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Qualitative Profiling of Antimalarial Compounds from Endophytic Fungi Associated with Rhizophora mucronata Suhendar, Usep; Fawziah, Rieskha; Lohita Sari, Bina; Yoshida Srie Rahayu, Sata; Sulastri, Lilik; Wulandari, Ratna; Anisa, Dede; Namira, Raisa
Sains Natural: Journal of Biology and Chemistry Vol. 15 No. 3 (2025): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v15i3.816

Malaria remains one of the deadliest infectious diseases worldwide, underscoring the urgent need for novel antimalarial sources. Endophytic fungi associated with mangrove roots of Rhizophora mucronata represent promising candidates, as they are capable of synthesizing secondary metabolites such as alkaloids, flavonoids, and terpenoids with known antiplasmodial activity. This study aimed to qualitatively identify antimalarial bioactive compounds from endophytic fungal extracts previously exhibiting the highest heme polymerization–inhibition activity. Fungal isolates were fermented in liquid medium for 21 days and extracted with ethyl acetate. The extracts were profiled by Thin-Layer Chromatography (TLC) using two solvent systems: n-hexane : ethyl acetate (5:1) and dichloromethane : methanol (10:1). Band visualization was performed under UV light (254 nm and 366 nm) and with semi-specific reagents (Dragendorff and citro-boric), followed by Rf value comparison. TLC analysis revealed blue-green fluorescent bands corresponding to flavonoids and brown-orange bands indicative of alkaloids, with optimal Rf values of 0.46 (n-hexane : ethyl acetate) and 0.54 (dichloromethane : methanol). These findings confirm the presence of key antimalarial compound classes in the endophytic fungal extract, supporting its potential as a coastal bioresource for drug discovery and development.

Empowerment of Youth in Cikarawang Village, Bogor Regency through Training and Assistance in Manufacturing Pharmaceutical Technology-Based Kitchen Seasoning Powder Utami, Novi Fajar; Suhendar, Usep; Utami, Munifa Putri; Nhestricia, Nhadira
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 1 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i1.58

Cikarawang Village, Dramaga District, Bogor Regency has a Merdesa community which engaged in plantations. This community has become UMKM but has not been able to significantly improve people's welfare. From the team's initial discussion with the Kebun Merdesa Community, information was obtained that Cikarawang Village has potential resources that has not been maximized in its empowerment, especially in downstream of Merdesa plantation products. The empowerment of youth who are involved in the downstream activities of Kebun Merdesa products will be carried out in stages of starting from socialization, consulting with the Kebun Merdesa community, establishing a micro business plan for downstream seasoning powder products, and building production facilities, along with assistances. The program is held with assistance to processing units for plantation products using pharmaceutical technology in several stages. Furthermore, assistance is carried out to the product packaging unit for seasoning spices and digital technology-based marketing units. This program also involved educational units. Promotional media in the form of billboards and banners are made and installed in strategic locations for partners to complement this program which also serves as a means of information for the village community. This activity involved 2 lecturers and student from Pharmacy Bachelor Programwith combined the program of Merdeka Belajar Kampus Merdeka (MBKM) which oriented towards community service.The formation of micro-business units in Cikarawang Kebun Merdesa Village, increasing the productivity and creativity of Cikarawang Village’s youth, and also providing added value economically, socially, and culturally were implemented.

Empowerment of Youth in Cikarawang Village, Bogor Regency through Training and Assistance in Manufacturing Pharmaceutical Technology-Based Kitchen Seasoning Powder Utami, Novi Fajar; Suhendar, Usep; Utami, Munifa Putri; Nhestricia, Nhadira
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 1 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i1.58

Cikarawang Village, Dramaga District, Bogor Regency has a Merdesa community which engaged in plantations. This community has become UMKM but has not been able to significantly improve people's welfare. From the team's initial discussion with the Kebun Merdesa Community, information was obtained that Cikarawang Village has potential resources that has not been maximized in its empowerment, especially in downstream of Merdesa plantation products. The empowerment of youth who are involved in the downstream activities of Kebun Merdesa products will be carried out in stages of starting from socialization, consulting with the Kebun Merdesa community, establishing a micro business plan for downstream seasoning powder products, and building production facilities, along with assistances. The program is held with assistance to processing units for plantation products using pharmaceutical technology in several stages. Furthermore, assistance is carried out to the product packaging unit for seasoning spices and digital technology-based marketing units. This program also involved educational units. Promotional media in the form of billboards and banners are made and installed in strategic locations for partners to complement this program which also serves as a means of information for the village community. This activity involved 2 lecturers and student from Pharmacy Bachelor Programwith combined the program of Merdeka Belajar Kampus Merdeka (MBKM) which oriented towards community service.The formation of micro-business units in Cikarawang Kebun Merdesa Village, increasing the productivity and creativity of Cikarawang Village’s youth, and also providing added value economically, socially, and culturally were implemented.

Political Perceptions and Dynamics in The Formation of Southern Garut Regency: An Analysis of DPRD Members’ Perspectives Suhendar, Usep; Djuyandi, Yusa; Solihah, Ratnia
International Journal of Science and Society Vol 6 No 3 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i3.1232

This research analyzes the political perceptions of faction members in the Garut Regency Regional House of Representatives (DPRD) regarding the formation of Southern Garut Regency. Findings indicate broad support for the expansion, motivated by the need to enhance public services, accelerate development, and improve community welfare in the southern region. Despite this, some factions express skepticism, emphasizing the necessity for in-depth studies and administrative readiness. Utilizing political perception theory, the study explores how DPRD members form their views based on information and interpret their political and social contexts. The research also highlights theoretical limitations, such as insufficient consideration of broader power dynamics and structural influences, including central government policies and local economic interests. These findings underscore the need for further theoretical development to comprehensively capture the complexities of the regional expansion process.

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