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All Journal Signifikan : Jurnal Ilmu Ekonomi JURNAL BISNIS STRATEGI MANDALA of Health Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention MEDISAINS JIET (Jurnal Ilmu Ekonomi Terapan) Journal Of Vocational Health Studies Iqtishoduna: Jurnal Ekonomi Islam Sulawesi Tenggara Educational Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) el-Jizya: Jurnal Ekonomi Islam Journal of Business Management and Islamic Banking Jurnal Ekonomi, Manajemen, Akuntansi Ulil Albab
Joko Setyono
FK UNSOED
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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HUBUNGAN ANTARA MEROKOK DENGAN PENYAKIT PARKINSON DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Setyono, Joko; Noviani, Erni; Gunarto, Untung
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Cigarettes contain 2,3,6-trimethyl-4-napthoquinone which can inhibit the breakdown of dopamine;therefore, smoking can reduce the risk of Parkinson’s disease. On the other hand, smoking is the secondcause of death in the world. This study was aimed to investigate the relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease. This study was ananalytical observational research using case control approach that involved 34 patients of Parkinson’sdisease as a case group and 34 respondents that were non Parkinson as a control group. The former and thelater were age- and sex-matched control subjects selected by using purposive sampling technique. InParkinson group it was obtained that as much as 64.7% of the respondents were non smokers, 14.7% wereformer smokers, 8.8% were current less than daily smokers, and 8.8% were current daily smokers. In nonParkinson group, 41.2% of the respondents were non smokers, 23.5% were former smokers, 8.8% werecurrent less than daily smokers, and 26.5% were current daily smokers. The data were analyzed usingWilcoxon test and it was found that there was a significantly negative relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease (p<0,05). There was asignificantly negative relationship between smoking status, smoking duration, smoking quantity, types ofcigarettes and Parkinson’s disease.
POLIMORFISME GENA RESEPTOR MCP-1 (CCR2) SEBAGAI FAKTOR RISIKO NEFROPATI DIABETIKA PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD PROF DR MARGONO SOEKARJO DAN RSUP SARDJITO Setyono, Joko; Sadewa, A Hamim; Madiyan, Maliyah
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

The infiltration of the glomeruli and interstitium by immunocompetent cells are common finding ofkidney with diabetic nephropathy. On the other hand, there is an increasing synthesis of chemokines andother inflammatory mediators by glomerular and tubular cells in hyperglycemic conditions. Single nucleotidepolymorphisms (SNPs) G46295A of MCP-1 (CCR2 are thought playing a key role in the development ofdiabetic nephropathy in type 2 diabetes. Therefore, the aim of this research is to determine whether the riskof diabetic nephropathy is influenced by polymorphisms of CCR2. In addition, this research is also aimed todetermine whether the gender in the diabetic nephropathy patient is influenced by polymorphisms of CCR2 intype 2 diabetes in Indonesian population especially ethnic of Java. A case-control study was performed,including 60 type 2 diabetes patients, 31 subjects with diabetic nephropathy and 29 subjects with nondiabetic nephropathy in Margono Soekarjo Hospital and Sardjito hospital. Polymorphisms of CCR2 wereanalyzed by PCR-RFLP method. The results were analyzed by chi-square. Amount of male in the casesubjects (67,7%) more than amount of male in control subjects (44,8%). G46295A of MCP-1 (CCR2)receptor gene had higher risk of developing diabetic nephropathy in type 2 diabetes (X2 = 12.308, p =0.002). Male individual carry the GA genotype of CCR2 had significant risk of developing diabeticnephropathy (p = 0.004, OR 9.6). This study showed that G46295A MCP-1 (CCR2) receptor gene had higherrisk of developing diabetic nephropathy in type 2 diabetes in Indonesian population especially ethnics ofJava. Male with G46295A MCP-1 (CCR2) receptor gene were more than female and had higher risk ofdeveloping diabetic nephropathy in type 2 diabetes in Indonesian population, especially Java ethnic.
Karakteristik Penderita Dispepsia di RSUD Prof. DR. Margono Soekarjo Purwokerto Setyono, Joko; Prastowo, Agus; Saryono,
Jurnal Keperawatan Soedirman Vol. 01 No. 1 (2006)
Publisher : Jurusan Keperawatan FIKES UNSOED

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2006.1.1.54

Abstract

Life style and eat pattern changes are becoming one of the cause the digestive problems. Dyspepsia is one of the most digestive problems in patients. Dyspepsia can be caused by cigarettes, decreased of pressure of the lower sphincter oesophagus, emotionally stress, food which triggering sour secretion of abundant stomach like alcohol and coffee. This research aimed to know patient characteristic of dyspepsia at RSUD. Prof. Dr. Margono Soekarjo Purwokerto. This research is research of descriptive. This research has done in July 2005. Characteristic data of subject research taken by questionnaires. The Result shows that over a half of subject research is woman, of old age more than 40 year, lower education, and unemployed. Small parts of subject research are usually alcohol, coffee, and cigarette consumer. Almost ofall subject have normal nutrition status.
PERBEDAAN KESANGGUPAN KARDIOVASKULAR PADA KARYAWAN PRIA PEROKOK DAN NON PEROKOK DI FAKULTAS KEDOKTERAN UNIVERSITAS JENDERAL SOEDIRMAN Tiara Yusan, Rizak; Setyono, Joko; Kusuma, Moh Nanang Himawan; Wahyudin, Wahyudin; Zainuddin, Zainuddin; Nur, A Fahira
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 7 No. 3 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.046 KB) | DOI: 10.22487/htj.v7i3.459

Abstract

Aktivitas merokok merupakan salah satu faktor penyebab tingginya angka kejadian morbiditas dan mortalitas penyakit kardiovaskular. Adapun proporsi karyawan perokok cukup tinggi sebesar 34%. Aktivitas merokok menganggu kesehatan salah satunya dengan menurunkan kesanggupan kardiovaskular. Kesanggupan kardiovaskular yang buruk akan berpengaruh terhadap penurunan produktivitas dan efisiensi kerja karyawan. Metode : Desain penelitian ini adalah observasional analitik dengan pendekatan cross sectional. Jumlah sampel yang diteliti sebanyak 44 responden, dibagi menjadi 2 kelompok yaitu kelompok karyawan pria perokok dan non perokok masing-masing sebesar 22 responden, kemudian dilakukan pengukuran kesanggupan kardiovaskular dengan protokol Kasch Step Test. Kesanggupan kardiovaskular dinilai dengan menghitung Recovery Heart Rate. Adapun analisis data digunakan uji Chi Square dan Mann-Whitney. Hasil : Karyawan pria perokok memiliki kesanggupan kardiovaskular yang secara signifikan lebih rendah dibandingkan karyawan pria non perokok (p=0,001). Adapun hasil perhitungan Relative Risk didapatkan bahwa karyawan pria perokok memiliki risiko penurunan kesanggupan kardiovaskular 2,8 kali lebih besar dibandingkan karyawan pria non perokok. Kesimpulan : Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa kesanggupan kardiovaskular karyawan pria perokok lebih rendah dibanding karyawan pria non perokok
Etanolic extract of Ling Zhi Mushroom (Ganoderma lucidum) improves lipid profile, CRP and histopathological of liver in dislipidemia model rats Soegianto, Jap Yulius Billy; Samodro, Pugud; Wisesa, Sindhu; Hernayanti, Hernayanti; Setyono, Joko; Arjadi, Fitranto
Biogenesis: Jurnal Ilmiah Biologi Vol 11 No 2 (2023)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v11i2.38896

Abstract

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Hijrah Intention and Customer Decisions to Use Islamic Banks: Development of Theory of Planned Behavior Al Umar, Ahmad Ulil Albab; Setyono, Joko
IQTISHODUNA: Jurnal Ekonomi Islam Vol. 12 No. 1 (2023): April
Publisher : Program Studi Ekonomi Islam Fakultas Ekonomi dan Bisnis Islam Institut Agama Islam Syarifuddin Lumajang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54471/iqtishoduna.v12i1.2243

Abstract

This study aims to analyze the determinants of hijrah intention and customers' decisions to use Islamic banks. This study carries out the development of a theory of planned behavior which consists of attitude factors, subjective norms and behavior control. The development that is done is to modify the intention in the theory of planned behavior to become hijrah intention. Another development is adding the factor of Islamic branding to analyze its effect on hijrah intention and customer decisions. The next development is to link the influence of hijrah intention on customer decisions. Other developments also add a moderating construct, namely Islamic financial literacy with the aim of Islamic financial literacy can be a determinant of strengthening or weakening the variable of hijrah intention towards customer decisions. This study is a study with a quantitative approach. The population in this study are all customers of Islamic banks in Indonesia. The sample of this research is 275 respondents from 34 provinces in Indonesia. Data analysis used SEM with the SmartPLS 3 application. The results in this study indicate that the theory of planned behavior which consists of attitude variables, subjective norms and behavioral control and Islamic branding variables has a significant positive effect on hijrah intention. Islamic branding also has a significant influence on customer decisions. Hijrah intention has no significant effect on customer decisions. Islamic financial literacy weakens the effect of hijrah intention on customer decisions.
Inhibition breast carcinogenesis via PI3K/AKT pathway using bioactive compounds of Strychnine tree (Strychnos nux-vomica): in silico study Rispriandari, Aulia Ayu; Sarmoko, Sarmoko; Setyono, Joko; Wisesa, Sindhu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28242

Abstract

Breast cancer poses a significant global health challenge, with a notable prevalence in Indonesia. Given the intricate nature of breast cancer progression and classification, precise treatment strategies are imperative, particularly targeting signaling pathways like PI3K/AKT, pivotal in cell growth, proliferation, survival, and apoptosis. Bioactive compounds from the Strychnine tree demonstrate potential in enhancing apoptotic effects and inhibiting breast carcinogenesis. This potential is explored through in silico studies. This research aims to analyze potential targets of Strychnine tree compounds, along with binding energy and stability between ligands and receptors. Employing bioinformatics target analysis, molecular docking, and molecular dynamics simulation, the study reveals AKT1 as a potential target of Strychnine tree compounds. These compounds inhibit AKT1 at both active and allosteric sites, displaying notably low binding energy scores. For example, brucine exhibits a binding energy of -10.83 kJ/mol at the active site, surpassing the standard capivasertib. However, lupeol, with a binding energy of -11.14 kJ/mol, falls short of the MK-2206 standard at the allosteric site. Molecular dynamics simulations expose fluctuations in parameters like RMSD, RMSF, and binding energy within the initial 5 ns. In conclusion, Strychnine tree compounds, such as brucine and lupeol, showcase potential AKT1 inhibition at both active and allosteric sites, enhancing apoptotic effects. However, the stability of these compounds in binding to their receptors within the first 5 ns of the simulation warrants further investigation for prolonged interactions.   
IDENTIFICATION OF THE CTX-M GENE IN KLEBSIELLA PNEUMONIAE PRODUCING ESBLS IN UTI PATIENTS AT A PRIVATE HOSPITAL IN PURWOKERTO, BANYUMAS REGENCY, CENTRAL JAVA - CROSS SECTIONAL STUDY Kurniawan, Anang; Setyono, Joko; Utami Anjarawati, Dwi
Journal of Vocational Health Studies Vol. 7 No. 2 (2023): November 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I2.2023.90-94

Abstract

Background: The CTX-M gene in ESBLs-producing Klebsiella pneumoniae is associated with virulence factors and encodes for antibiotic resistance. There are currently 128 different varieties of CTX-M, which gene can hydrolyze beta-lactam medicines like cefotaxime. Purpose: Identify the CTX-M gene in Klebsiella pneumoniae from patients with Urinary Tract Infections (UTI) at a private hospital in Banyumas Region of Central Java, Indonesia. Method: Cross-sectional survey method was employed in this study. The subjects of the study comprised 40 patients with UTI admitted to a private hospital in Banyumas Region, Central Java, Indonesia. Using a direct molecular approach called Polymerase Chain Reaction (PCR) directed against the CTX-M gene, DNA was isolated from isolates cultured in CHROMagarTM ESBLs obtained from catheter urine samples. Result: A total of 4 out of 40 urine samples (10%) tested positive for ESBL-producing Klebsiella pneumoniae. The PCR was performed to detect the CTX-M gene in 100% of the strains. Conclusion: These findings suggest the presence of CTX-M gene found in ESBLs-producing Klebsiella pneumoniae in individuals with urinary tract infections in a private hospital in Purwokerto, Banyumas regency, Central Java, Indonesia. This information can be used to assess antibiotic administration practices.
Investigating the level of Hba1c and insulin level in β-thalassemia patients Mujiburrahman, Husnan; Santosa, Qodri; Setyono, Joko; Roestijawati, Nendyah; Rujito, Lantip
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.18362

Abstract

Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.Objective: This study aimed to describe HbA1c and insulin levels of β-thalassemia patients. The study also tested whether there was a significant difference in insulin and HbA1c levels among patients with different β-thalassemia categories. Method: This research was an analytic observational study. The samples were taken by total sampling and involved 30 patients, and the examination was carried out using the patient's blood plasma.Result: The study found that samples had low HbA1c levels. There was no significant mean difference (p>0.05) between insulin and HbA1c in the mild, moderate, and severe clinical degree groups. There was no significant difference in average (p>0.05) insulin and HbA1c in the thalassemia sufferers with allele β+ and β0 types.Conclusion: There was a decrease in insulin and HbA1c in patients with β-thalassemia, which may be caused by damage pancreatic organ damage.
Determinan Minat Berkarir Mahasiswa di Lembaga Keuangan Syariah Dengan Motivasi Sebagai Variabel Moderasi Nur Latifah , Ramadhani; Setyono, Joko
Journal of Business Management and Islamic Banking Vol. 1 No. 1 (2022)
Publisher : UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/jbmib.2022.011-02

Abstract

Research Aims: This study aims to determine the influence of personality and market considerations work on student career interests in Islamic financial institutions with motivation as a moderating variable. Design/methodology/approach: The research method used is a quantitative method. Population this research is a student of Islamic banking UIN Sunan Kalijaga Yogyakarta with a sample of 146 people obtained by purposive sampling method. Data that used is primary data, using an online questionnaire/google form. Data that obtained were analyzed using the Partial Least Square (PLS) analysis technique through SmartPLS software. Research Findings: The results of the study indicate that there is a positive and significant effect of personality variables and labor market considerations on student career interests. Motivation able to moderate the relationship between labor market considerations and students' career interests. However, motivation is not able to moderate the relationship between personality and career interest student.
Co-Authors . HERNAYANTI A Fahira Nur A Hamim Sadewa, A Hamim Agus Prastowo Ahmad Choiri Ahyar Ahyar Albab Al Umar, Ahmad Ulil Aminuddin Ardhi, Ardhi Ariga, Adi Dwi Utami Anjarwati Erni Noviani, Erni Fadlan, Arif Fareza, Muhamad Salman Febrian, Dicky Rizky Fitranto Arjadi Heru Ismaya K, Neneng Rika J. Kurniawan, Anang Kusuma, Muhammad Nanang Himawan Lantip Rujito Lintang, Ferlanda Mahfuzh, Muhammad Ady Maliyah Madiyan, Maliyah Mujiburrahman, Husnan Mukarromah, Lukluil Nendyah Roestijawati Nur Amalia Choironi Nur Latifah , Ramadhani Nur Rohman Qodri Santosa, Qodri Ramadan, Hendra Rispriandari, Aulia Ayu Riza, Alex Fahrur Samodro, Pugud Sarmoko Sarmoko Saryono, Siti Rahmawati Soegianto, Jap Yulius Billy Sujiran Tiara Yusan, Rizak Untung Gunarto, Untung Wahyu Wibowo Wahyudin Wahyudin Wisesa, Sindhu Yahya, Padli Pawaid Zainuddin Zainuddin