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All Journal HAYATI Journal of Biosciences Indonesian Journal of Cancer Chemoprevention Biomedical Engineering agriTECH Biology, Medicine, & Natural Product Chemistry Journal of Medicine and Health Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati JFIOnline Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Electrical Engineering and Computer Science
HANA RATNAWATI
Faculty Of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : HAYATI Journal of Biosciences

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Phytochemical Assay and Antiplatelet Activity of Fractions of Velvet Bean Seeds (Mucuna pruriens L.) WAHYU WIDOWATI; HANA RATNAWATI; UDJU DJUNAEDI RUSDI; WAHYU WINARNO; VICTOR IMMANUEL
HAYATI Journal of Biosciences Vol. 17 No. 2 (2010): June 2010
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.207 KB) | DOI: 10.4308/hjb.17.2.85

Abstract

Platelet aggregation is an important factor contributing to the formation of thrombus due to an uncontrolled blood clotting. An antiplatelet agent is a compound which decreases platelet aggregation and inhibits thrombus formation. The objectives of this study were to determine the class of compound employing phytochemical assay and to determine the in vitro antiplatelet activity of four fraction, namely hexane, ethyl acetate, butanol, and water fractions of velvet bean seeds (Mucuna pruriens L.) using epinephrine (EPN) as agonist of platelet aggregation. The antiplatelet activities were tested in human platelet rich plasma with hyperaggregation. To determine the activities, EPN was arranged at 4 level of concentrations  (300, 150, 75, and 30 μM), and antiplatelet agents were at 500 µg/ml. The results indicated that ethyl acetate, butanol and water fraction contained high flavonoids and moderate phenols. The water, butanol and ethyl acetate fractions of velvet bean seeds exhibited potential inhibition of EPN-induced platelet aggregation at all concentrations. The strongest antiplatelet agent was water fraction and had the same antiplatelet activity as aspirin at level 150, 75, and 30 μM of EPN. Butanol fraction had the same antiplatelet activity as aspirin at the lowest EPN (30 μM).
The Potency of Centella asiatica Leaf Extract on VEGF Expression and Angiogenesis in Second-Degree Burn Wound in Mice Utoyo, Frederick Surya; Widowati, Wahyu; Ratnawati, Hana
HAYATI Journal of Biosciences Vol. 32 No. 1 (2025): January 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.1.140-146

Abstract

Burn injuries present a significant global health challenge, with the highest incidence rates reported in Southeast Asia, including Indonesia. Healing burn wounds is a complex and dynamic process involving various cellular and molecular mechanisms, prominently featuring the role of Vascular Endothelial Growth Factor (VEGF) in tissue regeneration and wound repair. VEGF is crucial for inducing and regulating angiogenesis and supplying oxygen and nutrients to the healing tissue. This study aims to evaluate the potential of pegagan (Centella asiatica) leaf extract cream 1%, 3%, and 5% daily for 14 days in enhancing VEGF expression and angiogenesis in second-degree burn wounds in mice (Mus musculus). This study investigates the application of C. asiatica extract cream on second-degree burn wounds in mice, comparing its effects on VEGF protein expression and angiogenesis to those of base cream and silver sulfadiazine cream, with outcomes evaluated using immunohistochemistry (IHC) and hematoxylin and eosin (HE) staining methods. Our findings suggest that C. asiatica extract cream promotes reduced burn wound size, significant upregulated VEGF expression, and enhanced angiogenesis in treating burn wounds compared to positive control, with a 5% dose having the best result. The study concludes that C. asiatica extract cream may effectively treat burn wound healing through enhancing VEGF expression and angiogenesis.
Co-Authors - Lindayani Achmad R. Permadi, Achmad R. Angeline, Stephanie Ardo Sanjaya Ch. Retnaningsih, Ch. Chandra Risdian Chandra Risdian Diana Krisanti Jasaputra Felix Kasim Feri Eko Herman Ferry Sandra Gabriella Constantia Gabriella, Raissa I Dewa Gde Sathya Deva Ida AKT Bulan, Ida AKT Imam Cholissodin Lailil Muflikhah Liliana, Teresa Maesaroh Maesaroh Maesaroh Maesaroh Maratantiningtyas, Demes Chornelia Nashi Widodo Putri, Fanny Karuna Riyanarto Sarno Sariwidyantry, Raden Ghita Susi Tjahyani Susy Tjahyani Tati Herlina Teresa Liliana Wargasetia Tjandrawati Mozef Tjandrawati Mozef Udju D. Rusdi Udju Djunaedi Rusdi UDJU DJUNAEDI RUSDI Utoyo, Frederick Surya VICTOR IMMANUEL WAHYU WIDOWATI Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyu Widowati Wahyu Winarno WAHYU WINARNO WAHYU WINARNO Winsa Husin