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HUBUNGAN TINGKAT DEPRESI DENGAN DISFUNGSI EREKSI PADA KOMUNITAS LELAKI SEKS LELAKI (LSL) DI SURAKARTA Ervina Rosmarwati; Winda Wijayanti; Irene Ardiani Pramudya Wardhani; Ammarilis Murastami
Media Dermato-Venereologica Indonesiana Vol 50 No 1 (2023): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i1.407

Pendahuluan: Disfungsi ereksi menjadi perhatian di golongan homoseksual dan sering dikaitkan dengan depresi sebagai salah satu pemicunya. Tujuan: Mengetahui hubungan antara tingkat depresi dengan kejadian disfungsi ereksi di komunitas Lelaki Seks Lelaki (LSL) di Surakarta. Metode: Penelitian analitik observasional dilakukan di Surakarta periode Juni-Juli 2021. Subjek adalah 41 laki-laki berusia 20-50 tahun, orientasi seksual dengan sesama jenis dan menyetujui untuk mengikuti penelitian. Penilaian tingkat depresi menggunakan kuisioner Patient Health Questionnaire-9 (PHQ-9). Penilaian disfungsi ereksi menggunakan kuisioner International Index of Erectile Function (IIEF) dalam domain fungsi ereksi. Analisis data menggunakan uji korelasi spearman rank SPSS versi 21 dengan nilai signifikasi p<0,05. Hasil: Tingkat depresi dan faktor usia tidak memiliki hubungan yang signifikan dengan disfungsi ereksi (r=0,158 dan p=0,323; r=0,020 dan p=0,901). Variabel yang berhubungan signifikan dengan kejadian disfungsi ereksi adalah frekuensi hubungan seksual (r= -0,389 dan p=0,012) dimana semakin jarang subjek penelitian melakukan hubungan seksual maka semakin tinggi kemungkinan terjadinya disfungsi ereksi. Tingkat koefisien korelasi antara frekuensi hubungan seksual terhadap kejadian disfungsi ereksi adalah kategori lemah (r=0,200-0,399). Kesimpulan: Tingkat depresi tidak berkorelasi terhadap kejadian disfungsi ereksi, namun kejadian disfungsi ereksi berkorelasi negatif dengan frekuensi hubungan seksual pada komunitas LSL di Surakarta.

Prosedur Pembedahan pada Hiperhidrosis Aksilaris dengan Teknik Tumesen Liposuction-Curettage Danu Yuliarto; Wibisono Nugraha; Moerbono Mochtar; Ammarilis Murastami
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Hyperhidrosis is an excessive sweat production due to autonomic nerve dysfunction that occurs in areas with higher concentration of eccrine gland such as palms, soles of the feet, and axilla. Management of hyperhidrosis includes pharmacological and nonpharmacological approach. Patients with severe focal hyperhidrosis should consider surgical treatment or botulinum toxin injection. Tumescent liposuction with curettage is one of surgical technique option for the treatment of axillary hyperhidrosis. Case: A 32-year-old woman with complaint of excessive sweating, especially in the axillary area. The patient had received oral therapy from a dermatologist prior, but there was no improvement, so the patient was advised to undergo a surgical procedure. In this patient the tumescent liposuction-curettage procedure was performed. Discussion: Treatment of hyperhidrosis with both topical and systemic agents generally provides only temporary suppression of hyperhidrosis. In severe, disturbing cases, the treatment of choice for axillary hyperhidrosis is the surgical procedure. Combination of liposuction-curettage surgical method using tumescent anesthesia is relatively simple and safe. Reduction of apocrine gland secretion after liposuction-curettage takes a relatively long time. This surgical technique has many advantages, such as relatively minimal injury dan short recovery period. Follow-up after this combined liposuction-curettage procedure should be performed subjectively and objectively at 3, 6, and 12 months postoperative.

Profil Pasien Infeksi Menular Seksual di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi Surakarta Periode Januari 2016−Desember 2020 Achmad Satya Negara; Ammarilis Murastami
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/8bjbj417

Latar belakang: Infeksi menular seksual (IMS) merupakan infeksi yang disebabkan oleh bakteri, virus, maupun parasit yang sebagian besar ditularkan melalui hubungan seksual secara vaginal, anal, atau oral. Prevalensi IMS di seluruh dunia diperkirakan mencapai 333 juta kasus per tahun dan setiap hari terjadi lebih dari 1 juta kasus IMS. Pelaporan data IMS saat ini diestimasikan hanya mewakili 50−80% dari total keseluruhan penyakit IMS di Amerika Serikat, yang mencerminkan keterbatasan screening, kurangnya informasi mengenai transmisi penyakit, serta rendahnya tingkat pelaporan data. Data mengenai IMS penting diketahui sebagai bahan kajian perencanaan dalam upaya pencegahan dan pengendalian penyakit. Tujuan: Mengetahui profil penyakit IMS di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi periode Januari 2016 sampai Desember 2020. Metode: Penelitian ini merupakan penelitian retrospektif dengan menggunakan data sekunder berupa rekam medis dan buku registrasi di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi, Surakarta, periode Januari 2016−Desember 2020. Hasil: Didapatkan jumlah kasus baru IMS rawat jalan di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi sebanyak 275 kasus selama 5 tahun terakhir. Terdapat 192 kasus kondiloma akuminata, 16 kasus ulkus genital, 35 kasus keluarnya cairan dari genitalia laki-laki, dan 20 kasus keluarnya cairan dari genitalia perempuan. Kesimpulan: Penderita IMS yang berobat di RSUD Dr. Moewardi mayoritas berjenis kelamin laki-laki dengan diagnosis terbanyak adalah kondiloma akuminata. Data ini dapat menjadi acuan dalam upaya pengendalian IMS dengan meningkatkan anamnesis, pemeriksaan fisik dan penunjang, serta memberikan edukasi terkait tindakan preventif pada pasien.

Prevalence and Risk Factors of Sexually Transmitted Infections in a Tertiary Hospital in Surakarta, Indonesia Lidjaja, Lifesia Natali; Ammarilis Murastami; Endra Yustin Ellistasari; Ivani; Vrenda Alia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1195

Background: Sexually transmitted infections (STIs) remain a significant public health concern globally, with millions of new cases occurring annually. Understanding the prevalence and risk factors associated with STIs is crucial for effective prevention and control programs. This study aimed to investigate the prevalence and risk factors of STIs among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital, a tertiary hospital in Surakarta, Indonesia. Methods: A retrospective descriptive study was conducted using secondary data from medical records of patients diagnosed with STIs between January 2020 and December 2023. Data collected included sociodemographic characteristics, sexual behaviors, clinical diagnoses, and HIV status. Descriptive statistics and chi-square analysis were used to analyze the data. Results: A total of 249 patients were diagnosed with STIs during the study period. The most common STI was condyloma acuminata (51%), followed by male genital discharge (18.1%), female vaginal discharge (16%), other STIs (10.9%), and genital ulcers (4%). The majority of patients were male (62.2%), aged 25-44 years (49.1%), had a high school education (49.5%), and reported heterosexual orientation (67.1%). Multiple sexual partners were reported by 62.7% of the participants, and 36.1% were HIV positive. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Conclusion: Condyloma acuminata was the most prevalent STI among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Understanding these correlations can help healthcare providers identify individuals at higher risk for specific STIs and implement targeted prevention and intervention strategies. Targeted interventions focusing on these high-risk groups are needed to reduce the burden of STIs in Surakarta, Indonesia.

Single-Dose Intralesional Bacillus Calmette-Guérin (BCG) Immunotherapy Induces Complete and Sustained Remission of Recalcitrant Anogenital Condylomata: A Mechanistic Case Series Azhar Arrosyid; Prasetyadi Mawardi; Endra Yustin Ellistasari; Ammarilis Murastami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1472

Background: Anogenital condylomata acuminata caused by Human Papillomavirus (HPV) presents a significant therapeutic challenge due to high recurrence rates after conventional cytodestructive therapies. Intralesional immunotherapy aims to induce a host-mediated immune response, offering a promising alternative. This report investigates the efficacy, safety, and immunological rationale of a novel, single-dose Bacillus Calmette-Guérin (BCG) protocol in an immunologically primed population. Methods: In this prospective case series, three immunocompetent patients with extensive, therapy-refractory anogenital condylomata were enrolled. Following a standardized protocol, each patient received a single, calculated intralesional injection of BCG vaccine into the largest index lesion. The primary outcome was complete clinical and dermoscopic clearance. Patients were evaluated at regular intervals for efficacy and safety over a 12-month follow-up period. Result: All three patients achieved complete clinical and dermoscopic clearance of both the injected and distant, untreated lesions within a rapid timeframe of 6 to 10 weeks. The treatment was well-tolerated, with adverse events limited to anticipated and transient local inflammatory reactions. No recurrences were documented in any patient during the 12-month follow-up period. Conclusion: Single-dose intralesional BCG immunotherapy appears to be a highly effective, durable, and safe therapeutic strategy for recalcitrant anogenital condylomata. The observed pan-lesional clearance strongly suggests the induction of a systemic, cell-mediated anti-HPV immune response. These compelling preliminary findings provide a strong rationale for validation through larger, randomized controlled trials.

Intralesional Mumps, Measles, Rubella (MMR) Vaccine as Therapy for Recurrent Condyloma Acuminata: A Case Report Sambodo, Shelly Lavenia; Prasetyadi Mawardi; Endra Yustin Ellistasari; Ammarilis Murastami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1092

Background: Condyloma acuminata (CA), a prevalent sexually transmitted infection caused by the human papillomavirus (HPV), presents challenges in treatment due to its high recurrence rate. While various treatment modalities exist, intralesional immunotherapy with the mumps, measles, rubella (MMR) vaccine has shown promise in managing HPV-related conditions. This case report investigates intralesional MMR vaccine in treating recurrent CA. Case presentation: A 24-year-old female presented with recurrent CA lesions on the labia majora and perianal region. Despite prior treatment with trichloroacetic acid (TCA), the lesions had reappeared. Intralesional MMR vaccine injections were administered twice, one month apart, resulting in complete lesion resolution within six weeks of the second injection. No recurrence was observed during a six-month follow-up period, and the patient reported only mild, transient pain at the injection sites. Conclusion: This case report highlights the potential of intralesional MMR vaccine as an effective and well-tolerated treatment option for recurrent CA. Further research is warranted to validate these findings and establish optimal treatment protocols.

Intralesional Mumps, Measles, Rubella (MMR) Vaccine as Therapy for Recurrent Condyloma Acuminata: A Case Report Sambodo, Shelly Lavenia; Prasetyadi Mawardi; Endra Yustin Ellistasari; Ammarilis Murastami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1092

Background: Condyloma acuminata (CA), a prevalent sexually transmitted infection caused by the human papillomavirus (HPV), presents challenges in treatment due to its high recurrence rate. While various treatment modalities exist, intralesional immunotherapy with the mumps, measles, rubella (MMR) vaccine has shown promise in managing HPV-related conditions. This case report investigates intralesional MMR vaccine in treating recurrent CA. Case presentation: A 24-year-old female presented with recurrent CA lesions on the labia majora and perianal region. Despite prior treatment with trichloroacetic acid (TCA), the lesions had reappeared. Intralesional MMR vaccine injections were administered twice, one month apart, resulting in complete lesion resolution within six weeks of the second injection. No recurrence was observed during a six-month follow-up period, and the patient reported only mild, transient pain at the injection sites. Conclusion: This case report highlights the potential of intralesional MMR vaccine as an effective and well-tolerated treatment option for recurrent CA. Further research is warranted to validate these findings and establish optimal treatment protocols.

Prevalence and Risk Factors of Sexually Transmitted Infections in a Tertiary Hospital in Surakarta, Indonesia Lidjaja, Lifesia Natali; Ammarilis Murastami; Endra Yustin Ellistasari; Ivani; Vrenda Alia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1195

Background: Sexually transmitted infections (STIs) remain a significant public health concern globally, with millions of new cases occurring annually. Understanding the prevalence and risk factors associated with STIs is crucial for effective prevention and control programs. This study aimed to investigate the prevalence and risk factors of STIs among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital, a tertiary hospital in Surakarta, Indonesia. Methods: A retrospective descriptive study was conducted using secondary data from medical records of patients diagnosed with STIs between January 2020 and December 2023. Data collected included sociodemographic characteristics, sexual behaviors, clinical diagnoses, and HIV status. Descriptive statistics and chi-square analysis were used to analyze the data. Results: A total of 249 patients were diagnosed with STIs during the study period. The most common STI was condyloma acuminata (51%), followed by male genital discharge (18.1%), female vaginal discharge (16%), other STIs (10.9%), and genital ulcers (4%). The majority of patients were male (62.2%), aged 25-44 years (49.1%), had a high school education (49.5%), and reported heterosexual orientation (67.1%). Multiple sexual partners were reported by 62.7% of the participants, and 36.1% were HIV positive. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Conclusion: Condyloma acuminata was the most prevalent STI among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Understanding these correlations can help healthcare providers identify individuals at higher risk for specific STIs and implement targeted prevention and intervention strategies. Targeted interventions focusing on these high-risk groups are needed to reduce the burden of STIs in Surakarta, Indonesia.

Single-Dose Intralesional Bacillus Calmette-Guérin (BCG) Immunotherapy Induces Complete and Sustained Remission of Recalcitrant Anogenital Condylomata: A Mechanistic Case Series Azhar Arrosyid; Prasetyadi Mawardi; Endra Yustin Ellistasari; Ammarilis Murastami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1472

Background: Anogenital condylomata acuminata caused by Human Papillomavirus (HPV) presents a significant therapeutic challenge due to high recurrence rates after conventional cytodestructive therapies. Intralesional immunotherapy aims to induce a host-mediated immune response, offering a promising alternative. This report investigates the efficacy, safety, and immunological rationale of a novel, single-dose Bacillus Calmette-Guérin (BCG) protocol in an immunologically primed population. Methods: In this prospective case series, three immunocompetent patients with extensive, therapy-refractory anogenital condylomata were enrolled. Following a standardized protocol, each patient received a single, calculated intralesional injection of BCG vaccine into the largest index lesion. The primary outcome was complete clinical and dermoscopic clearance. Patients were evaluated at regular intervals for efficacy and safety over a 12-month follow-up period. Result: All three patients achieved complete clinical and dermoscopic clearance of both the injected and distant, untreated lesions within a rapid timeframe of 6 to 10 weeks. The treatment was well-tolerated, with adverse events limited to anticipated and transient local inflammatory reactions. No recurrences were documented in any patient during the 12-month follow-up period. Conclusion: Single-dose intralesional BCG immunotherapy appears to be a highly effective, durable, and safe therapeutic strategy for recalcitrant anogenital condylomata. The observed pan-lesional clearance strongly suggests the induction of a systemic, cell-mediated anti-HPV immune response. These compelling preliminary findings provide a strong rationale for validation through larger, randomized controlled trials.

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