Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

2.233

P-Index

This Author published in this journals

All Journal Jurnal Veteriner International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Indonesian Journal of Cardiology Tunas Medika Jurnal Kedokteran & Kesehatan Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Penyakit Dalam Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian

Prayudi Santoso

Departemen Respirologi Dan Perawatan Kritis Penyakit Dalam, Fakultas Kedokteran Universitas Padjadjaran. RS Hasan Sadikin, Bandung, Indonesia

Author-ID : 371054

Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Veterinary

Published : 20 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

The Effect of Treadmill Aerobic Exercise on Walking Distance, Lung Function and Quality of Life in Tuberculosis Patients Muhamad Ilham; Marina Moeliono; Prayudi Santoso
Indonesian Journal of Physical Medicine & Rehabilitation Vol 4 No 01 (2015): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Objective: To observe the effect of treadmill aerobic exercise on walking distance, lung functionand QoL in lung tuberculosis patients.Methods: It was an interventional study using controlled random sampling with pre- and post- interventionobservation. The study took place at Hasan Sadikin Hospital, Bandung. Subjects were post-category IImedicationpulmonary TB patients with negative AFB conversion, males and females aged 18-60 years,normal BMI (according to Indonesian Ministry of Health 2003), able to comprehend spoken, writtenand signed instructions (mini mental state examination - MMSE 22-30), able to undergo a six-minuteswalking test (6MWT), cooperative and willing to participate in the study. This study analyzed data from30 subjects divided into two groups (interventional vs control group, each 15 subjects). Control groupwas given educational program, breathing techniques and chest- expansion exercises to do at home for6 weeks (3 times a week), whereas the study group received additional aerobic exercise for 6 weeks(walking on a treadmill, 3 times a week, 30-60 minutes per session) with the intensity of 80% of the speeddetermined from the result of the 6MWT. Pre- and post- six weeks, walking distance (6MWT), lungfunction and St. George’s Respiratory Questionnaire (SGRQ) evaluation were obtained from subjects.Results: Walking distance of interventional group (mean 75.53 m, p<0.05) increased significantly after6 weeks. There were also significant difference between two groups in the SGRQ components exceptfor symptoms. Lung functions as shown on FVC and FEV1 increased significantly in interventionalgroup. However, this increase was not confirmed by the change of breathing impairment pattern.Conclusion: The significant difference between the study and the control groups showed that aerobicexercise using treadmill gives better improvement on the quality of life. This fact demonstratesthat exercise program in pulmonary rehabilitation remains the core program to increase functionalcapacity and quality of life.Keywords: lung tuberculosis, aerobic exercise, treadmill, walking distance, quality of life, SGRQ

EFEKTIVITAS TERAPI BEDAQUILIN DAN DELAMANID PADA PENGOBATAN MULTIDRUG-RESISTANT TUBERCULOSIS (MDR-TB): SEBUAH REVIEW Evita Sari; Neily Zakiah; Prayudi Santoso; Melisa I Barliana
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 9, No 1 (2020)
Publisher : Sekolah Tinggi Farmasi Indonesia

Bedaquilin dan delamanid merupakan kombinasi obat yang sering digunakan untuk pengobatanTuberkulosis Resistan Obat Ganda (TB-MDR) atau Multidrug-Resistant Tuberculosis (MDR-TB).Selama penggunaannya bedaquilin dan delamanid dikaitkan dengan efektivitasnya dalam konversikultur dan potensi efek sampingnya. Ulasan ini menguraikan efektivitas terapi dan efek samping dalampenggunaan obat tersebut. Desain penulisan ini adalah study literature review. Beberapa hasil penelitianmenunjukkan bahwa bedaquilin dan delamanid dinilai dapat meningkatkan hasil pengobatan pada TBMDR karena mampu mempercepat terjadinya konversi kultur bakteri yaitu di atas waku rata-rata yangtelah ditetapkan oleh WHO. Namun dari segi keamanan, beberapa penelitian menyebutkan bahwapenggunaan bedaquilin dan delamanid memiliki potensi efek samping perpanjangan interval QTsehingga perlu monitoring ketat selama penggunaannya. Data keamanan efektivitas terapi obatbedaquilin dan delamanid dibutuhkan dalam rangka pengobatan TB-MDR untuk meningkatkanpelayanan dan keamanan terhadap pasien.Kata kunci : Bedaquilin, delamanid, efektivitas, efek samping

Thoracic Radiography Findings of Multi Drug Resistant Tuberculosis at Dr. Hasan Sadikin General Hospital Bandung Mareta Tada Kurnia; Iyus Maolana Yusuf; Prayudi Santoso
Althea Medical Journal Vol 9, No 3 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n3.2618

Background: The prevalence of multidrug-resistant pulmonary tuberculosis (MDR-TB) continues to increase, especially in Indonesia. Thoracic radiography examination plays a role in the TB diagnosis by providing findings of typical lesions in patients. The aim of the study was to determine the thoracic radiography findings in MDR-TB patients.Methods: This was a cross-sectional retrospective descriptive study. This study had explored secondary data from medical records of patients who previously had a clinical diagnosis of MDR-TB and underwent thoracic radiography examinations at the Department of Radiology, Dr. Hasan Sadikin General Hospital, Bandung on July - August 2020 Result: Of 110 data collected, the average age was 37±12.6 years with male patients were predominantly prevalent and 65.5% had large lesions. The most frequent findings of lesions were calcification (94.5%) and fibrosis (90.9%). Other major findings were infiltration (88.2%), consolidation (55.5%), cavity (65.5%), ground-glass opacity (60.9%) while other were found in less than half of the cases such as bronchiectasis (23%), nodule (34.5%), atelectasis (36.4%), lymphadenopathy (34.5%), and others. Interestingly, the miliary pattern was not found.Conclusion: Large lesions, calcification, fibrosis, infiltration, consolidation, cavities, and ground-glass opacities are the main features of the radiographic findings in the majority of MDR-TB patients.

Effective Visual Media to Increase Knowledge and Comprehension of Multidrug Resistant Tuberculosis Among Patients and Their Caregivers Lidya Chaidir; Dyshelly Nurkartika Pascapurnama; Claudia Selviyanti; Cindy Natasha; Muti'ah Nurul Jihadah; Prayudi Santoso
Majalah Kedokteran Bandung Vol 55, No 2 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n2.2986

Indonesia ranks thirdamong countries with the largest number of TB cases after India and China. Globally, more than 3-4% of all TB cases are Multidrug-Resistant Tuberculosis (MDR TB). MDR TB is a more complicated TB that needs extra treatments, which extend treatment time and increase adverse effects. Thus, MDR TB patients and their families often feel demotivated about completing treatment, leading to loss to follow up, which contributes to the never-ending transmission and greatly affects the success rate of the national TB control program. Thus, better knowledge and perception on MDR treatment for patients and families plays a crucial role in dealing with this issue. A cross-sectional study was performed from April to June 2019 to evaluate the effectiveness of visual educational media for TB patients and their caregivers. Participants consisted of 144 patients diagnosed with MDR TB and their caregivers or family members (n=22). A pre-test was administered before an education session by a nurse and visual media were used as the educational material. At the end of the session, a post-test was performed. The post-test score was then compared to the pre-test score to evaluate the session’s effectiveness using the paired t-test. Result showed significant increase in the post-test score (t= 3.249, df=3, p=0.04), with the caregivers attained a higher score, showing better improvement in knowledge after the session compared to the patient group. Hence, the MDR TB educational intervention using visual media is considered effective to increase participants ‘understanding of MDR TB. It is expected that with increased knowledge on MDR TB, the treatment success rate will increase and becomes the catalyst for the nationwide TB control strategy.

Prevalensi dan Karakteristik Pasien Tuberkulosis Paru Resisten Obat (TB-RO) dengan Diabetes Melitus Tipe 2 di Klinik TB-RO Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung Maulida, Diva Harnum; Dewi, Intan Mauli Warma; Santoso, Prayudi; Cahyadi, Adi Imam; Kusumawati, Maya; Kulsum, Iceu Dimas
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction. Diabetes mellitus (DM) patients have a higher risk of tuberculosis (TB) infection, including the risk of drug- resistant (DR)-TB infection, compared to those without DM. Data on the characteristics of pulmonary DR-TB with DM in Indonesia are still very limited. The management of pulmonary DR-TB with DM should consider multiple factors, such as drug interactions between DM medication and anti-TB drugs, as well as potential exacerbation of DM complications by anti-TB drugs side effects. Effective management of pulmonary DR-TB patients with DM will improve treatment outcomes. This study aimed to determine the prevalence and characteristics of pulmonary DR-TB patients with type 2 DM at the DR-TB clinic of Dr. Hasan Sadikin Central General Hospital, Bandung. Methods. This cross-sectional study was conducted at the Drug Resistant Tuberculosis (DR-TB) Clinic of Dr. Hasan Sadikin Central General Hospital, Bandung, during the period of January 2020 to May 2023. Data were obtained from the medical records of patients with drug resistant pulmonary tuberculosis and type 2 DM. The study included patients diagnosed with drug resistant pulmonary tuberculosis and type 2 DM who were aged 18 years or older. Data analysis was performed using descriptive statistical methods, and normality test was conducted using the Kolmogorov-Smirnov test. Results. The prevalence of pulmonary DR-TB cases with Type 2 DM was 11.17%. Out of a total of 82 samples, more than half had normal BMI (61.04%), diagnosed with MDR-TB (74.39%). The duration of Type 2 DM were in average between 1-5 years (53.16%), with an HbA1c value ≥7% in 94.20% of the patients. Infiltrates were found in 46.27% of radiological findings. Anemia was present in 54,88% of participants, with an average and standar deviation hemoglobin level of 12.15 (± 1.75) g/dL. Conclusions. The prevalence of pulmonary drug-resistant tuberculosis with type 2 DM at Dr. Hasan Sadikin Central General Hospital, Bandung, is 11,17%. The majority of patients had uncontrolled type 2 DM (HbA1c ≥7%), normal BMI, positive sputum mycobacteriology, and the primary chest X-ray finding is infiltrate. Future studies are necessary to determine the clinical and treatment outcome of these patients.

ARTICLE REVIEW: THE TREATMENT PROBLEM AND ADVERSE DRUG REACTIONS IN THE TREATMENT OF MULTIDRUG-RESISTANT TUBERCULOSIS Sartika Aprianti; Prayudi Santoso; Melisa Intan Barliana; Ivan Surya Pradipta
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.988

Multidrug-resistant tuberculosis (MDR-TB) is the resistance of Mycobacterium tuberculosis to at least two tuberculosis (TB) drugs, rifampicin and isoniazid. The disease requires a long treatment duration with several second-line drugs. This leads to a globally low success rate of approximately 56% for MDR-TB treatment. Studies have reported that adverse drug reactions (ADRs) contribute to high rates of non-compliance, treatment discontinuation, and failure. This narrative review aimed to provide information about MDR-TB treatment modalities, various ADRs, challenges encountered in MDR-TB treatment, and instances of ADRs that can impact treatment success. This narrative review study was conducted by searching for scientific information from the primary electronic databases PubMed and Google Scholar, covering 2012-2022. Based on the literature search results, 14 studies were identified, demonstrating challenges in TB and MDR-TB treatment, along with 6 ADRs that can influence treatment success in MDR-TB patients. ADRs during MDR-TB treatment can affect patients’ physical, mental, and social well-being as well as their beliefs and behaviors related to treatment. Comprehensive support from families, communities, and healthcare providers is essential to assist patients in addressing treatment challenges and adverse ADRs. Rapid identification and strategies for monitoring and managing treatment challenges and ADRs can improve compliance and success of MDR-TB treatment. Keywords: Adverse Drug Reactions, Drug Side Effects, Multi Drug-Resistant Tuberculosis (MDR-TB), Treatment Success

The Combination of Gardenia jasminoides, Boswellia serrata, Commiphora myrrha, Foeniculum vulgarae, and Daucus carota Essential Oil Blend Improved the Inflammatory and Clinical Status in Respiratory Tract Infection of COVID-19 Patients: A Multicentre, Randomized, Open-label, Controlled Trial Keri Lestari; Haig Babikian; Iceu Dimas Kulsum; Ferdy Ferdian; Efriadi Ismail; Yelsen Sumalim; Setiawan Setiawan; Prayudi Santoso; Yovita Hartantri; Arief Riadi Arifin; Anna Meiliana; Ida Paulina Sormin; Erizal Sugiono
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3023

BACKGROUND: Essential oils (EO) are complex volatile, naturally synthesized compounds from aromatic plants. It considers as healthy, effective, and safe since they were coming from nature. Gardenia jasminoides, Boswellia serrata, Commiphora myrrha, Foeniculum vulgarae, and Daucus carota are known to have antimicrobials, antioxidants, antiinflammation properties against respiratory tract infection. However, despite its natural content, a safety profile needs to be observed. Therefore, in this study, EO blend (EOB) made from the combination of these 5 plants was assessed for its efficacy and safety for respiratory tract infection in human.METHODS: A multicentre, randomized, open-label, phase II controlled trial involving 80 hospitalized adults with COVID-19 was conducted. One group of subjects only received standard of care (SoC), while the other group receive SoC and EOB orally for 10 days.RESULTS: There were significant decrease in interleukin (IL)-6 level (p=0.016) and interferon (IFN)-γ level (p=0.012), as well as better respiratory rate (p=0.024) for the group receiving SoC and EOB compared to the group receiving SoC only. However, there was no significant differences in aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and the corrected QT interval (QTc) prolongation value in both groups. All subjects with adverse effects were improved and recovered, and there were no serious adverse events found.CONCLUSION: The combination of G. jasminoides, B. serrata, C. myrrha, F. vulgarae, and D. carota EOB could improve the inflammatory and clinical status and safe to be used as adjuvant therapy for treating COVID-19 in adults.KEYWORDS: essential oils, COVID-19, inflammation, safety

Proportion of Extrapulmonary MDR-TB Confirmed by GeneXpert® in Dr. Hasan Sadikin General Hospital, West Java, Indonesia Year 2012–2021 Dhestina, Winnery; Santoso, Prayudi; Sahiratmadja, Edhyana
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 2 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i2.33768

As the third-highest country with tuberculosis (TB) incidence worldwide in 2020, Indonesia has increasing TB cases resistant to various anti-TB therapy or multidrug-resistant (MDR)-TB, and ranked fifth for its high incidence reported in Global Tuberculosis Report 2020. Moreover, extrapulmonary TB (EPTB) is rising, and data studies on EPTB with MDR-TB in Indonesia are scarce. This study aimed to explore the proportion of extrapulmonary MDR-TB among TB cases in Dr. Hasan Sadikin General Hospital Bandung, West Java, Indonesia. A descriptive retrospective and cross-sectional study design were conducted, retrieving medical records from all suspect MDR-TB adult patients examined by GeneXpert®, at Dr. Hasan Sadikin General Hospital Bandung, West Java period 2012–2021. Those with EPTB were further analyzed, and the demographic data was collected as well as clinical history, behavioral history, sites of extrapulmonary MDR-TB, and drug resistance. Of a total 7,013 TB cases, 1,900 (27.1%) were MDR-TB cases, of whom 0.08% (n6) were extrapulmonary MDR-TB cases and 0.16% (n11) were combined with PTB. The main characteristics of cases with extrapulmonary MDR-TB were median age 27-year-old (range 25–34), male gender (64.7%), underweight BMI (84.6%), and predominantly were primary cases (35.3%). The anti-TB drug resistance in MDR-TB were pre-XDR-TB (11.7%), XDR-TB (5.6%), MDR-TB (42%), and RR-TB (40.7%). Although the proportion of extrapulmonary MDR-TB among all TB cases is small (0.2%), this disease can't be ignored and has a great potential to be explored. Most of them are rifampicin-resistant. Further studies need to include a larger population to have more overview of MDR-TB with EPTB.

Characteristics of Extraneural Tuberculosis in Patients with Tuberculous Meningitis Hospitalized at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2017–2021 Grazielle, Grazielle; Ganiem, Ahmad Rizal; Sobaryati, Sobaryati; Dian, Sofiati; Santoso, Prayudi
Althea Medical Journal Vol 11, No 4 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n4.3205

Background: Tuberculous (TB) meningitis is the most severe manifestation of extrapulmonary TB and contributes to a high mortality rate. The presence of extraneural TB may raise suspicion of TB meningitis (TBM). This study aimed to explore the characteristics of extraneural TB in TBM patients.Methods: This was a cross-sectional descriptive study using secondary data from medical records of TBM patients admitted at Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2017 to 2021. Demographic and clinical data were collected, including HIV status. TBM cases were classified into grades I, II, and III using Medical Research Counsil (MRC) criteria that were based on Glasgow Coma Scale (GCS) score and the presence of focal neurological deficits. The clinical classification diagnosis of TBM was made based on the Marais diagnostic criteria which included several diagnostic items and corresponding scoring which further divides TBM into three classes. Extraneural TB is defined as the finding of TB outside the nervous system. Disseminated TB was diagnosed based on the finding of ≥2 infected locations.Results: During the study period, 497 medical records were analyzed. Most TBM patients experienced Grade II (76.9%) and extraneural TB site was found in 65.4%, with pulmonary TB as the common site (77%). The highest mortality rate was in disseminated TB (50%). The finding of extraneural TB did not differ between HIV-negative and HIV-positive patients (67.8% vs. 67.9%; p=0.101).Conclusion: The presence of extraneural TB is common in patients with TBM. Therefore, extraneural TB evaluation is important to ensure TBM diagnosis. Further studies are needed to explore factors related to TBM diagnosis to ensure TBM patient’s wellbeing.

Faktor Risiko Pneumonia Paska Operasi Bedah Pintas Arteri Koroner Fadhilah, Vita Karima; Achmad, Chaerul; Afrianti, Rien; Santoso, Prayudi
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1789

Background: Postoperative pneumonia (POP) is a common infectious complication of coronary artery bypass grafting (CABG), leading to significant morbidity, mortality, and increased healthcare costs. This study found that the prevalence of POP was nearly double that reported in previous studies, underscoring the urgent need to identify specific risk factors. These findings emphasize the importance of local data in refining preventive strategies and improving clinical outcomes in CABG patients. Material and Methods: This is a retrospective cohort study. The subjects comprised patients who underwent CABG procedures at a single institution between June 2020 and June 2024. A logistic regression analysis model for evaluating the risk of POP was established. Results: This study observed a POP rate of 41.7%, significantly exceeding the 2–24% range reported in previous studies. Key risk factors included elevated creatinine levels, eGFR <60 ml/min/1.73 m², and low early postoperative albumin. POP strongly correlated with prolonged hospitalization, with an odds ratio of 13.043 (95% CI: 6.130–27.751, p < 0.0001), underscoring its substantial impact on patient outcomes. Conclusions: The present study delineates renal impairment and hypoalbuminemia postoperative as pivotal risk factors for POP following CABG. It emphasizes the importance of tailored interventions, structured institutional practices, and continuous research to enhance preventive strategies and patient outcomes.

Co-Authors Adi Imam Cahyadi Adrian Sebastian Suhendro Afiatin Afiatin Afrianti, Rien Ahmad Rizal Ganiem, Ahmad Rizal Ali Djamhuri Alif Bagus Rakhimullah Anna Meiliana Arief Riadi Arifin Arto Yuwono Soeroto Astried Indrasari Bachti Alisjabana, Bachti Bachti Alisjahbana Chaerul Achmad Cindy Natasha Claudia Selviyanti Dewi Kartika Turbawaty Dewi, Intan Mauli Warma Dhestina, Winnery Dyshelly Nurkartika Pascapurnama Edhyana Sahiratmadja Efriadi Ismail Elsa Pudji Setiawati Erizal Sugiono Evita Sari Fadhilah, Vita Karima Fani Rahma Yenita Farida Arisanti Ferdy Ferdian Grazielle, Grazielle Haig Babikian Hanna Goenawan Iceu Dimas Kulsum Ida Parwati Ida Paulina Sormin Ivan Surya Pradipta Iwan Setiawan Iyus Maolana Yusuf Juniati, Rianita Keri Lestari Khairani, Alya Putri Kusumawati, Maya Lidya Chaidir Mareta Tada Kurnia Marina Moeliono Maulida, Diva Harnum Melindah, Melindah Melisa I Barliana Melisa Intan Barliana Menik Herdwiyanti Muti'ah Nurul Jihadah Nataprawira, Heda M Neily Zakiah Nova Sylviana Ria Bandiara Riswari, Silvita Fitri Ronny Lesmana Rudi Wisaksana Sartika Aprianti Setiawan Setiawan Silvita Fitri Riswari Sobaryati, Sobaryati Soeroto, Arto Y Sofiati Dian Suhendro, Adrian Sebastian Sukesi, Lilik Unang Supratman Vita Murniati Tarawan Vitriana Vitriana Yana Akhmad Supriatna, Yana Akhmad Yelsen Sumalim Yovita Hartantri Yuni Susanti Pratiwi Zul Dahlan

Title

Found 20 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 20 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 20 Documents
Search