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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan JURNAL FARMASIMED (JFM) International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengmas Kestra (JPK) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Novidawati Boru Situmorang
Institut Kesehatan Medistra Lubuk Pakam
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation

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Formulation and Evaluation of Maggot Extract Nanocream (Hermatia illucens) as a Future Anti-Aging Candidate Situmorang, Novidawati Boru; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2399

Abstract

Background: Premature aging is a serious problem, especially for women. Skin aging is mainly caused by solar radiation. Ultraviolet (UV) A and B rays from sunlight induce the formation of reactive oxygen species in the skin and cause oxidation. Antioxidants are compounds that can neutralize free radicals by slowing down oxidation reactions. Maggots are widely consumed by the public and used as topical medicines because they have high levels of lauric acid, which acts as an anti-inflammatory, antibacterial, and antiprotozoal. Purpose: to analyze the formulation of nanocream preparations, antioxidant activity and evaluate the physical stability of maggot extract nanocream. Research method: The method used was the maceration method with n-hexane, antioxidant testing using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method, and testing the physical stability of the preparation. The results of the antioxidant activity test showed an IC50 value of maggot extract of 40.36 ± 1.21 µg / mL. Results: It shows that the sample has very strong antioxidant activity. Based on the organoleptic test, the nanoceram preparation in Formula 1, 2, 3 and 4 has a milky white color which is influenced by the difference in the amount of extract, a distinctive aroma and semi-solid consistency. The pH examination of nanocream preparation must be adjusted to the skin pH, which is 5-7. The results of the viscosity test on the maggot extract have met the requirements, which are 2,000-5,000 cps. Conclusion: formulation and evaluation of the nanocream extract meet the requirements as a good nanocream and have the ability as an anti-aging.
Aktivitas Antihiperurisemia Ekstrak Etanol Biji Mahoni (Swietenia macrophylla) Terhadap Tikus Jantan Situmorang, Novidawati Boru; Dakhi, Juniaro Virgilius; Marbun, Romauli Anna Teresia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 1 (2022): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3392

Abstract

Asam Urat merupakan penyakit yang paling banyak dialami oleh masyarakat Indonesia. Allopurinol sebagai inhibitor spesifik dari enzim canthin oksidasi (XO) terbukti efektif dalam menurunkan kadar asam urat, tetapi efek sampingnya dapat menyebabkan gagal hati, hepatitis, hiperbilirubinemi, diare serta mual muntah. Penelitian ini bertujuan untuk mengetahui potensi pemberian Ekstrak Etanol Biji Mahoni (EEBM) (Swientenia macrophylla) terhadap penururnan kadar asam urat pada tikus. Metode penelitian secara in vivo dengan penginduksi potassium oxonate dan jus hati ayam pada tikus. Sebanyak 5 kelompok tikus (Na-CMC 0,5%, tablet Allopurinol 3,6 mg/kgBB, EEBM (125, 250,375 mg/kgBB)) dilakukan selama 14 hari. Hasil uji ANOVA (p<0,05) menunjukkan adanya perbedaan rerata yang bermakna antara pretes 9,980 mg/dL dan postes  6,612 mg/dL sehingga EEBM berpotensi terhadapat penurunan kadar asam urat dalam darah tikus dengan jumlah rata-rata penurunan 3,392 mg/dL. Penurunan kadar asam urat tersebut diduga karena adanya kandungan senyawa flavonoid. Senyawa tersebut merupakan inhibitor xantin oksidase terkuat karena disebabkan oleh adanya gugus hidroksil C5 dan C7 selain itu, disebabkan juga oleh adanya C2 dan C3 sehingga lebih memudahkan interaksi dengan xantin oksidase. Mekanisme utama dari flavonoid berupa aktifitas inhibitor enzim dan antioksidan untuk radikal bebas.
Phytochemical Screening And Test For Reducing Uric Acid Levels In Male Rats After Administration Of Ethanol Extract Of The Herb Binara (Artemisia vulgaris L.) Situmorang, Novidawati Boru; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.868

Abstract

Hyperuricemia is a metabolic disease generally characterized by high uric acid levels in the blood. The general treatment strategy for hyperuricemia is to decrease uric acid production using xanthine oxidation reductase inhibitors such as allopurinol and uricosuric agents. However, the drugs showed side effects, including skin rashes, diarrhoea and liver damage. To overcome the side effects of synthetic drugs, alternatives are used, namely by researching to find plants that have activity in reducing uric acid levels. The activity of reducing uric acid levels in plants is likely due to the presence of flavonoid compounds as antioxidants. Flavonoids active in reducing uric acid levels are kaempferol through xanthine oxidase inhibitors. Quercetin also has the potential to reduce uric acid levels through inhibition of the xanthine oxidase enzyme. Binara plant (Artemisia vulgaris L.) has flavonoids, tannins, alkaloids, glycosides and saponins which have potential as antioxidants and analgesics, anti-inflammatory, immunomodulating, and hepatoprotective, through secondary metabolites of flavonoids, terpenes, and phenolic acids. The Karo people have traditionally used Binara leaves to treat wounds, diarrhoea and heartburn by chewing some of the leaves and then placing them on the wounds outside the body, such as cuts and for diarrhoea and stomach ulcers and placing them around the sick stomach. This study was conducted to know the anti-hyperuricemia effect of the Ethanol Extract of Herba Binara (Artemisia vulgaris L.) on gout rats; phytochemical screening was carried out first to determine the content of Herba Binara (Artemisia vulgaris L.) compounds. The results showed that Herb Binara fulfilled the simplicia characterization requirements and contained secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, saponins and steroids. Herb Binara Ethanol Extract has been shown to reduce uric acid levels in hyperuricemia rats, with the best concentrations being 400 and 800 mg/kg body weight. This was based on significantly different results p>0.05 compared to the positive control group.
Optimization of the Preventive Potential of Andaliman (Zanthoxylum acanthopodium DC) as a Natural Biofilter Against Cigarette SmokeExposure Through TNF-α Expression Novidawati Boru Situmorang; Andy Febriady
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d1tsbq73

Abstract

Background: Indonesia ranks third in the world for the highest smoking prevalence after China and India. Smokers often smoke both indoors and outdoors, exposing others to harmful cigarette smoke. Cigarette smoke can trigger oxidative stress, which induces the release of pro-inflammatory cytokines such as Tumor Necrosis Factor (TNF-α). Objective: This study aimed to analyze the optimization of andaliman (Zanthoxylum acanthopodium DC) as a natural biofilter against cigarette smoke exposure through TNF-α expression as a potential preventive measure. Methods: An experimental method was used by measuring TNF-α expression in serum isolated from mice blood using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: TNF-α levels measured by ELISA showed that andaliman extract at doses of 50–400 mg/kg body weight significantly reduced TNF-α levels in mice exposed to cigarette smoke compared to the negative control group (p < 0.05). This reduction is likely related to the presence of flavonoids and alkaloids in andaliman, which act as antioxidants and immunomodulators that inhibit inflammatory pathways triggered by oxidative stress from cigarette smoke. With its anti-inflammatory potential, andaliman can be developed as an eco-friendly natural biofilter to prevent the harmful effects of cigarette smoke, although further studies are needed regarding its optimal dosage and long-term safety. Conclusion: Andaliman extract (Zanthoxylum acanthopodium DC) effectively reduced TNF-α levels in mice exposed to cigarette smoke, demonstrating anti-inflammatory potential as a natural biofilter. Its flavonoid and alkaloid content act as antioxidants and immunomodulators that suppress inflammatory pathways induced by cigarette smoke toxins. Andaliman shows promise as an environmentally friendly natural preventive agent to mitigate the negative impacts of cigarette smoke exposure.
The Effect of Administering Ethanol Extract of Tempuyung Leaves(Sonchus arvensis L.) on Decreasing Uric Acid LevelsIn Mile Mice Novidawati Boru Situmorang; Azahra Salsabila Mahriza
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/ak6ez231

Abstract

Background: When serum uric acid levels are higher than normal, this condition is known as hyperuricemia. This condition is caused by increased breakdown of nucleic acids, decreased excretion, increased production of uric acid from purine-rich foods, or a combination of these. In traditional Indonesian medicine, tempuyung leaves (Sonchus arvensis L.) have traditionally been used to treat various diseases, including gout and kidney stones. Methods: Antihyperuricemic activity tests were conducted on 24 mice divided into six treatment groups. Hyperuricemia was induced by oral administration of chicken liver juice at a rate of 0.5 mL/20 gBW. Results: From days 1-6 after induction, uric acid levels in the test group increased progressively. In addition, the groups treated with allopurinol, 0.5% Na-CMC, and ethanol extract of tempuyung leaves (EEDT) at doses of 100, 300, and 500 mg/kgBW showed a decrease in uric acid levels on days 7 to 13. At doses of 500 mg/kgBW, 300 mg/kgBW, and 100 mg/kgBW, the allopurinol group experienced the greatest reduction, followed by the EEDT group. Conclusion: After allopurinol, the 500 mg/kgBW dose had the best antihyperuricemic efficacy, based on the percentage reduction in uric acid levels. Because the extract contains a large number of secondary metabolites, increasing the extract dose decreased the increase in effectiveness.
Socialization and Education on the Utilization of Binara Herb (Artemisia vulgaris L.) as a Herbal Anti-Aging Cosmetic Ingredient Romauli Anna Marbun; Ratih Anggraeni; Yanna Rotua Sihombing; Novidawati Boru Situmorang; Cucu Arum Dwi Cahya
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/40epy157

Abstract

Background: Premature aging is a common skin health problem caused by exposure to ultraviolet radiation, pollution, and free radicals. Antioxidants play an important role in preventing skin damage by neutralizing free radicals that contribute to premature aging. Binara herb (Artemisia vulgaris  L.) is known to contain flavonoids and other bioactive compounds with strong antioxidant activity. Previous studies have shown that the ethanolic extract of binara herb formulated as a Nanocream exhibits high antioxidant activity, good physical stability, and is safe for topical application. However, information regarding the potential of binara herb as a herbal anti-aging candidate remains limited among the public and students. Objective: his community service activity aimed to provide socialization and education regarding the utilization of Nanocream containing binara herb extract as a safe and innovative natural-based anti-aging product candidate. Methods: The activity was conducted through an online educational program involving students of the Pharmacy Study Program at the Medistra Institute of Health, Lubuk Pakam. Participants’ knowledge was evaluated using pre-test and post-test questionnaires. Results: The educational materials covered the antioxidant benefits of binara herb, the concept of Nanocream, findings from anti-aging activity studies, product safety, and the potential development of herbal cosmetic products based on nanotechnology. The evaluation results showed that more than 90% of participants understood the benefits of binara herb as a natural antioxidant source and recognized the potential of Nanocream as a future anti-aging formulation. The success indicator of the activity was achieved, with more than 80% of participants obtaining post-test scores above 75. Conclusion: The educational and socialization program successfully improved students’ knowledge regarding the utilization of Nanocream containing binara herb extract as a natural-based anti-aging candidate. The students also demonstrated interest in conducting further research related to the development of herbal cosmetics and nanotechnology applications in the pharmaceutical field.
Co-Authors Aminah Aminah Andy Febriady Azahra Salsabila Mahriza Cahya, Cucu Arum Dwi Dakhi, Juniaro Virgilius Fatima, Nurdilla Gabena Siregar, Mas Iskandar Markus Sembiring Juniaro Virgilius Dakhi Monica Marpaung, Dorima Octora, Debi Dinha Poppy Anjelisa Z. Hasibuan Pranata, Chandra Purba, Rosa Aldora Ramadhani, Lili Ratih Anggraeni Romaulianna Theresia Marbun Sinulingga, Amanda Safithri Syarifuddin, Aminah Nur Urip Harahap Widya Ningsih, Silvia Yanna Rotua Sihombing