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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Mandala Pharmacon Indonesia SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Agama Buddha dan Ilmu Pengetahuan Indonesian Journal of Pharmaceutical Education JURNAL PENDIDIKAN INDONESIA: Teori, Penelitian, dan Inovasi EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Bengawan :Jurnal Pengabdian Masyarakat
Endang Sri Rejeki
Faculty of Pharmacy, Setia Budi University
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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ANALISIS LOGAM TIMBAL (Pb) PADA PENSIL ALIS YANG BEREDAR DI KABUPATEN TULUNGAGUNG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Rosyidah, Semi; Harmastuti, Nuraini; Rejeki, Endang Sri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p179-186

Abstract

Eyebrow pencil is a cosmetic that is used to correct less symmetrical eyebrows. The colors marketed are very diverse. Lead is also obtained from tools used during the production process. This study aims to determine the lead content in eyebrow pencils and to determine the lead levels in eyebrow pencils circulating in Tulungagung by atomic absorption spectrophotometry (AAS) still meets the requirements of BPOM No. 12 of 2019. Sampling using a purposive sampling technique. Preparation samples were carried out using the dry deconstruction method. The research began with chemical and physical qualitative analysis. The determination of lead levels using AAS at a wavelength of 283.3 nm was then determined. The AAS analytical method is suitable for lead based on the results of method verification meeting the requirements including linearity with a value of r = 0.9929, accuracy of 102%, LOD 0,1189 mg/L, but did not meet the LOQ of 0.3964 mg/L. The results showed that 3 out of 5 samples were positive for lead with levels ranging from 4.9339-5.4896 mg/kg. The results still meet the BPOM contamination limit requirements, which are not more than 20 mg/kg, thus all samples are still within safe limits according to the requirements set by BPOM.
Formulasi Orally Disintegrating Tablet (ODT) Furosemide Menggunakan Fast Disintegrant Crospovidone dan Croscarmellose Sodium dengan Metode Kempa Langsung Prastika, Delia Ayu; Rejeki, Endang Sri; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p17-27

Abstract

Orally Disintegrating Tablets (ODT) are tablets that disintegrate or break down in less than one minute. Furosemide is a potent diuretic (loop diuretic) used in the treatment of edema associated with hypertension, congestive heart disease, heart failure, liver cirrhosis and kidney disease. Crospovidone is a fast disintegrating agent which is very porous so it can speed up the tablet disintegration time. Croscarmellose sodium is able to absorb water and expand quickly, thereby accelerating the disintegration of the tablet. The aim of this research was to determine the effect of the fast disintegrants crospovidone and croscarmellose sodium on the physical properties and dissolution profile of furosemide ODT, and to find out which fast disintegrant is better in producing good furosemide ODT. This study used seven formulas, namely three formulas with variations of crospovidone 1%, 3% and 5%, three formulas with variations of crosscarmelosse sodium 1%, 3% and 5% and one formula as a control. Furosemide ODT is made by direct compression method. Evaluation of the physical properties of furosemide ODT includes hardness test, brittleness test, and disintegration time test. Tablet dissolution profile testing was carried out in-vitro. The data obtained were analyzed using the one way ANOVA test with a confidence level of 95%. The results showed that the addition of rapid disintegrating crospovidone and croscarmellose sodium at a concentration of 5% was able to influence the hardness, friability and disintegration time of the tablet, as well as increasing the dissolution profile. A better rapid disintegrating agent that produces good furosemide ODT is croscarmellose sodium.
ANALISIS LOGAM BERAT PADA SEDIAAN EYE SHADOW BENTUK CAKE YANG BEREDAR DI ONLINE SHOP SECARA SPEKTROFOTOMETRI SERAPAN ATOM Pujianto, Dina Lisdiana; Supriyadi, Supriyadi; Rejeki, Endang Sri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p147-153

Abstract

Eye shadow is an eyelid makeup that is used to make the eyes appear darker so that the eyelids look more sunken in. Heavy metals are generally impurities in the basic ingredients of cosmetics that arise during production. The purpose of the study was to determine the levels of heavy metals in eye shadow in accordance with BPOM RI No. 12 Tahun 2019. This study used purposive sampling method. Sample preparation was carried out using the dry deconstruction method. The study began with qualitative analysis indicated by the appearance of heavy metal absorbance in reading with a selective cathode lamp in atomic absorption spectrophotometry (SSA). Determination of heavy metal levels using atomic absorption spectrophotometry (SSA) at a wavelength of 197.3 nm for arsenic, 228.8 nm for cadmium, and 283.3 nm for lead. The results of heavy metal levels were then analysed using SPSS 26.0 one-sample T-tests. The results showed that all samples A, B, C, D, and E were positive for arsenic, cadmium, and lead with respective levels ranging from 0.19227-0.81752 mg/kg; 0.37014-1.05215 mg/kg; and 1.44905-6.22936 mg/kg. The results obtained still meet the BPOM contamination limits, which are < 5 mg/kg for arsenic, < 5 mg/kg for cadmium, and < 20 mg/kg for lead, thus all samples are still within safe limits in accordance with the requirements of BPOM RI No. 12 Tahun 2019.
Uji Akltivitas Antioksidan, Kadar Flavonoid, dan Fenolik Total Ekstrak dan Fraksi Daun Asam Jawa (Tamarindus indica L.) Nainggolan, Rully Mukti; Rahayu, Mamik Ponco; Rejeki, Endang Sri
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.554

Abstract

Daun Asam Jawa (Tamarindus indica L.) merupakan suatu tanaman yang mengandung senyawa metabolit sekunder berupa fenolik dan flavonoid. Senyawa tersebut berpotensi sebagai antioksidan alami untuk mencegah terjadinya penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan, kadar flavonoid, dan fenolik total pada ekstrak, fraksi n-heksan, etil asetat dan air daun Asam Jawa. Daun Asam Jawa diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%, kemudian difraksinasi. Ekstrak dan fraksi daun Asam Jawa diuji kandungan kimianya dengan metode reaksi tabung, diuji aktivitas antioksidan menggunakan metode DPPH, ditetapkan kadar flavonoid totalnya dengan AlCl3 menggunakan baku kuersetin, dan ditetapkan kadar fenolik totalnya menggunakan baku asam galat dengan alat instrumen spektrofotometri UV-Vis.Hasil menunjukkan bahwa ekstrak, fraksi n-heksan, etil asetat, dan air daun Asam Jawa memiliki aktivitas antioksidan dengan nilai IC50 berturut-turut sebesar 44,53 ± 0,8; 306,61 ± 2,23; 27,27 ± 1,02; dan 47,04 ± 1,30 ppm, sedangkan baku kuersetin memiliki nilai IC50 sebesar 2,83 ± 0,04 ppm. Ekstrak etanol, fraksi n-heksan, etil asetat dan air daun Asam Jawa memiliki kandungan flavonoid total berturut-turut sebesar 8,52±0,29; 4,61±0,14; 24,43±1,97 dan 14,52±0,20 QE mg/g, sedangkan fenolik totalnya sebesar 57,21±0,44; 42,55±0,32; 93,31±0,62; dan 44,67±1,23 GAE mg/g. Hasil penelitian ini menunjukkan bahwa fraksi etil asetat memiliki aktivitas antioksidan terkuat dengan kategori sangat kuat, serta memiliki kadar flavonoid dan fenolik total tertinggi dibandingkan dengan ekstrak dan fraksi lainnya.
Co-Authors . Sardjiman Azizah, Asma Endin Mujahidin Ghani Nurfiana Fadma Sari Hartono6, Rudi Illah, Galuh Sekar Rahma Ismi Rahmawati Maemunah Mamik Ponco Rahayu Nainggolan, Rully Mukti Naman, Putri Ekawani Melianthi Nuraini Harmastuti Pramukantoro, Ganet Eko Prastika, Delia Ayu Priyanto, Widodo Pujianto, Dina Lisdiana Purnamasari, Nur Aini Dewi Putra, Sudi Sasana Rosyidah, Semi Silviani, Meliza Siti Aisyah Sole, Teresa Ayustin Getrisya Supriyadi Supriyadi Turahman, Taufik Widitasari, Ayunda Syifa Yusup, Ainiyah Hidayanti