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All Journal E-Jurnal Medika Udayana e-CliniC JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Cancer
Setiawan, I Gede Budhi
Divisi Bedah Onkologi, Departemen Ilmu Bedah, Fakultas Kedokteran Universitas Udayana, RSUP Prof Dr. I.G.N.G. Ngoerah, Denpasar
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KUALITAS HIDUP PASIEN KANKER KEPALA DAN LEHER DI RSUP SANGLAH Nirmala, Made Sinta Ayu Suci; Tusta Adiputra, Putu Anda; Setiawan, I Gede Budhi; Yuniawaty Wetan, Ni Gusti Ayu Agung Manik
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P02

Abstract

Head and neck cancer ranked as the fifth most common cancer in the world. A series of treatment is likely to cause changes in the quality of life in cancer patients. This study aims to determine the factors that affect the patient's quality of life and the relationship between EORTC QLQ-H&N35 and Karnofsky Performance Scale (KPS). This study is analytic with a cross sectional approach. The technique is total sampling adjusted to the inclusion and exclusion criteria. Data obtained were gender, age, anatomical location of head and neck cancer, stage of cancer, therapy, KPS, and EORTC QLQ-H&N35. Data was collected for 3 months and 45 samples were obtained. There were 24 patients ((53.3%) above 45 years old. 33 men (73.3%) and 12 women (26.7%). The most cases were nasopharyngeal cancer is 25 people (55.6%). A total of 19 patients (42.2%) were in stage IV. The most used therapies were surgery, chemotherapy, and radiotherapy is 19 people (41.3%). The mean KPS is 72.23 ± 16.992. The factor affect the quality of life of head and neck cancer patients the most is weight loss with a mean of 59.49 ± 49.989 and a significant correlation (p=0.000, p<0.05) between EORTC QLQ-H&N35 and KPS.
Gambaran Karakteristik Kanker Payudara Metastasis Berdasarkan Subtipe Molekuler di RSUP Sanglah Tahun 2014- 2019 Bernadette, Natasha Lumongga; Setiawan, I Gede Budhi; Suryawisesa, IB Made Made; Wetan, Ni G.A.A. Manik Yuniawaty
E-Jurnal Medika Udayana Vol 11 No 2 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i02.P07

Abstract

ABSTRAK Angka kejadian kanker payudara meningkat setiap tahunnya. Subtipe molekuler merupakan prediktor yang baik dalam memprediksi kejadian metastasis. Studi Epidemiologi ini dilakukan untuk mempelajari karakteristik pasien kasus kanker payudara di Indonesia, khususnya di Rumah Sakit Umum Pusat Sanglah, Denpasar selama periode 2014-2019. Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan potong lintang. Penelitian ini menggunakan data sekunder Cancer Registry Perhimpunan Ahli Bedah Onkologi Indonesia (PERABOI), Divisi Bedah Onkologi RSUP Sanglah. Metode pengambilan sampel adalah total sampling. Dari 161 sampel kasus kanker payudara metastasis diperoleh hasil kejadian metastasis kanker payudara paling banyak mengalami metastasis ke paru-paru yaitu sebanyak 108 kasus (48,9%). Kejadian metastasis kanker payudara paling banyak dialami oleh pasien dengan subtipe molekuler Luminal B-positif yaitu sebanyak 45 kasus (28%). Pasien dengan metastasis tulang cenderung memiliki subtipe molekuler Luminal B-positif yaitu sebanyak 19 (32,2%). Pasien dengan metastasis paru-paru cenderung memiliki subtipe molekuler HER2+ yaitu sebanyak 28 (14,2%). Pasien dengan metastasis otak cenderung memiliki subtipe molekuler HER2+ yaitu sebanyak 6 (50%). Pasien dengan metastasis liver, cenderung memiliki subtipe molekuler HER2+ dan Luminal B-positif yaitu sebanyak 11 kasus (26,2%). Hasil penelitian ini dapat digunakan sebagai dasar penelitian lebih lanjut untuk mempelajari kejadian kanker payudara metastasis. Kata kunci : Kanker Payudara Metasasis, Organ Metasastasis, Subtipe Molekuler
High Hypoxia Inducible Factor-1α Expression and Positive Limphovascular Invasion as Risk Factors for Axillary Lymph Nodes Metastasis in Breast Cancer Setiawan, I Gede Budhi; Suanjaya, Made Agus; Suryawisesa, IB Made
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1302

Abstract

Background: Hypoxia-inducible factor-1α (HIF-1α) expression enables tumor cell proliferation and has a role in the processes of epithelial-mesenchymal transition, invasion, extravasation, and metastasis. Lymphovascular Invasion (LVI) causes a significant increase in the occurrence of axilla lymph node metastasis. This study aims to prove that high HIF-1α expression and LVI (+) as risk factors for axillary lymph node metastasis in breast cancer. Method: The study conducted was a case-control study involving all histopathologically confirmed breast cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital during the period from January 2019 to December 2022. In this study, the case group consisted of patients with breast cancer and axilla lymph node (+), while the control group included breast cancer patients without these characteristics. Data analysis was processed using SPSS version 26, which included descriptive statistical analysis, proportion comparison tests, and multiple logistic regression tests, with significance set at p 0.05.Results: LVI (+) has a risk of metastasis to lymph nodes (+) of 6 times (95% CI 1.53–23.44, P = 0.007) and adjusted OR 4.33 (95% CI 2.369–6.053; P = 0.025). The results of the HIF1-α ROC curve obtained a sensitivity value of 86.4% and specificity of 79.2% with a cut-off value of 5.4. A score ≥ 5.4 has a risk of metastasis to lymph nodes (+) of 24.01 times (95% CI 5.03–115.25; P 0.001) and adjusted OR 24.06 (95% CI 5.026–115.247; p 0.001). Conclusion: High HIF-1α expression and positive lymphovascular invasion as risk factors for axillary lymph node metastasis in breast cancer, with HIF-1α showing a particularly strong association. These findings suggest their potential as predictive biomarkers for metastasis. However, the study’s retrospective, single-center design limits generalizability. Future research should validate these results in larger, multicenter cohorts and explore the underlying mechanism to enhance clinical application.
Co-Authors Aqilah, Nadya Zalfa Bernadette, Natasha Lumongga Caryl Augustine Johanna Dewa Ayu Karunia Dewi Eka Wiratnaya Gede Sukma Pranata Darma Gusti Agung Made Siddhi Putra I Gde Raka Widiana I Gusti Ngurah Ari Aditya Satriya Wibawa I Gusti Ngurah Wien Aryana I Ketut Widiana I W. Sudarsa I. B. Tjakra Wibawa Manuaba Ida Bagus Made Suryawisesa Khema Metta Wijaya L. K. Widnyani Wulan Laksmi Larasati, Made Syanindita Putri Made Agus Suanjaya Made Karina Duta Dwijayanti Made Surya Dharmawan Manuaba, Ida Bagus Tjakra Wibawa Ni Putu Diah Rakasiwi Ni Putu Sriwidyani Nirmala, Made Sinta Ayu Suci Pradnyaswari, Kadek Enny Putra, Putu Krishna B. S. Putu Anda Tusta Adiputra Ronald Natawidjaja Soraya Juventia Primadanti Sri Maliawan Sumadi, I Wayan J. Suryawisesa, IB Made Suryawisesa, IB Made Made Tiara Awidia Damayanti Wetan, Ni G.A.A. Manik Yuniawaty Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wien Aryana, I Gusti Ngurah Yuniawaty Wetan, Ni Gusti Ayu Agung Manik