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All Journal Science and Technology Indonesia Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research GANDRUNG: Jurnal Pengabdian Kepada Masyarakat International Journal Of Science, Technology & Management (IJSTM) Narra J Nusantara Scientific Medical Research Journal Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi

Hafid Syahputra

Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan 20155, Indonesia

Author-ID : 2316283

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Pelayanan Informasi dan Konseling oleh Apoteker tentang Penyakit Degeneratif serta Pemeriksaan Kesehatan kepada Masyarakat di Desa Ndokum Siroga: Information and Counseling Services by an Apothecary about Degenerative Diseases and Health Checks to the Community in Ndokum Siroga Village Hafid Syahputra; Aminah Dalimunthe; Nazliniwaty Nazliniwaty; Lisda Rimayani Nasution
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 7 No. 4 (2022): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v7i4.3040

Degenerative disease is a disease experienced by many people, such as hypertension, coronary heart disease, diabetes mellitus, gout, and others. Pharmacists play a role in providing information and education about health, primarily pharmacological and non-pharmacological drugs. The purpose of the activity is to increase public understanding regarding degenerative diseases from the side of treatment by pharmacists by adopting a healthy lifestyle and understanding the importance of health checks as the first step to early detection of degenerative diseases. The implementation method is in the form of health checks in the form of blood pressure, cholesterol, uric acid, and blood sugar levels so that it can be early detection of degenerative diseases. Information and counseling services by pharmacists regarding healthy lifestyles and information related to treatment and degenerative diseases using brochures and individual direct delivery. The activity was carried out in Ndokum Siroga Village, Karo Regency. The service results were carried out at the village hall with 35 participants. The activity was full of enthusiasm, and many questions arose during the service by the pharmacist. It is known that participants' understanding of degenerative diseases is very low, with only 24% who know about degenerative diseases, 32% who know the symptoms of the disease, 27% who know the risks, and 30% who apply preventive and promotive efforts. 14% of participants do not know that they have the degenerative disease, so it can be concluded that this activity is very helpful and provides good benefits to the community.

Characterization, Phytochemical Screening of Phyllanthus emblica L. Fruit Nanoherbal and Determination of the Estrus Cycle of Female Rats Nurul Suci; Masfria; Aminah Dalimunthe; Hafid Syahputra
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.727

One of a plant that is thought to have quite high antioxidant activity is kemloko (Phyllanthus emblica L.). This plant is a material that is often used by the community as a traditional medicine. This plant in India has been used to treat cancer, diabetes, liver (liver), heart problems and anemia. This biological activity is thought to be caused by the presence of bioactive compounds from secondary metabolites contained therein, especially compounds from the phenolic and flavonoid groups. The short length of the estrus cycle of rats makes them ideal for investigation of changes occurring during the reproductive cycle. The estrus cycle lasts four days and is characterized as: proestrus, estrus, metestrus and diestrus, which may be determined according to the cell types observed in the vaginal smear. Since the collection of vaginal secretion and the use of stained material generally takes some time, the aim of the present work was to provide researchers with some helpful considerations about the determination of the rat estrus cycle phases in a fast and practical way. This study began with macroscopic examination, examination of water content, examination of water-soluble extract levels, examination of ethanol-soluble extracts, examination of total ash content, and also an examination of acid-insoluble ash levels, phytochemical screening of Phyllanthus emblica L. fruit nanoherbal and determination of the estrus cycle of female rats. The results of phytochemical screening showed that the compound of Phyllanthus emblica L. Fruit nanoherbal contained a class of secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. And the estrus cycle of female rats can be determined by observing changes in vaginal epithelial cells.

Antibacterial Activity Ethanolic Extract of Ocimum basilicum L. Leaves in Inhibiting the Growth of Escherichia coli and Pseudomonas aeruginosa Muhammad Fauzan Lubis; Hafid Syahputra; Ririn Astyka
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Infectious disease is the biggest problem in the world. The problem with this infection is related to antibiotic resistance if its use is not consistent. Utilization of kemangi leaves, which are always used as fresh vegetables, has potential as an antibacterial in inhibiting the growth of Escherichia coli and Pseudomonas aeruginosa bacteria. This study aims to analyze the inhibition of an ethanol extract of kemangi leaves against Escherichia coli and Pseudomonas aeruginosa. The Kirby-Bauer method with the disc diffusion method was used to determine the minimum inhibitory diameter and to calculate the activity index value. The test results at a concentration of 500 mg/mL showed activity in the strong category, namely 13.70 ± 0.10 mm (Escherichia coli) and 12.93 ± 0.06 mm (Pseudomonas aeruginosa), and the minimum inhibitory concentration was at a concentration of 3.125 mg/mL. Conclusion the ethanol extract of kemangi leaves shows antibacterial activity.

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Capsules Containing Phyllanthus emblica L. Fruit Nanoparticles Masfria; Sumaiyah; Hafid Syahputra; Marwin Witarman
Science and Technology Indonesia Vol. 8 No. 4 (2023): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.4.607-615

Phyllanthus emblica fruit has diuretic, antibacterial, hepatoprotective, antitumor, hypocholesterolemic, antioxidant, and antiulcerogenic activities making it possible as a traditional medicine in capsule form. Capsule preparations have the advantage of covering the unpleasant taste and smell of medicinal ingredients, easy to swallow, so they are practical to use. This study aimed to formulate Phyllanthus emblica fruit nanoparticles in capsules and to test the antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa and anti-inflammatory activity by observing denaturation inhibition in vitro. The method used to manufacture Phyllanthus emblica fruit simplicia nanoparticles was used using a High Energy Ball mill grinding machine. Capsule formulation was carried out with various doses of nanoparticles (100, 150, and 200 mg). Evaluation includes weight uniformity and disintegration time. Test of its antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa and its anti inflammatory activity in vitro. The study found that all formulas could be made into capsules that met the evaluation test requirements. The results of the evaluation of disintegration time ranged from 6.17-11.33 minutes. For the evaluation results of weight uniformity, it was found that weight deviations in columns A1 and A2 were in the range between 0.9% to 2.8% and 0.9 to 1.3%. The study reports on the antibacterial activity of Phyllanthus emblica fruit nanoparticle capsules (PFNP) against Streptococcus mutans and Pseudomonas aeruginosa. The results indicate that PFNP exhibits a dose-dependent antibacterial effect, with inhibition zone diameters of 10.83 mm, 11.6 mm, and 12.63 mm observed at 100 mg, 150 mg, and 200 mg, respectively, against Streptococcus mutans. Similarly, PFNP demonstrated a dose-dependent antibacterial effect against Pseudomonas aeruginosa, with inhibition zone diameters of 10.7 mm, 11.4 mm, and 12.1 mm observed at doses of 100 mg, 150 mg, and 200 mg, respectively. PFNP capsules showed inhibition results with a value of 5.63%, 6.13%, and 6.80%. It was concluded that Phyllanthus emblica fruit nanoparticles (Phyllanthus emblica L.) could be formulated in capsule dosage forms with doses of 100 mg, 150 mg, and 200 mg; has antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa, and has no anti-inflammatory activity.

KAJIAN KARAKTERISASI SELULOSA MIKROKRISTALIN DARI KERTAS BEKAS DENGAN VARIASI KONSENTRASI ASAM KLORIDA hafid Syahputra; Sri Yuliasmi; Sumaiyah Sumaiyah
Parapemikir : Jurnal Ilmiah Farmasi Vol 11, No 2 (2022): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v11i2.3209

Kandungan selulosa pada kertas HVS mencapai 90% dari beratnya. Salah satu turunan selulosa adalah selulosa mikrokristalin (MCC), dimanfaatkan sebagai eksipien untuk pencetakan tablet. Pembuatan MCC menggunakan asam klorida (HCl). Tujuan penelitian ialah memberikan informasi terkait proses pembuatan MCC dari kertas bekas dengan pengaruh konsentrasi HCl untuk alternatif lain pembuatan MCC dengan hasil yang optimal dari penggunaan HCl untuk hidrolisis. Metode penelitian ini dimana MCC diperoleh dengan memanaskan kertas dengan campuran NaN dalam HN 3,5% dan NaOH 2% dalam S 2%. Diputihkan dengan NaOCl 3,5% dalam air. Lalu panaskan dengan NaOH 17,5%, kemudian dihidrolisis dengan HCl konsentrasi 1N; 2,5N; 5N dan 10N. Selulosa mikrokristal ditentukan karakteristiknya. Hasil rendemen MCC terbanyak pada konsentrasi 1 N sebesar 80,82%. Hasil karakterisasi seluruh MCC kertas bekas konsentrasi HCl dan Avicel PH 102 diperoleh adalah uji organoleptik yaitu berwarna putih, tidak berbau, dan tidak berasa. Sifat fiskokimia meliputi pH memenuhi persyaratan; kelarutan dalam air semuanya memenuhi persyaratan. Selanjutnya bobot jenis nyata hanya 10N dan Avicel PH 102 yang memenuhi persyaratan, bobot jenis mampat tidak memenuhi persyaratan. Analisis FT-IR seluruh konsentrasi MCC dan Avicel PH 102 menunjukkan kemiripan spektrum. Kesimpulan didapatkan bahwa seluruh seluruh MCC kertas bekas konsentrasi HCl dan Avicel PH 102 memilki karakteristik yang hampir sama, dan dapat digunakan sebagai alternatif selulosa mikrokristal.

Relationship between interleukin-6 (IL-6) levels and chest X-ray severity scoring in COVID-19 patients Kardiasyah, Alzi; Syarani, Fajrinur; Bihar, Syamsul; Lubis, Netty D.; Mutiara, Erna; Syahputra, Hafid
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.690

The severity of coronavirus disease 2019 (COVID-19) may be measured by interleukin-6 (IL-6) and chest X-rays. Brixia score of the chest radiographs is usually used to monitor COVID-19 patients’ lung problems. The aim of this study was to demonstrate the relationship between IL-6 levels and chest radiographs (Brixia score) that represent COVID-19 severity. A retrospective cohort study was conducted among COVID-19 patients who had a chest X-ray and examination of IL-6 levels at H. Adam Malik General Hospital, Medan, Indonesia. A multinomial logistic regression analysis was conducted to evaluate the association between IL-6 levels and the severity of the chest radiograph. A total of 76 COVID-19 patients were included in the study and 39.5% of them were 60–69 years old, with more than half were female (52.6%). A total of 17.1%, 48.7%, and 34.2% had IL-6 level of <7 pg/mL, 7–50 pg/mL and >50 pg/mL, respectively. There were 39.5%, 36.8% and 23.7% of the patients had mild, moderate and severe chest X-rays based on Brixia score, respectively. Statistics analysis revealed that moderate (OR: 1.77; 95% CI: 1.05–3.32) and severe (OR: 1.33; 95% CI: 1.03–3.35) lung conditions in the chest X-rays were significantly associated with IL-6 levels of 7–50 pg/mL. IL-6 more than 50 pg/mL was associated with severe chest X-ray condition (OR: 1.97; 95% CI: 1.15–3.34). In conclusion, high IL-6 levels significantly reflected COVID-19 severity through chest X-rays in COVID-19 patients.

Stunting Prevention Movement Through Fortification of Moringa Leaves and Mung Bean Flour in Cookies as PMT (Supplementary Feeding) For Toddlers in Medan Sunggal District Denny Satria; Aminah Dalimunthe; Hafid Syahputra; Vivi Asfianti; Syukur Berkat Waruwu
GANDRUNG: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2025): GANDRUNG: Jurnal Pengabdian Kepada Masyarakat
Publisher : Fakultas Olahraga dan Kesehatan, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/gandrung.v6i2.4654

Stunting is a serious problem and is also a major nutritional problem. The problem of stunting has a quite serious impact. It can be short-term related to morbidity and mortality in infants and toddlers, medium-term related to low intellectual and cognitive ability, and long-term related to the quality of human resources and degenerative disease problems in adulthood. The average prevalence of stunting in Indonesia from 2015 to 2017 was 31.4%, far above the WHO limit of 20%. The government with Presidential Decree No. 42/2013 has established a national movement for the first 1000 days of life to improve the nutritional status of toddlers as an effort to handle stunting in Indonesia. Because of the mothers' lack of knowledge about stunting, we were moved to do community service in Medan Sunggal District. Based on this thought, this community service activity is carried out to educate women (community) about the importance of good and correct food processing regarding nutrition/nutrition intake for toddlers by making mothers health cadres in the family in the application of functional food processing from natural ingredients such as moringa leaves and mung beans for stunting prevention in Medan Sunggal District.

Uji Aktivitas Antioksidan Teh Herbal Biji Durian (Durio zibethinus Murr.) dengan Tambahan Daun stevia (Stevia rebaudiana Bertoni) sebagai Pemanis Alami dengan Metode DPPH Andry, Muhammad; Ramadaini, Tiara; Marseli, Cindy; Nurfitriyana, Nurfitriyana; Azzahra, Rafifah; Syahputra, Hafid; Shiyan, Shaum
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1070

Free radicals are an important health concern due to their role in the development of various diseases. Antioxidants, capable of neutralizing free radicals, are abundant in plants such as durian seeds (Durio zibethinus Murr.) and stevia leaves (Stevia rebaudiana Bertoni). Herbal tea formulated from these materials has potential as an alternative functional drink because both contain phenolic compounds with antioxidant activity. This study aimed to evaluate the potential of durian seeds and stevia leaves as herbal tea with antioxidant properties. The research involved sample collection, identification, preparation of simplicia, characterization, formulation of herbal tea, quality testing, and determination of antioxidant activity. The simplicia characteristics of durian seeds and stevia leaves showed water content of 6.16% each, water-soluble extract of 35% and 15.8%, ethanol-soluble extract of 25.5% and 14.6%, total ash of 0.73% and 0.3%, and acid-insoluble ash of 0.5% and 0.26%. Quality testing of the herbal tea showed water content of 2.18%, total ash of 3.90%, water-soluble ash of 73.85%, and acid-insoluble ash of 3.80%. Antioxidant activity based on IC50 values was 68.45 ± 1.32 ppm for durian seed tea, 61.6 ± 1.05 ppm for stevia tea, 39.28 ± 0.98 ppm (1:1), 44.64 ± 1.11 ppm (1:2), and 42.32 ppm ± 1.07 (2:1). These results indicate that combining durian seeds and stevia leaves can enhance antioxidant activity compared to individual extracts. Overall, durian seeds and stevia leaves can be developed into herbal tea formulations with very strong antioxidant activity, as reflected in their ability to reduce DPPH radicals. Radikal

Socialization and Education on The Benefits of Probiotics for Children's Health in Primary School Until Senior High School Students in Tanjung Morawa Cintya, Henni; Rimayani, Lisda; Syahputra, Hafid
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2021): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Dysbiosis is a condition in which there is an imbalance in the number of microorganisms in the human digestive tract. This condition often occurs in children. An imbalance in the number of microorganisms in the digestive tract in humans (microflora) occurs when bacterial overgrowth. This can cause infection or inflammation localized in the intestine which has the potential to cause various diseases. However, knowledge about probiotics is still not understood by the public. This community service activity aims to provide knowledge about the role of probiotic microorganisms for children's health, especially for elementary-high school children in Tanjung Morawa District. This Community Service activity was carried out by means of a lecture method by disseminating the activity plan to the children of the Yayasan Pauly Mandiri, then a demonstration by conducting counseling and displaying animated videos related to the socialization that was carried out. Community service activities in general received a very good response and high enthusiasm from students, and several teachers who attended as well as the chairman of the Pauly Mandiri Education Foundation in Kec. Tanjung Morawa asked to continue. The results of community service, especially practicing drinking probiotic drinks. The enthusiasm of the participants hopes that this outreach activity can be resumed regarding the manufacture of food or drinks containing probiotics so that children can apply them daily, and consume them to increase body immunity in the midst of a pandemic.

Training on the Use of Processed Herbal Plants as an Effort to Prevent Degenerative Diseases to the Community Masfria; Muchlisyam; Reveny, Julia; Syahputra, Hafid
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2023): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v8i1.9518

This community service aims to increase public knowledge in health and health efforts through promotive and preventive activities by conducting counselling and training in the use of medicinal plants and how to process herbal plants properly and correctly so that people in Ndokum Siroga village, Karo Regency understand the importance of health and a healthy paradigm. by using herbal plants. This community service activity is to increase public awareness of health by introducing a healthy paradigm. The implementation method used is lectures and training where lectures are conducted to increase public knowledge about the health paradigm and the importance of health as well as the introduction of herbal plants to make family medicinal plants while the training is carried out by providing facilities and infrastructure for community service activities to increase community knowledge and skills, including delivery papers on various types of herbal plants used, things to consider in-plant processing, and their properties, as well as the practice of processing plants into drinks that are easy to consume. The conclusion of this activity is very helpful and provides good benefits to the community because this activity can have a direct impact on the community. The analysis technique and activity results are seen from the knowledge of the community before and after the training and counselling by asking questions in an objective form that can describe the different levels of understanding of the participants.

Co-Authors Amana, Meuthia Rizka Aminah Dalimunthe Aminah Dalimunthe Bihar, Syamsul Cintya, Henni Denny Satria Erna Mutiara Julia Reveny Juwita, Nur Aira Kardiasyah, Alzi Lisda Rimayani Lubis, Netty D. Marseli, Cindy Marwin Witarman Masfria Masfria Masfria Muchlisyam Muhammad Andry Muhammad Fauzan Lubis Muhammad Rivai Nazliniwaty Nazliniwaty* Nurfitriyana Nurfitriyana Nurul Suci Rafifah Azzahra Ramadaini, Tiara Rimayani, Lisda Ririn Astyka Rohani, Ade Sri Shafira Mahrani Shaum Shiyan Sumaiyah Sumaiyah Sumaiyah Syarani, Fajrinur Syukur Berkat Waruwu Vivi Asfianti Yasmeen Nazhifah Yuliasmi, Sri

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