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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Journal of Public Health and Pharmacy
Dian Ayu Juwita
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Pharmaceutical and Sciences.

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Hubungan Lama Perawatan dengan Outcome Tekanan Darah dan Proteinuria pada Preeklampsia Berat Annisadillah, Dwi; Rachmaini , Fitri; Juwita, Dian Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1076

Abstract

Severe preeclampsia is a major obstetric complication associated with maternal and perinatal morbidity and mortality. Hospitalization duration may influence clinical outcomes, including blood pressure and proteinuria, particularly in patients receiving antihypertensive therapy with nifedipine or methyldopa. This study aims to evaluate the association between the length of hospital stay and changes in systolic and diastolic blood pressure, as well as proteinuria, in patients with severe preeclampsia treated with nifedipine or methyldopa. This retrospective study reviewed medical records of patients diagnosed with severe preeclampsia and admitted to Dr. M. Djamil Central General Hospital, Padang, between January and December 2023. Patients were categorized into two groups based on hospitalization duration: <5 days and ≥5 days. All patients received monotherapy with either nifedipine or methyldopa. Data on patient demographics, clinical parameters, and hospitalization length were collected. Statistical analyses were performed using the independent t-test and the Mann–Whitney test, with a significance level of p<0.05. Of 60 patients included, 44 (73.3%) were hospitalized for ≥5 days, while 16 (26.7%) stayed <5 days. Patients with ≥5 days of hospitalization experienced a significantly greater reduction in systolic blood pressure (40.93 mmHg vs. 29.00 mmHg, p=0.025) and proteinuria (23.06 vs 33.20, p=0.031) compared to the <5-day group. No significant difference was observed in diastolic blood pressure reduction (p=0.128).
Co-Authors Abdillah, Rahmad Afifah Machlaurin, Afifah Ahmadin, Almahdy Al Rizka, Nabila Almahdy A Almahdy Almahdy Almahdy Almahdy Annisadillah, Dwi Deni Noviza Desri, Nurul Qalbi Dita Permatasari Dita Permatasari Dolly Martha Dwi Afrianti, Rezy Dwisari Dillasamola Elsa Badriyya Fatma Sri Wahyuni Fatma, Rosalia Medisa Fitri Rachmaini Fitri, Maharani Reskia Hansen Nasif Helmi Arifin Heni Pujiastuti Hesti Rachmawati Putri Husni Muchtar Jaka Perdana Julio Fajar Rahmat Illahi Lailaturrahmi Lailaturrahmi Meliani Meliani Meliani, Meliani Melvi Auliya Rifqi Nadila Oktavia Nadila Oktavia Najmiatul Fitria Nelfa Yulianti Netty Suharti Nguyen, Thang Nurul Qalbi Desri Octy Aisyahharma Putri, Hesti Rachmawati Rachmaini , Fitri Rachmaini, Fitri Rahmad Abdillah Rahmah Rahmah Rahmah Rahmah Rahmi Yosmar Rifqi, Melvi Auliya Risa Hestia Rizka Afdhila Rizka Afdila Roslinda Rasyid Sabarita, Najah Suhatri Suhatri Tesa Inmerka Alwi Viviani, Ivana Regita Wira Sanjaya Yolanda Mayestika Wati