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EFEKTIVITAS ANTIFUNGI EKSTRAK METANOL BATANG PISANG MAULI (Musa acuminata) DAN Chlorhexidine gluconate 0,2% TERHADAP Candida albicans Permatasari, Dita; Budiarti, Lia Yulia; Laillyza Apriasari, Maharani
Dentino Vol 1, No 1 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACT Background: Mauli banana stem extract has antifungal effectiveness against Candida albicans because it has flavonoid, saponin, and tannin substances. Chlorhexidine gluconate 0,2% is widely used to treat oral candidiasis caused by Candida albicans fungal infection. Chlorhexidine gluconate 0,2% is known to have caused side effects. Purpose: The purpose of this study is to knowing the antifungal effectiveness differences between 25%, 80%, 100% mauli stem methanol extracts and chlorhexidine gluconate 0,2% against Candida albicans. Methods: This study was true experimental with post test-only with control group design consisted of 4 treatment groups. Treatment group I,II,III each was given 25%, 80%, 100% mauli banana stem methanol extract respectively and treatment group IV was given chlorhexidine gluconate 0,2% as positive control group. The repetition of each treatment was 7 times. Antifungal effectiveness was assessed by measuring inhibition zone of Candida albicans growth using diffusion method. Results: This research showed that mean inhibition zone of treatment group I (13 mm), treatment group II (17 mm), treatment group III (19 mm), and treatment group IV (21 mm). One-way Anova test indicated that there was significant difference between 25%, 80%, 100% mauli banana stem methanol extracts and chlorhexidine gluconate 0,2%. Conclusion: Based on the Post-hoc Bonferroni test, it can be concluded that 100% concentration mauli banana stem methanol extract had more prominent antifungal effectiveness than 25% and 80% against Candida albicans but still less effective than chlorhexidine gluconate 0,2%.Keywords: mauli banana stem extract, antifungal effectiveness, Candida albicans, chlorhexidine gluconate 0,2%ABSTRAK Latar Belakang: Ekstrak batang pisang mauli memiliki efektivitas antifungi terhadap Candida albicans karena mengandung senyawa flavonoid, saponin, dan tanin. Chlorhexidine gluconate 0,2% biasanya digunakan untuk mengobati kandidiasis oral yang disebabkan oleh infeksi jamur Candida albicans. Chlorhexidine gluconate 0,2% diketahui dapat menimbulkan efek samping. Tujuan: Tujuan penelitian ini adalah untuk mengetahui perbedaan efektivitas antifungi ekstrak metanol batang pisang mauli konsentrasi 25%, 80%, 100% dan chlorhexidine gluconate 0,2% terhadap Candida albicans. Metode: Penelitian ini merupakan penelitian eksperimental murni dengan post test-only with control group design yang terdiri dari 4 perlakuan. Perlakuan I,II,III masing-masing diberikan ekstrak metanol batang pisang mauli konsentrasi 25%, 80%, 100% dan perlakuan IV diberikan chlorhexidine gluconate 0,2% sebagai kontrol positif. Jumlah pengulangan setiap perlakuan adalah 7 kali. Efektivitas antifungi dinilai dari mengukur zona hambat pertumbuhan Candida albicans dengan metode difusi. Hasil: Penelitian ini menunjukkan bahwa rata-rata zona hambat yang terbentuk pada perlakuan I (13 mm), perlakuan II (17 mm), perlakuan III (19 mm), dan perlakuan IV (21 mm). Uji Oneway Anova menunjukkan bahwa terdapat perbedaan bermakna antara efektivitas antifungi ekstrak methanol batang pisang mauli konsentrasi 25%, 80%, 100% dan chlorhexidine gluconate 0,2%.Kesimpulan: Berdasarkan uji Post-hoc Bonferroni dapat disimpulkan bahwa efektivitas antifungi ekstrak metanol batang pisang mauli konsentrasi 100% lebih besar dibandingkan 25% dan 80%, tetapi masih kurang efektif dengan chlorhexidine gluconate 0,2%.

Pengenalan Pembicara untuk Menentukan Gender Menggunakan Metode MFCC dan VQ N, Youllia Indrawaty; ana, Andri; Permatasari, Dita
MIND Journal Vol 2, No 1 (2017): MIND Journal
Publisher : Institut Teknologi Nasional Bandung

Klasifikasi suara berdasarkan gender dibuat dengan tujuan agar komputer mampu mengenali suara laki-laki dan perempuan. Dengan kemampuan komputer yang mampu membedakan suara laki-laki dan perempuan pada pengembangan selanjutnya akan memperkuat tingkat suatu sistem keamanan yang menggunakan password dengan suara. Penelitian ini mengenai pengenalan gender dari pengucap/ pembicara dengan ucapan bergantung teks dan bergantung pembicara, dalam proses pengenalan tersebut digunakan algoritma ekstraksi yang disebut Mel Frequency Cepstral Coefficients (MFCC) digunakan untuk ekstraksi ciri dari sinyal wicara sedangkan proses pengelompokan menggunakan metode Vector Quantization (VQ). Dalam tahap pengenalan, ukuran distorsi berdasarkan minimisasi jarak Euclidean digunakan untuk mencocokkan penutur uji dengan penutur dalam database. Database wicara menggunakan 20 penutur, terdiri dari 10 penutur pria dan 10 penutur wanita dengan tingkat akurasi pria mencapai 90% dan wanita 80%.

Speaking Anxiety in Virtual Classroom Presentations: How Did Secondary School Students Experience It? Permatasari, Dita; Mobit, Mobit
Journal of Teaching of English Vol 6, No 3 (2021): Journal of Teaching of English
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/jte.v6i3.21072

In this era, speaking is very important for all sectors, particularly in the field of education. But, most students tend to be reluctant to speak in English due to several factors. One of them, they have anxieties which enable them burdened to speak in the target language. Therefore, this research aims to investigate students experiences on speaking anxiety in virtual classroom presentation and to figure out the way to manage it. The researcher used qualitative research and used narrative inquiry as the research design. The data collected through semi-structured interview. Two participants from Senior High School students in Bekasi are required to fully participate in the interview. The result of this research showed that the students have afraid feelings to speak English, the students are blank while it starting in speaking, question and answer session is the biggest challenge for student in virtual classroom presentation and supporting to keep in the virtual classroom presentation is important suggestion to students who feel anxiety, and also the students reduce the anxiety with practice.

Application of Home Medication Review (HMR) on Patient Adherence in Type 2 Diabetes Mellitus (T2DM) Blood Sugar Management Sari, Yelly Oktavia; Permatasari, Dita; Mariza, Wilnando; Fitria, Najmiatul; Lailiani, Resa
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.160-167.2022

Non-adherence of type 2 diabetes mellitus (T2DM) patients in treatment will impact expected clinical outcomes, risk of complications, and poor quality of life. Home medication review (HMR) is designed to help achieve optimal treatment, such as patient adherence. This study aimed to determine adherence levels and T2DM blood sugar management. This study with a pretest-posttest control group design was carried out at Andalas Public Health Center, Padang City, West Sumatra-Indonesia with 62 randomly selected respondents and then divided into two groups (pillbox and non-pillbox). The adherence levels were assessed by the pill count method. Changes in blood sugar levels are associated with adherence levels. The results showed an increase in the T2DM adherence level of patients using the pillbox at 7.360% and a decrease in blood sugar levels in those who used the pillbox at 61.161 mg/dL. There was a significant difference in the adherence between patients' levels using the pillbox and non-pillbox with a value of 0.011 (p <0.05). Similarly, the patient's blood sugar levels between the two groups showed a significant difference with a value of 0.007 (p<0.05). The application of HMR to patient adherence is considered to have a role in managing T2DM blood sugar.

The Effect of Medication Adherence and Asthma Control in Asthma Patients at a Public Health Center in Padang, Indonesia Permatasari, Dita; Juwita, Dian Ayu; Putri, Hesti Rachmawati; Desri, Nurul Qalbi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.190-195.2022

Asthma is characterized by reversible swelling or narrowing of the airways.Â Low adherence can negatively affect the effectiveness of therapy, increasing asthma morbidity and mortality. The long-term goal of asthma treatment is to achieve and maintain controlled asthma, but this goal is still challenging for most patients. This study examines the relationship between medication adherence and asthma control in patients. This study is observational, with a cross-sectional approach conducted on 40 asthma patients who received treatment atÂ a Public Health Center. Patient medication adherence was measured by Medication Possession Ratio (MPR) method, and the level of control was measured by the Asthma Control Test (ACT) questionnaire. The results showed that most patients based on sociodemographic characteristics were female (80.0%), elderly group â‰¥60 years (45.0%), high school education (55.0%), andÂ housewivesÂ (45.0%). The category of medication adherence was divided into 47.5% adherent patients and 52.5% non-adherent patients. The level of patient control was divided into fully controlled (2.50%), partly controlled (35.0%), and uncontrolled (62.5%). There was a significant relationship between adherence and asthma control (r=0.508;Â p<0.05).Â Therefore, improving patientÂ medication adherence can potentially improve asthma control levels.

Comparative Utility of Doxorubicin, Cyclophosphamide, and Docetaxel in Breast Cancer Treatment in West Sumatera. Fitria, Najmiatul; Nur Rahmadani, Intan; Permatasari, Dita; Handayani, Fitri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.40914

The large number of breast cancer cases in Indonesia and the high cost of treatment cause the need for utility analysis. West Sumatra province ranks second with the highest prevalence of breast cancer in Indonesia. This study aimed to determine the quality of life of breast cancer patients at the national referral hospital Dr. M. Djamil, West Sumatra, who underwent chemotherapy. This study used a cross-sectional design from January to April 2024. Data collection was done prospectively by filling out questionnaires at the Chemotherapy Unit. Utility value was obtained from filling out a questionnaire with the EQ-5D-5L instrument. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests. The data obtained was 47 respondents who received Doxorubicin and Cyclophosphamide chemotherapy regimen (24 respondents) and a Docetaxel chemotherapy regimen (23 respondents), all of whom met the inclusion criteria in this study. The average utility value obtained for the doxorubicin and cyclophosphamide regimes is 0.637, and the average utility value for the docetaxel regimen is 0.704. Age did not affect utility (p>0.05), while recent education, occupation, and patient origin affected utility (p<0.05). Both regimens provided similar perceived quality of life and overall health status as measured by utility and VAS scores, suggesting comparable patient-reported quality of life outcomes between these chemotherapy treatments.

Comparative Utility of Doxorubicin, Cyclophosphamide, and Docetaxel in Breast Cancer Treatment in West Sumatera. Fitria, Najmiatul; Nur Rahmadani, Intan; Permatasari, Dita; Handayani, Fitri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.40914

The large number of breast cancer cases in Indonesia and the high cost of treatment cause the need for utility analysis. West Sumatra province ranks second with the highest prevalence of breast cancer in Indonesia. This study aimed to determine the quality of life of breast cancer patients at the national referral hospital Dr. M. Djamil, West Sumatra, who underwent chemotherapy. This study used a cross-sectional design from January to April 2024. Data collection was done prospectively by filling out questionnaires at the Chemotherapy Unit. Utility value was obtained from filling out a questionnaire with the EQ-5D-5L instrument. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests. The data obtained was 47 respondents who received Doxorubicin and Cyclophosphamide chemotherapy regimen (24 respondents) and a Docetaxel chemotherapy regimen (23 respondents), all of whom met the inclusion criteria in this study. The average utility value obtained for the doxorubicin and cyclophosphamide regimes is 0.637, and the average utility value for the docetaxel regimen is 0.704. Age did not affect utility (p>0.05), while recent education, occupation, and patient origin affected utility (p<0.05). Both regimens provided similar perceived quality of life and overall health status as measured by utility and VAS scores, suggesting comparable patient-reported quality of life outcomes between these chemotherapy treatments.

Patient Satisfaction with Pharmaceutical Services at a Hospital Outpatient Pharmacy in West Sumatra, Indonesia Juwita, Dian Ayu; Desri, Nurul Qalbi; Permatasari, Dita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.324-330

Background: Patient satisfaction stands as a metric for evaluating the quality of pharmaceutical services. The presence of community requests for high-quality pharmaceutical services has driven pharmacy personnel to enhance these services, aiming to establish patient satisfaction. Objective: The objective of this research is to assess the degree of patient satisfaction with pharmaceutical services in the outpatient pharmacy and to explore how this satisfaction is linked to the patients' sociodemographics. Methods: Conducted at Padang Panjang Hospital's Outpatient Pharmacy in West Sumatra, Indonesia, this descriptive research employed a questionnaire administered directly to patients. The method used involves a questionnaire consisting of 20 questions divided into two dimensions: Friendly Explanation (containing 11 questions) and Managing Therapy (containing nine questions). The questionnaire's validity (r > 0.632) and reliability (0.97). Data analysis was performed utilizing the Likert scale. Results: There were a total of respondents in this study (365 patients). Most of them (64.4%) were female, in the pre-elderly age group (45.2%), had completed high school (41.1%), and were housewives (31.8%). In general, the level of patient satisfaction is categorized as satisfied, with an average score of 3.49. Specifically, the "Friendly Explanation" got a score of 3.69, and the "Management of Therapy" got a score of 3.25. The study indicated notable statistical disparities in patient satisfaction levels based on age, education, and occupation (p<0.05), but gender did not have a significant impact (p>0.05). Conclusion: In summation, the study found that patients were satisfied with the pharmaceutical services at Padang Panjang Hospital's Outpatient Pharmacy.

EDUKASI PENGGUNAAN OBAT BERBASIS KUNJUNGAN RUMAH UNTUK MENINGKATKAN PENGETAHUAN MASYARAKAT DI NAGARI SIKUCUR, KABUPATEN PADANG PARIAMAN Lailaturrahmi, Lailaturrahmi; Badriyya, Elsa; Fauzana, Annisa; Permatasari, Dita
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 1 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i1.450

The trend of independent drug use behavior (self-medication) among Indonesian people, especially in West Sumatra Province, continues to increase. Without knowledge about the correct use of drugs, people will be at risk to drug use problems. Therefore, education on drug use needs to be implemented to increase public knowledge regarding drug use. By increasing their knowledge, the public will have rational drug use behavior. The aim of this community outreach is to increase public knowledge regarding the use of over-the-counter drugs and limited over-the-counter drugs in treating health problems. The method of activity carried out is education through face-to-face home visits. This activity was carried out in Nagari Sikucur, V Koto Kampung Dalam District, Padang Pariaman Regency. There were 30 community members or family representatives who were the targets of this drug use education and home visit. The implementation of this activity involved five teams consisting of pharmacy lecturers with pharmacists’ qualification, Master of Pharmacy students who had registered as pharmacists, and Bachelor of Pharmacy students. The activity started with an introduction, continued with a pre-test, providing education, post-test, and handing over self-medication drug packages to the community. The results of this home visit-based education show that the community's knowledge score regarding drugs is higher than before the education. It can be concluded that the objectives of this activity were achieved well. To achieve better activity results, preliminary studies, collaboration with stakeholders, time allocation, and adequate technical preparation of activities are required.

Analisis Interaksi Obat-Obat Kardiovaskular pada Pasien Jantung Koroner dengan Riwayat Hipertensi Febriyenti, Amanda; Yosmar, Rahmi; Permatasari, Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1074

Coronary heart disease (CHD) accompanied by hypertension often necessitates the use of multiple cardiovascular agents. The concurrent use of multiple drugs increases the risk of drug-drug interactions (DDIs), which may alter drug metabolism, reduce therapeutic efficacy, or cause adverse effects. This study aimed to characterize the potential, mechanisms, and severity of drug interactions; to assess differences in the average number of drugs used per day in relation to the potential for drug interactions; and to assess the clinical profile based on DDI severity levels. A retrospective, analytic, observational method was applied, utilizing secondary data from hospital medical records. Statistical analysis included the Mann–Whitney test to compare the mean number of drugs per day between the interaction potential groups. A total of 52 patients met the inclusion criteria through purposive sampling. The results showed that most CHD patients with a history of hypertension were male (75%) and aged 18–64 years (73.1%). A total of 405 potential DDIs were identified. From these, 80 unique drug-pair interactions were selected for detailed analysis of their mechanisms and severity. Most were pharmacodynamic (77.5%), with aspirin–nitroglycerin the most frequent (7.6%). Among the 80 interactions analyzed in detail, those with moderate severity predominated (58.8%), followed by minor (35%) and major (6.2%). Polypharmacy (defined as the use of three or more medications) was observed in all patients who experienced DDIs. There was a significant difference in the average number of medications per day between patients with potential drug interactions and those without, p = 0.023 (p < 0.05).

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