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All Journal International Journal of Public Health Science (IJPHS) Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Majalah Kedokteran Universa Medicina Paediatrica Indonesiana Majalah Kedokteran Andalas Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Kedokteran Meditek
Taniawati Supali
Departement Of Parasitology, Faculty Of Medicine, University Of Indonesia, Jakarta 10430, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Buana, Ria; Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.206-212

Abstract

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.
Hubungan antara Infeksi Cacing dan Alergi Yolazenia Yolazenia; Taniawati Supali; Heri Wibowo
Jurnal Ilmu Kedokteran Vol 4, No 2 (2010): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (39.246 KB) | DOI: 10.26891/JIK.v4i2.2010.71-78

Abstract

Many researches showing the evidence of a reverse relation between helminthiasis and allergic diseases in tropicaldeveloping countries, supported by hygiene hypothesis. There is relationship between the inflammation caused byallergic and helminthiasis. Both, allergic and helminthiasis, show the increase of IgE level, eosinophilia, mastocytosis,and release of IL-4, IL-5 and IL-13 cytokines by Th2. Several mechanisms explaining the decrease of allergicmanifestation in people with helminthiasis are polyclonal IgE blocking, suppression of anti-inflammatory cytokines(IL-10 and TGF-â), and IgG4 blocking antibody.
FLOTAC Technique for Soil-Transmitted Helminth Infection Diagnosis Helena Ullyartha Pangaribuan; Taniawati Supali; Heri Wibowo
Majalah Kedokteran Bandung Vol 53, No 4 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2545

Abstract

Human helmintiasis is a neglected disease with significant economic impacts caused by its effects on performance and cognition. The burden of many helminth infections is not well understood due to the lack of progress in detecting low-intensity infection in elimination programs. Furthermore, the decision for individual and community treatments, as well as the community-based control program evaluation, obviously depends on the technics used for parasitological diagnostic. A well-established diagnostic technic will be beneficial to detect and eliminate the disease. Therefore, this study aimed to compare the performance of FLOTAC and FECT technics for detecting helminth infections in human stool. A total of 149 fecal specimens were collected from schoolchildren in Nangapanda village, Ende District, East Nusa Tenggara Province in 2012. The sensitivity of both technics was analyzed using the kappa analysis. Positive results from both technics were used as the gold standard. The sensitivity of FLOTAC for diagnosing T. Trichiura, A. lumbricoides and hookworm infections were 100%, 100%, and 82%, respectively, while the sensitivity of FECT was 80%, 7%, and 18%, respectively. FLOTAC yielded considerably higher mean faecal egg counts (11,452, 1,038, and 19 eggs per gram stool (EPG) for A. lumbricoides, T. Trichiura, and hookworm). FLOTAC technique was considerably more sensitive than FECT in diagnosing soil-transmitted helminth infections. In conclusion, FLOTAC can be used as a diagnosis tool for future helminth control programs.
Peran Cacing Usus dalam Menekan Kejadian Atopi Taniawati Supali; Freggy S Joprang
Majalah Kedokteran UKI Vol. 26 No. 1 (2008): JANUARI-MARET
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Infeksi cacing usus merupakan jenis infeksi yang paling sering ditemukan pada anak di banyak negara di dunia terutama di negara yang belum berkembang dimana hygiene dan sanitasi buruk. Lebih dari satu miliyar orang didunia terinfeksi cacing usus. Spesies nematode yang paling sering menginfeksi adalah Ascaris Lumbricoides, Trichuris trichiura dan cacing tambang. Kejadian alergi meningkat dinegara barat pada saat praktek hygiene pribadi dan sanitasi lebih baik. Hal ini menunjukan adanya relasi negatif antaracacing usus dan penyakit atopi/ alergi. Di daerah dengan intensitas transmisi cacing usus rendah atau jarang (misalnya daerah urban dengan status sosiologi ekonomi tinggi), reaktifitas alergi tinggi. Sebaliknya didaerah urban atau rural dengan pajanan terhadap infeksi tinggi, kejadian reaktivitas alergi rendah. Respon imun akibat infeksi cacing bergeser kea rah Th2 (IL -4, IL-5 dan IL-13) dan aktivitas Treg (IL-10 dan TGF-β) yang merupakan mediator anti radang. Atopi juga menginduksi respons imun Th2. Infeksi usus kronik akan mengkatkan kadar IL-10 yang akan menekan aktivitas Th2 dan mengurangi resiko atopi. Kata Kunci : cacing usus, atopi, Thelper-2 (Th2), Interleukin-10 (IL-10), Tregulatory (Treg) Abstract Intestinal helminth infections are the most prevalent infection in children in many countries worldwide, especially in poor-developing countries. In these countries the hygiene and sanitation practice are poor. More than one billion humans are infected with helminth worldwide. Among those nematodes, Ascaris lumbricoldes, Trichuris trichiura, and hookworm are the most prevalent species. Allergy in western countries has his eventhough good practices of personal hygiene and sanitation is important, showed that there is a negative relationship between intestinal helmiths and atopy/ allergic diseases. In the areas where intensity of intestinal helmith transmission is low or infrequent (e.q among urban group exposed to high and intense transmission/infection, allergic reactivity is low. The immune reponse from intestinal helminth infecton skewing toward TH2 (IL-4, IL-5, and IL-13) and Treg activation (IL-10 and TGF- β) which is an anti-inflamatory mediator. Atopy is also induced Th2 immune response. The chronic intestinal helminth infection will elevate the IL-10 titer which suppressed the Th2 activation and reduce atopy. Key words : Intestinal helminth, atopy, Thelper-2 (Th2), interleukin-10(IL-10), Tregulatory (Treg)
Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol Jane Florida Kalumpiu; Yenny Djuardi; Taniawati Supali
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.121-128

Abstract

BackgroundSoil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.MethodsAn experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. ResultsOf the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). ConclusionsIn children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.
Plasmodium falciparum infection and the risk of anemia in school children Suriyani Tan; Taniawati Supali; Heri Wibowo
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.128-134

Abstract

BACKGROUNDAccording to the World Health Organization, malaria is the major cause of death from tropical infections in children and pregnant women. Severe anemia is a common complication of malaria, particularly malaria caused by Plasmodium falciparum. The purpose of the present study was to determine any association between Plasmodium falciparum infection and anemia in school children.METHODSThis was an observational study with cross-sectional approach. A total of 540 whole blood samples of school children after administration of anthelminthic treatment for 30 days, were collected for measurement of hemoglobin concentration and preparation of Giemsa-stained thin and thick blood smears.The species of Plasmodium was confirmed by real-time polymerase chain reaction (PCR). Chi-square and prevalence ratio (PR) tests were used to determine the relationship between Plasmodium falciparum infection and anemia.RESULTSThe prevalence of Plasmodium infection in school children of malarial endemic areas was 3.51%. There were 43 cases of anemia with 41 cases of mild anemia and 2 cases of moderate anemia. Among the 41 mild cases of anemia,Plasmodium falciparum infection was found in only 3 cases. The 2 cases of moderate anemia and the remaining 38 cases of mild anemia were not caused by Plasmodium falciparum infection. Subjects with Plasmodium falciparum infection had a 1.91-fold higher risk of suffering from anemia than subjectswithout Plasmodium falciparum infection, but not significant (PR=1.91; 95% C.I.=0.65-5.62).CONCLUSIONSPlasmodium falciparum infection did not significantly increase the risk of anemia in school children. Efforts to improve strategies for controlling anemia and malaria are needed.
HUBUNGAN INFEKSI CACING USUS DAN ATOPI PADA ANAK SEKOLAH DASAR Nora Harminarti; Taniawati Supali; Heri Wibowo
Majalah Kedokteran Andalas Vol 32, No 1: April 2008
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22338/mka.v32.i1.p56-69.2008

Abstract

AbstrakPeningkatan kasus alergi di wilayah yang berhasil menurunkan infeksi keca-cingan dibandingkan dengan yang infeksi kecacingannya masih tinggi membuat hubungan respon imun terhadap infeksi cacing usus dan alergi sangat penting untuk dipelajari. Hal ini di dukung oleh laporan mengenai rendahnya prevalensi atopi pada penderita infeksi cacing usus akibat kemampuan cacing memodulasi respon IgE poliklonal yang dapat menekan atopi/alergi. Adanya laporan kontroversial dengan hasil yang sebaliknya menjadikan hubungan cacing dan alergi semakin menarik untuk dipelajari lebih lanjut. Penelitian ini bertujuan untuk mengetahui hubungan infeksi cacing usus dengan manifestasi atopi pada anak Sekolah Dasar di desa Anaranda dan Nangapanda, kabupaten Ende, Flores, Nusa Tenggara timur (NTT). Atopi dilihat dari tes uji kulit (skin prick test) yang positif terhadap aero-allergen (tungau debu rumah dan kecoa) dan food-allergen (kacang). ELISA digunakan untuk menentukan kadar IgE total. Di Anaranda lebih banyak ditemukan atopi (80,0%) dan infeksi cacing usus (75,6%) dibandingkan dengan Nangapanda yang prevalensi atopi 61,8% dan cacing usus 65,5%.Tidak ditemukan pengaruh infeksi cacing usus terhadap atopi (p=0,469). Kadar IgE total secara signifikan lebih tinggi pada yang atopi (p=0,031), sedangkan pada yang terinfeksi cacing usus tidak berbeda bermakna (p=0,607). Dari penelitian ini dapat disimpulkan infeksi cacing usus tidak mempengaruhi manifestasi atopi pada anak-anak Sekolah Dasar di daerah endemis cacing usus.Kata kunci: infeksi cacing usus, atopi, IgE total, anak Sekolah DasarAbstractThe reports of increasing allergy in areas of decreased helminth infestation compared with the endemic areas make the study of the correlation between helminth infestations and allergy very important. It is also supported by researchers showing that low atopy prevalence in helminth infested humans is caused by helminth ability in modulating IgE polyclonal response which could suppress atopy/allergy. On the contrary, some researchers also show different results and make this correlation interesting for further study. This study aimed to determine relationship between helminth infestation and atopy in school children in Anaranda and Nangapanda villages at Ende district, Flores, Nusa Tenggara Timur (NTT). Helminth infestation status was determined by microscopic examination, while skin prick test was performed to study the prevalence of atopy for aeroallergen (mite and cockroach) and food allergenARTIKEL PENELITIAN59(peanut). ELISA was used to determine the titer of total IgE. Atopy is more prevalent in Anaranda (80.0%) where helminth infestation was also higher (75.6%), while in Nangapanda atopy is 61.8% and helminth prevalence is 65.5%. We found no impact on intestinal helminth infection to atopy (p=0.469). Total IgE titer is significantly higher in atopic children (p=0.031) while not significantly different in intestinal helminth infested children (p=0.607). We conclude that intestinal helminth infestation does not affect atopy manifestation in elementary school children in endemic area.Keywords: Intestinal helminth infection, atopy, Total IgE, elementary school children
Perbandingan Uji Diagnostik Mini FLOTAC dengan Kato-Katz Sebelum dan Sesudah Pengobatan Albendazol Dosis Tunggal pada Anak yang Terinfeksi Cacing Usus Monica Puspa Sari; Taniawati Supali; Heri Wibowo
Jurnal Kedokteran Meditek Vol. 21 No. 55 Januari - April 2015
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v21i55.1200

Abstract

AbstrakUntuk memantau pengobatan anthelmintik, diperlukan teknik pemeriksaan yang lebih akurat dan sensitif dibandingkan dengan  Kato-Katz yang merupakan teknik standar yang ada saat ini.  Penelitian ini merupakan uji diagnostik yang dilakukan terhadap anak sekolah dasar dilakukan pada bulan Maret 2013 di Kelurahan Kalibaru, Kecamatan Cilincing, Jakarta Utara. Sampel tinja diperiksa menggunakan metode Kato-Katz dan Mini FLOTAC sebelum dan sesudah  pemberian obat albendazol 400 mg dosis tunggal pada hari ke 7,14, dan 21. Dari 209 subyek penelitian, terjaring 197 subyek yang bersedia ikut serta.  Sebelum pengobatan, sensitivitas dan NPV (negative predictive value)   Kato-Katz     dan  Mini FLOTAC masing–masing 94%, 96%  dan 81%, 88% terhadap infeksi A. lumbricoides. Terhadap T. trichiura 88%, 92% dibandingkan Mini FLOTAC 100%. Nilai kappa agreement antara teknik Kato-Katz dan Mini FLOTAC adalah 0.773 untuk diagnosis infeksi A. lumbricoides dan 0.895 untuk  infeksi T. trichiura. Terhadap Ascaris,  19.79% tergolong infeksi ringan dengan Kato-Katz. Sedangkan 25.88% tergolong infeksi ringan dengan Mini FLOTAC. Terhadap Trichuris,  34.51% tergolong infeksi ringan dengan Kato-Katz dan 42.13% tergolong infeksi ringan dengan Mini FLOTAC. Setelah diberikan pengobatan, Kato-Katz lebih sensitif dibandingkan  Mini FLOTAC dalam mendeteksi infeksi A. lumbricoides, terutama pada hari  7 dan 14 dan sebaliknya Mini FLOTAC lebih sensitif terhadap infeksi T. trichiura.Teknik Mini FLOTAC dapat dipakai sebagai alternatif dari teknik Kato-Katz dalam mendeteksi infeksi cacing usus dan lebih sensitif mendeteksi T. trichiura dibanding Kato-Katz.  Kata Kunci : Kato-Katz, Mini FLOTAC, Albendazol, Infeksi cacing usus  Abstract            To monitor anthelmintic treatment, will require examination techniques that are more accurate and sensitive than the Kato-Katz technique which is the current standard. This study is a diagnostic examination performed on primary school children. It was conducted in March 2013 in   Kalibaru village, Cilincing Sub-District, North Jakarta. Stool samples were examined using the Kato-Katz  and Mini FLOTAC methods on day 7,14, and 21 after the administration of a single dose of 400 mg albendazole. Of the 209 study subjects, 197 subjects were willing to participate. Before treatment, the sensitivity and the NPV (negative predictive value) against A. lumbricoides infection were 94%,96%, respectively for Kato-Katz and 81%, 88%, respectively for Mini FLOTAC. For T. trichiura, sensitivity and the NPV of Kato-Katz were 88%, 92%, respectively,while for Mini FLOTAC both values were 100%. Kappa value of agreement between Kato-Katz and Mini FLOTAC techniques was 0.773 for the diagnosis of A. lumbricoides infection and 0.895 for T. trichiura. For Ascaris, 19.79% versus 25.88% of infected children have light infection by Kato-Katz and Mini FLOTAC, respectively. For Trichuris, 34.51% versus 42.13% of infected children have light infection with Kato-Katz and Mini FLOTAC, respectively. After the treatment was given,  Kato-Katz  was more sensitive compared to Mini FLOTAC in detecting A. lumbricoides infection, especially at day 7 and day 14. On the contrary, Mini FLOTAC was more sensitive in detecting T. trichiura infection. The Mini FLOTAC technique can be used as an alternative for Kato-Katz in detecting  helminth infections. Mini FLOTAC was more sensitive to detect T. trichiura compared to Kato-Katz.  Keywords  :  Kato-Katz, Mini FLOTAC, Albendazole, Soil transmitted helminthes  
Detection of Submicroscopic Soil-Transmitted Helminth Infections from Fecal Samples in Nangapanda, Ende, Using Real-Time Polymerase Chain Reaction Maylasari, Roospita; Wulandhary, Sendy; Supali, Taniawati; Abinawanto, Abinawanto
Makara Journal of Science Vol. 18, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Soil-transmitted helminth (STH) infections (Necator americanus (hookworm), Ancylostoma duodenale (hookworm), and Ascaris lumbricoides) can lead to anemia, malnutrition, and iron deficiency. Traditionally, STH infections have been diagnosed using microscopy to detect eggs in human fecal samples. However, there are several limitations of this method. The aim of this research was to detect the percentage of submicroscopic STH infections from human fecal samples (children, 5–18 years old) in Nangapanda, Ende, using the real-time polymerase chain reaction (PCR) method. The fecal samples were collected in two time periods, which were before and after treatment, using 400 mg of Albendazole. There were 242 samples in total, but only 45 negative samples from microscopic detection were tested with real-time PCR. The DNA samples were isolated and amplified wih primers of internal transcribed spacer (ITS-1 and ITS-2) region of rDNA. The detection of samples with real-time PCR generated an amplification curve in VIC, FAM, and Texas Red fluorophore. Three samples (6.7%) in pre-treatment were low load of DNA (N. americanus and A. lumbricoides) (Ct > 35). Four samples (9.1%) were low load of DNA (N. americanus) (Ct > 35) in post-treatment. Five samples (11.4%) were moderate load of DNA (A. lumbricoides) (30 < Ct < 35) in post-treatment. This study showed that real-time PCR could detect submicroscopic infections from specific species of hookworm and A. lumbricoides
Spatial study of the implementation of ivermectin, diethylcarbamazine citrate, and albendazole in an urban area Nafilata, Ikrimah; Supali, Taniawati; Wahyono, Tri Yunis Miko; Prihartono, Nurhayati Adnan; Hikmah, Kholisotul; Devi, Yuli Puspita
International Journal of Public Health Science (IJPHS) Vol 14, No 1: March 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i1.24822

Abstract

Studies on lymphatic filariasis (LF) in Indonesia have mostly focused on the disease determinants with limited focus on spatial-based and the determinants of implementing ivermectin, diethylcarbamazine citrate, and albendazole (IDA). This study aimed to identify the causes of program failure. A cross-sectional survey was conducted from November to December 2022 in nine urban villages with high endemic records and one sentinel village in Pekalongan City, Central Java, Indonesia. The analysis using Quantum Geographical Information System (QGIS) and Pearson correlation. Slum settlements were linked to the presence of open sewers (p=0.000; r=0.974) and overcrowding (p=0.033; r=0.672), while the first round of IDA medication adherence correlated with knowledge of medication (p=0.054; r=-0.623) and willingness to take the medication in the second round (p=0.051, r=0.603). Adverse effects of the treatment are strongly correlated with drug boredom from taking medication (p=0.003; r=0.828) and assistance from health workers (p=0.027; r=0.791). We identified gaps in slum settlements, open sewers, overcrowding and medication adherence, including low knowledge of medication, unwillingness to take second-round medication, adverse effects, and boredom with taking medication. We recommend effective strategies by engaging health education between health workers, local leaders, and private sectors as key to ensuring elimination program.
Co-Authors A.A. Ketut Agung Cahyawan W Abinawanto Abinawanto Abinawanto Agnes Kurniawan Bintari Rukmono Dante S. Harbuwono Endang S. Wardhani Felix Partono Freggy S Joprang Gina Aulia Helena Ullyartha Pangaribuan Heri Wibowo Hikmah, Kholisotul I Ketut Suada Ikrimah Nafilata Jane Florida Kalumpiu, Jane Florida Laurentius A. Pramono Lisawati Susanto Lisawati Susanto Maylasari, Roospita Monica Puspa Sari Nafilata, Ikrimah Nora Harminarti Pradana Soewondo Prihartono, Nurhayati Adnan Purnomo Purnomo Ria Buana, Ria Rita Ekarina Roospita Maylasari Sari, Monica Puspa Sarwono Waspadji Sendy Wulandhary Srisasi Gandahusada Srisasi Gandahusada Suharko Suharko Suriyani Tan Tjahaya Haerani Tri Yunis Miko Wahyono Tri Yunis Miko Wahyono Wulandhary, Sendy Yenny Djuardi Yolazenia Yolazenia Yuli Puspita Devi Yuliana Yuliana