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All Journal Syntax Literate: Jurnal Ilmiah Indonesia CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia SULUH: Jurnal Abdimas Jurnal Kimia dan Kemasan MAHESA : Malahayati Health Student Journal Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat

Noviyantih, Noviyantih

Fakultas Farmasi Universitas Pancasila, Jl. Serengseng Sawah, Depok

Author-ID : 3683399

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Dentistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Imobilisasi Propanolol HCl Pada Hidrogel Poli(Vinil Alkohol) - Natrium Alginat Dengan Teknik Radiasi Erizal Erizal; Erlina Widianti Pratiwi; Dian Pribadi Perkasa; Noviyantih Noviyantih; Basril Abbas; Sudirman Sudirman
Jurnal Kimia dan Kemasan Vol. 40 No. 1 April 2018
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v40i1.2755

Penelitian ini bertujuan memanfaatkan hidrogel sebagai matriks imobilisasi obat dengan teknik iradiasi gamma untuk mengontrol laju pelepasan obat terkendali. Imobilisasi propanolol HCl dalam hidrogel poli(vinil alkohol) (PVA)-g-natrium alginat (NaAlg) telah dilakukan. Larutan PVA/NaAlg (5/0,5, %berat) yang mengandung propanolol HCl (8 mg sampai dengan 16 mg), dibeku-lelehkan (3 siklus) dan diradiasi dengan variasi dosis (10 kGy sampai dengan 30 kGy). Hidrogel dikarakterisasi dengan spectrophotometer Fourier Transform-Infra Red (FT-IR) dan Scanning Electron Microscope (SEM). Fraksi gel dan daya serap air ditentukan secara gravimetri. Uji pelepasan propanolol HCl dari hidrogel dilakukan dalam larutan encer fosfat (pH 6,8) pada suhu 37 °C diukur dengan spectrofotomer Ultraviolet Visible (UV-Vis). Hasil evaluasi menunjukkan peningkatan dosis iradiasi dari 10 kGy hingga 30 kGy, peningkatan fraksi gel hidrogel, dan kemampuan menyerap air hidrogel relatif turun. Pelepasan kumulatif obat dari matriks hidrogel dengan meningkatnya dosis iradiasi hingga 30 kGy relatif turun. Pengamatan menggunakan SEM, menunjukkan hidrogel PVA-NaAlg mempunyai struktur pori yang tidak teratur. Hidrogel PVA-g-NaAlg selayaknya dapat digunakan sebagai matriks pelepasan obat.

Penetapan Simultan Kadar Fenilpropanolamin Hidroklorida dan Klorfeniramin Maleat dalam Tablet secara Spektrofotometri FARIDAH FARIDAH; NOVI YANTIH; NETTY HERAWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1725.079 KB)

Simultaneous determination of phenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets by spectrophotometry was carried out. The method is based upon total absorption of the two compounds in a mixture which can be applied to quantify each ofthe component. The absorption of phenylpropanolamine hydrochloride and chlorpheniramine maleate in 0.1 N hydrochloric acid were measured at the maximum Wavelength of phenylpropanolamine hydrochloride (256.7 nm) and that of chlorpheniramine maleate (262.6 nm), with a correlation coefficient of 0.999. A high precision could be obtained as shown by the CV of 0.2139-0.4962% for phenylpropanolamine hydrochloride and 0.3182- 0.5289% for chlorpheniramine maleate, While the recoveries ofphenylpropanolamine hydrochloride and chlorpheniramine maleate were 99.93% ± 0.43% and 99.76% ± 0.39%, respectively. The proposed method is simple, with a high accuracy and suitable for the simultaneous determination ofphenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets, Without prior separation.

Selektivitas Pemisahan Isoniazid dan Asetilisoniazid dalam Plasma Manusia In-vitro secara Kromatografi Cair Kinerja Tinggi Novi Yantih; Yahdiana Harahap; Wahono Sumaryono; Rianto Setiabudy; Lestari Rahayu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Bioanalysis method is needed to pharmacokinetic study of INH as antituberculosis. The main problem is INH structure is similar to that of acetyl isoniazid (AcINH) as its metabolite. Therefore, a selective separation method is needed to separate the INH from its metabolite and matrix. The aim of this study was to test the selectivity of separation method of INH and AcINH in human plasma in-vitro by high performance liquid chromatography (HPLC). The HPLC system used a reversed phase with UV detector and hexane sulphonate as an ion counter. The optimum conditions was obtained by using C18 as stationary phase, hexane sulphonate (pH 2.47)-methanol (65:35) as mobile phase, with flow rate of 1mL/min, and UV detector at wavelength of 265nm. The selectivity of method separation was indicated by a resolution value of ≥ 1.5. The tailing factor for INH and AcINH were 1.297, dan 1.912, respectively. The k values ware less than 10 and N values were greater than 5000 indicate good separation efficiency. The developing of HPLC was a selective for separating of INH and AcINH in human plasma in-vitro.

Pemisahan Delapan Vitamin Larut Air secara Kromatografi Pasangan Ion NOVI YANTIH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1553.92 KB)

Ion-pair chromatography is applicable for separating mixtures of acids and bases, either in ionic or nonionic form, such as mixture of ascorbic acid, thiamine hydrochloride, riboilavin, nicotinamide, pyridoxine hydrochloride, folic acid, and cyanocobalamine, and menadion sodium bisulphite. Separation using ion-pair chromatography is highly influenced by the type and concentration of the counter ion and the selected pH of mobile phase. Eight Water soluble vitamins Were separated in a single analysis Withtotal analysis time never exceeded 12 minutes by using a reversed-phase column (CS) with a mixture of methanol and solution of 5 mM sodium hexanesulphonate at pH 3.50 (49: 151) as mobile phase, at a flow rate of l ml per minute, and ultraviolet detector at 275 nm. Satisfactory separation was shown by the resolution values of more than 1.5, which were between 3.8-10.6.

Isolasi dan Karakterisasi Golongan Senyawa Antibakteri Streptococcus mutans dari Ekstrak Etanol Daun Sosor Bebek (Kalanchoe pinnata (Lamk.) Pers. NOVI YANTIH; LISIA MARGARET; KARTININGSIH KARTININGSIH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1292.859 KB)

Streptococcus mutans is one of the microbes which is responsible for the cause of bad breath. The activity of Kalanchoe pinnata (Lamk.) Pers. leaves ethanol extract is four times stronger than the water extract in inhibiting the growth of Streptococcus mutans. The aim of research is to isolate and characterize an antibacterial compound of ethanol extract of Kalanchoe pinnata (Lamk.) Pers. leaves. The extract was fractionated using column chromatography. The fractions were purified by TLC and the isolate were tested for its purity using HPLC. Isolate was characterized using UV-Vis spectrophotometry and FTIR. Fractionation by column chromatography generated 9 fractions. The fraction VII have the highest diameter of inhibitory against Streptococcus mutans. The yield of isolate was 9.18% of the fraction VII or 0.84% of the ethanol extract with purity of 95%. Isolate was suspected as a group of saponin compound.

Pengembangan Kromatografi Cair Kinerja Tinggi yang Sederhana untuk Analisis Kurkumin dalam Plasma Manusia In-Vitro Novi Yantih; Endah Giyah Wahyuningsih; Deni Rahmat; Yunahara Farida
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.947

Curcumin has antioxidant, antiinfl ammatory, antitumor, apoptotic-inducing, andantiangiogenesis eff ects. In order to study the pharmacokinetics of curcumin, a method for analysisof curcumin in plasma levels is required. The aim of this study was developing of a simple HighPerformance Liquid Chromatography (HPLC) for analysis curcumin in human plasma in-vitro. TheHPLC system was using isocratic technique in column reversed phase of C18 (Reliant® RP-18ecolumn (4.6x250 mm; 5 μm)) and mobile phase of acetonitrile–acetic acid–aquabidest (60:1:39) at fl owrate of 1.0 mL/min. Irbesartan was used as an internal standard. Detector was performed at a wavelengthof 428 nm for curcumin and 270 nm for irbesartan. Linearity test shown linear results with a correlationcoeffi cient (r) of 0.9970. LLOQ value was 0.0196 μg/mL with a diff erentiation value of 10.48-18.09%.The accuracy and precision of this method met requirement with a diff erentiation value and relativestandard deviation of between -5.51-3.04 % and 1.04-1.86 %, respectively. Recovery of this method was94.74-103.12%. This method provides good selectivity for the analysis curcurmin in human plasma.The developed of HPLC was a simple and valid method for analysis curcumin in human plasma.

Produk Esktraseluler Isolat Kapang Endofi t C.1.1 dan C.3.3 dari Ranting Cempaka Kuning (Michelia champaca L.) Sebagai Antimikroba Adefira Elisyia Juniharti; Desi Nadya Aulena; Novi Yantih; Nur Miftahurrohmah; Shirly Kumala
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.985

Michelia champaca L. is known to have effi cacy as an antimicrobial, antioxidant, and anticancer.In general, endophytic fungi that live in plant tissues is capable of producing secondary metabolites as theirhost plant. The objective of this research is to examine the antimicrobial potential of endophytic mold isolates C.1.1 and C.3.3 from yellow cempaka branches (Michelia champaca L.). Isolates obtained from previous research, fi rst was rejuvenated on PDA. Fermentation was carried out on each isolate for 12 days. The fermented supernatant was then extracted partially with n-hexane, ethyl acetate, and n-butanol solvent. The extract was then concentrated and tested for antimicrobial activity using disk diff usion and microdilution methods. N-butanol extract of endophytic fungi isolates of yellow champaca branches was able to inhibit the microbial growth with the largest inhibition area in isolate C.1.1 in Staphylococcus aureus ATCC 6538 (12.26 mm), Escherichia coli ATCC 8739 (11.40 mm), Candida albicans ATCC 10231 (10.50 mm), and Metichillin-Resistant Staphylococcus aureus (11.30 mm) with Minimum Inhibitory Concentration and Minimum Concentration of 12,5% . It was concluded that both endophytic fungi isolates of yellow champaca branches had the potential to inhibit the growth of pathogenic microbes.

Partial Validation of High Performance Liquid Chromatography for Analysis of Isoniazid in Rat Plasma Novi Yantih; Siti Hafilah; Yahdiana Harahap; WAHONO SUMARYONO; Rianto Setiabudy
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Nicotinic acid derivatives such as isoniazid have the strongest anti-tuberculosis properties. For pharmacokinetics studying of isoniazid (INH), a method is needed to determine the levels of INH in plasma. Objective: The aim of this research is to partial validate of high performance liquid chromatography (HPLC) for analysis of INH in rat plasma. Method: For the preliminary study, rat plasma was used. The HPLC system used is a stationary phase C18 with length 250mm and temperature of 30°C, mobile phase hexane sulphonate acid 20mM pH 2.47–methanol (65:35). The analytical parameters in partial validated were linearity, lower limit of quantification (LLOQ), precision, accuracy, and recovery. Results: The results of linearity test of INH showed r value of 0.9996. LLOQ of this method was 0.1258μg/mL. The resulting accuracy and precision value met FDA requirements with a percent recovery ranging from 96.57–107.99%. Conclusion: The HPLC system was a valid method for analysis of INH in rat plasma.

Analysis of SGPT and SGOT on Rats Induced By Isoniazid to Determine Dose and Hepatoprotective Characteristic of Unripe Pineapple Juice (Ananas comosus L. Merr) Lestari Rahayu; Novi Yantih; Yoana Supomo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

As a consequence of Isoniazid (INH) consumption in longterm is the damage on the liver cells which is detected in high level of SGPT and SGOT in blood. Unripe pineapple fruits contained higher level of phenolic acid and flavonoids compounds than the ripe pineapple fruits, and as a result the unripe pineapple fruits juice has higher hepatoprotective potency than ripe pineapple fruits juice. The hepatoprotective activity of unripe pineapple fruits juice was determined by measuring the SGPT and SGOT level on rat blood. There were prepared 24 rats, divided into 6 groups, i.e. normal control group, positive control group, negative control group, and 3 test goups that were induced by INH and each was given the unripe pineapple fruits juice at 1 hour before and 1 hour after INH induction, with the dose of 2 mL and 4 mL. Treatment was conducted in 14 days, consecutively. To each of the rat groups, blood was taken out through the eye orbital sinus, i.e. on the first day, on the hour-0 and hour-3, and then the SGPT and SGOT level were measured. Later on, blood were taken out on the day-4, day-7, and day-14. On the rat blood that were taken out, were analyzed descriptively and statistically to determined the optimum dose and the time of the unripe pineapple fruits juice feeding in related with a hepatoprotective potency. Result showed that feeding of the unripe pineapple fruit juice 1 hour after INH induction with the dose of 2 mL during 14 days has the best hepatoprotective activity.

Peningkatan Daya Saing Minuman Belimbing Wuluh Produksi Santri Pondok Pesantren Minhajusshobirin Melalui Penerapan Sanitasi dan Higiene Novi Yantih; Desi Nadya Aulena; Andri Prasetyo; Muhamad Yamin
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 3 (2021): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v3i3.881

Kegiatan PKM ini bertujuan untuk meningkatkan pengetahuan santri pondok mengenai sanitasi dan higiene selama proses persiapan, pembuatan, penyimpanan, dan pemasaran minuman belimbing wuluh, serta untuk peningkatan daya saing produk. Metode yang dilakukan meliputi: Persiapan, penyuluhan, pelatihan, pengujian mutu parameter mikrobiologi produk, monitoring dan evaluasi, Alat ukur untuk menilai pengetahuan dan sikap santri adalah melalui kuesioner, dimana pengambilan informasi dilakukan sebelum dan setelah penyuluhan dan pelatihan. Penilaian terhadap peningkatan daya saing dapat dicermati dari waktu stabil yang memadai berdasarkan 2 paramater mutu uji mikrobiologi dari produk. Hasil Uji Stabilitas Produk Minuman Belimbing Wuluh varian warna merah untuk parameter mikrobiologi Angka Lempeng Total (ALT) sebelum PKM tidak memenuhi syarat yaitu 2.03 x 106 CFU/mL yang menunjukkan bahwa proses pembuatan produk belum menerapkan sanitasi dan higiene. Setelah dilaksanakan PKM, menunjukkan adanya peningkatan daya saing produk minuman belimbing wuluh Produksi Santri Pondok Pesantren Minhajusshobirin melalui penerapan sanitasi dan higiene dalam proses produksi produknya.

Co-Authors Adefira Elisyia Juniharti Andri Prasetiyo Anggiyasari Anggiyasari Arfin Ahsanul Ihsan Basril Abbas Deni Rahmat Desi Nadya Aulena Dian Pribadi Perkasa Endah Giyah Wahyuningsih Erizal Erizal Erlina Widianti Pratiwi FARIDAH FARIDAH Fauzia Noprima Okta Fikha Amelia Rachim Fitria Angeliqa Gumilar Adhi Nugroho Iha Haryani Hatta Indah Masri Kartiningsih Kartiningsih Lestari Rahayu Lha Haryani Hatta Lidya Pratiwi Afri Tjaja Lidya Pratiwi Tjaja LISIA MARGARET Miftahurrohmah, Nur Muhamad Yamin Mulatsari, Esti Nathalia Perdhani Soemantri NETTY HERAWATI Nikita Tumbelaka Olvina Margaretta Qodriah, Rahmatul Rianto Setiabudy Rianto Setiabudy Shirly Kumala Siti Hafilah Sri Widyastuti Sudirman Sudirman Trisna Permadi Wahono Sumaryono Yahdiana Harahap YAHDIANA HARAHAP YATI SUMIYATI Yoana Supomo Yunahara Farida Zahra Afifah

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