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All Journal Jurnal Matematika & Sains Acta Pharmaceutica Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Current Research on Biosciences and Biotechnology Jurnal Sains dan Kesehatan
Siti Kusmardiyani
Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, ITB
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

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Kandungan Kapsaisin dan Dihidrokapsaisin Pada Berbagai Buah Capsicum Sukrasno Sukrasno; Siti Kusmardiyani
Jurnal Matematika & Sains Vol 2, No 1 (1997)
Publisher : Institut Teknologi Bandung

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Abstract

Search for the hotest chilli pepper (Capsicum) fruits which was based on their capsaisinoid contents has been conducted. Chilli pepper fruits were collected from various places in Indonesia and two of them from Japan. From the 25 kinds of chilli pepper analysed, it was found that all C. frutescens contained capsaicinoids while in some C. annuum these compounds were not detected. Capsaicinoid content in chilli pepper fruits is affected by the their age and the highest content found in mature fruits before ripening which is indicated by the change of colour from green or pale yellow to red.
Telaah Fitokimia Daun Srikaya (Annona squamosa L.) yang Berasal dari Dua Lokasi Tumbuh Kusmardiyani, Siti; Wandasari, Ferlin; Wirasutisna, Komar Ruslan
Acta Pharmaceutica Indonesia Vol 37, No 1 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Daun srikaya (Annona squamosa L., Annonaceae) digunakan dalam pengobatan tradisional sebagai penurun kadar gula darah. Simplisia yang berasal dari dua lokasi tumbuh dibandingkan kandungan kimianya. Penapisan fitokimia kedua simplisia, karakteristik simplisia, dan pola kromatogram ekstrak menunjukkan hasil yang mirip. Simplisia diekstraksi secara refluks menggunakan pelarut dengan kepolaran meningkat, yaitu n-heksana, etil asetat, dan metanol. Ekstrak n-heksana salah satu simplisia disaponifikasi, difraksinasi secara kromatografi cair vakum, dilanjutkan dengan kromatografi kolom. Fraksi dipisahkan menggunakan kromatografi lapis tipis preparatif dan isolat dikarakterisasi menggunakan spektrofotometri ultraviolet-sinar tampak dan spektrofotometri inframerah serta penampak bercak Liebermann-Burchard. Isolat merupakan triterpenoid dengan gugus fungsi O–H, CH, dan C=C serta tidak memiliki ikatan rangkap terkonjugasi.Kata Kunci: Annona squamosa L., daun Srikaya, triterpenoid Sugar apple (Annona squamosa L., Annonaceae) leaf has been traditionally used to treat high blood glucose level. Crude drugs obtained from plants growing at two different locations were studied to evaluate whether there were differences in their phytochemical constituents. Phytochemical screening of those two crude drugs, the quality, and extract chromatographic pattern showed similar results. Crude drugs were extracted by reflux using n-hexane, ethyl acetate, and methanol. N-hexane extract from one of the crude drugs was saponified, followed by fractionation using vacuum liquid chromatography and column chromatography. The fractions were separated using preparative thin layer chromatography and one isolate was characterized using Liebermann-Burchard reagent, ultraviolet-visible and infrared spectrophotometry. The isolate was a triterpenoid with O-H, C-H, and C=C groups and did not have any conjugated double bond.Keywords: Annona squamosa L., sugar apple leaf, triterpenoid
Penetapan Kadar Genistein Biji Kedelai (Soya max Piper) Lokal dan Impor Secara Densitometri Lapis Tipis dan KCKT Kusmardiyani, Siti; Dwijayanti, Asri; Wirasutisna, Komar Ruslan
Acta Pharmaceutica Indonesia Vol 37, No 1 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Biji kedelai (Soya max Piper) impor sangat banyak digunakan di Indonesia terutama sebagai bahan baku utama makanan olahan seperti tahu dan tempe. Genistein, senyawa isoflavon dalam biji kedelai, dilaporkan memiliki aktivitas estrogenik dan antioksidan kuat. Penelitian ini bertujuan menetapkan kadar genistein biji kedelai lokal dan impor serta menemukan metode penetapan kadar tanpa preparasi sampel yang dapat dikerjakan dalam waktu singkat. Simplisia biji kedelai diekstraksi dengan cara panas menggunakan metanol. Sebagian simplisia didelipidasi terlebih dahulu dengan n-heksana sebelum diekstraksi. Kadar genistein ditetapkan secara densitometri lapis tipis dan kromatografi cair kinerja tinggi (KCKT). Secara berurutan, kadar genistein biji kedelai lokal dan impor ditetapkan secara densitometri lapis tipis adalah 19,51±4,59 μg/g dan 21,69±3,98 μg/g. Sedangkan secara KCKT adalah 19,99±3,79 μg/g dan 21,12±3,19 μg/g. Kadar genistein biji kedelai lokal dan impor secara densitometri lapis tipis dan KCKT tidak berbeda bermakna pada aras keberartian 0,05.Kata kunci : Soya max, kedelai, genistein.Imported soybean seed is widely used in Indonesia especially as the main ingredient for tofu and soybean cake (tempe). Genistein, an isoflavone in soybean seed, has an estrogenic activity and act as a strong antioxidant. Besides quantifying genistein in the local and imported soybean seeds, this research was also aimed to find a fast and simple quantitative method. Soybean seed crude drugs were extracted by reflux using methanol. Some parts of the crude drug were delipidated using n-hexane before extracted. Genistein was determined using thin layer densitometry and high performance liquid chromatography (HPLC). Quantity of genistein in local and imported soybean seeds determined by thin layer densitometer were 19.51±4.59 μg/g and 21.69±3.98 μg/g, respectively. While the quantity obtained by HPLC were 19.99±3.79 μg/g and 21.12±3.19 μg/g, respectively. Both methods showed no significant difference in probability of 0.05.Keywords: Soya max, soybean, genistein.
Telaah Fitokimia Daun Srikaya (Annona squamosa L.) yang Berasal dari Dua Lokasi Tumbuh Siti Kusmardiyani; Ferlin Wandasari; Komar Ruslan Wirasutisna
Acta Pharmaceutica Indonesia Vol. 37 No. 1 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Daun srikaya (Annona squamosa L., Annonaceae) digunakan dalam pengobatan tradisional sebagai penurun kadar gula darah. Simplisia yang berasal dari dua lokasi tumbuh dibandingkan kandungan kimianya. Penapisan fitokimia kedua simplisia, karakteristik simplisia, dan pola kromatogram ekstrak menunjukkan hasil yang mirip. Simplisia diekstraksi secara refluks menggunakan pelarut dengan kepolaran meningkat, yaitu n-heksana, etil asetat, dan metanol. Ekstrak n-heksana salah satu simplisia disaponifikasi, difraksinasi secara kromatografi cair vakum, dilanjutkan dengan kromatografi kolom. Fraksi dipisahkan menggunakan kromatografi lapis tipis preparatif dan isolat dikarakterisasi menggunakan spektrofotometri ultraviolet-sinar tampak dan spektrofotometri inframerah serta penampak bercak Liebermann-Burchard. Isolat merupakan triterpenoid dengan gugus fungsi O"“H, CH, dan C=C serta tidak memiliki ikatan rangkap terkonjugasi.Kata Kunci: Annona squamosa L., daun Srikaya, triterpenoid Sugar apple (Annona squamosa L., Annonaceae) leaf has been traditionally used to treat high blood glucose level. Crude drugs obtained from plants growing at two different locations were studied to evaluate whether there were differences in their phytochemical constituents. Phytochemical screening of those two crude drugs, the quality, and extract chromatographic pattern showed similar results. Crude drugs were extracted by reflux using n-hexane, ethyl acetate, and methanol. N-hexane extract from one of the crude drugs was saponified, followed by fractionation using vacuum liquid chromatography and column chromatography. The fractions were separated using preparative thin layer chromatography and one isolate was characterized using Liebermann-Burchard reagent, ultraviolet-visible and infrared spectrophotometry. The isolate was a triterpenoid with O-H, C-H, and C=C groups and did not have any conjugated double bond.Keywords: Annona squamosa L., sugar apple leaf, triterpenoid
Penetapan Kadar Genistein Biji Kedelai (Soya max Piper) Lokal dan Impor Secara Densitometri Lapis Tipis dan KCKT Siti Kusmardiyani; Asri Dwijayanti; Komar Ruslan Wirasutisna
Acta Pharmaceutica Indonesia Vol. 37 No. 1 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Biji kedelai (Soya max Piper) impor sangat banyak digunakan di Indonesia terutama sebagai bahan baku utama makanan olahan seperti tahu dan tempe. Genistein, senyawa isoflavon dalam biji kedelai, dilaporkan memiliki aktivitas estrogenik dan antioksidan kuat. Penelitian ini bertujuan menetapkan kadar genistein biji kedelai lokal dan impor serta menemukan metode penetapan kadar tanpa preparasi sampel yang dapat dikerjakan dalam waktu singkat. Simplisia biji kedelai diekstraksi dengan cara panas menggunakan metanol. Sebagian simplisia didelipidasi terlebih dahulu dengan n-heksana sebelum diekstraksi. Kadar genistein ditetapkan secara densitometri lapis tipis dan kromatografi cair kinerja tinggi (KCKT). Secara berurutan, kadar genistein biji kedelai lokal dan impor ditetapkan secara densitometri lapis tipis adalah 19,51±4,59 μg/g dan 21,69±3,98 μg/g. Sedangkan secara KCKT adalah 19,99±3,79 μg/g dan 21,12±3,19 μg/g. Kadar genistein biji kedelai lokal dan impor secara densitometri lapis tipis dan KCKT tidak berbeda bermakna pada aras keberartian 0,05.Kata kunci : Soya max, kedelai, genistein.Imported soybean seed is widely used in Indonesia especially as the main ingredient for tofu and soybean cake (tempe). Genistein, an isoflavone in soybean seed, has an estrogenic activity and act as a strong antioxidant. Besides quantifying genistein in the local and imported soybean seeds, this research was also aimed to find a fast and simple quantitative method. Soybean seed crude drugs were extracted by reflux using methanol. Some parts of the crude drug were delipidated using n-hexane before extracted. Genistein was determined using thin layer densitometry and high performance liquid chromatography (HPLC). Quantity of genistein in local and imported soybean seeds determined by thin layer densitometer were 19.51±4.59 μg/g and 21.69±3.98 μg/g, respectively. While the quantity obtained by HPLC were 19.99±3.79 μg/g and 21.12±3.19 μg/g, respectively. Both methods showed no significant difference in probability of 0.05.Keywords: Soya max, soybean, genistein.
Phytochemistry and pharmacological activities of Annona genus: A review Siti Kusmardiyani; Yohanes Andika Suharli; Muhamad Insanu; Irda Fidrianny
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/KNIA7708

Abstract

Plants have been significantly used in traditional medicine by a variety of societies since antiquity, and knowledge of their safety, efficacy, and quality value can be developed through further research. The Genus Annona consisting of 119 species has been extensively researched and proven to have a diverse range of pharmacological activities such as antioxidant, antiulcer, antidiarrheal, and antiparasitic. This is because the Annona plants possess a great number of phytochemicals found in almost every part of the plant, which can be isolated to be developed into herbal medicine. Phytochemicals are classified into several classes, such as Annonaceous acetogenin, alkaloids, flavonoids, and essential oils. This article was created by collecting 137 research articles which discuss phytochemical compounds from 38 species and the pharmacological activity from 13 species.
PENGARUH PEMBERIAN DAGING SIPUT SAWAH (Filopaludina javanica v.d Busch 1844)TERHADAP PENYEMBUHAN TUKAK LAMBUNG PADA TIKUS WISTAR BETINA YANG DIINDUKSI ASETOSAL Rizka Mulya Miranti; Andreanus A. Soemardji; Siti Kusmardiyani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 1 (2020): September 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

ABSTRAK Siput sawah (Filopaludina javanica v.d Busch 1844) telah digunakan oleh masyarakat Jawa Barat untuk mengobati tukak lambung secara empiris, namun belum ada penelitian yang membuktikan efek tersebut. Pengujian ini merupakan pengujian farmakologi yang bertujuan mengetahui penurunan indeks tukak lambung pada tikus yang diinduksi asetosal. Induksi asetosal dosis 405 mg/kg diberikan selama 10 hari. Daging siput sawah yang telah direbus diberikan selama tiga hari dengan dosis 3,310 g/kg dan dosis 6,620 g/kg. Obat pembanding yang digunakan adalah Lansoprazol dosis 5 mg/kg. Hasil pengujian menunjukan bahwa persentasi penyembuhan dosis 3,310 g/kg adalah sebesar 4,92 % dan dosis 6,620 g/kg sebesar 8,20 %. Indeks tukak lambung pada tikus kelompok uji lebih rendah dari kelompok kontrol positif dengan signifikasi P>0,05. Kata kunci : Siput sawah, Filopaludina javanica v.d Busch 1844, antitukak lambung, asetosal ABSTRACT People in West Java consume rice field snail (Filopaludina javanica v.d Busch 1844) to treat peptic ulcers but no scientific studies have proven that effect. This research is a pharmacological test that aims to determine the reduction in the index of peptic ulcers in mice indusced by acetosal. Rat-peptic ulcer model was induced with acetosal 405 mg/kg body weight for 10 days. Boiled rice snail meat is given for three days at a dose of 3,310 g / kg and a dose of 6,620 g / kg. The comparison drug used is Lansoprazol dose of 5 mg / kg. The results showed that the gastric ulcer healing dose 3,310 g/kg and 6,620 g/kg were 4,92% and 8,20%. Peptic ulcer index in the test group mice was lower than the positive control group even though there was no significant difference (P> 0.05). Keyword: Rice field snail, Filopaludina javanica v.d. Busch 1844, Peptic ulcer activity, Acetosal
HISTOCHEMICAL ANALYSIS OF THE LEAVES OF FOUR ERICALES MEDICINAL PLANTS Nurma Sabila; Siti Kusmardiyani; Muhamad Insanu
Acta Pharmaceutica Indonesia Vol. 47 No. 1 (2022)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v47i1.16256

Abstract

Active chemical compounds from medicinal plants are mostly secondary metabolites that can be histochemically tested. It enables the identification and localization of diverse secondary metabolites within the tissue, which is not possible with screening phytochemicals. In this study, the histochemistry of the leaf blades of Ericales plants i.e., cantigi (Vaccinium varingiaefolium (Blume) Miq.), persimmon (Diospyros kaki Thunb.), sapodilla (Manilkara zapota (L.) van Royen), and star apple (Chrysophyllum cainito L.) were evaluated. These species have been reported as folk medicines that have secondary metabolites. Each leaf tissue was observed under a microscope, and phytochemical compounds presence and location were detected by using specific reagents. The results showed that those four leaves contained phenols, flavonoids, and terpenes, while quinones were only found in cantigi leaves. The secondary metabolites were present in the idioblast of parenchymal and epidermal tissues. The persimmon and star apple leaves had secretory cavities in trichomes with terpenes and phenolic compounds.
Aktivitas Antidiabetes Serbuk Semut Jepang (Tenebrio molitor Linn.) pada Mencit Swiss Webster Jantan yang Diinduksi Aloksan Erwin Samsul; Andreanus A. Soemardji; Siti Kusmardiyani
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.150

Abstract

Diabetes mellitus is a disease caused by metabolic disorders with hyperglycemia conditions that can occur due to impaired insulin secretion, insulin sensitivity or both. Semut Jepang (SJ) are used by people of Indonesians as a drug to reduce blood sugar levels, but have not been scientifically studied as antidiabetic. Therefore, this study aims to examine the antidiabetic activity of Japanese ant powder in mice. Method: The study was carried out using the antihyperglycemic method in mice induced by alloxan. In the antihyperglycemic method in alloxan induced mice, mice were divided into 6 groups, namely 1% normal Na CMC control group (not alloxan induced), 1% Na CMC pain control group (alloxan induced), glibenclamide 5 mg / kg bw comparison group, and 3 test groups were given Japanese ant powder with a dose of 9 mg / kg bw (SJ 9), 45 mg / kg bw (SJ 45), and 90 mg / kg bw (SJ 90). Blood glucose levels were measured on the first day, day 3, day 7, and day 14. Results: The use of SJ 45 and SJ 90 were better in lower blood glucose compared to the glibenclamide comparison group. Conclusion: Japanese ant powder at doses of 45 and 90 mg / kg bw give an antidiabetic effect that is better than glibenklamid 5 mg / kg bw in reducing blood glucose levels in mice induced by alloxan. Keyword : Semut jepang powder, diabetes mellitus, blood glucose level
Co-Authors Andreanus A. Soemardji Asri Dwijayanti Dwijayanti, Asri Erwin Samsul Ferlin Wandasari Irda Fidrianny Komar Ruslan Wirasutisna Muhamad Insanu Nurma Sabila Rizka Mulya Miranti Samsul, Erwin Sukrasno Sukrasno Wandasari, Ferlin Wirasutisna, Komar Ruslan Wirasutisna, Komar Ruslan Yohanes Andika Suharli