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All Journal International Journal of Biosciences and Biotechnology Indonesian Journal of Pharmaceutical Science and Technology WIDYABHAKTI Jurnal Ilmiah Populer Manuju : Malahayati Nursing Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Medicamento Jurnal Pengabdian kepada Masyarakat COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Eduvest - Journal of Universal Studies Glosains: Jurnal Sains Global Indonesia
Puguh Santoso
Universitas Mahasaraswati Denpasar
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Skrining Fitokimia, Formulasi dan Antioksidan Sediaan Granul Effervescent Ekstrak N-Butanol Buah Dewandaru (Eugenia uniflora L.) Puguh Santoso; Debby Juliadi; Ni Nyoman Wahyu Udayani; I Putu Pasek Jaya Separsa; Ida Ayu Gede Syntya Mahayani; I Gede Yodhi Trismawan
Malahayati Nursing Journal Vol 5, No 2 (2023): Volume 5 Nomor 2 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v5i2.7509

Abstract

ABSTRAK Kandungan metabolit sekunder tanaman yang berkhasiat obat sebagai acuan pemanfaatan untuk membuat sebuah produk, Dewandaru (Eugenia uniflora L), merupakan salah satu tanaman daerah tropis yang belum banyak di gali dan di manfaatkan secara ilmiah. Tujuan penelitian ini  mengetahui metabolit sekunder, uji mutu fisik sediaan effervescent dan uji antioksidan ekstrak buah buah Dewandaru. Metode penelitian eksperimenal ini menujukkan bahwa hasil metabolit sekunder ekstrak n- butanol buah Dewandaru menunjukkan adanya senyawa alkaloid, tannin, flavonoid, dan saponin, hasil uji mutu fisik sdiaan effervescent menunjukkan mutu fisik yang baik di semua jenis pengujian, Pada pengujian pH, sediaan memiliki pH 6. Dari hasil penelitian yang telah dilakukan maka dapat disimpulkan bahwa sediaan granul effervescent memiliki mutu fisik yang baik, uji antioksidan formula effervescent mendapatkan hasil 21,196 ppm.  Termasuk antiosidan yang sangat kuat. Kata Kunci: Antioksidan, Efervescent, Mutu Fisik, Skrining  ABSTRACT The content of secondary metabolites of plants that have medicinal properties as a reference for use to make a product, Dewandaru (Eugenia uniflora L), is one of the tropical plants that has not been widely explored and used scientifically. The purpose of this study was to determine secondary metabolites, test the physical quality of effervescent preparations and test the antioxidants of Dewandaru fruit extracts. This experimental research method showed that the results of secondary metabolites of the n-butanol extract of Dewandaru fruit showed the presence of alkaloids, tannins, flavonoids, and saponins, the results of the physical quality test of effervescent preparations showed good physical quality in all types of tests. 5. From the results of the research that has been done, it can be concluded that the effervescent granule preparation has good physical quality, the antioxidant test of the effervescent formula obtained 21.196 ppm results. Including very strong antioxidants. Keywords: Antioxidant, Effervescent, Physical Quality, Screening
Uji Iritasi dan Aktivitas Penumbuh Rambut Hair Tonic dari Tanaman Usada Bali pada Mencit Putu Era Sandhi Kusuma Yuda; Puguh Santoso; Erna Cahyaningsih; Gusti Ayu Made Indah Siantari
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5502

Abstract

The existence of side effects from drugs used for hair loss treatment urges the need for safer alternatives, especially from natural ingredients. The purpose of this study was to determine the effectiveness and safety of hair tonic from Usada Bali (containing Polycias scutellaria, Hibiscus tiliaceus, Trigonella foenum graecum, and Cananga odorata) in mice. Experimental animals were divided into four groups: negative control was given a carrier fluid, positive control was given hair tonic on the market, and the treatment group was given hair tonic with simplicia concentration of 10% and 20%. Hair length was measured on days 7 and 21 with the treatment given daily topically on the backs of shaved mice. The irritation test was carried out at 24 and 48 hours. The data obtained were tested statistically by ANOVA test followed by Tukey's test with 95% confidence level. The results showed that the hair tonic formula contained alkaloids, flavonoids, saponins, tannins and triterpenoids. The irritation test did not show any irritation on the skin of the mice. The hair growth activity test of the herbal hair tonic formula combination of Polycias scutellaria leaf, Hibiscus tiliaceus leaf, Trigonella foenum graecum seed and Cananga odorata flower showed significantly faster hair growth than the negative control at both concentrations and not significantly different from the positive control. This hair tonic formula has the potential to be developed into a natural hair growth agent without irritation to the skin.
Molecular docking activity of peristrophe bivalvis on non small cell lung cancer Puguh Santoso; Ketut Agus Adrianta; Agung Ari Chandra Wibawa; I Wayan Suardi Adi Gunawan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1505.7 KB) | DOI: 10.30604/jika.v8i2.1935

Abstract

Cancer is a genetic disease in which cells are unable to control their functions normally. As cancer develops, old cells will survive when they should die, and new cells will grow when they are not needed. These extra cells can divide endlessly and can form growths called tumors . This research was carried out to know whether peristrophine, apioside, and pelargonidin 3-Sambubioside compounds could be developed as a drug in Non-Small Cell Lung Cancer (NSCLC) with the in silico method at the ROS1 receptor with the Protein Data Bank code 3ZBF with the native ligand crizotinib. Peristrophine, apioside, and pelargonidin 3-Sambubioside compounds have an affinity for ROS1 protein with binding energies of -6.12 kcal/mol on peristrophine, -6.74 kcal/mol on apioside, and -7.54 kcal/mol of pelargonidin 3-Sambubioside. Peristrophine, apioside, and pelargonidin 3-Sambubioside have a molecular mechanism in inhibiting ROS1 in Non-Small Cell Lung Cancer (NSCLC) through the formation of hydrogen bonds in the protein ROS1. From Lipinski's analysis, the peristrophine test compound has met the requirements and seen from the LD50 value of the peristrophine test compound, apioside and pelargonidin 3-Sambubioside has the same toxicity class as the comparison compound, namely crizotinib at class 4 toxicity.
The Effect of n-Butanol Extract of Dewandaru Fruit (Eugenia uniflora L.) on the Leukocyte Count in Mice Exposed to Cigarette Smoke Puguh Santoso; Ni Putu Febi Andani
Eduvest - Journal of Universal Studies Vol. 6 No. 5 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i5.53082

Abstract

Dewandaru (Eugenia uniflora L.) is a medicinal plant that has been widely used in traditional medicine. Cigarettes are addictive substances that pose a significant threat to health and life sustainability. The principal toxic constituents of cigarettes are nicotine, tar, and carbon monoxide (CO). Long-term smoking can increase the total leukocyte count, particularly the number of polymorphonuclear neutrophils (PMN) in the peripheral blood circulation, due to free radical generation and inflammatory reactions. Dewandaru fruit (Eugenia uniflora L.) contains antioxidant and anti-inflammatory compounds that may inhibit leukocyte activation induced by oxidative stress associated with cigarette smoke exposure, thereby contributing to a reduction in the total leukocyte count. This study employed an experimental design with a posttest-only control group, using a sample of 30 male mice (Mus musculus) divided into three groups. Group I served as the negative control and received cigarette smoke exposure and distilled water. Groups II and III were designated as treatment groups and received 30 minutes of cigarette smoke exposure per day for 30 days, along with oral administration of n-butanol extract of dewandaru fruit at doses of 100 mg/kgBW and 200 mg/kgBW, respectively. On day 31, peripheral blood samples were collected from all subjects. The findings of this study indicate that administration of n-butanol extract of dewandaru fruit (Eugenia uniflora L.) resulted in a reduction in the total leukocyte count in male mice receiving the extract compared to the control group.
Qualitative Synthesis of In Vitro α-Glucosidase Inhibitory and Antioxidant Activities of Eugenia uniflora Extracts Puguh Santoso; I Made Agus Sunadi Putra
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 4 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i4.924

Abstract

Background: Eugenia uniflora L. (pitanga) is traditionally used in South America for gastrointestinal disorders. Although in vitro studies have highlighted its antioxidant and α-glucosidase inhibitory properties, quantitative synthesis evaluating its potency and relative predominance remains limited. Objective: To systematically review and synthesize the evidence on the in vitro antioxidant and α-glucosidase inhibitory effects of E. uniflora extracts, with a focus on digestive enzyme inhibition and implications for intestinal health. Methods: Studies published between 2015 and 2025 that evaluated the antioxidant activity of E. uniflora using DPPH, FRAP, and ABTS assays and its α-glucosidase inhibitory activity were analyzed. Data from secondary sources were evaluated using source triangulation to compare plant parts, extraction methods, phytochemical characteristics, and biological activities. Results: E. uniflora consistently exhibited potent α-glucosidase inhibitory activity across extraction methods, particularly in leaf extracts, making enzyme inhibition its most reproducible biological activity. In contrast, antioxidant activity showed greater variability depending on the assay used (DPPH, ABTS, or FRAP), plant organ, and solvent. Conclusion: E. uniflora demonstrates strong potential as a natural α-glucosidase inhibitor. This mechanism may delay carbohydrate digestion, improve postprandial glycemic regulation, and reduce intestinal oxidative stress and osmotic load. Although its antioxidant effects may provide complementary protection, these effects are more variable. Standardized phytochemical characterization, in vivo studies, and clinical trials are needed to confirm its therapeutic efficacy.
Co-Authors Agung Ari Chandra Wibawa Debby Juliadi Dewa Ayu Ika Pramitha Erna Cahyaningsih Gusti Ayu Made Indah Siantari Gusti Ayu Putu Eka Darmayanti I Gede Yodhi Trismawan I Made Agus Sunadi Putra I Putu Pasek Jaya Separsa I Putu Tangkas Suwantara I Wayan Suardi Adi Gunawan Ida Ayu Gede Syntya Mahayani Ketut Agus Adrianta Maria Malida Vernandes Sasadara Megawati, Fitria Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Nyoman Wahyu Udayani Ni Putu Agustini Ari Dewi Ni Putu Febi Andani Putra, I Made Agus Sunadi Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Putu Windra Gunawan Wardani, I Gusti Agung Ayu Kusuma