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All Journal Jurnal Kesehatan Lingkungan indonesia MANDALA of Health Jurnal NERS Biomedika Journal of Health Promotion and Behavior Buletin Poltanesa Jurnal Neuroanestesi Indonesia Mandala of Health : A Scientific Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Medical and Health Journal
Joko Mulyanto, Joko
Faculty of Medicine and Health Sciences Jenderal Soedirman University Jl Gumbreg no 1, Purwokerto 53146
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBANDINGAN LUAS LESI PADA FOTO RONSEN TORAKS ANTARA PASIEN TUBERKULOSIS PARU KASUS BARU BTA POSITIF DENGAN BTA NEGATIF STUDI KOHORT RETROSPEKTIF DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Destriana, Desy; Rahmawati, Indah; Mulyanto, Joko
MANDALA of Health Vol 7, No 3 (2014): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Pulmonary tuberculosis (Pulmonary TB) infected one third of the world population. Since 2009, Indonesia was  the fifth that had the highest tuberculosis case in the world. In 2011, Case Detection Rate (CDR) of Central Java was 49,24%. The prevalence of pulmonary TB in RSUD Prof. dr. Margono Soekarjo  Purwokerto was 472 patients in 2012 until August 2013. Chest x-ray was the first investigation to diagnose pulmonary TB. The aims of this study was to knowing the differences  of lesion area on chest x-ray between new cases of  pulmonary TB patient with AFB smear  positive and AFB smear negative. This is  an Observational analytic with cohort retrospektif study, conducted 22 pulmonary TB patients with AFB smear positive and 22 pulmonary TB patients with AFB smear negative in RSUD Prof. dr. Margono Soekarjo Purwokerto. Data were analyzed by Chi-square with significance level of p<0,05. Univariate analysis showed that the highest number of respondents were male (56,8%), and the highest of the age group  was 15-25 years old group (27,3%). Bivariate analysis using Chi-square was obtained  p= 0,011 (p<0,05). There were differences lesion area on chest x-ray between new cases of  pulmonary TB patient with AFB smear positive  and AFB smear negative.
STATUS SOSIAL EKONOMI SEBAGAI FAKTOR RISIKO KEJADIAN OBESITAS DI KABUPATEN BANYUMAS Mulyanto, Joko; Darmawan, Anton B
MANDALA of Health Vol 7, No 1 (2014): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Obesity is a significant global and national health problem, and has declared by WHO as global epidemic.The prevalence of obesity in developed and mostly developing countries has dramatically increased during the last decade. Socio-economic status has been identified as one of significant predictors of obesity.  However, studies in different countries showed various result regarded the relationship between socioeconomic status and obesity. The study objective was to identify socio-economic status as an risk factor of obesity at Banyumas District. This study was a secondary analysis with cross-sectional approach using the data from Riset Kesehatan Dasar 2007 at Banyumas District. Samples of study were 1827 adult household members represented the residence of Banyumas District. The main independent variable was socioeconomic status measured by the quintile of income. The dependent variable was obesity measured by BMI with cut of point 27kg/m2. The confounding variabeles controlled by study were gender, age, marital status, employment, geographical location, and physical activity.  Data analyzed by multivariate analysis using multiple logistic regressions and stratification analysis by gender. Study result showed that the prevalence of obesity at Banyumas District is 22,3% for total sample of the study, while by gender the prevalence of obesity is 14,8 % for male and 29,1% for female respectively. After adjusted for confounding variables, socioeconomic status was risk factor of obesity at Banyumas District with OR 1,57 (95%CI:1,07-2,29) at 5th income quintile. For the male respondents, socioeconomic status has the OR 2,55 (95%CI, 1,29-5,0) at 5th income quintile. These results showed that the prevelance of obesity at Banyumas District was relatively high, and higher socioeconomic status significantly increased the odd of becoming obese.
GFR and Blood Lead Levels in Gas Station Workers Based on δ-Alad Gene Polymorphisms Rujito, Lantip; Hanief, Muhammad Nur; Gozali, Paulus; Mulyanto, Joko
Jurnal NERS Vol 10, No 1 (2015): Vol. 10 Nomor 1 April 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.002 KB) | DOI: 10.20473/%oj.Ners101%y74-79

Abstract

Introduction: Lead is a well-known toxic agent that makes an organ’s failure. Lead serum itself is infl uenced by δ-ALAD gene polymorphisms (Amino Levulinic Acid Dehydratase). δ-ALAD gene encodes an ALAD enzyme used for heme synthesis. The Characteristic of gene polymorphism may result in Glomerulo Filtration Rate (GFR) value as mark of renal failure. The goal of this study was to fi nd correlations between blood lead levels with GFR in terms of δ ALAD gene polymorphisms. Method: A cross-sectional design was used to perform this research. Thirty-eight gas stations workers in Banyumas were recruited in this study. δ-ALAD gene polymorphisms were characterized using PCR-RFLP method, while lead serum levels were quantifi ed by Atomic Absorption Spectrophotometer (AAS). In addition, Creatinin serum was done with a spectrophotometer and GFR value was formulated by means of the Schwartz method. Result: The studyshowed that the proportion of ALAD genotype for ALAD 1-1, 1-2 and 2-2 were 94.7%, 5.3%, and 0% respectively. The mean of serum levels in homozygous 1-1 was 15.94 ppb and heterozygote 1-2 was 1.15 ppb. GFR of participants ranged from 71.11 mL/min to 185.20 mL/min with a mean of 117.34mL/min. There was no correlation between serum Pb and GFR (p = 0.19). Study also could not determine the correlation between GFR and ALAD gene Polymorphism. Discussion: Study then concluded that there was no correlation between blood lead levels in the GFR on each δ-ALAD genotypes.Keywords: Lead intoxication, GFR, δ-ALAD, gas station workers
CORRELATIONS OF CADMIUM EXPOSURE WITH THE UREUM AND CREATININE SERUM LEVELS IN BATURADEN ORNAMENTAL PLANT FARMERS Nafiisah, Nafiisah; Laksana, Agung Saprasetya Dwi; Mulyanto, Joko
Biomedika Vol 12, No 2 (2020): Biomedika Agustus 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i2.10416

Abstract

ABSTRACT  Baturaden ornamental plant farmers use pesticides and fertilizers containing cadmium to increase growth and plant diseases control. Cadmium is a very toxic heavy metal. Small doses of cadmium exposure in over a long time through respiratory tract, digestion, and skin penetration causes a workload on the kidneys. It resulting kidney damage that characterized by increased ureum and creatinine serum levels. The aimed of this study was determine the correlation of cadmium exposure to kidney function in terms of urea and creatinine serum levels. The research design was an observational analytic approach with cross sectional method. The respondents were 43 farmers. Research data were collected by interviews, measured the  urea and creatinine serum levels, also the cadmium urine levels. Data were analyzed by Spearman test. The results showed that there was a weak significant correlation between cadmium urine to ureum (r= 0.399 and p= 0.008) and creatinine serum levels (r= 0.331 and p= 0.03). We concluded that cadmium exposured correlated with increased ureum and creatinine serum levels.Keywords: Cadmium, Urea Serum Level, Creatinine Serum Level, Ornamental Plant Farmers                                                                                                       ABSTRAK Petani tanaman hias di Baturaden menggunakan pestisida dan pupuk yang mengandung kadmium untuk meningkatkan pertumbuhan dan pengendalian penyakit tanaman. Kadmium adalah logam berat yang sangat beracun. Paparan kadmium dosis kecil dalam jangka waktu yang lama melalui saluran pernafasan, pencernaan, dan penetrasi kulit menyebabkan beban kerja pada ginjal. Hal tersebut mengakibatkan kerusakan ginjal yang ditandai dengan peningkatan kadar ureum dan kreatinin serum. Penelitian ini bertujuan untuk mengetahui hubungan paparan kadmium terhadap fungsi ginjal ditinjau dari kadar ureum dan kreatinin serum. Desain penelitian adalah observasional analitik dengan metode cross sectional. Respondennya sebanyak 43 petani. Pengumpulan data penelitian dilakukan dengan wawancara, pengukuran kadar urea dan kreatinin serum, serta kadar kadmium urin. Data dianalisis dengan uji Spearman. Hasil penelitian menunjukkan bahwa terdapat hubungan bermakna yang lemah antara kadar kadmium urin dengan kadar serum ureum (r= 0,399 dan p= 0,008) dan kreatinin (r= 0,331 dan p= 0,03). Kami menyimpulkan bahwa paparan kadmium berkorelasi dengan peningkatan kadar ureum dan kreatinin serum.Kata Kunci: Kadmium, Kadar Ureum Serum, Kadar Kreatini Serum, Petani Tanaman Hias
VITAMIN D PADA PASIEN ACNE VULGARIS DAN KORELASI DENGAN LUARAN KLINIS: REVIEW SISTEMATIK Pratama, Radya Putra; Arjadi, Fitranto; Mulyanto, Joko
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11004

Abstract

Background: Vitamin D is thought to have a role in the pathogenesis of acne vulgaris through anti-inflammatory effects. Research regarding the relationship between vitamin D and the severity of acne vulgaris still shows mixed results. Objective: To determine the correlation between vitamin D levels and clinical severity in acne vulgaris patients. Method: This systematic review uses Pubmed, Google Scholar, and Science Direct databases. Of the 362 articles, 13 articles that met the inclusion criteria were analyzed narratively. Results: Of 13 studies, 4 showed significant differences in serum vitamin D levels between degrees of acne severity. Meanwhile, the other 9 did not show any significant differences. One study showed significant differences in tissue vitamin D levels with severity. Conclusion: Overall, results are still inconsistent. There is evidence of a higher risk of vitamin D deficiency and decreased tissue vitamin D levels in people with acne vulgaris as severity increases. It is suspected that this is related to the role of vitamin D in suppressing inflammation. Further studies considering confounding factors are needed to clarify this association.
Educational Intervention to Improve Knowledge and Attitudes about Thalassemia Premarital Screening Surveys among Muslim Societies: A Pilot Study in Indonesia Rujito, Lantip; Pusparini, Indah; Lestari, Dyah Woro Dwi; Mulyanto, Joko
Jurnal Keperawatan Soedirman Vol 18 No 1 (2023): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.121 KB) | DOI: 10.20884/1.jks.2023.18.1.6253

Abstract

Premarital screening is an effective preventive intervention to decrease the prevalence of thalassemia. However, the use of premarital screening is still low in Indonesia. This study assesses the effect of educational interventions on the knowledge and attitudes of Muslim couples regarding premarital screening for thalassemia in Indonesia. This pilot study used a pre-posttest design that included 17 premarital couples in Banyumas District. The participant’s knowledge and attitude regarding premarital screening for thalassemia were measured using a paper-based questionnaire before and after the intervention. The participants received a class-based lecture about thalassemia screening and were provided a handbook containing lecture material to read at home. The knowledge and attitude score was analyzed using Wilcoxon and Kruskal-Wallis test. The knowledge score significantly increased after the intervention, but the proportion of positive attitudes did not differ significantly. The participants knew that premarital screening for thalassemia was necessary; however, it did not affect their marriage decision. Thus, educational intervention increases the knowledge and shapes the attitude of couples toward thalassemia premarital screening but is inadequate for changing their behavior. Further exploration of the factors that affect the behavior of couples is needed to increase the use of premarital screening among couples in Indonesia.
CHALLENGES IN PARKINSON’S DISEASE MANAGEMENT IN PRIMARY CARE IN INDONESIA: A NARRATIVE REVIEW Rahmawati, Fitriana; Mulyanto, Joko
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.13791

Abstract

Parkinson's disease (PD) is a rapidly growing neurological disorder with significant health implications, especially in low- and middle-income countries (LMICs) like Indonesia. This review analyzed the challenges and opportunities for managing PD in Indonesian primary care. The prevalence of PD in Indonesia has surged by 143% since 1990, reaching 89.91 per 100,000 people in 2019, which is likely underestimated owing to healthcare system limitations. Primary care is critical for early PD detection, although diagnostic accuracy is a concern. Enhancing the primary care capacity for early identification is essential through specialized training, telemedicine, and PD-specific assessment tools. Continuous monitoring of medication adherence, treatment efficacy, and symptom progression is vital for its effective management. Integrating palliative care principles and supporting caregivers is crucial for providing comprehensive care. This review recommends a structured approach to PD management in Indonesia, incorporating it into chronic disease programs, improving diagnostic tools, and developing caregiver support systems to address the growing PD burden and optimize patient outcomes in resource-limited settings.
Association between Air Pollutants and Levels of Macrophage Inflammatory Protein-2 in Purwokerto Informal Workers Rosy, Freshyama Daniar; Roestijawati, Nendyah; Mulyanto, Joko
Jurnal Kesehatan Lingkungan Indonesia Vol 24, No 1 (2025): Februari 2025
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.24.1.1-8

Abstract

Judul : Hubungan Pencemaran Udara dengan Kadar Protein Inflamasi Makrofag-2 pada Pekerja Informal PurwokertoLatar belakang: Tingkat polusi udara di Indonesia telah meningkat secara signifikan dalam dekade terakhir, yang sejalan dengan peningkatan insidensi gangguan pada sistem pernapasan, termasuk Penyakit Paru Obstruktif Kronik (PPOK). Deteksi dini gangguan sistem pernapasan akibat polusi udara menggunakan penanda biologis berpotensi mencegah keparahan penyakit meskipun masih diperlukan penelitian lebih lanjut. Penelitian ini bertujuan untuk Penelitian ini bertujuan menganalisis hubungan antara pajanan polutan udara dengan kadar Macrophage Inflammatory Protein-2 (MIP-2) pada pekerja sektor informal di Purwokerto, Kabupaten Banyumas, Provinsi Jawa Tengah.Metode: Studi belah lintang dilakukan pada 35 pekerja parkir luar ruang dan 35 pekerja informal dalam ruang di Purwokerto pada Maret 2021. Kadar particulate matter (PM) diukur menggunakan particle counter sebagai parameter tingkat polusi udara. Kadar. MIP-2 diukur dari sampel darah partisipan dengan menggunakan metode ELISA. Data dianalisis menggunakan Uji Mann-Whitney, Korelasi Spearman, dan analisis multivariat dengan Generalized Linear Model untuk mengevaluasi hubungan antara paparan polutan udara dan kadar MIP-2.Hasil: Kadar polutan udara di luar ruangan lebih tinggi dibandingkan di dalam ruangan (p=0,00), dan kadar MIP-2 lebih tinggi pada pekerja di luar ruangan dibandingkan pekerja di dalam ruangan (p=0,00). Kadar debu tidak berkorelasi dengan kadar MIP-2, baik pada pekerja di dalam ruangan (r=0,03; p=0,85), pekerja di luar ruangan (r=-0,31; p=0,07), maupun secara keseluruhan (r=0,20; p=0,09). Lama kerja total dan per hari juga tidak memiliki korelasi dengan kadar MIP-2 pada pekerja. Analisis multivariat menunjukkan tidak adanya hubungan antara durasi paparan dan kadar MIP-2 setelah dikendalikan oleh variabel usia dan kadar polusi udara.Simpulan: Terdapat perbedaan signifikan antara kadar debu dan kadar MIP-2 di lokasi luar ruangan dibandingkan dengan dalam ruangan. Pajanan polutan udara, baik dari segi tingkat maupun durasi, secara konsisten tidak berkorelasi dengan kadar MIP-2 pada pekerja. Penelitian lebih lanjut diperlukan untuk memahami interaksi antara paparan polutan udara, kadar MIP-2, dan kondisi klinis gangguan pernapasan yang disebabkan oleh polusi udara. ABSTRACTBackground: Air pollution level has significantly increased in Indonesia followed by the increase in respirational disorders such as Chronic Obstructive Pulmonary Disease (COPD) in the last decade. Early detection of air pollution-related respiratory disorders using biological markers potentially reduces the severity of these diseases, but further studies are still required. This research seeks to evaluate the relationship between exposure to air pollutants and Macrophage Inflammatory Protein-2 (MIP-2) levels among informal workers in Purwokerto, Banyumas District, Central Java Province. Method:  A cross-sectional study was carried out in March 2021 involving 35 informal outdoor workers and 35 indoor workers in Purwokerto. Particulate matter (PM) concentration was assessed using a particle counter, serving as an indicator of air pollution level. MIP-2 serum level was measured from participants' blood samples using the ELISA method. The Mann-Whitney test, Spearman correlation test, and multivariate analysis using the Generalized Linear Model were employed to assess the relationship between air pollutant exposure and MIP-2 serum levels.Result: The levels of air pollution (p=0.00) and MIP-2 serum (p=0.00) were significantly elevated in outdoor environments compared to indoor environment.  Exposure to air pollutants did not show a significant correlation with MIP-2 serum levels in outdoor workers (r=-0.31; p=0.07), indoor workers (r=0.03; p=0.85), or overall (r=0.20; p=0.09). The overall and daily working duration did not show a correlation with the MIP-2 serum levels in the workers. Multivariate analysis indicated that there was no association between the duration of exposure and MIP-2 levels when adjusted for age and air pollution level.Conclusions:  There were notable differences in air pollutant levels and MIP-2 serum levels between indoor and outdoor environments. Air pollutant exposure, both in duration and level, consistently did not correlate with the MIP-2 serum level of workers. Further studies are required to understand the interactions among air pollutant exposure, MIP-2 serum level, and clinical conditions of air pollution-related respiratory disorders.
Study of Knowledge, Attitude, Anxiety and Perception of Mental Health Service Needs Related to the COVID-19 Pandemic in Banyumas Regency, Central Java, Indonesia: A Cross-sectional Study Wibowo, Yudhi; Mulyanto, Joko; Siswandari, VM Wahyu; Munfiah, Siti
Journal of Health Promotion and Behavior Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: In Banyumas, as of 27 June 2021, there were 15,809 confirmed cases and 669 deaths. Social restrictions with forced quarantine to fight the spread of diseases that have psychosocial impacts such as acute panic, anxiety, obsessive behavior, buildup, paranoia, depression and post-traumatic stress disorder. Community knowledge and attitudes affect compliance with the prevention and control of COVID-19. This study aimed to examine Knowledge, Attitudes, Anxiety & Perception of Mental Health Service Needs during the Covid-19 Pandemic.Subjects and Method: This was a cross-sectional study, conducted in Banyumas, Central Java, from July to August 2021. A total of 687 subjects was selected by snowball sampling. The dependent variable was anxiety. The independent variables were demographic data (initials, age, gender, home location, occupation, education level), marital status, pregnancy status, history of COVID-19, knowledge, attitudes, and perceptions of mental health service needs. The data were collected by questionnaire and analyzed using a multiple logistic regression. Results: The anxiety level increased wit age >60 years (OR= 0.60; 95% CI= 0.29 to 1.27; p= 0.001), not working (OR= 0.65; 95% CI= 0.29 to 1.46; p= 0.004), low level of education (OR= 2.07; 95% CI= 0.88 to 4.84; p=0.021), unmarried status (OR= 2.51; 95% CI= 1.67 to 3.78; p<0.001), COVID-19 survivors (OR= 1.96; 95% CI= 1.27 to 3.02; p= 0.003).Conclusion: Age, occupation, education level, unmarried status, COVID-19 survivors had a correlation with anxiety level. Keywords: knowledge, attitudes, anxiety, mental health service needs, COVID-19Correspondence: Yudhi Wibowo. Department of Public Health and Community Medicine, Medical Faculty, Jenderal Soedirman University. Jl. Dr. Gumbreg No.1, Mersi, Purwokerto, Banyumas, Central Java, Indonesia. Email: yudhi.wibowo@unsoed.ac.id. Mobile: +628112621904Journal of Health Promotion and Behavior (2022), 07(02): 142-151DOI: https://doi.org/10.26911/thejhpb.2021.07.02.06
Impact of Slow Deep Breathing on Pain in Head Injury Patients: A Systematics Review Kogoya, Neger; Mulyanto, Joko
Jurnal Neuroanestesi Indonesia Vol 14, No 1 (2025)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v14i1.642

Abstract

Head injury is a global health problem that often resulted from traffic accidents, and has a serious impact on brain and nervous system function. One of the main symptoms of head injury is intense pain, which often affects patients' quality of life. Although pain medications are widely used, non-pharmacological interventions such as the Slow Deep Breathing (SDB) technique have been proposed as an effective alternative to reduce pain in head injury patients. This study was aimed to evaluate the impact of SDB on pain reduction in patients with head injury. This systematic review was conducted using the PRISMA method with journal searches in several databases such as Google Scholar and PubMed. The search focused on studies published between 2020 to 2024. Screened articles had to meet the inclusion criteria involving observational studies on SDB in head injury pain. In this systematic review, information was collected by highlighting key elements, including the population group, type of intervention measures, outcomes observed, and methodological approach chosen. the result of the 425 journals identified, 95 articles were screened, and 4 journals met the criteria for further discussion. The results of the four studies showed that the SDB technique significantly reduced pain intensity in head injury patients. SDB helped lower heart rate, blood pressure, and improve blood oxygenation, all of which contributed to pain reduction. Slow Deep Breathing technique was shown to be effective as a non-pharmacological treatment for managing pain in head injury patients. Despite some limitations in sample size and study design, consistent results support the use of SDB as a complementary therapy in pain management. Future research is needed to inform the maximum therapeutic activity of SDB and explore the potential for combination with other therapies
Co-Authors Agung Saprasetya Dwi Laksana, Agung Saprasetya Dwi Anton B Darmawan, Anton B Arih Diyaning Intiasari Budi Aji, Budi Desy Destriana, Desy Diyah Woro Dwi Lestari Fajriana, Dina Rahmah Fitranto Arjadi Fitriana Rahmawati Indah Pusparini Indah Rahmawati Kogoya, Neger Lantip Rujito Muhammad Nur Hanief, Muhammad Nur Nafiisah, Nafiisah Nendyah Roestijawati Paulus Gozali, Paulus Pratama, Radya Putra Rosy, Freshyama Daniar Siswandari, VM Wahyu Siti Munfiah Wahdah, Vina Nurdiana Yudhi Wibowo, Yudhi