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All Journal Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Susi S. Suwardi
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Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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EFEKTIVITAS SUPLEMENTASI VITAMIN A DOSIS TINGGI TERHADAP TINGKAT PENYEMBUHAN DAN STATUS IMUN ANAK BALITA PENDERITA TUBERKULOSIS PARU Susi S. Suwardi; Ance Murdiana; Muhilal Muhilal; Endi Ridwan; Effendi Rustan; Susilowati Herman; Sri Martuti; Tita Miawati
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) JILID 22 (1999)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v0i0.1533.

Abstract

Effectiveness of High Dose Vitamin A Supplementation on The Recovery Rate and Immune Status of Underfive Children Suffering From Tuberculosis.Tuberculosis (TB), the infectious disease, is still one of the health problems in Indonesia. TB does not just make the people sick physically, but also interfere the immunity. As we have known that vitamin A can improve the immunity. The aimed of this randomized double blind study was to know the effect of high dose vitamin A on the improvement, immune status and the relationship between vitamin A and immune status in TB. Sixtyfive underfive children were selected from the Pediatrics Wards for out patient in Salak and Clsarua Hospital. They were grouped into 11 treatment group who received standard regimen therapy for TB plus high dose vitamin A in each month for 6 months and 21 control group who received the same TB regimen plus placebo also in each month for 6 months. Data on physical examination, weight, height, hemoglobin (Hb), hematocrit (Ht), blood sedimen rate (BSR), serum vitamin A, immunoglobulin G (IgG) to TB, chest X ray (CXR) and food consumption were collected before and after (6 months) intervention. Information on morbidity and socioeconomic also were recorded. To evaluate the degree of improvement, score on nutritional status, BSR and CXR were made. The results showed that after 6 month there were improvement in anthropometry status, morbidity rate, Hb, Ht, BSR, IgG and CXR for both groups. The treatment group was improved in 7.2% subjects meanwhile the control group was improved in 58% subjects. Analysis for scoring improvement showed that the treatment group had better improvement 2,4 times than the control group. The conclusions are that the high dose vitamin A has a positive effect on the recovery and immune status of underfive children suffering TB. This study suggests to give high dose vitamin A to the regimen therapy for TB in children to get better results.Keywords: tuberculosis, vitamin A supplementation, IgG, recovery rate.
TINGKAT KESEMBUHAN TB PARU PADA ANAK BALITA YANG MENDAPAT SUPLEMENTASI VITAMIN A DOSIS TINGGI Susi S. Suwardi; Muherdiyantiningsih Muherdiyantiningsih
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 25 No. 1 (2002)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v25i1.1419.

Abstract

THE RECOVERY RATE OF PULMONARY TUBERCULOSIS OF THE UNDERFIVE CHILDREN SUPPLEMENTED BY HIGHDOSE VITAMIN A.Background: Tuberculosis (TB) is the most common cause of death among other Infection disease. It Is recognized thattuberculosis affects various age groups, Including underfive children. The complete and fast treatments are needed to reduce the prevalence and Incidence of TB in the communities. Considering the role of vitamin A In reducing the severely of Infection, supplementation of hlghdose (200.000 IU) vitamin A in every two months for 6 months will be helpful to increase recovery rate of pulmonary tuberculosis.Design: This study was conducted at the hospital in Bogor region. Sample size was 66 children of underfive years old, whowere suffered pulmonary TB according to Mantoux test, clinical examination, and chest x-ray (CXR). Physical examination, morbidity, and anthropometric data were assessed every month. Food consumption recall, serum vitamin A concentration, hemoglobin content, hematocrit, blood sedimen rate (BSR), and CXR were assessed at 0 and 6 months. The children wererandomly assigned to either vitamin A-supplemented (AS, n=33) group or vitamin A-unsupplemented (AUS, n=37). All of the children were treated by isoniazide, ethambutol and rifampicin. The recovery rate was assessed according to the score of 3 variabels: nutrition status, BSR, and CXR.Results: Nutrition status and hemoglobin increased significantly in both groups (p<0,05). The clinical symptoms subsided and BSR decreased in both groups, but was not significant different between groups. The CXR data showed there were improvement in 84,5% of AS group and 67,7% of AUS group. There were scoring improvement of the recovery rate in bothgroups, but was not significant different between groups.Conclusions: There was significant relation between vitamin A status and the recovery rate of pulmonary tuberculosis, but was not significant different between groups.Keywords: tuberculosis, vitamin A supplementation, recovery rate
Co-Authors Ance Murdiana Effendi Rustan Endi Ridwan Muherdiyantiningsih Muherdiyantiningsih Muhilal Muhilal Sri Martuti Susilowati Herman Tita Miawati