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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmiah Farmasi Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Poltekita : Jurnal Ilmu Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Pharmaceutical and Health Research MAHESA : Malahayati Health Student Journal Nusantara Hasana Journal Indonesian Journal of Multidisciplinary Science Jurnal Keperawatan Cakrawala Medika: Journal of Health Sciences Indonesian Journal of Health Research Innovation

I Gede Angga Adnyana

Universitas Islam Al-Azhar

Author-ID : 3922535

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Pengaruh Susu Kuda Liar Sumbawa Terhadap Kadar TNF-a pada Tikus Gastritis yang Diinduksi Indometasin Musyarrafah, Musyarrafah; Wanadiatri, Halia; Merta, Putu Demas Ardina; Adnyana, I Gede Angga; Rozikin, Rozikin; Luktiana, Metha
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 4: December 2021
Publisher : Universitas Aisyah Pringsewu

Gastritis is an inflammatory, irritating, or erosive condition that affects the mucosa submucosa of the stomach. Uncontrolled use of NSAIDs for a long time can cause excess stomach acid that will lead injury to the gastric lumen which results in the immune system release of pro-inflammatory factors, one of which is TNF-a. This study aims to determine the effect of Sumbawa’s mare milk (SMM) on TNF-a Levels in Wistar Rats with Indomethacin-induced gastritis. This study used 24 male Wistar rats which were divided into 4 treatment groups, namely negative control group (group 1), positive control group (group 2), SMM treatment group + Indomethacin (group 3), and SMM treatment group (group 4). Treatment was given for 14 days analyzed using an ELISA reader. Group 3 showed the highest levels of TNF-a (median=52.36). While group 4 got the lowest TNF-a level (median=24.49). In the control group, TNF-a levels were higher in group 1(median=35.14) than in group 2 (median=30.14). Results showed that SMM had a significant effect on TNF-a levels (p less than 0.05). Effects that can be given vary, either decreasing or increasing TNF-a depending on the conditions in the tissue. SMM has the potential not only as a preventive treatment but also as a curative treatment.Abstrak: Gastritis adalah kondisi inflamasi, iritasi, maupun erosif yang mengenai daerah mukosa dan submukosa lambung. Pemakaian NSAID yang tidak terkontrol dalam waktu lama dapat mengakibatkan asam lambung berlebih sehingga mukosa lambung terkikis. Perlukaan pada lumen lambung akan membuat sistem imun mengeluarkan faktor proinflamasi, salah satunya adalah TNF-a, sehingga terjadi gastritis. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kuda liar Sumbawa terhadap kadar TNF-a pada Tikus Gastritis yang diinduksi Indometasin. Penelitian ini menggunakan 24 ekor tikus jantan galur Wistar yang dibagi menjadi 4 kelompok perlakuan yaitu kelompok kontrol negatif (kelompok 1), kelompok kontrol positif (kelompok 2), kelompok perlakuan SKL (Susu Kuda Liar) Sumbawa + Indometasin (kelompok 3), dan kelompok perlakuan SKL (kelompok 4). Perlakuan diberikan selama 14 hari dan dilakukan analisis menggunakan ELISA-reader. Kelompok 3 menunjukkan kadar TNF-a tertinggi (median=52,36). Sedangkan kelompok 4 mendapatkan kadar TNF-a terendah (median=24,49). Pada kelompok kontrol, kadar TNF-a lebih tinggi pada kelompok 1 (median=35,14) dibandingkan dengan kelompok 2 (median=39,74). Hasil penelitian menunjukkan bahwa susu kuda liar Sumbawa berpengaruh terhadap kadar TNF-a secara signifikan (p kurang dari 0,05). Pengaruh yang dapat diberikan beragam, baik menurunkan maupun meningkatkan kadar TNF-a tergantung dengan kondisi di jaringan tersebut. SKL Sumbawa tidak hanya berpotensi sebagai pengobatan preventif namun juga sebagai pengobatan kuratif.

The Relationship between Worm Infection and Stunting in Children in Central Lombok Regency, West Nusa Tenggara Province Ananta Fittonia Benvenuto; I Gede Angga Adnyana; Velia Maya Samodra; Fahriana Azmi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 2: June 2022
Publisher : Universitas Aisyah Pringsewu

Stunting is a condition of weight that is not in accordance with the height for children his age, caused by internal factors, namely low nutrition, inadequate maternal nutritional intake during pregnancy and external factors, namely pregnancy infection in the mother and the presence of infectious diseases in children. Worm infection is one of the most common diseases in children. This study aims to determine the relationship between intestinal worm infection and the incidence of stunting in children and the risk factors associated with intestinal worm infection in Central Lombok district, NTB province. A cross-sectional survey was conducted on 170 children with stunting in Central Lombok Regency, West Nusa Tenggara Province. This research took place from January-March 2021. The sample of this study was children with stunting in 8 Puskesmas in Central Lombok Regency. This study used a purposive sampling method, the independent variable was intestinal worm infection and the dependent variable was stunting. The children's parents were given an informed consent form, a set of personal protective equipment in the form of a mask and a pair of handscones, a stool pot, plastic, and oil paper. Children were also taken blood for ELISA examination, the primary data obtained in this study. Data analysis with SPSS is univariate test. There were 19 (11.17%) of the total 170 subjects infected with intestinal worms in Central Lombok Regency with a mean age of 32.64±13.75. Intestinal worm species include Ascaris lumbricoides 18 (10.59%) and Trichuris trichiura 1 (0.58%). There was no significant risk factor between intestinal helminth infection and stunting in children (95% CI = 33.47-49.36, with p value = 0.695) on blood examination using the ELISA method for levels of IL-4 as a marker of intestinal worm infection and on stool examination by the Lugol method in children in Central Lombok Regency. However, there was a significant relationship between anemia and intestinal worm infection in stunted children (p = 0.029). There is a relationship between intestinal worm infection and stunting in children in Central Lombok Regency, NTB Province. Anemia is a risk factor associated with the incidence of intestinal worm infection. However, the small number of samples and the short time in this study showed insignificant results between the two variables.

Co-Authors Agus saputra, I Putu Bayu Aji Kresnapati, I Nyoman Bagus Ana Andriana Ana Andriana Ananta Fittonia Benvenuto Andriana, Ana Ardian Ansari Arjita, I Putu Dedy Asary, Teguh Mayadi Ayu Anulus Azmi, Fahriana David Maulana Abdurraman Qudus Deny Sutrisna Wiatma Effendi, Raden Gunawan Hady Anshory Hardinata Herlinawati I Putu Bayu Agus Saputra I Putu Ryan Aryadana Icha Aisyah Icha Aisyah Kadek Dwi Pramana Khairunnisai T. Kresnapati, I Nyoman Bagus Aji Lalu Afrial Imam Anugrah Lalu Afrial Imam Anugrah Lubis, Nayna Aulia Luktiana, Metha Made Rika Anastasia Pratiwi Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Merta, Putu Demas Ardina Metha Luktiana Muhamad Sasiar Tajiwalar Musyarrafah, Musyarrafah Nyoman Cahyadi Tri Setiawan Nyoman Cahyadi Tri Setiawan Putu Demas Ardina Merta Rozikin Rozikin Rozikin, Rozikin Rusmiatik Rusmiatik Santosa, Hilda Siti Safira Khairunnisa Surasmaji, Lalu Irawan Susanti, Mahida Rina Velia Maya Samodra Wanadiatri, Halia Yunan Jiwintarum Yunan Jiwintarum

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