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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Bioma : Berkala Ilmiah Biologi Jurnal Kedokteran Brawijaya Pharmascience Jurnal Teknologi Laboratorium JRST (Jurnal Riset Sains dan Teknologi) JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Medica Hospitalia Jurnal Karinov Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical Care Anwar Medika Jurnal Ilmiah Medicamento Prosiding Seminar Nasional Pengabdian Masyarakat KOPEMAS
Martina Kurnia Rohmah
Universitas Anwar Medika
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Effect of Sappan Wood Ethanol Extract in CRP Level and Phagocytic Index Between Group of Mice Infected with S. aureus and E. coli Rohmah, Martina Kurnia; Hisbiyah, A'yunil; Octivani, Amellya; Anwari, Farida
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.10040

Abstract

S.aureusand E.coli are pathogenic bacterial that cause many infectious disease in the world. Immunomodulator is needed to prepare the immune system to be able against the infection. Some parameters usually used to assess the immunomodulatory activity such as C-Reactive Protein (CRP) and phagocytic index. This study aims to investigate the difference effect of sappan1wood extract  in CRP level and phagocytic index between group mice infected with S. aureus and E. coli.  Two treatment groups of mice were prepared for S. aureus and E. coli test. Each group subjected to 7 treatments i.e. (1) Normal mice1(CMC-Na 1 %- Merck® 217277), 1(2) Negative Control (bacterial infection + CMC-Na 1 %),11(3) Positive Control (bacterial infection + Imboost force®1treatment, PT SOHO Industri Pharmasi), (4) Bacterial infection and EESW treatment 25 mg/kg BW, (5) 50 mg/kg BW, (6) 100 mg/kg BW, and (7) 200 mg/kg BW. Mice blood was taken to detect the CRP and phagocytic index after treatment. The T test showed that there was a significant difference between CRP levels (p0.05) and phagocytic index (p0.05) of S. aureus and E. coli group. EESW 200 mg/kg BW reduced CRP level to 11 mg/dL (S. aureus) and 6 mg/dL in (E. coli). EESW 200 mg/kg BW increased phagocytosis to 1.54 folds (S. aureus) and 4.62 folds (E. coli). Sappan wood ethanol extract effect to CRP level and phagocytic index1in mice group infected with E. coli is better than S. aureus1infection group.
EDUKASI KESEHATAN BERBASIS KETANGGUHAN KELUARGA SEHAT DALAM MENGHADAPI PANDEMI COVID-19 BERBASIS TELEMEDICINE DAN MEDIA SOSIAL Martina Kurnia Rohmah; Farida Anwari; Arif Rahman Nurdianto
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2021
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pandemi COVID-19 merupakan permasalah global yang saat ini sedang dihadapi oleh seluruh masyarakat dunia. Tingginya angka kasus baru dan kasus kematian akibat COVID-19 menjadi latar belakang perlunya pemahaman kepada masyarakat terkait dengan pemeliharaan kesehatan keluarga di masa COVID-19. Keluarga merupakan tatanan terkecil masyarakat yang terdiri dari anggota dengan berbagai usia dengan permasalahannya masing-masing. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemahaman kepada masyarakat Desa Trosobo dan Pertapaan tentang kesehatan keluarga di masa pandemi yang dilakukan secara virtual dengan memanfaatkan teknologi digital seperti telemedicine dan media sosial seperti youtube dan Whatsapp. Hasil kegiatan menunjukkan terdapat peningkatan pemahaman masyarakat tentang kesehatan keluarga di masa COVID-19 di kedua desa Trosobo dan Pertapaan mencapai 40 – 60%
Uji Aktivitas Antiplatelet, Antikoagulan, dan Trombolitik Alkaloid Total Daun Pepaya (Carica papaya L.) secara in Vitro Rohmah, Martina Kurnia; Fickri, Djelang Zainuddin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.115-125.2020

Abstract

Papaya leaves have a number of alkaloid compounds (carpaine, pseudocarpaine, dehydrocarpaine I, dehydrocarpaine II, and emetine). This study aimed to determine the antiplatelet, anticoagulant, and thrombolytic activities of total alkaloids of papaya leaves in vitro. This study was divided into 5 groups: negative control, positive control, and total alkaloids of papaya leaves (0.5, 1.0, and 2.0 mg/mL) with 5 parameters: % platelet aggregation inhibition, CT, PT, APTT, and % thrombolytic. Based on statistical analysis, there was a significant difference between percentage of aggregation inhibition of total alkaloids and negative controls, but was not different with positive control (clopidogrel). Anticoagulant test showed that total alkaloid of papaya leaves significantly extended CT, PT, and APTT values compared with negative control, but was not significantly different with positive control (heparin). Thrombolytic test showed that total alkaloid of papaya leaves increased trombolitic percentage and significantly different from the negative control, but was not significantly different from positive control (nattokinase).
Co-Authors Achmadita Prameswari Andre Giovano Antoni Setiawan Anwari, Farida Arista Wahyu Ningsih Azis, Rosidi Bagus Kurniawan Romadhon Damasari, Karina Putri Diana Lyrawati Djelang Zainuddin Fickri Djelang Zainuddin Fickri Djelang Zainuddin Fickria Ella Rahman Yulianti Etik Wijayanti Fickri, Djelang Zainuddin Fodeni Yolinda Herni Setyawati Herni Setyawatia Hisbiyah, A'yunil Kasifa, Wahyu Kenichi Yano Liya Fitroh Nurlaila Mila Ayu Puji Lestari Novita E. Winarni Nur Novia Dayanti Nurdianto, Arif Rahman Nurul Maulidatus Sholichah Octivani, Amellya Pahri Samsiyeh, Nur Arzy Siti Lutfiyah Muf’idah Rizki Valentino Krismonico Caesarius Wahyuni, Khurin In Yani Ambari Yani Ambari Yani Ambari