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Analysis of Risk Factors and Body Mass Index Against Degrees of Severity of Psoriasis Vulgaris Lidjaja, Lifesia Natali; Muhammad Eko Irawanto; Nur Rachmat Mulianto; Arie Kusumawardani; Ivani; Vrenda Alia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1104

Background: Psoriasis vulgaris (PV) is a chronic inflammatory skin disease with a multifactorial etiology, including genetic, immunological, and environmental factors. Obesity, characterized by a high body mass index (BMI), has been increasingly recognized as a potential risk factor for PV and may influence its severity. This study aimed to analyze the relationship between various risk factors, particularly BMI, and the severity of PV. Methods: A cross-sectional study was conducted at a dermatology outpatient clinic of Dr. Moewardi Surakarta Hospital. Patients with a confirmed PV diagnosis were enrolled. Demographic data, medical history, lifestyle factors (smoking, alcohol consumption), and anthropometric measurements (height, weight, BMI) were collected. PV severity was assessed using the psoriasis area and severity index (PASI). Statistical analysis, including univariate and multivariate logistic regression, was performed to identify associations between risk factors and PV severity. Results: The study included 200 PV patients with a mean age of 45.2 years (SD = 12.8) and a male predominance (58%). The mean PASI score was 12.4 (SD = 8.6), indicating a wide range of disease severity. Multivariate analysis revealed that obesity (BMI ≥ 30 kg/m2) was significantly associated with increased PV severity (odds ratio [OR] = 2.8, 95% confidence interval [CI] = 1.5-5.2, p = 0.001). Smoking (OR = 1.9, 95% CI = 1.1-3.3, p = 0.02) and a family history of psoriasis (OR = 2.3, 95% CI = 1.3-4.1, p = 0.004) were also identified as independent risk factors for higher PASI scores. Alcohol consumption showed a borderline association with increased severity (OR = 1.6, 95% CI = 1.0-2.6, p = 0.05). Conclusion: Obesity, smoking, and a family history of psoriasis are significant risk factors for increased PV severity. These findings underscore the importance of addressing modifiable risk factors, such as weight management and smoking cessation, in the holistic management of PV. Further research is warranted to elucidate the underlying mechanisms linking these risk factors to PV severity and to develop targeted interventions to improve patient outcomes.

Sukralfat as a Therapy for Reducing Itching and Repairing the Skin Barrier: A Systematic Review Alia, Vrenda; Widhiati, Suci; Oktavriana, Triasari; Lidjaja, Lifesia Natali; Noviani, Laura
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1508

Sucralate is an aluminum salt from sucrose octasulfate that is known for its anti-ulcer activity, mucosal protection, and anti-mucositis potential. Recently, sucralfat has been used topically for the healing of various epithelial wounds, including ulcers, inflammatory dermatitis, mucositis, and burns. This systematic review aimed to evaluate the effectiveness of sucralfat as a topical therapy in reducing itching (pruritus) and improving the skin barrier. The analysis method used is Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). A literature search was conducted on studies from 2004 to 2024 using keywords such as "sucralfate", "pruritus", "dermatitis", and "skin barrier" on PubMed, ProQuest, Science Direct, and Scopus databases. Inclusion criteria include topic relevance, research design, human subjects, and United Kingdom-speaking studies. Of the 141 articles found, 7 articles met the inclusion criteria. These studies involved a total of 605 subjects from different countries and used clinical trial methods and randomized controlled trials. The results showed that topical sucralfat was effective in reducing itching and improving the skin barrier in various skin conditions such as diaper dermatitis, chronic ulcers, and postoperative wounds. Sukralfat shows great potential in wound healing and skin barrier repair through the mechanism of protective layer formation, increased expression of epidermal growth factors, and anti-inflammatory properties. This effect indirectly helps reduce pruritus which often occurs due to damage to the skin barrier. Topical succulthate is effective in reducing itching and repairing the skin barrier, making it a promising therapy for a variety of inflammatory and ulcerative skin conditions.

Profile of Generalized Pustular Psoriasis Inpatient Installation at Dr. Moewardi General Hospital Surakarta from January 2018-December 2022 Hidayati, Nurul; Mulianto, Nurrachmat; Noviani, Laura; Lidjaja, Lifesia Natali
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1584

Generalized pustular psoriasis (GPP) is a form of psoriasis characterised by the presence of sterile pustules. Its prevalence is between 2 and 3.5% of the population worldwide and in Indonesia it is 2.5% of the population. It can cause severe physical and psychosocial distress affecting the patient's quality of life. Objective: To describe the profile of GPP patients treated in the inpatient installation of Dr. Moewardi Hospital, Surakarta in the period of January 2018-December 2022. A retrospective descriptive study was conducted using the secondary data of medical records of GPP patients treated in the inpatient installation of Dr. Moewardi Hospital from January 2018 to December 2022. Results: In the 5-year period, there were 23 GPP inpatients, predominated by female (78.26%) with the age ranged from 5 to 74 years old. Generalised pustular psoriasis mostly affected the age group of 41- 50 years old (26.04%). Most patients were hospitalized for 6–10 days (39.13%). The most common therapy was immunosuppressant (65.2%) followed by oral corticosteroids (26.1%) and zinc (17.4%). Most patients also received moisturizer therapy (56.5%). Generalised pustular psoriasis mostly affects people aged between 41 and 50 years old. Females are more prone to GPP. The therapy given are oral immunosuppressive regimens, oral corticosteroids, zinc, topical corticosteroids and moisturizers.

Investigating The Impact of Pruritus on The Quality of Life of the Elderly in Surakarta Nursing Home Oktavriana, Triasari; Mawardi, Prasetyadi; Murastami, Ammarilis; Murasmita, Alamanda; Pradestine, Sesia; Putri, Osdatilla Esa; Lidjaja, Lifesia Natali; Alia, Vrenda; Kusumasari, Nila
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1641

Background: The elderly population has been growing rapidly in recent decades. Research has shown that the prevalence of itching (pruritus) increases with age, with 20.8% of individuals aged 60-69 years experiencing it, 22.9% for those aged 70-79 years, and 26% for those aged 75 years and above. Assessing the skin's barrier function by measuring transepidermal water loss (TEWL) using a tool called a Tewameter is important for objectively evaluating dry skin, which is the most common cause of itching in the elderly. It's important to understand how itching affects the quality of life of the elderly, particularly in nursing homes. Objective: This study aims to determine how itching affects the quality of life of the elderly in nursing homes in Surakarta City, especially at PMI Peduli and Aisyiyah Nursing Homes. Methods: This research used an observational, cross-sectional design. Data was collected through interviews using the 5D itch scale questionnaire, and the quality of life was measured using the DLQI (Dermatology Life Quality Index) questionnaire. TEWL levels were also measured using a Tewameter. Results: 29 subjects participated in the interviews, with 69% being women and 31% being men. Most subjects were aged 60-69 years (41%), and the most common comorbidity was hypertension (41%). The 5D Itch Scale questionnaire revealed that itching affected the subjects for less than 6 hours daily (66%), and during the last 2 weeks, itching did not significantly impact the subjects' activities, including sleep, hobbies, housework, and work (51%-69%). The most common location of itching was the back (14%). The DLQI data showed that itching had a severe impact on the subjects (65.5%), followed by a moderate impact (24.1%), and a very severe impact (10.3%). TEWL data indicated that all subjects had an increase of >10 g/h/m2. Conclusion: The study found that itching had a mild impact on the lives and activities of the subjects in general, lasting for less than 6 hours a day. The statistical results showed a positive and significant relationship between the intensity of itching and the quality of life of the elderly with pruritus.

Profile of Skin Diseases in The Ederley at Nursing House Surakarta Mawardi, Prasetyadi; Oktavriana, Triasari; Murastami, Ammarilis; Murasmita, Alamanda; Pradestine, Sesia; Esa Putri, Osdatilla Esa; Lidjaja, Lifesia Natali; Alia, Vrenda; Kusumasari, Nila
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1640

Background: The elderly population has been rapidly increasing over the past few decades. In Indonesia, the percentage of elderly residents is 8.75% of the total population. Aging is an unavoidable process, but it requires care to ensure a good quality of life for the elderly. One of the issues affecting the quality of life in the elderly is skin aging. Skin aging causes various complaints, especially itching or pruritus, which can reduce the quality of life for the elderly. Knowledge of the pathophysiology of skin diseases and skin aging, as well as the factors that affect them, particularly skin hydration, is necessary. This research is expected to be beneficial for medical professionals as well as family members of the elderly. The elderly residents at Wreda Griya PMI Peduli and Aisyiyah Nursing Home come from various regions and economic backgrounds. Therefore, the researchers consider the nursing home to be an appropriate place to conduct this study, as it can represent the elderly population from diverse backgrounds across Indonesia.Objective: This study aims to analyze the various skin disease profiles at the Griya PMI Peduli and Aisyiyah nursing homes in the city of Surakarta. Methods: This type of research is a survey using an observational study method with a descriptive design. Results: There were a total of 45 subjects at the Wreda PMI Peduli and Aisyiyah Nursing Home in Surakarta. Among them, 34 subjects had skin complaints, while 11 subjects were excluded because they did not have any skin complaints (7 subjects) or were uncooperative (4 subjects). The most common diagnosis was xerosis cutis (53%). The majority of patients did not have comorbidities (65%), with the most common comorbidity being hypertension (26%). Conclusion: The results of this study indicate that all the main skin complaints among the elderly at Panti Wreda in Kota Surakarta were dominated by itching or pruritus, with xerosis cutis being the primary etiology of pruritus in the elderly subjects of the study, accounting for 53%.

Prevalence and Risk Factors of Sexually Transmitted Infections in a Tertiary Hospital in Surakarta, Indonesia Lidjaja, Lifesia Natali; Ammarilis Murastami; Endra Yustin Ellistasari; Ivani; Vrenda Alia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1195

Background: Sexually transmitted infections (STIs) remain a significant public health concern globally, with millions of new cases occurring annually. Understanding the prevalence and risk factors associated with STIs is crucial for effective prevention and control programs. This study aimed to investigate the prevalence and risk factors of STIs among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital, a tertiary hospital in Surakarta, Indonesia. Methods: A retrospective descriptive study was conducted using secondary data from medical records of patients diagnosed with STIs between January 2020 and December 2023. Data collected included sociodemographic characteristics, sexual behaviors, clinical diagnoses, and HIV status. Descriptive statistics and chi-square analysis were used to analyze the data. Results: A total of 249 patients were diagnosed with STIs during the study period. The most common STI was condyloma acuminata (51%), followed by male genital discharge (18.1%), female vaginal discharge (16%), other STIs (10.9%), and genital ulcers (4%). The majority of patients were male (62.2%), aged 25-44 years (49.1%), had a high school education (49.5%), and reported heterosexual orientation (67.1%). Multiple sexual partners were reported by 62.7% of the participants, and 36.1% were HIV positive. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Conclusion: Condyloma acuminata was the most prevalent STI among patients attending the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi General Hospital. The correlation analysis reveals that various sociodemographic, behavioral, and health-related factors are associated with different STIs. Understanding these correlations can help healthcare providers identify individuals at higher risk for specific STIs and implement targeted prevention and intervention strategies. Targeted interventions focusing on these high-risk groups are needed to reduce the burden of STIs in Surakarta, Indonesia.

Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Study on Causative Agents and Patient Profiles in an Indonesian Hospital Setting Nurrachmat Mulianto; Lidjaja, Lifesia Natali
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1327

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent rare, severe mucocutaneous adverse drug reactions characterized by extensive epidermal necrosis and significant morbidity and mortality. Understanding the specific causative agents and patient profiles within local populations is crucial for early diagnosis and management. This study aimed to characterize SJS/TEN cases in a tertiary hospital setting in Indonesia. Methods: A retrospective descriptive study was conducted using secondary data from medical records of patients diagnosed with SJS, SJS/TEN overlap, and TEN admitted to the inpatient installation of Dr. Moewardi General Hospital, Surakarta, Indonesia, between January 2022 and December 2024. Data collected included demographics (age, gender), comorbidities, diagnosis classification (SJS, SJS/TEN overlap, TEN), suspected causative drugs, length of hospital stay, SCORTEN score, and patient outcome (discharged alive or deceased). Total sampling was employed, excluding records with incomplete data. Data were compiled and analyzed descriptively. Results: Fifty-one patients were included, with a slight female predominance (52.94%). The largest age group affected was 19-59 years (60.78%). The distribution of diagnoses was SJS (41.18%), SJS/TEN overlap (31.37%), and TEN (27.45%). The mean SCORTEN score for the cohort was 2. The most common suspected causative drug classes were antibiotics (25.71%), followed by analgesic-antipyretics (24.29%), and anticonvulsants (22.86%). Carbamazepine (11.43%) and amoxicillin (10%) were frequent individual culprits. Epilepsy (13.73%) and diabetes mellitus (11.76%) were common comorbidities, although a significant portion (33.33%) had no recorded comorbidity. The mean length of stay was 9 days. Overall mortality was 15.68%, with higher rates observed in TEN (28.57%) compared to SJS (9.52%) and SJS/TEN overlap (12.5%). Conclusion: SJS/TEN affected predominantly adults, with antibiotics, analgesics, and anticonvulsants being the most implicated drug classes. While mortality was considerable, it appeared lower than some international reports, particularly for TEN. Recognizing common causative agents and patient risk factors, such as specific comorbidities like epilepsy and diabetes, can aid clinicians in early identification and prompt management of these life-threatening conditions.

Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Retrospective Study on Causative Agents and Patient Profiles in an Indonesian Hospital Setting Nurrachmat Mulianto; Lidjaja, Lifesia Natali
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1327

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent rare, severe mucocutaneous adverse drug reactions characterized by extensive epidermal necrosis and significant morbidity and mortality. Understanding the specific causative agents and patient profiles within local populations is crucial for early diagnosis and management. This study aimed to characterize SJS/TEN cases in a tertiary hospital setting in Indonesia. Methods: A retrospective descriptive study was conducted using secondary data from medical records of patients diagnosed with SJS, SJS/TEN overlap, and TEN admitted to the inpatient installation of Dr. Moewardi General Hospital, Surakarta, Indonesia, between January 2022 and December 2024. Data collected included demographics (age, gender), comorbidities, diagnosis classification (SJS, SJS/TEN overlap, TEN), suspected causative drugs, length of hospital stay, SCORTEN score, and patient outcome (discharged alive or deceased). Total sampling was employed, excluding records with incomplete data. Data were compiled and analyzed descriptively. Results: Fifty-one patients were included, with a slight female predominance (52.94%). The largest age group affected was 19-59 years (60.78%). The distribution of diagnoses was SJS (41.18%), SJS/TEN overlap (31.37%), and TEN (27.45%). The mean SCORTEN score for the cohort was 2. The most common suspected causative drug classes were antibiotics (25.71%), followed by analgesic-antipyretics (24.29%), and anticonvulsants (22.86%). Carbamazepine (11.43%) and amoxicillin (10%) were frequent individual culprits. Epilepsy (13.73%) and diabetes mellitus (11.76%) were common comorbidities, although a significant portion (33.33%) had no recorded comorbidity. The mean length of stay was 9 days. Overall mortality was 15.68%, with higher rates observed in TEN (28.57%) compared to SJS (9.52%) and SJS/TEN overlap (12.5%). Conclusion: SJS/TEN affected predominantly adults, with antibiotics, analgesics, and anticonvulsants being the most implicated drug classes. While mortality was considerable, it appeared lower than some international reports, particularly for TEN. Recognizing common causative agents and patient risk factors, such as specific comorbidities like epilepsy and diabetes, can aid clinicians in early identification and prompt management of these life-threatening conditions.

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