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Aktivitas Anti Jamur Fraksi Aktif Ekstrak Etanol Umbi Bawang Rambut (Allium Chinense G.Don) terhadap Jamur Candida Albicans Supomo Supomo; Idriana Idriana; Audinah Eka; Indra Indra; Miftahul Huda; Husnul Warnida
JI-KES (Jurnal Ilmu Kesehatan) Vol 4, No 2 (2021): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v4i2.188

Abstract

AbstrakTumbuhan umbi bawang rambut (Allium chinense G.Don) memiliki efek sebagai antijamur karena mengandung metabolit sekunder seperti flavanoid, alkaloid dan saponin. Tujuan penelitian ini adalah mengetahui aktivitas antijamur ekstrak umbi bawang rambut melalui proses fraksinasi menggunakan pelarut N-heksan, etil asetat, kloroform dan etanol-air. Penelitian yang dilakukan adalah penelitian eksperimental. Sampel yang digunakan adalah umbi bawang rambut yang diperoleh di kampung Kelasan kecamatann Sungai Payang Kutai Kartanegara. Penelitian ini menggunakan metode maserasi dengan pelarut etanol 70%, metode uji aktivitas antijamur berdasarkan metode difusi cakram terhadap jamur Candida albicans dengan konsentrasi 5%, 10%, 25%, dan 50%, dengan kontrol negatif DMSO 50%. Hasil penelitian menunjukkan bahwa semua fraksi dari ekstrak etanol umbi bawang rambut memiliki aktivitas antijamur. Aktivitas antijamur fraksi etil asetat memberikan daya hambat yang paling besar terhadap Candida albicans diantara fraksi lainnya. Kata kunci:  candida albicans; Allium chinense G. Don; antijamur; fraksi AbstractAllium chinense has an antifungal effect because it contains secondary metabolites such as flavonoids, alkaloids and saponins. The purpose of this research is to investigate the antifungal activity of Allium chinense extract through fractionation process using N-hexane solvent, ethyl acetate, chloroform and ethanol-water. The research is experimental research. Samples used are the Allium chinense found in  Kelasan Sungai Payang  Kutai Kartanegara. Using maseration method with 70% ethanol solvent, antifungal activity test method based on disc diffusion method on Candida albicans fungi with concentration of 5%, 10%, 25%, and 50%, with negative control of DMSO 50%. The results showed that all fractions of Allium chinense ethanol extract had antifungal activity. The antifungal activity of the ethyl acetate fraction provides the greatest resistance to Candida albicans among other fractions. Keywords:  candida albicans, allium chinense G. Don, antifungal, fraction
Uji Aktivitas Antibakteri EkstrakEtanol dan Fraksi Batang Kuning (Fibraurea Tinctoria Lour) terhadap Bakteri Escherichia coli dan Staphylococcus aureus Lusi Mardika Ariyanti; Supomo Supomo; Hayatus Sa’adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
JI-KES (Jurnal Ilmu Kesehatan) Vol 5, No 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.323

Abstract

Abstrak Akar kuning (Fibraurea tinctoria Lour) merupakan tumbuhan khas yang dapat dijumpai di Kalimantan serta biasa dimanfaatkan oleh masyarakat setempat sebagai obat gatal, penyakit kuning dan diare. Salah satu senyawa kimia yang terkandung dalam akar kuning adalah berberin yang berpotensi memiliki khasiat sebagai antidiabetes, antivirus, antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk  mengetahui potensi tumbuhan Akar Kuning (Fibraurea tinctoria Lour.) sebagai antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan menggunakan metode disc diffusion. Ekstrak etanol difraksinasi dengan menggunakan pelarut n-heksan dan etilasetat, ekstrak dan fraksi yang telah didapat ditimbang dengan konsentrasi 2,5%, 5% dan 10%. Kontrol positif yang digunakan yaitu amoxicillin dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ektrak etanol dan fraksi akar kuning (Fibraurea tinctoria Lour.) memiliki potensi untuk menghambat pertumbuhan bakteri. Aktivitas zona hambat terbesar yang terbentuk pada ekstrak etanol yaitu pada konsentrasi 10% dengan diameter zona hambat 9,18 mm terhadap bakteri Escherichia coli dan 12,16 mm terhadap bakteri Staphylococcus aureus sedangkan fraksi batang akar kuning yang memiliki aktivitas antibakteri paling kuat terhadap bakteri Escherichia coli dan Staphylococcus aureus yaitu fraksi sisa. Staphylococcus aureus memiliki sensitifitas lebih tinggi terhadap akar kuning (Fibraurea tinctoria Lour) dari pada bakteri Escherichia coli. Kata kunci  : antibakteri, akar kuning, berberin, Fibraurea tinctoria Lour. Abstract Akar kuning (Fibraurea tinctoria Lour.) is typically plant that can be found in Kalimantan usually used by local people as itch medicine, jaundice and diarrhea. Berberin, one of the chemical compounds contained in the akar kuning, berberin has the potential to act as an anti-diabetic, antiviral, antibacterial, and anti-inflammatory. This study aimed to determine the activity of akar kuning as an antibacterial against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Ethanol extract are fractionated using n-Heksan and Etilasetat solvents, the obtained of extract and fraction are weighed to 2,5%, 5% and 10%. Positive control antibacterial used amoxicillin and DMSO as negative control. The results showed that ethanol extracts and fraction of akar kuning (Fibraurea tinctoria Lour.) are have potential to inhibited bacteria growth. The highest antibacterial activity that showed at 10% concentration of ethanol extract with diameter inhibition is 9,18 mm to Escherichia coli and 12,16 mm to Staphylococcus aureus while the fraction of akar kuning which has the stronger antibacterial activity to Escherichia coli and Staphylococcus aureus is the rest fraction. Staphylococcus aureus were more susceptible to akar kuning (Fibraurea tinctoria Lour.) extract and fraction than Escherichia coli.Keywords:           antibacterial, akar kuning, berberin, Fibraurea tinctoria Lour
UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BATANG SEKILANG (Embeliaborneensis Scheff) TERHADAP BAKTERI Propionibacterium acnes dan Staphylococcus epidermidis Ari Saptowo; Risa Supriningrum; Supomo supomo
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 7, No 2 (2022)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.939 KB) | DOI: 10.31602/ajst.v7i2.6331

Abstract

Plants as medicinal ingredients have potential as antimicrobials and antioxidants, with various molecules that can protect the human body from pathogens and cellular oxidation. This is closely related to the secondary metabolitescontained in these plants. Currently there are several bacteria that are resistant to antibiotics, therefore it is necessary to find an alternative to overcome this resistance by conducting research on medicinal plants. Sekilang (Embeliaborneensis) is a plant that is used by the Dayak tribe in Kalimantan as an ingredient for catching fish, repelling leeches and hair care and does not rule out having medicinal properties. So it is necessary to do research on these plants, especially the bark. The purpose of this study was to determine the antibacterial activity of sekilang bark extract against Propionibacterium acnes and Staphylococcus epidermidis bacteria. Extraction of the active substance was carried out by maceration with ethanol solvent and antibacterial activity test using the disc diffusion method. The results of phytochemicalscreening showed that the bark extract of sekilang contains saponins, flavonoids, alkaloids and tannins. The results of the antibacterial activity test against Propionibacterium acne at a concentration of 2.5%; 5% ; 10% and 20% are 6.5 mm, respectively; 8.36 mm ; 7.5mm; 7.33mm. Antibacterial activity against Staphyllococus epidermidis at a concentration of 2.5%; 5% ; 10% and 20% are 7.0 mm, respectively; 7.7mm; 6.33mm; 7.8mm. It was concluded, that the bark extract of sekilang have antibacterial activity against Propionibacterium acne and Staphyllococus epidermidis with moderate category. The positive control used was clindamycin and the negative control was Dimethyl sulfoxy.
TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF YELLOW PUMPKIN (Cucurbita moschata Duch) FRUIT EXTRACT Yudha Pratama; Risa Supriningrum; Supomo Supomo
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 10, No 1 (2024)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v10i1.14302

Abstract

Pumpkin (Cucurbita moschata Duch) is a food rich in vitamin A, vitamin C, minerals, carbohydrates, and flavonoid compounds. Flavonoids have several pharmacological activities, including as antioxidants to ward off free radicals. This study aims to determine the total flavonoid content and antioxidant activity of pumpkin fruit. The extraction of pumpkin fruit was done by the maceration method in a 70% ethanol solvent. The total flavonoid test used the colorimetric method with a 10% AlCl3 reagent and quercetin as a positive control. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results obtained for the total flavonoid content of the ethanol extract of pumpkin fruit amounted to 1.741 mgQE/g ± 0.2438 and an IC50 value of 379.44 ppm, including the category of weak antioxidant, compared with the positive control.
TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF YELLOW PUMPKIN (Cucurbita moschata Duch) FRUIT EXTRACT Yudha Pratama; Risa Supriningrum; Supomo Supomo
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 10, No 1 (2024)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v10i1.14302

Abstract

Pumpkin (Cucurbita moschata Duch) is a food rich in vitamin A, vitamin C, minerals, carbohydrates, and flavonoid compounds. Flavonoids have several pharmacological activities, including as antioxidants to ward off free radicals. This study aims to determine the total flavonoid content and antioxidant activity of pumpkin fruit. The extraction of pumpkin fruit was done by the maceration method in a 70% ethanol solvent. The total flavonoid test used the colorimetric method with a 10% AlCl3 reagent and quercetin as a positive control. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results obtained for the total flavonoid content of the ethanol extract of pumpkin fruit amounted to 1.741 mgQE/g ± 0.2438 and an IC50 value of 379.44 ppm, including the category of weak antioxidant, compared with the positive control.
Co-Authors Ari Saptowo Audinah Eka Eka Siswanto Syamsul Hardi Astuti Witasari Hayatus Sa’adah Husnul Warnida Idriana Idriana Indra Indra Kintoko, Kintoko Lusi Mardika Ariyanti Miftahul Huda Risa Supriningrum Yudha Pratama