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All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Bandung Althea Medical Journal The Indonesian Biomedical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Medica Hospitalia Contagion: Scientific Periodical Journal of Public Health and Coastal Health Medika Kartika : Jurnal Kedokteran dan Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Instrumentasi Jurnal Ilmu Bedah Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Lex Scientia Law Review Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Reno Rudiman
Department Of Surgery, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Konsensus Perhimpunan Dokter Spesialis Bedah Digestif Indonesia tentang Pedoman Diagnosis dan Tatalaksana Batu Saluran Empedu Muhammad Iqbal Rivai; Arnetta Naomi Louise Lalisang; Adianto Nugroho; Agung Ary Wibowo; Adeodatus Yuda Handaya; Fransiscus Arifin; Indah Situmorang; Erik Prabowo; Irwan Irwan; Maria Mayasari; Michael Tendean; Reno Rudiman; Kunsemedi Setyadi; Muhammad Shobachun Niam; Bambang Suprapto; Jeffri Putra; Tommy Lesmana; Yarman Mazni; Adi Muradi Muhar; I Made Mulyawan; Warsinggih Warsinggih; Toar Jean Maurice Lalisang
Majalah Kedokteran Indonesia Vol 74 No 2 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.2-2024-1188

Abstract

Introduction: Choledocholithiasis, the presence of stones in the common bile duct (CBD), is a challenge in the field of digestive surgery due to the wide range of cases with varying levels of difficulty. Until now, the options for diagnostic and therapeutic modalities have been increasingly evolving, ranging from non-invasive to invasive procedures. Therefore, the Indonesian Society of Digestive Surgeons provides recommendations for the management of CBD stone cases in Indonesia.Method: The consensus was developed using the Delphi survey method involving digestive surgery experts from various cities in Indonesia. Several issues related to the diagnosis and management of CBD stones were formulated and answered based on current research, while also considering the opinions of the experts.Result: This consensus consists of two parts: 15 recommendations related to the selection of diagnostic modalities and 10 recommendations related to management options. Recommendations regarding diagnosis include the use of ultrasonography, abdominal CT-scan, and magnetic resonance cholangiopancreatography (MRCP). In addition to standard therapeutic procedures, this consensus also provides recommendations regarding contemporary procedures such as endoscopic retrograde cholangiopancreatography (ERCP), laparoscopic common bile duct exploration (LCBDE), and open common bile duct exploration (OCBDE).Conclusion: These recommendations are aimed to assist digestive surgery experts in providing the best management for CBD stone cases.
Relationship between Clinicopathological Features and Expression of COX-2 among Colorectal Cancer Patients: A Prospective Observational Study Mohamad Romdhoni; Kiki Lukman; Reno Rudiman; Andriana Purnama; Bambang Am'am Setya Sulthana Degrees; Tommy Ruchimat; Alma Wijaya; Yunia Sribudiani Degrees; Prapanca Nugraha
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.24233

Abstract

Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related mortality. Cyclooxygenase-2 (COX-2) plays a critical role in CRC pathogenesis by promoting inflammation, tumor proliferation, and metastasis. COX-2 inhibitors, such as NSAIDs, have shown potential in reducing CRC progression. However, the relationship between COX-2 expression and clinicopathological features remains controversial. This study aims to assess the correlation between COX-2 expression and clinicopathological characteristics in CRC patients in Indonesia. A prospective observational study was conducted on 81 CRC patients at a tertiary hospital in West Java, Indonesia, from January to June 2024. COX-2 expression was quantified using qPCR from tumor tissue samples. Clinicopathological data, including age, sex, tumor grade, stage, and complications, were collected and analyzed. Among the 81 participants, 81.5% were over 50 years old. Low-grade adenocarcinoma was the most prevalent histopathological type (73%), followed by high-grade adenocarcinoma (11%) and mucinous adenocarcinoma (11%). The majority of cases were in regional or early stages (74%), while 26% were in late stages. Higher COX-2 expression was more frequent in males, rectal tumors, high- grade adenocarcinomas, advanced stages, and metastatic cases. Although no statistically significant association was found, a trend toward increased COX-2 expression in advanced CRC was observed. No significant association was found between COX-2 expression and clinicopathologic characteristics of CRC. However, higher COX-2 expression may be associated with advanced disease. Keyword: Clinicopathological features, Colorectal cancer, Cyclooxygenase-2, Inflammation, Metastasis
Skoring Pre-Operasi Memprediksi Keganasan pada Pasien dengan Ikterus Obstruktif di Rumah Sakit Hasan Sadikin Benita Putri Permata; Reno Rudiman; Tommy Ruchimat
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.6558

Abstract

Obstructive jaundice is commonly caused by both benig n and malignant hepatobiliary disorders. Early identification of malignancy remains challenging, especially in settings with limited access to advanced diagnostic modalities. To evaluate the diagnostic accuracy of the Probability of Malignancy (P-MAL) score in predicting malignant causes of obstructive jaundice. A prospective analytic study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, from December 2024 to August 2025. Forty-eight patients with obstructive jaundice were enrolled consecutively. Clinical characteristics and laboratory parameters were collected to calculate the P-MAL score. Final diagnosis was confirmed by histopathological examination. Diagnostic performance was assessed using receiver operating characteristic analysis. Among 49 patients, 15 (31.3%) were diagnosed with malignant obstructive jaundice. Patients with malignancy were significantly older and had higher levels of total bilirubin and alkaline phosphatase. The P-MAL score demonstrated good diagnostic accuracy with an area under the curve of 0.832 (95% CI 0.720–0.945; p < 0.001). A cut-off value ≥0.9994 yielded a sensitivity of 93.3% and specificity of 54.5%. The P-MAL score shows good accuracy for predicting malignancy in obstructive jaundice and may serve as a useful preoperative screening tool.
Surgical Outcomes and Recurrence in Adult Abdominal Cocoon (Sclerosing Encapsulating Peritonitis): A Systematic Review and Meta-Analysis of Pooled Proportions Eko Nur Febrianto; Zuldi Erdiansyah; Reno Rudiman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 9 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i9.1653

Abstract

Background: Abdominal cocoon, also termed sclerosing encapsulating peritonitis (SEP) or encapsulating peritoneal sclerosis (EPS), is a rare cause of intestinal obstruction in which the small bowel is encased within a fibrocollagenous membrane, producing the prototypical frozen abdomen. Its surgical outcomes had never been pooled quantitatively. Objective: To quantitatively pool the surgical outcomes of adult abdominal cocoon — peri-operative mortality, morbidity, recurrence and pre-operative diagnostic yield — in patients undergoing operative management. Methods: PubMed, Scopus, the Cochrane Library and Google Scholar were searched for observational studies reporting the operative management and outcomes of adult abdominal cocoon. Ten case series (179 operated patients) were included. As all studies were single-arm, proportions were pooled with the Freeman–Tukey transformation under a DerSimonian–Laird random-effects model; robustness was tested with a logit-normal model, leave-one-out analysis and the Egger test, and quality with the Joanna Briggs Institute checklist. Results: Pooled peri-operative mortality was 4.5% (95% CI 0.2–12.1%; k=7); because zero-event studies influence the double-arcsine transformation, a logit-normal model gave 13.1% and the crude proportion 7.9%, so mortality is best summarised as low-to-moderate. Pooled morbidity was 19.5% (95% CI 5.9–36.9%; k=5), recurrence 3.3% (95% CI 0.0–21.8%; k=3) and pre-operative diagnostic yield 19.1% (95% CI 6.0–36.0%; k=4). Leave-one-out kept mortality between 3.0% and 8.5%. Conclusion: Surgery for adult abdominal cocoon achieved low-to-moderate mortality and acceptable morbidity with infrequent recurrence, supporting membrane excision and adhesiolysis in selected patients, while the low pre-operative diagnostic rate signals a need for greater awareness.
Concordance of KRAS Mutation in Tumor Tissues and Fecal Samples of Colorectal Carcinoma Patients Ahmad Bahrudin; Reno Rudiman; Andriana Purnama; Kiki Lukman; Yunia Sribudiani; Prapanca Nugraha
The Indonesian Biomedical Journal Vol 18, No 4 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i4.4279

Abstract

BACKGROUND: Colorectal cancer (CRC) is a major global health problem associated with high cancer-related mortality. Profiling of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status has become a decisive predictive biomarker in the management of CRC. However, KRAS mutation testing is commonly performed using tumor tissue obtained through invasive biopsy or surgery; therefore, fecal DNA analysis might offer a promising non-invasive alternative. This study was conducted to evaluate the concordance of KRAS mutations between matched tumor tissue and fecal samples and their association with clinicopathological characteristics.METHODS: This cross-sectional study included 94 patients confirmed of CRC. Tumor tissue specimens were obtained during surgical resection or biopsy, while fecal samples were collected pre-operatively. KRAS mutations were analyzed using polymerase chain reaction (PCR) and DNA sequencing, and the associations with clinicopathological variables were statistically evaluated.RESULTS: KRAS mutations were detected in 45.74% of tumor tissue and 26.60% of fecal samples. The overall concordance rate was 65.96%, with a Cohen’s Kappa of 0.291 (95% CI: 0.110–0.472), indicating "fair agreement". Notably, allele-specific concordance was 100% among double-positive cases. The fecal assay demonstrated 41.86% sensitivity, 86.27% specificity, 72.00% positive predictive value (PPV), and 63.77% negative predictive value (NPV). Tumor location (colon versus rectum) was significantly associated with fecal KRAS detection (p=0.028); other variables showed no significant association (p>0.05).CONCLUSION: KRAS mutations were more frequently detected in tissue than in fecal samples, with fair agreement. High allele-specific concordance suggests fecal DNA accurately reflects the tumor's mutational profile. Tumor location significantly influences DNA detectability, supporting fecal-based KRAS testing as a potential non-invasive approach for CRC molecular assessment.KEYWORDS: colorectal neoplasms, feces, KRAS protein, human, mutation, neoplasm tissue
Legal Construction of Telesurgery in National Health Law Dewi Bunga; Reno Rudiman; Putu Kussa Laksana Utama; Desyanti Suka Asih K.Tus; Ni Made Rai Kristina
Lex Scientia Law Review Vol. 10 No. 2 (2026): November, 2026
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lslr.v10i2.18349

Abstract

The development of health technology must be accompanied by the establishment of robust healthcare laws to safeguard both healthcare professionals and patients from potential risks and losses arising from errors in telesurgery. In light of this, three key issues are formulated in this study: namely the development of telesurgery in the legal framework, the legal construction of telesurgery and legal responsibility in the event of errors in telesurgery. This study is a normative legal analysis examining the regulatory framework governing telesurgery and the legal responsibilities arising from potential errors. A literature review serves as the primary method for collecting both primary and secondary legal sources. The research employs a legislative and conceptual legal approach, with qualitative analysis used to address the identified issues. Legal frameworks for the regulation of telesurgery must be developed at both the international level, particularly in relation to jurisdiction, and the national level, focusing on medical standardization in its implementation. The practice of telerobotic surgery must be regulated by law, derived from policy regulations, and regulated by internal guidelines from surgeons. At a minimum, several legal elements must be addressed, including jurisdiction, ethics committees within surgical organizations, inter-ministerial collaboration, the legal relationship between patients and physicians, pre-operative explanations and informed consent, legal accountability, medical confidentiality, medical team requirements, and information security management systems.  Legal liability for failed surgical procedures may arise in cases of errors, whether intentional or due to negligence.
Co-Authors Abdul Mughni Adeodatus Yuda Handaya Adi Muradi Muhar Adianto Nugroho Aditya, Raka Agung Ary Wibowo Ahmad Bahrudin Akhsan, Alfie Barkah Alfie Barkah Akhsan Alma Wijaya Andriana Purnama Andriana Purnama Andriana Purnama Andriana Purnama Andriana Purnama, Andriana Arnetta Naomi Louise Lalisang Ayundra, Muhammad Hilmy Bambang Am&#039;am Setya Sulthana Degrees Bambang Suprapto Barr, Tubagus Izzul Bella Renata Benita Putri Permata Cytra Givanni Rossy Desyanti Suka Asih K.Tus Dewi Bunga Dimas Erlangga Nugrahadi Edwin Saleh Siregar, Edwin Saleh Eko Nur Febrianto Erik Prabowo Fransiscus Arifin Gema Putra Lesmana Gisela Karina Hapsari, Putie Harry Galuh Nugraha Hendrik Stevanus I Made Mulyawan Ignatius Riwanto Indah Situmorang Irwan Irwan Jeffri Putra Kendry Savira Kiki Lukman Kiki Lukman Kunsemedi Setyadi Kuswinarti Kuswinarti Lawrence, Christoph Maman Wastaman Rodjak Marcella, Marcella Maria Mayasari Michael Tendean Mohamad Romdhoni Muhammad Iqbal Rivai Muhammad Shobachun Niam Mulyadi, Noeray Pratiwi Narendra Kurnia Putra Ni Made Rai Kristina Nova Octoria Novi Christina Indrajaya Nugraha, Prapanca Nurhayat Usman Nurhayat Usman Octoria, Nova Prapanca Nugraha Prapanca Nugraha Pratomo, Nugroho Rizky Putie Hapsari Putu Kussa Laksana Utama Raden Lyana Sulistyanti Raden Yohana, Raden Rani Septrina Risangtumi, Ayu Gareta Rizky, Kiki A Rodjak, Maman Wastaman Silalahi, Fonda R.P Singarimbun, Wilner Stevanus, Hendrik Sulistyanti, Raden Lyana Sulthana, Bambang Am am Setya Suprijanto, Suprijanto Suraya Adnyana, Ida Bagus Budhi Tjokorda Gde Dalem Pemayun Toar J.M. Lalisang Tommy Lesmana Tommy Ruchimat Tommy Ruchimat Tommy Ruchimat Tommy Ruchimat Tommy Ruchimat Usman, Nurhayat Vandra Bina Riyanda Warsinggih Warsinggih Wilner Singarimbun Yan Aditya Yarman Mazni Yossi Andila Yunia Sribudiani Zuldi Erdiansyah