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All Journal Universa Medicina Journal of Innovation in Community Empowerment (JICE) Linggamas: Jurnal Pengabdian Masyarakat National Journal of Occupational Health and Safety
Nendyah Roestijawati
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Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers Roestijawati, Nendyah; Maurits, Lintje Setyawati; Sugiyanto, Sugiyanto
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.42-48

Abstract

BACKGROUNDCadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers.METHODSThe study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test.RESULTSMean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p<0.05) and between blood Cd levels and IGF-1 (p <0.05).CONCLUSIONSThere was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.
High serum iron and zinc decrease glutathione S-transferase among women with breast cancer Roestijawati, Nendyah; Ernawati, Dwi Arini; Krisnansari, Diah
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.25-30

Abstract

BACKGROUNDBreast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.METHODSAn observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.RESULTSThe results showed that there was a significant relationship of serum iron with GST (r=-0.487; p<0.05) and serum zinc with GST (r=-0.409; p<0.01).CONCLUSIONOur study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.
Sosialisasi Peningkatan Pengetahuan dan Praktik Pencegahan dan Penanggulangan Covid-19 Di Kelurahan Rejasari, Purwokerto Barat Wibowo, Yudhi; Nendyah Roestijawati; Joko Mulyanto; Dyah Krisnansari; Siti Munfiah; M Fikri Marhadhani; Machfira Bulantrisna
The Journal of Innovation in Community Empowerment Vol 4 No 1 (2022): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v4i1.663

Abstract

ABSTRAK Per tanggal 21 November 2020, di Kabupaten Banyumas, tercatat 1.341 kasus dan 43 kasus kematian. Di Kec. Purwokerto Barat tercatat 64 kasus dan di Rejasari tercatat 13 kasus dengan kematian 2 orang. Kelurahan Rejasari berada di Kecamatan Purwokerto Barat, terdiri dari 9 RW dan RW 3 merupakan kantong masyarakat tidak mampu yaitu 263 KK dari 391 KK termasuk keluarga pra-sejahtera. Upaya memutus rantai penularan covid-19 melalui 3M. Pengetahuan dan sikap masyarakat sangat mempengaruhi kepatuhan terhadap upaya pencegahan dan pengendalian covid-19. Tujuan kegiatan ini adalah meningkatkan pengetahun dan praktik pencegahan dan penangulangan covid-19. Metode dengan penyuluhan, simulasi dan praktik menggunakan masker dan cuci tangan menggunakan hand sanitizer yang benar sesuai ketentuan. Hasil uji Firedman dan Post Hoc Wilcoxon didapatkan peningkatan pengetahuan sebelum penyuluhan dibandingkan setelah penyuluhan, evaluasi 1 dan 2 serta berbeda signifikan secara statistik (p=0,005, p=0,032 dan p=0,043). Untuk sikap tidak berbeda signifikan secara statistik sebelum penyuluhan dengan setelah penyuluhan, evaluasi 1 dan 2 (p=0,393) dengan uji Friedman. Implikasinya bahwa penyuluhan meningkatkan pengetahuan peserta tentang covid-19. Simpulan bahwa masyarakat perlu diberi penyuluhan dan role model disiplin protokol kesehatan.
Sosialisasi Peningkatan Pengetahuan, Praktik Pencegahan dan Penanggulangan Covid-19 di Kelurahan Purwokerto Lor Wibowo, Yudhi; Roestijawati, Nendyah; Mulyanto, Joko; Krisnansari, Diah; Munfiah, Siti; Rahman, Fadel; Aryadenta, Ivory Benaziria; Budiyanto, Budiyanto
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 1 (2023): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2023.1.1.9360

Abstract

Per tanggal 3 Oktober 2021, pandemi covid-19 telah menyebar ke 219 negara, tercatat 234.551.981 kasus dan 4.796.171 kematian. Di Indonesia tercatat 4.220.206 kasus dan 142.261 kematian. Di Jawa Tengah tercatat 482.353 kasus dan 32.050 kematian. Sedangkan menurut Dinas Kesehatan Kabupaten (DKK) Banyumas, tercatat 34.474 kasus dan 1.920 kasus kematian. Kepatuhan memakai masker 91-100%, namun kepatuhan menjaga jarak hanya 61-75%. Di Kelurahan Purwokerto Lor, sejak pandemi covid-19, tercatat 442 kasus terkonfirmasi dan 19 kematian covid-19, sementara itu kepatuhan memakai masker dan manjaga jarak berstatus merah atau < 60%. Pengetahuan dan sikap masyarakat sangat mempengaruhi kepatuhan terhadap upaya pencegahan dan pengendalian covid-19. Tujuan kegiatan ini adalah meningkatkan pengetahun dan praktik pencegahan dan penangulangan covid-19. Metode dengan penyuluhan, simulasi dan praktik menggunakan masker dan cuci tangan menggunakan hand sanitizer yang benar sesuai ketentuan. Hasil uji Friedman tidak didapatkan perbedaan rerata skor peningkatan pengetahuan sebelum dan setelah penyuluhan, evaluasi 1 dan 2 (p=0,147). Untuk sikap tidak berbeda signifikan secara statistik sebelum penyuluhan dengan setelah penyuluhan, evaluasi 1 dan 2 (p=0,088) dengan uji Repeated Anova. Implikasinya bahwa penyuluhan tetap bermanfaat menginformasikan pengetahuan terkini tentang covid-19. Simpulan bahwa masyarakat perlu diberi informasi terkini dan role model disiplin protokol kesehatan.
Differences in Levels of Prostate Specific Antigen and Insulin-like Growth Factor 1 in GSTP1 Gene Polymorphism among Workers Roestijawati, Nendyah; Wibowo, Yudhi; Lestari, Tri
National Journal of Occupational Health and Safety Vol. 1, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cadmium (Cd) is classified as a carcinogen in humans (IA). In addition to causing lung cancer, the incidence of prostate cancer due to Cd exposure based on epidemiological research has also increased. This study aims to identify the GSTP1 genotypic frequency distribution and its correlation with PSA and IGF-1 levels in Cd exposed and unexposed workers. The research design used was cross sectional in 23 exposed groups (weld workers) and 40 unexposed groups (office employees) with a total of 63 people. The measurement of PSA and IGF-1 levels was carried out using the ELISA method and identification of the GSTP1 gene polymorphism using the PCR-RFLP method. Data analysis using Mann-Whitney and Spearman correlation test. The results showed that there was a relationship between PSA levels and IGF1 (p0.05). There was a relationship between PSA and IGF1 (p0.05). There was a relationship between PSA and IGF1 (p0.05).
Co-Authors Aryadenta, Ivory Benaziria Budiyanto Budiyanto Diah Krisnansari Diah Krisnansari Dyah Krisnansari Ernawati, Dwi Arini Joko Mulyanto Joko Mulyanto, Joko Lintje Setyawati Maurits, Lintje Setyawati M Fikri Marhadhani M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Machfira Bulantrisna Rahman, Fadel Siti Munfiah Tri Lestari Yudhi Wibowo, Yudhi