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Coriejati Rita

Department Of Clinical Pathology, Faculty Of Medicine, Padjadjaran University/Dr. Hasan Sadikin Hospital Bandung

Author-ID : 361862

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Red Ear Fungi (Auricularia Auricula) Infusion Reduce Blood Triglyceride Level in Dyslipidemic Rats Widi, Nareswara Anugrah; Sitorus, Truly D.; Rita, Coriejati
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Background: Dyslipidemia is a risk fastor in atherosclerosis. In the long run, it can cause complications such as coronary artery disease and stroke. Dyslipidemia can be halted by beta glucan, a soluble fiber found in some species of fungi. This study was conducted to find the effect of red ear fungi infusion in reducing blood triglyceride level and the concentration that will give optimal reduction of blood triglyceride level.Methods: This was an analytical study using experimental laboratoric method. The study conducted in 25 male Wistar rats sorted in 5 groups during the period of September to October 2012 in Pharmacology Laboratory of General Hospital Hasan Sadikin, Bandung.Results: The result showed that mean difference of all three treatment group, which is group 3, group 4, and group 5 (87.08, 90.40, and 82.70 respectively) showed significancy compared to the positive control (group 2). Out of the three group, group 4 with 36% infusion concentration has the lowest mean difference from all of the treatment groups.Conclusions: Red ear fungi infusion reduce blood triglyceride level and infusion with 36% concentration was the optimal concentration in reducing blood triglyceride level. A further study can be done to find concentration range in which the infusion reduce blood triglyceride level optimally.Key words: beta glucan, red ear fungi infusion, triglyceride

The Effect of Leunca Fruit (Solanum nigrum Linn) Infusion in Inhibiting the Increase of Serum Glutamate Pyruvate Transaminase Level in CCL4 Induced Hepatitis Wistar Rats Kuswinarti Kuswinarti; Syifa Karmani; Coriejati Rita
Althea Medical Journal Vol 6, No 4 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Hepatitis may cause liver cell damage due to the oxidation processes and can be inhibited by antioxidant components. Antioxidant acts as hepatoprotector by slowing down the oxidation process. Leunca fruits (Solanum nigrum Linn) contain antioxidants such as vitamin C and flavonoid. This study aimed to explore the effect of Leunca fruit infusion to inhibit the increase of serum Glutamate Pyruvate Transaminase (SGPT) level in Wistar rats’ blood.Methods: This was an experimental study using male Wistar rats, conducted in the Animal Laboratory, Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran between September−October 2012. The Hepatitis rats model was induced with carbon tetrachloride (CCl4) in 10% paraffin intraperitoneally as much as 8 mL/kgBW on day 8th. A 3 mL of leunca fruit infusion was given with a concentration of 22.5 g, 45 g, and 90 g per 100 mL, respectively. On the 10th day, serum was taken and SGPT was examined. Only food and distilled water were given to the negative control group. The result was analyzed by using a Kruskal-Wallis non-parametric test, followed by Mann-Whitney post hoc.Results: There was a significant difference between the negative control and hepatitis positive control group (p=0.009), indicating that the induction was successful. The dose 90 g/100 mL leunca had a significant different in SGPT concentration (p=0.047), suggesting that leunca fruit infusion had a significant effect on reduced SGPT level.Conclusions: Leunca fruit infusion has a hepatoprotective effect by inhibiting the increase of the SGPT level in CCl4 induced rats. Studies on the leunca effectiveness in human hepatitis need further exploration.

Red Ear Fungi (Auricularia Auricula) Infusion Reduce Blood Triglyceride Level in Dyslipidemic Rats Nareswara Anugrah Widi; Truly D. Sitorus; Coriejati Rita
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.438 KB)

Background: Dyslipidemia is a risk fastor in atherosclerosis. In the long run, it can cause complications such as coronary artery disease and stroke. Dyslipidemia can be halted by beta glucan, a soluble fiber found in some species of fungi. This study was conducted to find the effect of red ear fungi infusion in reducing blood triglyceride level and the concentration that will give optimal reduction of blood triglyceride level.Methods: This was an analytical study using experimental laboratoric method. The study conducted in 25 male Wistar rats sorted in 5 groups during the period of September to October 2012 in Pharmacology Laboratory of General Hospital Hasan Sadikin, Bandung.Results: The result showed that mean difference of all three treatment group, which is group 3, group 4, and group 5 (87.08, 90.40, and 82.70 respectively) showed significancy compared to the positive control (group 2). Out of the three group, group 4 with 36% infusion concentration has the lowest mean difference from all of the treatment groups.Conclusions: Red ear fungi infusion reduce blood triglyceride level and infusion with 36% concentration was the optimal concentration in reducing blood triglyceride level. A further study can be done to find concentration range in which the infusion reduce blood triglyceride level optimally.Key words: beta glucan, red ear fungi infusion, triglyceride

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