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All Journal Journal of Agromedicine and Medical Sciences Smart Medical Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Respiratory Science
Isbaniah, Fathiyah
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Emerging Bedaquiline Resistance in Pulmonary Tuberculosis Patients of a Tertiary Hospital in Jakarta, Indonesia Fathiyah Isbaniah; Budi Haryanto; Nabila Assakinah Lubis; Cindy Refina Maharani; Heidy Agustin; Faiza Hatim; Riyadi Sutarto; Raden Rara Diah Handayani; Muhammad Nashirul Islam; Muhammad Hibban Heldian; Fathia Amalia Faizal; Aulia Rizkia Herawati
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.20-26

Abstract

Introduction: Tuberculosis (TB) continues to pose significant health and economic challenges globally. Drug-resistant TB (DR-TB), particularly resistance to bedaquiline (BDQ), threatens the efficacy of current treatment regimens. Limited phenotypic drug susceptibility testing (DST) capacity exacerbates the issue, delaying appropriate interventions. This study examined BDQ resistance patterns among pulmonary DR-TB patients in Indonesia, where evidence on BDQ resistance remains scarce. Methods: A retrospective analysis of 393 DR-TB cases was conducted using data from the National TB Database (SITB) at Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia, between 2021 and 2023. Patients were classified based on the World Health Organization (WHO) 2022 DR-TB guidelines. Resistance patterns were determined through phenotypic DST using the BACTEC Mycobacteria Growth Indicator Tube (MGIT) system. Descriptive statistics summarized patient demographics and resistance profiles. Results: Among the 393 patients, 10 (2.54%) demonstrated BDQ resistance, with 8 cases arising without prior BDQ exposure. Mono/poly-resistance to Rifampicin and/or Isoniazid was the most prevalent pattern (44.29%). Multidrug-resistant TB (MDR-TB) was observed in 40.20% of cases, while pre-extensively DR and extensively DR-TB constituted 7.90% and 0.25%, respectively. Comorbidities, predominantly diabetes mellitus (DM), were identified in 33.59% of patients. Conclusion: This study revealed an alarming BDQ resistance rate (2.50% in MDR-TB cases), underscoring the urgent need for improved access to DST and TB management infrastructure in Indonesia. Strengthening diagnostic capacity and monitoring systems is critical to mitigating the spread of resistance and supporting effective treatment strategies.
Risk and Prevention of Infections in the Bronchoscopy Room Wahju Aniwidyaningsih; Indah Puspita Sari; Anis Karuniawati; Fathiyah Isbaniah; Mia Elhidsi; Ni Putu Laksmi Ananda Martini
Respiratory Science Vol. 6 No. 3 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i3.217

Abstract

Bronchoscopy is a widely used diagnostic and therapeutic procedure in pulmonary medicine, with increasing utilization as technology advances. However, it is also associated with a risk of infection, which may negatively impact patient outcomes, particularly in individuals with underlying lung disease or immunocompromised conditions. The Centers for Disease Control and Prevention (CDC) has reported that endoscopic procedures, including bronchoscopy, are among the most frequently implicated medical devices in healthcare-associated outbreaks. Post-bronchoscopy infections, although relatively uncommon (0.2–5.2%), may lead to serious complications such as pneumonia, lung abscess, and empyema. These infections can originate from endogenous respiratory flora or from exogenous contamination related to inadequate bronchoscope reprocessing. This narrative review aims to summarize current evidence on infection risks, sources of transmission, and preventive strategies in the bronchoscopy setting, including occupational risks to healthcare workers. Strengthening infection control practices is essential to improve patient safety and reduce the risk of transmission in bronchoscopy units.
Pneumonia Corona Virus Infection Disease-19 (COVID-19) Fathiyah Isbaniah; Agus Dwi Susanto
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-235

Abstract

Since the beginning of 2020 there has been an increase in the number COVID-19 virus infection, previously known as 2019-nCov. It is known that up to February 2020, more than 70,000 positive cases of COVID-19 infection have been confirmed. COVID-19 is known to be a virus from the coronaviridae family, which is also a family of the SARS-CoV and MERS-CoV viruses that caused an outbreak in 2002 and 2012. The exact pathogenesis of COVID-19 is not clearly known, but is thought to be similar to the pathogenesis of SARS-CoV and MERS-CoV. The average COVID-19 mortality was 2.3%, lower than the SARS-CoV and MERS-CoV mortality. The COVID-19 outbreak was also thought to have started from a local seafood sales market in winter, an environment that was almost the same as the SARS virus outbreak. This scientific article will discuss in depth the operational definitions that can be used in the management of patients with suspected COVID-19 infection. It will also discuss clinical manifestations and management in patients with suspected and confirmed COVID-19 infection.
Co-Authors Agus Dwi Susanto Agustin, Heidy Amien, Bagus Radityo Ananta, Muammar Emir Anis Karuniawati Aria Kekalih Astrid Mariam Khairani Siregar Audina, Dea Putri Aulia Rizkia Herawati Brayanna Infinita Laviashna Saputro Budhi Antariksa Budi Haryanto Cindy Refina Maharani Darwis, Andi Dewi Yenita Diah Handayani Diah Handayani Dwi Rendra Hadi Elhidsi, Mia Eri Widianto Erlina Burhan Fadhillah, Muhamad Rizqy Faisal Yunus Faisal Yunus Faiza Hatim Faiza Hatim Fariz, Nurwidya Fathia Amalia Faizal Flora Ekasari Heidy Agustin Herman Mulijadi Ibrahim Nur Insan Putra Dharmawan Indah Puspita Sari Indah S. Widyahening Ismulat Rahmawati Klara Sinabutar Lily Indriani Octovia Muhammad Hibban Heldian Muhammad Ilham Dhiya Rakasiwi Muhammad Nashirul Islam Murniati Murniati Nabila Assakinah Lubis Ni Putu Laksmi Ananda Martini Putra, Andika Chandra Raden Ena Sarikencana Raden Rara Diah Handayani Rania Imaniar Ratnawati Ratnawati Retno Wibawanti Rina Diana Nurfitri Ririn Astuty Ningsih Riyadi Sutarto Sabila, Ginindha Izzati Samoedro, Erlang Sita Laksmi Andarini Soehardiman, Dicky Tomu Juliani Triya Damayanti Triya Damayanti Wahju Aniwidyaningsih Wahyu Aniwidyaningsih Zaini, Jamal