Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Jurnal Ilmiah Medicamento Jurnal Farmasi Sains dan Praktis
ZULLIES IKAWATI
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Evaluasi Drug Related Problems (DRPs) Antibiotik pada Pasien Sepsis di Rumah Sakit di Yogyakarta SAMUEL BUDI; ZULLIES IKAWATI; IWAN DWIPRAHASTO; TITIK NURYASTUTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.055 KB)

Abstract

Sepsis is a manifestation of the most severe acute infections that can lead to the various organ failure generally ends with death in 30-50% of cases. The number of sepsis deaths in developed countries can be reduced to 11-15%, but in developing countries it was reported above 45%. Proper and adequate use of empirical antibiotics may decrease the risk of death in sepsis and may at least shorten patient duration of care in the hospital. Aim to this study was determine the pattern of antibiotic use, the incidence of Drug Related Problems (DRPs) and clinical outcomes in septic patients in hospital X at Yogyakarta. An observational study was carried out during the period of January-December 2015 in hospital X at Yogyakarta. Data were collected retrospectively among patients with sepsis, age > 15 years old, hospitalized during the the study period. From 632 cases, 162 patients were diagnosed as sepsis and met the inclusion criteria of the study. The antibiotics used were cephalosporin (42.58%), quinolone (17.46%), carbapenem (10.77%), aminoglycoside (9.33%), imidazole (8.85%) and macrolide (4.88%). Poor clinical outcomes associated with DRPs (64.29%) were greater than those that showed good clinical outcomes (35.71%). The incidence of DRPs in sepsis treatment is still high (60.49%), and is generally associated with antibiotic needs, the inappropriate selection of antibiotics, inadequate dosage and the presence of antibiotic interactions.
Efek Samping Penggunaan Terapi Oral Pada Pasien Asma Heni Lutfiyati; Zullies Ikawati; Chairun Wiedyaningsih
Jurnal Farmasi Sains dan Praktis Vol 1 No 1 (2015)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v1i1.64

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh terapi oral terhadap hasil terapi pasien asma. Penelitian ini merupakan penelitian observasional dengan pengambilan data secara prospektif dari Februari-April 2014. Data diambil dari penelusuran rekam medis, wawancara dan lembar pengumpul data. Pasien yang memenuhi kriteria inklusi sebanyak 75 pasien tetapi hanya 71 pasien yang mengikuti seluruh proses penelitian. Hasil penelitian menunjukkan dari 71 pasien yang mendapat terapi oral sebanyak 19 orang (26,7%) muncul adanya efek samping. Efek samping yang paling banyak dirasakan oleh pasien adalah gastritis atau gangguan pencernaan pada pasien yang mendapat terapi Methylprednisolon, Cetirizin, kapsul (aminofilin, salbutamol dan GG) yaitu 8 pasien (11,3%), dan berdebar sebanyak 3 pasien (4,2%). Pada pasien yang mendapatkan terapi kombinasi Methylprednisolon, Cetirizin, dan salbutamol sebanyak 3 pasien (4,2%) juga mengalami gastristis.
Antidepressant Activity Of 80% Bitter Melon-Leaf Ethanol Extract (Momordica Charantia L.) And ? -Sitosterol Compound In Vivo Ani Kristiyani; Zullies Ikawati; Andayana Puspitasari Gani; Zaenal Muttaqien Sofro
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30310

Abstract

Depression is a psychiatric disorder that affects mood and physical health and contributes greatly to the global burden of disease. Herbal remedies can be used as an alternative to the treatment of depression. The purpose of this study is to determine the activity of 80% ethanol extract of bitter melon leaves (Momordica charantia Linn) as an antidepressant and ?-sitosterol compound which is a marker compound in bitter melon leaf extract. In this study, ?-sitosterol compounds in bitter melon leaf extract were identified qualitatively using Fourier Transform InfraRed (FTIR) and in vivo antidepressant activity tests. The in-vivo test used 30 mice with a weight of 20-30 grams which were randomly divided into 6 groups, namely the normal group (not receiving treatment), the negative control group (Na-CMC 1%), the positive control group (fluoxetine 2.5 mg/kg), the ?-sitosterol group (?-sitosterol 30 mg/kg), the bitter melon leaf extract group dose 1 (200 mg/kg), and the group of bitter melon leaf extract dose 2 (400 mg/kg). The mice received stressors using the Chronic Unpredictable Mild Stress (CUMS) method for 28 days. On the 15th day after the mice received CUMS, the mice were exposed to test extracts and drugs for 14 days according to the treatment group. Weight measurements were taken on day 1 and on day 29. The behavioral test used the Forced Swimming Test (FST) and Novel Suppressed Feeding (NSF) with feeding time parameters, and the immobility time was carried out on the 29th day, in addition to that the number of necrosis in gastric and the number of hippocampal pyramidal cells were also measured. The results showed that at all absorption peaks in the FTIR of bitter melon leaf extract, there were -OH, C-H, C=C, - CH2-, C-O groups which are the characteristic peaks of the ?-sitosterol compound. In weight measurement, bitter melon leaf extract had antidepressant activity by not causing significant weight changes compared to the normal group (P>0.05). The ?-sitosterol and bitter melon leaf extract group dose 2 had antidepressant activity by maintaining appetite which was shown with a higher feeding time value compared to the negative group (P<0.05). The positive control group, ?-sitosterol, and bitter melon leaf extract doses 1, and 2 when compared to the negative control group, although not significant (P>0.05) had antidepressant activity values by lowering despair indicated by smaller immobility time values, lowering the number of necrosis in gastric lower and protecting the hippocampal pyramidal cell count higher. Conclusion: 80% ethanol extract of bitter melon leaves contains active compounds ?-sitosterol and has activity as an antidepressant by not causing weight changes, maintaining appetite, lowering despair, protecting gastric from necrosis and protecting hippocampal pyramidal cells.
Understanding the Safety Profile of Imatinib in Asian Chronic Myeloid Leukemia Patients: A Systematic Review Niky Budiarti; Zullies Ikawati; Arief Nurrochmad; Thendi Abdul Arief
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13296

Abstract

Background: The treatment of chronic myeloid leukemia has advanced substantially since the introduction of tyrosine kinase inhibitors, particularly imatinib. However, adverse events associated with imatinib may affect adherence and quality of life, highlighting the importance of understanding safety outcomes across populations.Objective: This systematic review aimed to synthesize evidence on hematologic and non-hematologic adverse events associated with imatinib use among chronic myeloid leukemia patients in Asia.Methods: A systematic literature search was conducted in PubMed, Scopus, and ScienceDirect for studies published between January 2020 and July 2025. Eligible studies were synthesized narratively due to methodological heterogeneity. Adverse events were extracted as reported and graded using standardized toxicity criteria, and causality assessment was applied when available. Study quality was evaluated using established critical appraisal tools. Five studies from India, China, and Taiwan met the inclusion criteria.Results: The most frequent hematologic adverse event was anemia, followed by neutropenia and thrombocytopenia. Common non-hematologic adverse events included gastrointestinal symptoms, peripheral or periorbital edema, muscle cramps, and hyperpigmentation, with regional variations. Most events were mild to moderate (grades 1–2), while severe fluid retention, including pleural and pericardial effusions, was reported in isolated cases. No studies reported permanent discontinuation of imatinib due to adverse events.Conclusion: This review summarizes imatinib-related adverse events among chronic myeloid leukemia patients from selected Asian regions—East and South Asia, specifically India, China, and Taiwan—showing predominantly mild to moderate toxicities and providing practice-informed insights for clinical monitoring. However, the absence of data from other Asian regions precludes generalization to the entire Asian continent.
Digitalization of HYPOGLYRISK and Evaluation of Its Utility for Pharmacist-Led Hypoglycemia Risk Assessment in Type 2 Diabetes Mellitus Made Krisna Adi Jaya; Zullies Ikawati; Fita Rahmawati; Nanang Munif Yasin; I Gusti Ngurah Anom Cahyadi Putra
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13619

Abstract

Background: We developed a tool for pharmacists to facilitate screening of medication-related hypoglycemia risk in patients with type 2 diabetes mellitus (T2DM), called HYPOGLYRISK. Although this instrument has been validated and proven reliable, the paper-based version was considered inefficient and prone to human error during routine screening.Objective: This study aimed to digitalize HYPOGLYRISK and evaluate its utility compared with the printed version.Methods: A mixed-method study design combining software development and a quasi-experimental trial was used. In the development stage, the application was created using Android Studio and validated through Black Box Testing and User Acceptance Testing (UAT). In the trial stage, 46 pharmacists participated and were divided into two groups using either the digital or paper-based HYPOGLYRISK to assess simulated ambulatory T2DM patients representing different hypoglycemia risk categories. The primary outcome was assessment time efficiency, while the secondary outcome was the potential for human error. Data were analyzed using the Mann-Whitney U test, chi-square test, and relative risk analysis.Results: The digital HYPOGLYRISK demonstrated significantly shorter assessment time compared with the conventional version (p<0.05) and reduced the probability of scoring errors by 3.3 times (p<0.05). The digital application also provided additional advantages, including efficiency, scalability, ease of use, rapid data access, and simplified data management.Conclusion: These findings suggest that digital HYPOGLYRISK can enhance pharmacist-led hypoglycemia risk assessment among ambulatory patients with T2DM.
Co-Authors Andayana Puspitasari Gani Ani Kristiyani ARIEF NURROCHMAD Chairun Wiedyaningsih Heni Lutfiyati I Gusti Ngurah Anom Cahyadi Putra IWAN DWIPRAHASTO Made Krisna Adi Jaya Nanang Munif Yasin Niky Budiarti Nurul Latifah Rahmawati, Fita SAMUEL BUDI Sofro, Zaenal Muttaqien Thendi Abdul Arief Titik Nuryastuti Tri Murti Andayani