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All Journal Journal of Pharmaceutics and Pharmacology Indonesian Journal of Cancer Chemoprevention Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM)
Julia Reveny
Universitas Sumatera Utara
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation

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Journal : Jurnal Ners

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Aktivitas Antibakteri Minyak Habbatusauda (Nigella Sativa L.) dalam Menghambat Pertumbuhan Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Bukit, Darmanta; Reveny, Julia; Masfria, Masfria
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47399

Abstract

ABSTRACTAcne is a common skin disorder associated with the proliferation of Propionibacterium acnes and Staphylococcus aureus. This study aims to evaluate the antibacterial activity of Nigella sativa (black seed) oil against these two bacteria and investigate its mechanism of action. The methods included disc diffusion assay for inhibition zone measurement, determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), and analysis of ion leakage and intracellular content release using spectrophotometry. The results revealed that black seed oil demonstrated antibacterial activity, with the highest inhibition zone at 100% concentration: 16.16 mm for P. acnes and 16.43 mm for S. aureus. MBC values were determined at 12.5% for P. acnes and 6.25% for S. aureus. The oil also induced leakage of Ca²⁺ and K⁺ ions, as well as nucleic acids and proteins from bacterial cells, indicating membrane disruption as its primary mechanism. These findings support the potential use of black seed oil as a natural therapeutic agent for acne treatment. Keywords: black seed oil, acne, antibacterial, Propionibacterium acnes, Staphylococcus aureus.
Aktivitas Antibakteri Minyak Jarak (Castor Oil) dalam Menghambat Pertumbuhan Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Simbolon, Yuni Angelia; Reveny, Julia; Masfria, Masfria
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47407

Abstract

Abstract Acne is a skin disorder caused by chronic inflammation of the pilosebaceous follicles, commonly associated with increased sebum, bacterial colonization, and local inflammation. The primary bacteria involved are Propionibacterium acnes and Staphylococcus aureus. Long-term use of synthetic antibiotics can lead to bacterial resistance, thus encouraging the search for natural-based alternatives. This study aimed to evaluate the antibacterial activity of castor oil against both bacterial species. The research applied a disc diffusion method to assess the inhibition zones, followed by tests for minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cellular leakage analysis using UV-Vis spectrophotometry and atomic absorption spectroscopy (AAS). Results demonstrated that castor oil exhibits moderate antibacterial activity, with the highest inhibition observed at 100% concentration: 12.86 mm for P. acnes and 10.3 mm for S. aureus. Furthermore, castor oil induced leakage of Ca²⁺, K⁺, protein, and nucleic acids from bacterial cells. These findings confirm the potential of castor oil as a natural topical antibacterial agent for acne treatment.Keywords: castor oil, antibacterial, acne, Propionibacterium acnes, Staphylococcus aureus
Co-Authors Aminah Dalimunthe Arianto, Anayanti Arianto Bukit, Darmanta Dharmawan, Hariyadi Ervina Syahfitri Lubis Fajriah, Nurul Fitri, Raissa Hafid Syahputra Herawaty Ginting Juanita Tanuwijaya Juwita, Nur Aira Lely Sari Lubis Maha, Hetty Lendora Masfria Muchlisyam Nasri Nazliniwaty Nazliniwaty* Rohani, Ade Sri Simbolon, Yuni Angelia Sudarmi Sumaiyah Sumaiyah Surjanto Surjanto Suwarso, Edy Urip Harahap Wiryanto Wiryanto Yoan Dasawanti