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All Journal BIO-SITE |BIOLOGI Sains Terapan HERBAPHARMA : Journal of Herb Farmacological Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Borneo Journal Of Pharmascientech Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Organisms: Journal of Biosciences Jurnal Pengabdian Kepada Masyarakat Babakti Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) Jurnal Medika Farmaka
Kartikawati, Endah
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Al-Ghifari, Bandung, Indonesia
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Standardization, Quantification of Total Phenolics, Flavonoid Content, and Antibacterial Activity of Yellow Root (Arcangelisia flava (L.) Merr.) Herawati, Irma Erika; Dewi, Lisna; Kartikawati, Endah; Saepudin, Syumillah
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.29746

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) has been used empirical in West Sumatra, Indonesia, for stomach disease, anti-malaria, and tumors. The present study aims to characterize non-specific and specific parameters, total phenolic content (TPC), total flavonoid content (TFC), and antibacterial activity of yellow root. Standardization of yellow root extract tests was carried out in accordance with the Indonesian Herbal Pharmacopeia. TPC was determined by the Folin-Ciocalteu colorimetric method. TFC was calculated using an aluminum chloride colorimetric assay, and antibacterial activity was evaluated against Propionibacterium acnes ATCC 1223 by the agar diffusion method using the extract and fractions. The results for non-specific parameters showed the water content of the extract (10.1%) and the shrinkage-dried extract (12%). Specific parameters revealed that the extract had a distinct odor, a bitter taste, a brownish-yellow color, and a thick consistency. Microscopic parameters revealed fragments including fibrous sclerotic cells, parenchymal cells, exocarpic stone cells, stone cells, essential oil cells, and tracheal cells. The value of water-soluble compounds was 5.25%, and the value of the ethanol-soluble compounds was 19.75%. Thin-layer chromatography from the extract showed the presence of spots of alkaloids, phenolics, flavonoids, and saponins. The yellow root extract contained total phenolic and flavonoid contents of 87.37 mg GAE/g and 73.80 mg QE/g, respectively. At 800 ppm, the ethanolic extract and fractions, with an inhibition zone of 20.53±0.58 mm, approached the value for clindamycin phosphate (21.90±0.40 mm). Overall, these findings demonstrate that the standardized ethanolic extract of Arcangelisia flava (L.) Merr. roor possesses promising antibacterial activity against P. acnes, supporting its potential as a source of bioactive compounds for further development as a natural anti-acne agent.
Co-Authors Aan Azkiyah Ajeng, Nurtina Dwi Al-Azzahra, Yunita Ayu Lestari Destiati, Yinyin Dewi, Lisna Dhyta Andri Deswati Dytha Andri Deswati Hadisoebroto, Ginayanti Henny Setiawati Herawati, Sinta Oktaviani Herliyani, Widya Hesty Nuur Hanifah Hidayat, Taufik Septiyan inayah, ita Irma Erika Herawati Irma Erika Herawati Ita Inayah Kusdi Hartono, Kusdi Lisna Dewi M Bagas Wiraatmaja Maria Ulfah Marni, Aulia Natalia Heidy Nugroho, Andika Puspito Pulungan, Habiba Fikri Farika Putri Ananda Qurayssiah, Qurayssiah Rahayu, Iseu Sagita, Riris Siti Nurhaliza Slamet , Tuty Syulastri Effendi Syumillah Saepudin Vicky Imam Adi PP Wana Diah Meranti Widiyaningrum, Eva Mutba Wulan Deti Yuni , Mutiara Khairati Yunita Al-Azzahra Yus Hargono Cahyaning Yudi Yus Hargono Cahyaning Yudi Yus Hargono Cahyaning Yudi