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All Journal Acta Biochimica Indonesiana BIOVALENTIA: Biological Research Journal Berita Biologi
Rahmawati Ridwan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology

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EFFECT OF LIME APPLICATION ON INDIGENOUS NITROGEN-FIXING BACTERIA IN TIDAL SOILS MANAGED FOR THAN 30 YEARS Ridwan, Rahmawati; Budianta, Dedik; Widjajanti, Hary
BIOVALENTIA: Biological Research Journal Vol. 3 No. 2 (2017)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1119.549 KB) | DOI: 10.24233/BIOV.3.2.2017.70

Abstract

The study was conducted to determine the effect of land typology and lime on the population of indigenous nitrogen-fixing bacteria and soil pH, and to analyze the effect of soil typology interaction and lime on the population of indigenous nitrogen-fixing bacteria and soil pH. Sampling of soil in tidal land of Mulya Sari and Banyu Urip Village of Banyuasin Regency, South Sumatera. Then the sample was studied at the Laboratory of Microbiology, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Inderalaya. During January-May 2017. Based on the results of the study known the soil typology of the total population of nitrogen-fixing bacteria, the highest population of nitrogen inhibitor bacteria in the second week of soil typology D was 6.0x107 and the highest pH of 5.18 in typology B on week Third, the lime treatment that affected the population of indigenous nitrogen-fixing bacteria, obtained the population of bacteria as much as 9.3x105 in the second week and the highest soil pH 4.93 in the second week, while the results of the interaction between soil typology and lime treatment only affect the population of bacterial inhibitor Indigenous nitrogen, with bacterial population of 3.5x107 in soil typology D in the second week, but this interaction did not significantly affect soil pH, with the highest pH measurement of 5.33 on the soil typology D.Keywords: nitrogen-fixing bacteria, tidal land, lime treatment
ISOLATION AND IN VITRO BIOASSAYS OF ENDOPHYTIC FUNGI ASSOCIATED WITH LIDAH BUAYA (Aloe vera (L.) Burm.f.) Raunsai, Marlin Megalestin; Octavia Siti Nurhayati; Andi Saptaji Kamal; Praptiwi; Kartika Dyah Palupi; Muhammad Ilyas; Rahmawati Ridwan; Evana; Andria Agusta
Berita Biologi Vol 23 No 2 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.3879

Abstract

Endophytic fungi are fungi that live in plant tissues that do not cause disease symptoms, do not harm the host plant, and can produce secondary metabolites such as antibacterial, antifungal, and antiviral compounds. This study was conducted to isolate and evaluate the antibacterial and antioxidant activities of endophytic fungi from Aloe vera (L.) Burm.f. against Staphylococcus aureus and Escherichia coli bacteria. The antibacterial activity test was carried out qualitatively by thin layer chromatography-direct-bioautography (TLC-DB), and microdilution methods were used for the antibacterial assay against Staphylococcus aureus and Escherichia coli. Antioxidant activity was determined against DPPH using TLC-DB and the microdilution assay. Antibacterial results showed that the extracts LBB-2.4, LBB-2.2, LBAu-1.1 and LBAu-2.1 could inhibit the growth of S. aureus. Meanwhile, extracts of endophytic fungi with the isolate codes LBB-2.4, LBB-2.1, LBAp-3, LBAp-1, LBAu-1.1 and LBAu-2.1 could inhibit the growth of E.coli. The results of Minimum Inhibitory Concentration (MIC) showed that isolate LBB-2.1 had moderate antibacterial activity with a MIC value of 256 μg/mL against S.aureus. The extracts showed weak antioxidant activity against DPPH. It can be concluded that endophytic fungi extracts from Aloe vera have potential activity as antibacterial agents.
Efficacy of liposomal amphotericin B eye drops at two concentrations in experimental aspergillus keratomycosis in rabbits Amalia, Husnun; Ridwan, Rahmawati; Estuningtyas, Ari; Sitompul, Ratna; Adawiyah, Robiatul; Freisleben, Hans-Joachim
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.240

Abstract

Background: Keratomycosis, a fungal corneal infection prevalent in tropical regions, frequently leads to visual impairment and blindness. Liposomal amphotericin B (L-AmB) offers improved efficacy and reduced toxicity compared to conventional amphotericin B deoxycholate and represents a promising option for topical ophthalmic use. Objective: To evaluate and compare the therapeutic efficacy of L-AmB eye drops at 0.15% and 0.5% concentrations in experimental Aspergillus keratomycosis in New Zealand White rabbits. Methods: Four rabbits received midstromal corneal inoculation with a mixed suspension of Aspergillus flavus, A. fumigatus, A. niger, and A. terreus (2 x 10⁴ CFU/0.05 mL). L-AmB eye drops were applied hourly from day 8 post-inoculation until corneal cultures became negative. Antifungal susceptibility was assessed by disc diffusion. Clinical response was monitored by slit lamp examination using a modified scoring system. Results: Negative corneal cultures were achieved in all treated eyes within 10 to 18 days (mean 15 days, L-AmB 0.15%) and 11 to 15 days (mean 14 days, L-AmB 0.5%). No toxic effects were observed. Complete corneal transparency without cicatrix was achieved in one eye treated with L-AmB 0.15%. Conclusion: Both concentrations were effective and safe. Liposomal AmB 0.15% appears as efficacious as 0.5% for experimental Aspergillus keratomycosis. Clinical studies in humans are warranted.
Co-Authors Andi Saptaji Kamal ANDRIA AGUSTA Ani R. Prijanti Ari Estuningtyas, Ari Dedik Budianta Evana HANS-JOACHIM FREISLEBEN Hary Widjajanti Husnun Amalia Kartika Dyah Palupi Mohamad Sadikin Muhammad Ilyas Octavia Siti Nurhayati Praptiwi Ratna Sitompul Raunsai, Marlin Megalestin Robiatul Adawiyah Tiwuk Susantiningsih