Ferry Safriadi
Department Of Of Urology, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung

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Accuracy of Urine Cytology In Detecting Bladder Cancer Ahlan Syahreza; Ferry Safriadi
Majalah Kedokteran Bandung Vol 53, No 4 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n4.2460

Abstract

One of the most prevalent and deadly cancers in men is bladder cancer. To achieve the best possible outcome, physicians need to diagnose it promptly. The gold standard for diagnosis is tissue biopsy, but this method is invasive. There is another option for non-invasive diagnostic using urine cytology. The purpose of this study was to measure the accuracy of urine cytology in diagnosed bladder cancer patients. This study extracted data from patients medical records in a tertiary hospital in Indonesia from 2009–2019. The diagnostic accuracy was then compared between urine cytology and biopsy as the gold standard. Data on subjects’ baseline characteristics and diagnostic accuracy (sensitivity, specificity, PPV, and NPV) were collected. Results were then stratified according to the American Joint Committee on Cancer pathology staging for bladder cancer. Of 124 study subjects, male was more dominant (male,88% versus female, 12%) Seventy-five patients had a T1-tumor stage. Overall, the diagnostic accuracy was as follows:sensitivity, 47.8%; specificity, 90.9%; PPV, 98.2%; and NPV, 14.5%. High-grade tumors were shown to have a higher sensitivity. The highest accuracy was found in the MIBC grade T3, which was 90.68%. For diagnostic accuracy, urine cytology offered high specificity, but low sensitivity. The exploration of other markers is needed to establish a non-invasive but accurate method to diagnose bladder cancer.
ASSESSMENT OF TOBACCO SCREENING AND SMOKING CESSATION RECOMMENDATION AMONG UROLOGISTS IN INDONESIA : A CROSS SECTIONAL ANALYSIS USING NATIONAL SURVEY Pramana, Henry; Pramod, Sawkar Vijay; Safriadi, Ferry
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.877

Abstract

Objective: This study aims to assess the urologist role on tobacco screening and smoking cessation among bladder cancer patients in Indonesia. Material & Methods: A questionnaire regarding tobacco uses screening and smoking cessation recommendation practice patterns was sent to urologists in Indonesia via Ikatan Ahli Urologi Indonesia (IAUI) or Indonesian Urological Association (IUA). The survey was established by Google Form and was sent by email. Responses were automatically integrated to Google spreadsheet. Results: Total of 111 responses from 569 urologists in Indonesia were received, and of the respondents 96% were male and 4% were female. 70% urologists always educate their patients about smoking as one of risk factor for bladder cancer and only 4% never did it. Most common answer for the reason is patients never ask their urologists about it (7%). More than half (59%) of urologists sometimes discuss smoking cessation and 78% always recommend quitting smoking. The majority of responders have never smoked cigarettes (56%), 35% were former smokers, and 9% were current smokers. Conclusion: This study revealed that majority of urologists always educate that smoking is one of risk factor for bladder cancer and recommend to quit smoking. However, only 37% always discuss tobacco use cessation with their patients. Keywords: Tobacco use, smoking cessation, bladder cancer, urologist.
ASSOCIATION OF SMOKING STATUS, TYPE OF CIGARETTES AND OBESITY AS RISK FACTORS AMONG RENAL CELL CARCINOMA HISTOLOGICAL SUBTYPES Pramod, Sawkar Vijay; El Haq, Faris; Safriadi, Ferry
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.882

Abstract

Objective: This study aims to know the relationship between smoking and obesity as a risk factor among renal cell carcinoma histological subtypes. Material & Methods: This was a retrospective case-control study, with 67 patients with Renal Cell Carcinoma (RCC) at the Department of Urology, Hasan Sadikin Academic Medical Center Bandung from January 2012 to December 2021 as the case group, and 13 patients with benign tumors as the control group. The odds ratio and its significance were calculated. Results: In clear cell RCC, smokers (p-value=0.008), showed strong relationship to cigarette types (p-value=0.013), and obesity (p-value=0.042). In papillary RCC, smokers (p-value=0.035) showed a strong relationship to cigarette types (p-value=0.041). Cloves have a higher risk compared to filtered cigarettes (OR 2.25, 95% CI [0.54-9.25]). Conclusion: Clear cell RCC is most prevalent in smokers. Obesity is associated with clear cell RCC. Cloves pose the greatest risk of clear cell and papillary RCC. Keywords: Obesity, RCC, smoking, cigarette.
Characteristics of Kidney Cancer Patients At Hasan Sadikin Hospital, Bandung Ardiansyah, Novan; Safriadi, Ferry
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1125

Abstract

Background:  Kidney cancer accounts for 5% and 3% of all malignancies in men and women, respectively, representing the 7th most common cancer in men and the 10th most common cancer in women. In Asia, especially in Indonesia, the incidence of kidney cancer has not been widely reported. Therefore, researchers intend to investigate the characteristics of Kidney Cancer at Hasan Sadikin Hospital, Bandung, during the period 2015–2019. Methods: This research is a descriptive retrospective study taken from the medical records of patients with kidney cancer in the Department of Urology, Universitas Padjadjaran, Hasan Sadikin Hospital. The study was conducted from June 2019 until all the medical record data for the sample were fulfilled. The data included age, gender, and histopathological findings. Results: From the data collection, it was found that there were a total of 126 patients with kidney cancer, occurring in 83 male patients (65.8%) and 43 female patients (34.2%). The age group 0–10 years dominated the occurrence of kidney cancer, with 32 out of 126 patients (25.4%), followed by the 41–50 age group with 30 patients (23.8%), and the 21–30 age group had the fewest diagnoses of kidney cancer. A total of 78 patients (61.9%) were diagnosed with Renal Cell Carcinoma (RCC). Clear cell RCC was more common, with 64 cases (50.7%), compared to papillary RCC with 13 cases (10.3%) and Chromophobe RCC with 1 case (0.8%). The most commonly found kidney cancer was Wilm’s tumor, with 33 patients (26.1%), occurring in individuals under 20 years of age. Conclusion: This study found that kidney cancer is more common in males than in females. RCC is the most frequently diagnosed type, with clear cell subtype being predominant, especially in patients over 40 years of age. Wilm’s tumor dominates kidney cancer cases in individuals under 20 years of age.
Stone recurrence among Indonesian kidney stone formers: a comprehensive analysis of genetic polymorphism, demographic, and clinical factors Atmoko, Widi; Savira, Missy; Fajriani, Rosalina; Wistara, Sevita Sathya; Asmarinah; Harahap, Alida Roswita; Witjaksono, Fiastuti; Werdhani, Retno Asti; Safriadi, Ferry; Hamid, Agus Rizal Ardy Hariandy; Birowo, Ponco; Rasyid, Nur; Taher, Akmal
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247596

Abstract

BACKGROUND The recurrence rate of kidney stone disease (KSD) can exceed 50% within 5 years. This study aimed to investigate factors associated with stone recurrence based on single nucleotide polymorphisms (SNPs) of the calcium-sensing receptor (CaSR) rs1801725 and rs1042636, demographic, and clinical profiles. METHODS We collected data on the demographic and clinical characteristics of 80 adult kidney stone formers from April 2021 to September 2022, including peripheral blood samples, morning and 24-hour urine, and 7-day water intake records. Real-time polymerase chain reaction was used to evaluate SNP. Comparisons were made between patients with recurrent and first-time stones. RESULTS 41% of 80 patients have experienced stone recurrence. Recurrent stone formers exhibited significantly higher 24-hour urine calcium excretion (p = 0.03) and lower serum calcium levels (p = 0.019) than first-time stone formers. Hypocitraturia (100%), low urine volume (78%), and hyperoxaluria (55%) were the main abnormalities of all patients. No significant differences were found in CaSR gene polymorphisms and other demographic, biochemical, or clinical parameters. CONCLUSIONS Recurrent stone formers had higher 24-hour urine calcium excretion and lower serum calcium levels. Other risk factors and CaSR polymorphisms may insignificantly affect KSD recurrence.
Success Rate and Complications of Percutaneous Nephrolithotomy (PCNL) in Nephrolithiasis Patients Stein, Lambok Kevin; Safriadi, Ferry
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3809

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Percutaneous Nephrolithotomy (PCNL) is the standard management method for kidney stones due to its high success rates. This process is associated with risks, including complications such as infection and bleeding. This study aimed to evaluate the complications and success rates of PCNL in nephrolithiasis patients and provide important insights for clinical decision-making. Data were collected from patients undergoing PCNL for nephrolithiasis at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, in the form of demographic data, stone parameters, and postoperative complications. Data were then analyzed statistically to identify the associated factors. This study was conducted at the Urology Department of the hospital from January to December 2023, involving 80 nephrolithiasis cases. Predominantly, 67.5% of patients were males, with 63.7% in the age group of above 50 years. Multiple stones were the most common (55%), with stone sizes of ≥1.5 cm prevalent in 95% of cases. Left-sided stones (43.75%) were most frequent, followed by right-sided (36.25%) and bilateral stones (20%). Hydronephrosis complications were present in 36.25% of cases, with 100% stone clearance found in Guy Stone Score (GSS) grade 1 cases, while GSS grade 4 cases exhibited the lowest stone clearance rate at 45.45%. This study provided insights into nephrolithiasis demographics, stone characteristics, and postoperative outcomes. Male predominance, multiple stones, high rates of stone clearance, and postoperative complications, particularly in the Guy's score system, underscore the need for proper management strategies and further research in this field.
OBESITY PROFILE AS A RISK FACTOR IN RENAL CELL CARCINOMA PATIENTS: A LITERATURE REVIEW Ilham Bagas Setyawan; Ferry Safriadi
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.929

Abstract

Objective: This study aims to determine the profile of obesity as a risk factor for developing RCC. Material & Methods: This study is a library research study with journals, articles, and opinions of related experts taken from Google Scholar and Pubmed which was uploaded in 2019-2023. Results: 7 articles met the inclusion, exclusion and topic relevance criteria. Several journals stated that obesity is a strong risk factor for the development of renal cell carcinoma (RCC), although opposite results were found in one study regarding obesity and the prognostic outcome of RCC patients. Discussion: The mechanism of obesity in increasing the risk of RCC is a complex process, which involves the process of insulin resistance, inflammation by pro-inflammatory cytokines, angiogenesis, and proliferative effects as a result of the role of insulin as one of the most important anabolic hormones capable of stimulating cell proliferation, and is exacerbated by imbalanced cell anti-apoptotic mechanisms. Conclusion: No relationship was found between the lipid profile and the incidence of RCC. Little research has been done on lipid profiles for RCC, considering that the largest RCC subtype, ccRCC, is characterized by the accumulation of lipids and glycogen, which has implications for changes in fatty acid and glucose metabolism in its etiology. Further studies are needed to examine the effect of lipid profiles on the risk of renal cell carcinoma. Keywords: Carcinogenesis, obesity profile, renal cell carcinoma.
Prostate Specific Antigen (PSA) Profile in Prostate Disease at Hasan Sadikin Bandung General Hospital Ramadhan, Muhammad Sangaji; Safriadi, Ferry
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2211

Abstract

PSA is a serine protease that functions to break down and liquefy semen clots that form after ejaculation. PSA is a product of the prostatic epithelium and is normally secreted in semen. The PSA test is usually used to diagnose prostate cancer, but it has a number of limitations. PSA can be increased in conditions of prostate gland disease, both benign and malignant. This is because PSA is specific for certain organs but is not specific only for cancer. This study aims to determine the profile of PSA in prostate disease at Hasan Sadikin Bandung General Hospital. This study involved 375 patients and is a retrospective descriptive study by taking medical record data from patients with prostate disease who went to the Urology Polyclinic during the period January-December 2019. The results of the study were processed with descriptive statistics and then presented in the form of tables and explanatory narratives. Based on the results of the study, patients with Benign Prostatic Hyperplasia (BPH) had a mean PSA value of 8.05 + 32.31 ng/ml, prostate cancer patients had a mean PSA value of 188.75 + 344.67 ng/ml and in prostatitis patients had the average PSA value is 2.1 + 0.76. There are differences in PSA values in patients with BPH, prostate carcinoma, and prostatitis.
COMPLICATION AND SAFETY OF TRANSPERINEAL PROSTATE BIOPSY USING NOVEL AFFORDABLE VY PROBE (TPPB-VY) IN CLINICAL PRACTICE : A PILOT STUDY Ali Ridho Al Haddar; Pramod, Sawkar Vijay; Ferry Safriadi
Indonesian Journal of Urology Vol 30 No 2 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i2.781

Abstract

Objective: This study was aimed to know the complication and safety of TPPB-VY in clinical practice. Material & Methods: TPPB were performed in 34 patients between January 2019 and Juni 2021. Ethical approval of this study was sought from the hospital authorities (IRB number: LB.02.01/X.6.5/ 55/2020). Patients underwent systematic 10-12 core TPPB depend on the prostate volume with intravenous light sedation. The patient was included to the study if PSA ≥ 4 ng/ml and/or Digital Rectal Examination (DRE) results suggestive of prostate cancer. Procedures were performed without any antibiotic prophylaxis or an enema before the procedure and post procedure the patients just get an oral fluoroquinolones and low potent analgetics (if needed). The complication include pain level post procedure (using VAS), perineal hematoma, fever and retention post biopsy were recorded. Results: In all, 34 patients were included in the study. The result showed that perineal pain perceived by patients post procedure were 76.47% (26 out of 34 patients) but the VAS score just mild around 0-2. There were 23.53% (8 out of 34 patients) hematuria, 5.88% (2 out of 34 patients) acute urinary retention and 2.9 % (1 out of 34 patients) perineal hematoma. No fever or clinical infection was observed and 82.35% (28 out of 34 patients) patients presented with minor complications (ClavienDindo I). Only one of the patients were hospitalized due to the post-biopsy complication that need intervention. Conclusion: This is the first study TPPB using Novel Affordable VY probe. The results show clinically insignificant complication without infection. TPPB using Novel Affordable VY probe is feasible and safe.
LATERAL PERCUTANEOUS NEPHROLITHOTOMY IN HORSESHOE KIDNEY: AN ALTERNATIVE APPROACH WITH HIGH SUCCESS RATE Wahyudi, Yuvi; Pramod, Sawkar Vijay; Safriadi, Ferry
Indonesian Journal of Urology Vol 32 No 1 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i1.884

Abstract

Objective: This case report was aimed to present a lateral percutaneous nephrolitotomy (PCNL) approach for a patient with horseshoe kidney, few comorbidities, and the outcome of this procedure. Case(s) presentation: A 70 years old obese male came into our hospital with pain in the left flank. Upon CT scan examination, we found that the patient has Horseshoe kidney with left hydronephrosis. The hydronephrosis resulted from obstruction caused by left kidney pelvic stone with a size of 25 x 20 mm. We decided to do lateral PCNL for this case with an excellent result. Discussion: With newer advancements in urology, different minimally invasive treatment modalities are available to manage stone disease in HSKs. PCNL has shown the better result with fewer complications to remove calculi from HSKs and is accepted as a routine treatment of large calculi in HSK, showing a high SFR ranging from 71% to 88%. Lateral percutaneous access of the renal collecting system is safe, as it is gained on the opposite side to where the renal blood vessels enter the kidney. Conclusion: Stone management in patients with horseshoe kidneys is a challenging procedure in endourology, however percutaneous nephrolithotomy is considered a safe and effective treatment option in patients with renal stones in a horseshoe kidney with acceptable result. Keywords: Horseshoe kidney, percutaneous nephrolithotomy, lateral PCNL.