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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Jurnal Farmasi Sains dan Praktis
ZULLIES IKAWATI
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluasi Drug Related Problems (DRPs) Antibiotik pada Pasien Sepsis di Rumah Sakit di Yogyakarta SAMUEL BUDI; ZULLIES IKAWATI; IWAN DWIPRAHASTO; TITIK NURYASTUTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.055 KB)

Abstract

Sepsis is a manifestation of the most severe acute infections that can lead to the various organ failure generally ends with death in 30-50% of cases. The number of sepsis deaths in developed countries can be reduced to 11-15%, but in developing countries it was reported above 45%. Proper and adequate use of empirical antibiotics may decrease the risk of death in sepsis and may at least shorten patient duration of care in the hospital. Aim to this study was determine the pattern of antibiotic use, the incidence of Drug Related Problems (DRPs) and clinical outcomes in septic patients in hospital X at Yogyakarta. An observational study was carried out during the period of January-December 2015 in hospital X at Yogyakarta. Data were collected retrospectively among patients with sepsis, age > 15 years old, hospitalized during the the study period. From 632 cases, 162 patients were diagnosed as sepsis and met the inclusion criteria of the study. The antibiotics used were cephalosporin (42.58%), quinolone (17.46%), carbapenem (10.77%), aminoglycoside (9.33%), imidazole (8.85%) and macrolide (4.88%). Poor clinical outcomes associated with DRPs (64.29%) were greater than those that showed good clinical outcomes (35.71%). The incidence of DRPs in sepsis treatment is still high (60.49%), and is generally associated with antibiotic needs, the inappropriate selection of antibiotics, inadequate dosage and the presence of antibiotic interactions.
Perbandingan Efektivitas Cefazolin dan Ceftriaxone Sebagai Antibiotik Profilaksis Bedah Ortopedi Open Reduction Internal Fixation (ORIF) Fraktur Tertutup Nurul Latifah; Tri Murti Andayani; Zullies Ikawati
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 3 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i3.52630

Abstract

Infeksi daerah operasi (IDO) merupakan infeksi yang terjadi hingga 30 hari setelah operasi atau satu tahun setelah operasi pada pasien yang menerima implan dan mempengaruhi sayatan atau jaringan dalam di lokasi operasi. Sefalosporin golongan pertama yaitu cefazolin merupakan antibiotik pilihan sebagai proflaksis bedah karena merupakan antibiotik spektrum luas, memiliki profil farmakokinetik yang baik, angka kejadian efek samping yang kecil, serta harga relatif murah. Pada praktek klinis, ceftriaxone banyak digunakan karena merupakan antibiotik yang lebih murah dibanding cefazolin. Tujuan penelitian ini adalah untuk mengetahui efektivitas dan keamanan cefazolin dibandingkan dengan ceftriaxone sebagai antibiotik profilaksis pasien bedah ortopedi Open Reduction Internal Fixation (ORIF) fraktur tertutup. Penelitian ini merupakan penelitian observasional analitik dengan rancangan kohort retrospektif dari rekam medis pasien yang menjalani ORIF fraktur tertutup periode 1 Januari hingga 31 Desember 2020 di sebuah rumah sakit swasta tipe B di Yogyakarta. Luaran klinis yang diamati dalam penelitian ini adalah kejadian IDO dan kejadian efek samping selama 90 hari sejak pasien dilakukan prosedur bedah. Terdapat 59 pasien yang menjalani ORIF yang masuk kriteria inklusi pada penelitian ini yang terbagi mejadi dua kelompok yaitu pasien yang mendapat antibiotik profilaksis cefazolin (n=25) dan ceftriaxone (n=34). Hasil dari penelitian ini menunjukkan bahwa angka kejadian IDO pada pasien yang menjalani ORIF fraktur tertutup sebesar 5,08% dari total subjek atau 8,82% dari  yang diberikan ceftriaxone dan 0% dari pasien yang diberikan cefazolin. Perbedaan probabilitas kejadian IDO pada pemberian ceftriaxone sebagai antibiotik profilaksis tidak berbeda bermakna dengan pemberian cefazolin (RR = 1,097; 95% CI = 0,988 – 1,218; p = 0,064).
Efek Samping Penggunaan Terapi Oral Pada Pasien Asma Heni Lutfiyati; Zullies Ikawati; Chairun Wiedyaningsih
Jurnal Farmasi Sains dan Praktis Vol 1 No 1 (2015)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v1i1.64

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh terapi oral terhadap hasil terapi pasien asma. Penelitian ini merupakan penelitian observasional dengan pengambilan data secara prospektif dari Februari-April 2014. Data diambil dari penelusuran rekam medis, wawancara dan lembar pengumpul data. Pasien yang memenuhi kriteria inklusi sebanyak 75 pasien tetapi hanya 71 pasien yang mengikuti seluruh proses penelitian. Hasil penelitian menunjukkan dari 71 pasien yang mendapat terapi oral sebanyak 19 orang (26,7%) muncul adanya efek samping. Efek samping yang paling banyak dirasakan oleh pasien adalah gastritis atau gangguan pencernaan pada pasien yang mendapat terapi Methylprednisolon, Cetirizin, kapsul (aminofilin, salbutamol dan GG) yaitu 8 pasien (11,3%), dan berdebar sebanyak 3 pasien (4,2%). Pada pasien yang mendapatkan terapi kombinasi Methylprednisolon, Cetirizin, dan salbutamol sebanyak 3 pasien (4,2%) juga mengalami gastristis.
Antidepressant Activity Of 80% Bitter Melon-Leaf Ethanol Extract (Momordica Charantia L.) And ? -Sitosterol Compound In Vivo Ani Kristiyani; Zullies Ikawati; Andayana Puspitasari Gani; Zaenal Muttaqien Sofro
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30310

Abstract

Depression is a psychiatric disorder that affects mood and physical health and contributes greatly to the global burden of disease. Herbal remedies can be used as an alternative to the treatment of depression. The purpose of this study is to determine the activity of 80% ethanol extract of bitter melon leaves (Momordica charantia Linn) as an antidepressant and ?-sitosterol compound which is a marker compound in bitter melon leaf extract. In this study, ?-sitosterol compounds in bitter melon leaf extract were identified qualitatively using Fourier Transform InfraRed (FTIR) and in vivo antidepressant activity tests. The in-vivo test used 30 mice with a weight of 20-30 grams which were randomly divided into 6 groups, namely the normal group (not receiving treatment), the negative control group (Na-CMC 1%), the positive control group (fluoxetine 2.5 mg/kg), the ?-sitosterol group (?-sitosterol 30 mg/kg), the bitter melon leaf extract group dose 1 (200 mg/kg), and the group of bitter melon leaf extract dose 2 (400 mg/kg). The mice received stressors using the Chronic Unpredictable Mild Stress (CUMS) method for 28 days. On the 15th day after the mice received CUMS, the mice were exposed to test extracts and drugs for 14 days according to the treatment group. Weight measurements were taken on day 1 and on day 29. The behavioral test used the Forced Swimming Test (FST) and Novel Suppressed Feeding (NSF) with feeding time parameters, and the immobility time was carried out on the 29th day, in addition to that the number of necrosis in gastric and the number of hippocampal pyramidal cells were also measured. The results showed that at all absorption peaks in the FTIR of bitter melon leaf extract, there were -OH, C-H, C=C, - CH2-, C-O groups which are the characteristic peaks of the ?-sitosterol compound. In weight measurement, bitter melon leaf extract had antidepressant activity by not causing significant weight changes compared to the normal group (P>0.05). The ?-sitosterol and bitter melon leaf extract group dose 2 had antidepressant activity by maintaining appetite which was shown with a higher feeding time value compared to the negative group (P<0.05). The positive control group, ?-sitosterol, and bitter melon leaf extract doses 1, and 2 when compared to the negative control group, although not significant (P>0.05) had antidepressant activity values by lowering despair indicated by smaller immobility time values, lowering the number of necrosis in gastric lower and protecting the hippocampal pyramidal cell count higher. Conclusion: 80% ethanol extract of bitter melon leaves contains active compounds ?-sitosterol and has activity as an antidepressant by not causing weight changes, maintaining appetite, lowering despair, protecting gastric from necrosis and protecting hippocampal pyramidal cells.
Co-Authors Andayana Puspitasari Gani Ani Kristiyani Chairun Wiedyaningsih Heni Lutfiyati IWAN DWIPRAHASTO Nurul Latifah SAMUEL BUDI Sofro, Zaenal Muttaqien Titik Nuryastuti Tri Murti Andayani