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EFFECTS OF TAMSULOSIN 0.2 MILIGRAM AND TAMSULOSIN 0.4 MILIGRAM ON LOWER URINARY TRACT SYMPTOM SCORE OF USSQ IN PATIENTS WITH INDWELLING DJ STENTS Rizki, Dhika Ari; Safriadi, Ferry; Noegroho, Bambang S
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.582

Objective: To assess the difference in the administration of 0.2 mg and 0.4 mg tamsulosin to the patient's complaint with DJ stent based on USSQ parameters. Material & Methods: This was a prospective study conducted in Hasan Sadikin Hospital Bandung from October to December 2017. A total of 60 patients with indwelling DJ stents randomly divided into 2 groups (n=30). The first group was given tamsulosin 0.2mg daily and the second group was given tamsulosin 0.4 mg daily. LUTSs before and after tamsulosin administration for a week were evaluated in both groups using USSQ. Percentage decreases in USSQ score in both groups were then compared using Mann Whitney Test. Results: In group I, USSQ score means were 31.9 (20.0-40.0; SD 31.9) before tamsulosin 0.2 mg administration and 26.1 (15.0-35.0; SD 5.6) after tamsulosin 0.2 mg administration. Comparison test before and after tamsulosin 0.2 mg administration showed significant decrease in USSQ score. In group II, USSQ score means were 38.9 (31.0-44.0; SD 2.9) before tamsulosin 0.4 mg administration and 16.7 (13.0-21.0; SD 1.8) after tamsulosin 0.4 mg administration. Comparison test before and after tamsulosin 0.4 mg administration showed significant decrease in USSQ score. The percentage decreases in USSQ score were 18.7% in group I and 56.9% in group II. Different test score before and after treatment for both groups showed p-value<0.05. Scoring results after treatment showed the effectiveness of tamsulosin 0.4 mg was better than tamsulosin 0.2 mg. Conclusion: LUTS is the most common stent-associated symptom (SAS) in patients with indwelling DJ stent. Independent administration of tamsulosin 0.2 mg and 0.4 mg significantly alleviated SAS. Tamsulosin 0.4 mg had better effectiveness in alleviating SAS compared to tamsulosin 0.2 mg.

EFFECTS OF TAMSULOSIN 0.2 MILIGRAM AND TAMSULOSIN 0.4 MILIGRAM ON LOWER URINARY TRACT SYMPTOM SCORE OF USSQ IN PATIENTS WITH INDWELLING DJ STENTS Rizki, Dhika Ari; Safriadi, Ferry; Noegroho, Bambang S
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.582

Objective: To assess the difference in the administration of 0.2 mg and 0.4 mg tamsulosin to the patient's complaint with DJ stent based on USSQ parameters. Material & Methods: This was a prospective study conducted in Hasan Sadikin Hospital Bandung from October to December 2017. A total of 60 patients with indwelling DJ stents randomly divided into 2 groups (n=30). The first group was given tamsulosin 0.2mg daily and the second group was given tamsulosin 0.4 mg daily. LUTSs before and after tamsulosin administration for a week were evaluated in both groups using USSQ. Percentage decreases in USSQ score in both groups were then compared using Mann Whitney Test. Results: In group I, USSQ score means were 31.9 (20.0-40.0; SD 31.9) before tamsulosin 0.2 mg administration and 26.1 (15.0-35.0; SD 5.6) after tamsulosin 0.2 mg administration. Comparison test before and after tamsulosin 0.2 mg administration showed significant decrease in USSQ score. In group II, USSQ score means were 38.9 (31.0-44.0; SD 2.9) before tamsulosin 0.4 mg administration and 16.7 (13.0-21.0; SD 1.8) after tamsulosin 0.4 mg administration. Comparison test before and after tamsulosin 0.4 mg administration showed significant decrease in USSQ score. The percentage decreases in USSQ score were 18.7% in group I and 56.9% in group II. Different test score before and after treatment for both groups showed p-value<0.05. Scoring results after treatment showed the effectiveness of tamsulosin 0.4 mg was better than tamsulosin 0.2 mg. Conclusion: LUTS is the most common stent-associated symptom (SAS) in patients with indwelling DJ stent. Independent administration of tamsulosin 0.2 mg and 0.4 mg significantly alleviated SAS. Tamsulosin 0.4 mg had better effectiveness in alleviating SAS compared to tamsulosin 0.2 mg.

COMPARISON OF PERCUTANEOUS NEPHROLITOTOMY (PCNL) IN PRONE AND SUPINE POSITION: A SINGLE CENTRE EXPERIENCE REPORT Safriadi, Ferry; Ramdhan, Dadan
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.643

Objective: This study aims to compare outcomes of supine percutaneous nephrolithotomy to prone percutaneous nephrolithotomy as a traditional approach in Hasan Sadikin Hospital Bandung. Material & Methods: Data was taken from urology’s database between 2003-2012, which contain data of prone position (2003-2007), and supine position (2008-2012). Three hundred forty-nine patients were included in this study. We reviewed data on demography, stone burden, operating time, stone-free rate, transfusion rate, hospital stay, and major complications. Results: Of 174 patients underwent prone position, and 175 patients were part of the supine position. Age means of prone position was 51.0 years old, the supine position was 50.5 years old. The number of male patients was 65.5% for prone, and 66.1% for supine. The mean stone's largest diameter of prone was 23.87 mm, supine was 22.36 mm. The operating time of prone was 107 minutes; supine was 90 minutes. The stone-free rate of prone was 94.7%; supine was 91.3%. The mean hospital stays of prone was 14.3 days; supine was 9.6 days. The transfusion rate of prone position was 8.9%, supine was 7.2%. No major complications were recorded. Conclusion: Higher stone-free rates are achieved with patients in the prone position during PCNL. Supine position has shorter operating time, and hospital stay, lower blood transfusion rates. The complication rate is not different between the two positions.

PREDICTION OF HYPOECHOIC LESIONS ON ULTRASOUND OF PROSTATE CANCER BASED ON PSA INTERVAL AND GLEASON GROUP Ivan Mangunsong, Albert; Pramod, Sawkar Vijay; Safriadi, Ferry; Hernowo, Bethy S
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.676

Objective: To evaluate hypoechoic lesion in transrectal ultrasonography of prostate (TRUS-P) predictive value on prostate cancer based on PSA Interval and Gleason Group. Material & Methods: An observational analytic study with a cross-sectional design take place from January 2015 to December 2018 analyzing patients who had undergone TRUS-P Biopsy at Hasan Sadikin Hospital. Patients are divided into several subgroups according to different PSA levels. A p-value < 0.05 was considered statistically significant. PPV, NPV, and Youden’s index were all indexes reflecting the performance of a diagnostic test. Results: There were 35 cases (49.3%) with a visible hypoechoic lesion in TRUS and 36 cases (41.7%) without a visible hypoechoic lesion. In our study, 23.9% of the patients with hypoechoic lesions were diagnosed with prostate cancer on TRUSP-Biopsy. The results of the analysis with Youden’s index show that PSA at intervals of 10-20 is the best predictor of diagnostic values. Then we analyzed the overall detection rate based on PSA interval. Patients with PSA > 20 ng/ml, hypoechoic lesions were significantly associated with Gleason Group. Conclusion: We concluded in our study that the hypoechoic lesion in transurethral ultrasonography of prostate could improve the predictive efficacy for diagnosing prostate cancer.

Five-Year Profiles of Prostate Cancer Patients in A Tertiary Hospital in Indonesia Ferry Safriadi; Aidil Rahman Novesar
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2212

Prostate cancer is a malignant disease of the urogenital system, which is the second most common cancer in men and one of the leading causes of death in male population. In Bandung City, Indonesia, no data are available regarding the profile of prostate cancer patients. This study aimed to determine the profile of prostate cancer patients treated at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, which is the tertiary hospital in the most populated province in Indonesia, during the period of 2015-2019. This was a a retrospective descriptive study on secondary data from medical records. Results showed that most prostate carcinoma patients were was 67.95 ± 8.946 years old with most of them (n=92, 81.4%) had a history of hypertension and 62 patients (54.9%) did not have any history of smoking. Most patients had 20-40 cc prostate volume with hard consistency and without nodules; a PSA level of > 20 ng/ml; and a gleason score of 8-10 or poorly differentitated. Age affected increased incidence of prostate carcinoma with the highes prostate volume (20-40cc). The average PSA was 504.66 ± 10.26 and the median gleason score was 8 (6-10). The highest prostate volume is 20-40cc with hard consistency without nodule and the highest PSA value is > 20 ng/ml with a Gleason score of 8-10, showing a poorly differentiated condition.

Bacterial and Antibiotic Sensitivity Patterns in Patient Urine after Percutaneous Nephrostomy Steven Steven; Ferry Safriadi
Majalah Kedokteran Bandung Vol 53, No 3 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n3.2312

Percutaneous nephrostomy (PN) is a urine diversion procedure using a tube, stent, or catheter. Knowledge of bacterial sensitivity to antibiotics can guide the establishment of an appropriate and safe treatment to reduce the incidence of percutaneous nephrostomy-related infection (PNCI). The purpose of this study was to determine the suitability of antibiotics medication based on the results of bacterial culture and bacterial sensitivity test. This study was a retrospective descriptive observational study on medical records of patient diagnosed with obstructive uropathy who underwent PN in the period January 2017 to December 2019. A total of 20 bacterial isolates were classified as gram-positive bacteria isolates (16.53%) and 101 isolates presented gram-negative bacteria (83.47%). The most frequent gram-negative bacteria identified in these isolates were E. coli (n=42), Pseudomonas aeruginosa (n=22), and Klebsiella pneumonia (n=20). Meanwhile, Staphylococcus aureus was seen in ten isolates with gram-positive bacteria. Vancomycin antibiotics had the best sensitivity to gram-positive bacteria based on the antibiotic sensitivity tests. On the other hand, meropenem and amikacin had the best sensitivity to gram-negative bacteria (83.2%). This study showed that the most common bacteria identified from nephrostomy patients is E. coli with meropenem and amikacin as the most sensitive antibiotic for these patients. Thus, antibiotic therapy before and after PN procedure should be considered wisely to prevent resistant PNCI.

A Ten-Year Study on Risk Factors of Orchiectomy in Testicular Torsion Rulianov Rulianov; Kuncoro Adi; Ferry Safriadi
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2514

Testicular torsion is a common urological emergency among children, peaking in neonates and pubertal age with an incidence rate of 3.8 in 100.000 (0.004%) annually. This study aimed to explore the characteristics of testicular torsion cases and risk factors for orchiectomy in testicular torsion patients. This was a retrospective study on medical records of patients diagnosed with testicular torsion underwent surgery at the urology department of Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from January 2009 to August 2019. Patient characteristics including age, duration of symptom, location, etiology, and degree of torsion were analyzed. A total of 86 cases of testicular torsion were identified, with most cases (54 cases, 62.8%) occured at the mean age 14.67 ± 2.4 years old. Most patients (69 patients, 80.2 %) arrived more than six hours after the onset, and 65 (75.5%) and 4 (4.6%) of them underwent orchiectomy and orchidopexy, respectively. The remaining patients (17 patients, 19.8%) came less than 6 hours after the onset and only 8 (9.3%) and 9 (10.4%) underwent orchiectomy and orchidopexy, respectively. Both duration of torsion (p = 0.000, P<0.05) and degree of torsion (p = 0.006 , P<0.05) were significantly correlated with orchiectomy. In conclusion, the risk factor for orchiectomy is strongly related to duration and degree of torsion. The chance for testis salvation increases if torsion happens before 4.5 hours and the degree of torsion is below 180 degrees. Prompt diagnosis and treatment is the only key to testicular salvation.

Penanganan Metastasis Tulang dan Bone Loss pada Penderita Kanker Prostat FERRY SAFRIADI
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i3.206

Kanker prostat merupakan keganasan non-kulit terbanyak di negara barat atau keganasan keempat terbanyak pada pria setelah kanker kulit, paru, dan usus besar.Di negara maju, stadium awal ditemukan pada 75% penderita. Di Rumah Sakit Hasan Sadikin, Bandung, pada periode 2004-2010 ditemukan 57% kasus masih terbatas di organ dan locally advanced. Sedangkan sisanya, 43% termasuk stadium lanjut dari 320 kasus kanker prostat.Kanker prostat adalah keganasan di bidang urologi yang paling sering bermetastasis ke tulang sampai 70% kasus. Penyulitnya berupa nyeri hebat, fraktur patologis, sindrom kompresi tulang belakang, dan hiperkalsemia. Insidensi penyulit sekitar 46,1% mengakibatkan peningkatan biaya perawatan dan memperburuk prognosis pasien.Androgen Deprivation Therapy merupakan terapi kanker prostat yang telah bermetastasis. Terapi ini sendiri menyebabkan osteopenia atau osteoporosis.Bifosfonat merupakan obat yang paling banyak dipakai saat ini untuk terapi metastasis tulang. Bifosfonat menghambat secara langsung aktivitas osteoclast dan secara tidak langsung melalui osteoblast. Denosumab merupakan opsi terapi terkini pada kasus metastasis tulang dan lebih baik dari asam zoledronat.Kata kunci: kanker prostat, metastasis tulang, bone loss, terapi.

Prostatektomi Radikal: Morbiditas dan Mortalitas di RSUP dr. Hasan Sadikin, Bandung Ferry Safriadi
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kanker prostat merupakan salah satu jenis keganasan tersering pada pria. Prostatektomi radikal merupakan terapi pilihan pada kanker prostat yang masih organ confined. Tindakan ini merupakan tindakan operatif dengan derajat kesulitan tinggi, sehingga risiko morbiditas atau mortalitas harus menjadi perhatian. Tujuan penelitian ini adalah mengevaluasi morbiditas, mortalitas pasien, dan faktor yang berperan.Penelitian ini dilakukan secara retrospektif dengan mengumpulkan data dari rekam medis dan status khusus pasien kanker prostat yang telah menjalani operasi prostatektomi radikal dari 2005 sampai 2011 di RS Hasan Sadikin. Analisis univariat dilakukan dengan Chi-square untuk menilai faktor yang berperan terhadap morbiditas dan mortalitas.Sebanyak 90 pasien sebagai subjek penelitian. Usia rerata subjek 62,99 + 5,32 tahun, nilai PSA 31,89 + 29,13 ng/ml, volume prostat 53,24 + 29,13 ml, skor Gleason paling banyak ditemukan pada rentang 2-6 sebesar 58,9%. Rerata lama operasi 236,74 + 89,78 menit dengan jumlah perdarahan sebanyak 874,22 + 573,46 ml dan transfusi 318,11 ml.Morbiditas mayor ditemukan pada 8 kasus (0,08%); 6 kasus termasuk klasifikasi modikasi Clavien derajat 3 dan 2 kasus derajat 5. Analisis statistik tidak menunjukkan adanya kaitan antara usia, PSA, volume prostat, skor Gleason, dan stadium T terhadap terjadinya morbiditas dan mortalitas.Kesimpulannya, morbiditas pada penelitian ini sebesar 0,06% dan mortalitas 0,02%. Faktor usia, PSA, volume prostat, skor Gleason, dan stadium T tidak bermakna secara statistik. Penapisan pra-operasi yang baik akan mencegah terjadinya morbiditas dan mortalitas, selain faktor pengalaman operator.Kata kunci: kanker prostat, prostatektomi radikal, morbiditas, mortalitas.

Characteristics of Non-Muscle Invasive Bladder Cancer (NMIBC) in Patients Treated in an Indonesian Tertiary Hospital from 2008 to 2019 Ferry Safriadi; I Nyoman Palgunadi
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2418

Bladder cancer is the 10th most common cancer in both males and females with a ratio of 3:1. About 75% of bladder cancers are non-muscle invasive bladder cancers (NMIBC). The aim of this study was to identify the characteristics of Non-Muscle Invasive Bladder Cancer (NMIBC) patients treated in Dr. Hasan Sadikin General Hospital as one of the tertiary hospitals in Indonesia. This was a retrospective descriptive study that involved reviewing the medical records of patients diagnosed with NMIBC between January 2008 and December 2019. Characteristics reviewed were age, gender, body mass index (BMI), smoking history, urinary tract infection and stone history, intravesical chemotherapy and its side effects, and urinary cytology results. All data were tabulated and charted. Fifty-one out of 773 bladder cancer patients were diagnosed with NMIBC (6.59%). The mean age was 62.94 years old, with the majority of patients were in the 60-69 age group (31.37%). Males constituted the majority of the patients (n=44, 86.27%), with most patients had ideal BMI (66.66%), smoking history (72.54%), urinary tract infection history (56,86%), and urolithiasis history (5.88%). Thirty patients were given intravesical chemotherapy (58.82%), three patients experienced hematuria (10%), and four patients had painful urination (13.33%). Urinary cytology showed atypical cells (92.16%) in the majority of patients. The incidence of NMIBC in bladder cancer patients in our study was 6.59%, which differs from the incidence in developed countries of 75%, as shown in previous literature.

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