxicity of the curcumin and quercetin combination at various concentration of 1 IC50, ½ IC50, and ¼ IC50. The IC50 of the curcumin against the HeLa and Vero cells were 26.57 ± 2.00 μM and 73.89 ± 12.93 μM with a SI of 2.78. Whereas the IC50 of the quercetin against the HeLa and Vero cells were 149.52 ± 21.09 μM and 1094.47 ± 15.68 μM with a SI of 7.32. The CI of combinations of curcumin and quercetin at concentrations of ¼ IC50 was 0.78 indicating a mild-moderate synergistic effect, whereas the combination at a concentration of 1 IC50 or ½ IC50, the CI value was >0.9 indicating an antagonistic effect.

Hubungan Stres dengan Kejadian Burnout pada Mahasiswa Fakultas Kedokteran Universitas Ahmad Dahlan: Penelitian Shifa, Siti Ma'rifatus; Desvita, Widea Rossi; Qomariyah, Nurul
Cermin Dunia Kedokteran Vol 53 No 02 (2026): Februari 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i02.1551

Background: Burnout can occur in individuals exposed to intense and prolonged repetitive stress. The various activities of medical students require a change in learning style from high school to college, which has the potential to cause stress. This study aims to determine the relationship between stress and burnout among students of the Faculty of Medicine, Universitas Ahmad Dahlan. Methods: The research was conducted quantitatively with a cross-sectional design. The sample was 60 students in the 3rd, 5th, and 7th semesters chosen with a with random stratified sampling technique. Results: Most of the students (80.0%) had moderate stress levels and most of the burnout levels were low (45.0%). Bivariate analysis obtained p value < 0.001 and r value = 0.641 (r > 0). In addition, an R-squared of 0.411 was obtained, which shows that the stress level makes a statistical contribution of 41.1% to the variation in burnout, and the remaining 58.9% could be influenced by other factors. Conclusion: There was a significant positive relationship between stress and burnout among students of the Faculty Medicine, Universitas Ahmad Dahlan.

An Overview of Early Detection of Mental Health using SRQ 20 among Hospital Health Workers Rokhmayanti Rokhmayanti; Widea Rossi Desvita; Siti Kurnia Widi Hastuti; Fardhiasih Dwi Astuti; Rena Anjeli Wibowo; Pradisa Ryan Sukmatama; Muhammad Ali Fikri
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.3972

Good mental health is a state of well-being where individuals are able to cope with life's stresses, work productively, and contribute to their communities. In the workplace, good mental health promotes productivity and a positive work environment. Conversely, poor mental health can reduce performance and increase the risk of occupational hazards, especially in the health sector such as hospitals. This study aimed to identify the mental health of health workers in Yogyakarta using the Self-Reporting Questionnaire (SRQ-20). The research method used a descriptive survey involving 87 respondents who were given the SRQ-20 questionnaire. The results showed that 17.2% of the 87 respondents experienced mental emotional disorders, with the majority of symptoms being headaches, anxiety, and depression.

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