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All Journal Jurnal Sains dan Teknologi Pangan Jurnal Sains Teh dan Kina Jurnal Ilmiah Farmako Bahari Jurnal Ilmiah Farmasi Simplisia Jurnal Medika Farmaka Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Ardi Rustamsyah
Sekolah Farmasi Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology

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Xantine oxidase inhibition activity of infusion and ethanol extract of white tea Rustamsyah, Ardi; Islami, Sarah Nur; Fitriana, Fitriana; Kusmiyati, Mimin
Jurnal Penelitian Teh dan Kina Vol 19, No 2 (2016)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.733 KB) | DOI: 10.22302/pptk.jur.jptk.v19i2.112

Abstract

Research of xantine oxidase enzyme inhibition activity of infusion and ethanol extract of white tea were done. The aim of this research was to evaluate  xantine oxidase inhibitory activity of infusion and ethanol extract of white tea. Phytochemical screening on dry tea, infusion and ethanol extract of white tea showed that all samples contained alkaloid, flavonoid, quinone, tannin and tritherpenoid/ steroide. The IC50 value of samples were 76,64 μg/ml and 31,11μg/ml respectivelly. This study used allopurinol as standard with IC50 was 0,60 μg/ml.
Inhibition activity of α-glucosidase by infusion and ethanol extract of white tea and stevia combination Trinoviani, Elvi; Kholisoh, Ai; Ar-Rifa, Nisa Fitriani; Rustamsyah, Ardi
Jurnal Penelitian Teh dan Kina Vol 19, No 2 (2016)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (521.604 KB) | DOI: 10.22302/pptk.jur.jptk.v19i2.113

Abstract

Ethanol extract of white tea and its stevia liquor was observed for α-glukosidase inhibition. The research was divided into some steps;  white tea and stevia combination hedonic sensory test, phytochemical identification, and α-glucosidase inhibition activity. The result of hedonic sensory test incline towards formula 2 which consist 75% of white tea and 25% stevia. Further, this formulation was extracted by ethanol for α-glucosidase inhibition activity test. Formulation 2 liquor tested for enzyme inhibition activity showed IC50 value was 36,96 µg/ml, better than ethanol extract and acarbose. Phytochemical identification presented that both preparations contained alkaloids, flavonoids, saponins, tannins, triterpenes/steroid, and quinones.
Antioxidant activity, phenol total, and flavonoid total of green tea (Camellia sinensis (L.) O. Kuntze) from three West Java tea estate Kusmiyati, Mimin; Sudaryat, Yayat; Lutfiah, Isti Agnia; Rustamsyah, Ardi; Rohdiana, Dadan
Jurnal Penelitian Teh dan Kina Vol 18, No 2 (2015)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.507 KB) | DOI: 10.22302/pptk.jur.jptk.v18i2.71

Abstract

Green tea has bioactive component, it is polyphenol which has strong antioxidant. As the largest component of polyphenol, flavonoid is very effective as an antioxidant. The purpose of this study was to determine antioxidant activity, phenol total and flavonoid total in green tea from three different estates, they were Cikajang Kab. Garut, Taraju Kab. Tasikmalaya, and Ciwidey Kab. Bandung. The results of this study show that seven samples have good antioxidant activity, but green tea which came from Cikajang (P-IRT No. 810320501698) has the highest IC50 grade it was 21,44 μg/ml. Beside that samples from Cikajang (P-IRT No. 810320501698) has highest total phenol content it was 334,68± SD 0,89/100 g samples and also has the highest total flavonoid it was 0,34 mg Kuersetin/g samples ± SD 0,21. On the contrary, green tea which has the lowest IC50 grade came from Taraju, the grade was 28,03 μg/ml, the samples has the lowest total phenol content it was 208,91± SD 4,47 mgGAE/100 g, and also has the lowest total flavonoid it was 0,207 mg Kuersetin/g samples ± SD 0,00.
Peningkatan Nilai Ekonomi Modifikasi Pati Umbi Taka (Tacca leontopetaloides (L.) Kuntze) Sebagai Bahan Baku Pembuatan Biskuit Herbal Lubis, Novri Yanti; Fauziah, Nenden; Ilahi, Resa Restu; Rustamsyah, Ardi
Jurnal Sains dan Teknologi Pangan Vol 4, No 5 (2019): JURNAL SAINS DAN TEKNOLOGI PANGAN
Publisher : JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (683.341 KB) | DOI: 10.33772/jstp.v4i5.9405

Abstract

ABSTRACT This study aimed to observe the effect of the concentration of modified taka starch (Tacca leontopetaloides (L.) Kuntze) as well as the size of natural taka tubers and red ginger starch on the characteristics of the produced herbal biscuits. The taka starch was modified by using ginger oil components. Meanwhile, the size of natural taka tubers and red ginger starch granules was compared by using a scanning electron microscope. The study was classified into three stages, namely the taka starch manufacture, the taka starch modification, and the biscuit production. The results showed that the modified taka starch had a larger granule than the natural starch, with the size reached 36.9 µm and 34.4 μm, respectively. Meanwhile, the water, ash, fat, protein, and carbohydrate contents, as well as the calories reached 4.56%, 2.40%, 9.11%, 8.71%, 75.27 %, and 417.99 cal, respectively. In general, all parameters met the Indonesian National Standard for biscuits. Keywords: Biscuits, characteristics of starch granule, taka tuber ABSTRAK Penelitian ini ingin melihat pengaruh modifikasi pati taka (Tacca leontopetaloides (L.) Kuntze) dengan menggunakan komponen minyak jahe dan membandingkan ukuran granul pati umbi taka alami dan minyak jahe merah dengan menggunakan metode SEM (Scanning Electron Microscope), kemudian dijadikan produk pembuatan biskuit herbal. Metode penelitian diawali dengan pembuatan pati taka dan modifikasi pati taka kemudian dijadikan produk pangan. Pengujian karakterisasi pati taka dan pati taka termodifikasi dengan pengujan SEM menunjukkan, pati yang sudah dimodifikasi memiliki bentuk granul lebih besar 36,9 µm dari pati taka alami 34,4 µm. Hasil modifikasi pati umbi taka menghasilkan produk inovasi pangan berupa biskuit herbal, dengan hasil karakteristik meliputi kadar air 4,56%, kadar abu 2,40%, kadar lemak 9,11%, kadar protein 8,71%, kadar karbohidrat 75,27% dan kalori 417,99 kal. Secara umum, semua parameter sudah sesuai dengan SNI biskuit. Kata kunci: Biskuit, karakteristik granul pati, umbi taka
COMPARISON OF ABTS (2,2-AZINOBIS(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID) AND DPPH (1,1-DIPHENYL-2-PICRYLHYDRAZYL) ASSAYS TO MEASURE THE ANTIOXIDANT ACTIVITY OF ETANOL EXTRACT OF RED ALGA (Gelidium sp) Martiani, Isye; Rustamsyah, Ardi; Puspitasari, Tien Ellita Endah; Sujana, Dani
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3461

Abstract

Seaweeds have an ecological function as primary producers in marine waters. It also has an important economic value as a producer of hydrocolloids (alginate, agar, and carrageenan) used in various food and pharmaceutical industries. This study aims to determine the antioxidant activity of red algae (Gelidium sp). Extraction was done using the maceration method using 96% ethanol and concentrated by rotary evaporation. The antioxidant activity of the extract was tested using ABTS and DPPH methods. Antioxidant activity was seen from the IC50. The results showed that IC50 from ethanol extract of red algae (Gelidium sp) with the DPPH method is 3,9154 ppm. Then, using the ABTS method, IC50 from ethanol extract of red algae (Gelidium sp) is 9,1178 ppm. This result shows that the ethanol extract from red algae (Gelidium sp) has very strong antioxidant activity (<50 ppm).
Review Artikel: Kajian Senyawa Fitokimia dan Aktivitas Farmakologi Antidiabetes dari Syzygium cumini Rustamsyah, Ardi; Perdana, Farid; Zulfakor, Dava; Kusmiyati, Mimin
Jurnal Medika Farmaka Vol 1 No 2 (2023): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v1i2.13

Abstract

Introduction: Jamblang is a plant from the Myrtaceae family. It can be used as a traditional medicine, one of which can treat diabetes. The purpose of this review is to determine the phytochemical compounds of Syzygium cumini that have antidiabetic activity. Methods: The methods used in the preparation of this review article are to search for various sources that discuss antidiabetic activity and phytochemical studies of Syzygium cumini. Results: The results of the review that have been carried out explain the in vitro and in vivo testing of antidiabetic activity on the inhibition method and the induction method, resulting in jamblang potentially as an antidiabetic. Conclusion:The results of the review that have been carried out explain the phytochemical study using HPLC method there are groups of flavonoid, phenolic, and phenylpropanoid compounds, and on the TLC method there are groups of terpenoids. Oleic acid and ursolic acid compounds have antidiabetic activity.
Penetapan Kadar Flavonoid Total dan Uji Aktivitas Antioksidan Kombucha Daun Kitolod (Isotoma longiflora L.) Menggunakan Spektrofotometer Uv-Vis elvi trinovani; Kusmiyati, Mimin; Sudaryat, Yayat; Kusumah, Raden Minda; Rhamadianto, Muhamad Iqbal; Rustamsyah, Ardi
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 1 (2025): Juni 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i1.840

Abstract

Penyakit degeneratif menjadi penyebab kematian terbesar di dunia karena penurunan aktivitas fisik dan pola hidup yang disebabkan oleh kerusakan sel akibat reaktivitas senyawa radikal bebas. Radikal bebas dapat dihambat dengan senyawa antioksidan. Salah satu tumbuhan yang memiliki potensi sebagai antioksidan alami yaitu daun kitolod (Isotoma longiflora L.) terbukti mengadung senyawa flavonoid yang dapat menghambat radikal bebas. Untuk meningkatkan ketertarikan masyarakat dalam mengkonsumsi daun kitolod dibuat minuman tradisional yang difermentasi disebut dengan kombucha. Kadar flavonoid total menggunakan metode kolorimetri dan metode DPPH (2,2-difenil-1-pikrilhidrazil) untuk mengukur aktivitas antioksidan pada kombucha kitolod dianalisis menggunakan spektrofotometer UV-Vis. Kadar flavonoid total tiga sampel kombucha daun kitolod sampel A sebesar 1,6481 mg QE/g, kombucha daun kitolod sampel B sebesar 1,4056 mgQE/g, kombucha daun kitolod sampel C sebesar 1,5380 mg QE/g. Aktivitas antioksidan pada kombucha daun kitolod  memiliki nilai IC50 pada tiga sampel yaitu 540 ppm, 535 ppm, dan 539 ppm. Penelitian ini membuktikan bahwa kombucha daun kitolod mengandung senyawa flavonoid dan memiliki aktivitas antioksidan.
Review : Aktivitas Farmakologi Rumput Laut Genus Gracilaria (Rhodopyceae) Nurazizah, Siska; Rustamsyah, Ardi; Perdana, Farid; Sujana, Dani; Kusmiyati, Mimin
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 10 No. 1 (2023): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v10i1.4318

Abstract

Penyebaran rumput laut di Indonesia berada hampir diseluruh penjuru tanah air, namun produksi dan perdagangan rumput laut Indonesia sampai saat ini didominasi oleh genus Gracilaria dari kelas Rhodopyceae sebagai penghasil agar. Beberapa penelitian telah dilakukan dan menunjukan aktivitas dari Gracilaria. Tujuan review artikel ini adalah memberikan informasi tentang aktivitas farmakologi genus Gracilaria, dengan menggunakan metode studi literatur dari beberapa penelitian mengenai aktivitas dari Gracilaria. Beberapa spesies dari genus ini, berpotensi untuk aktivitas antioksidan, antibakteri, terapi adjuvans pada penyakit peridontal, antidiabetes, antiobesitas, antikolesterol, antiosteoklas, hepatoprotektor, antikanker, homeostatis, antikoagulan, antiulcer, dan imunostimulan.
Co-Authors . Elfahmi Ai Kholisoh, Ai Dadan Rohdiana Dani Sujana Elvi Trinovani, Elvi Elvi Trinoviani, Elvi Fauziah, Nenden Ilahi, Resa Restu Isti Agnia Lutfiah, Isti Agnia Komar Ruslan Wirasutisna Kusumah, Raden Minda Lubis, Novri Yanti Martiani, Isye Mimin Kusmiyati, Mimin Nisa Fitriani Ar-Rifa, Nisa Fitriani Nurazizah, Siska Perdana, Farid Puspitasari, Tien Ellita Endah Rhamadianto, Muhamad Iqbal Sarah Nur Islami, Sarah Nur Yayat Sudaryat Yoga Yuniadi Zulfakor, Dava