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Optimization of Theophylline Tablet Formula Using CoProcessed Excipients of Lactose and Avicel Hayatus Sa`adah; Achmad Fudholi
Indonesian Journal of Pharmacy Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.283 KB) | DOI: 10.14499/indonesianjpharm0iss0pp306-314

Abstract

Tablet  excipients  in  direct  compression  should  have  good  flowability  and compactibility.  Improvement  of  excipients  properties  may  be  obtained  by  coprocessing. Co-processing is defined as combining two or more excipients by an appropriate  process.  Co-processed  excipients  of  lactose  and  avicel,  which  were fabricated  by  spray  drying  technique,  would  be  used  as  filler-binder  in theophylline  tablet  formulation.  The co-processed excipients were evaluated for their  physical  properties,  i.e;  particle  size  distribution,  average  diameter, density,  flowability,  compactibility  and  water  absorption.  Simplex  lattice  design was  used  for  optimizing  flowability,  compactibility  and  water  absorption  of  coprocessed  excipients.  The  results  showed  that  proportion  of  lactose  and  avicel with  optimum  physical  properties  was  determined  by  the  ratio  1:1  with  a response of flowability was 8.79 ± 0.02 seconds, compactibility was 5.61 ± 0.08 kg and water absorption was 61.30 ± 0.40 mg/min. Superimposed contour plot of  theophylline  tablet  formulation  using  co-processed  excipients  as  filler-binder by  factorial  design  was  determined  by  the  optimum  proportion  of  magnesium stearate  and  eksplotab  (1:3.74)  with  the  response  of  hardness  was  5.54  ± 0.042  kg,  friability  was  0.303 ±  0.015%, disintegration  time was  1.83 ±  0.115 minutes and DE20was 85.66 ± 0.35%.Key words: theophylline tablets; co-processed excipients; lactose; avicel 
FORMULASI ORALLY DISINTEGRATING TABLET (ODT) ASETOSAL DENGAN VARIASI KONSENTRASI KOMBINASI AVICE Hayatus Sa'adah; Yulistia Budianti S.; Akhmad Andy Sandra
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 1 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.066 KB) | DOI: 10.36387/jiis.v4i1.216

Abstract

Acetylsalicylic acid or better known as acetosal or aspirin is a drug that has efficacy as an antiplatelet which is widely used as a drug to prevent and treat stroke. Currently acetosal is often found in many preparations, one of which is in conventional tablet preparations. Stroke sufferers really need a drug in tablet dosage form that is easy to consume, has a relatively fast duration of drug action, and with more practical drug administration. Therefore, an acetosal preparation is made in the form of Orally Disintegrating Tablet (ODT) which has several advantages, including being more practical to use because it can be consumed without using water and can be used by patients who are difficult to swallow conventional tablets. Research conducted on acetosal ODT formulation with variations in the combination concentration of Avicel PH 102 and mannitol as filler material. In this study, the physical properties of ODT acetosal were tested by varying the combination concentration of Avicel PH 102 and mannitol as a filler with a ratio of F1 = 0: 1, F2 = 0.25: 0.75, F3 = 0.5: 0.5 , F4 = 0.75: 0.25, and F5 = 1: 0. The ODT evaluation was carried out in the form of examining the weight uniformity test, hardness test, friability test, and tablet disintegrating time test. The results of the study obtained the best formula is F4 with a comparison of Avicel PH 102 and manitol 0.75: 0.25 that meets the requirements of physical properties of ODT with the average value of tablet weight uniformity test 382.5 mg ± 0.007, tablet 2 hardness test, 52 kg / cm2 ± 0.396, tablet friability test 0.53% ± 0.153, and tablet disintegrating time test 21 seconds ± 3.605.
KARAKTERISASI PARAMETER SPESIFIK DAN PARAMETER NON SPESIFIK AKAR KUNING (Fibraurea tinctoria) Supomo Supomo; Hayatus Sa`adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.786 KB) | DOI: 10.36387/jiis.v5i2.592

Abstract

One of the secondary metabolites from yellow root (Fibraurea tinctoria) that has the potential to be developed as medicine is berberine. Alkaloid class compounds are reported to have antimicrobial, anti-diarrheal, intestinal parasite infection inhibitors, antihypertensives, anti-tumor, anti-inflammatory, hepatoprotective, antimalarial and anticancer properties. In the development of natural ingredients as medicine, it is necessary to standardize simplicia and extracts The research objective was to determine the characterization of specific and non-specific parameters of yellow root plants. This research is an experimental research. The object of research used yellow roots obtained from KDKT Samboja, Kutai Kartanegara district, East Kalimantan Province. Samples were made of simplicia which were extracted using the maceration method with 70% ethanol solvent. The results of the extraction were carried out by characterization including: macroscopic, microscopic, water content, water-soluble extract, ethanol-soluble extract, ash content, and acid-insoluble ash, then phytochemical screening was carried out. Data were analyzed using descriptive methods. The results of macroscopic characterization of yellow root simplicia powder were Liana with a length of 10-20 m, with round stems, bark grayish brown, coarse, 2-7 cm in diameter and bright yellow powder color. The simplicia powder microscopy found stone cell fragments and tracheal fragments. Characterization of simplicia powder, water content of 67.3%, ethanol soluble extract content of 6.69%, water soluble extract content of 8.05%, ash content of 7.37%, acid insoluble ash content of 0.37%. The results of the identification of the chemical compound group were positive for containing chemical compounds in the form of alkaloids, flavonoids and saponins.
Formulation and Evaluation Lotion of Tengkawang Seed Fat (Shorea mecistopteryx Ridley) and Cocoa Fat (Theobroma cacao L.) as a Base Maria Elvina Tresia Butar-Butar; Yulia Sukawaty; Hayatus Sa'adah
Jurnal Farmasi Etam (JFE) Vol 1 No 1 (2021): Juni
Publisher : Unit Penelitian dan Pengabdian Kepada Masyarakat (UPPM) STIKES Dirgahayu Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.325 KB) | DOI: 10.52841/jfe.v1i1.188

Abstract

ABSTRAK Lemak biji tengkawang (Shorea mecistopteryx Ridley) merupakan salah satu tumbuhan khas Kalimantan yang memiliki karakteristik fisik menyerupai lemak kakao. Kandungan lemak nabati yang tinggi pada lemak biji tengkawang, seperti asam oleat sebesar 55,95%, asam palmitat 14,02%, miristat 0,05%, dan stearat 0,05% mendorong peneliti untuk melakukan penelitian dengan memanfaatkan lemak biji tengkawang sebagai basis dalam pembuatan sediaan kosmetika, seperti losion. Penelitian ini dilakukan dengan mengkombinasi lemak biji tengkawang dan lemak kakao sebagai basis losion. Kombinasi ini bertujuan untuk mengetahui karakteristik fisik losion yang dihasilkan dari perbedaan kosentrasi. Karakteristik fisik losion diketahui melalui beberapa evaluasi, yaitu organoleptis, homogenitas, viskositas, pH, daya lekat, penyusutan bobot, dan stabilitas secara mekanik. Berdasarkan evaluasi yang dilakukan diperoleh data yang menunjukkan adanya pengaruh yang disebabkan oleh perbedaan kosentrasi basis terhadap karakteristik fisik losion. Perbedaan karakteristik fisik yang mencolok terutama terlihat pada nilai viskositas yang menunjukkan formula I 1485,55 cp, formula II 3408,88 cp, formula III 2017,77 cp, dan formula IV 3314,44 cp. Viskositas meningkat seiring lama waktu penyimpanan dan ini berbanding lurus dengan kemampuan daya lekat losion. ABSTRACT Tengkawang seed fat (Shorea mecistopteryx Ridley) is one of the typical plants of Kalimantan that has physical characteristics resembling cocoa fat. The high content of vegetable fats in tengkawang seed fats, such as oleic acid by 55.95%, palmitic acid 14.02%, miristat 0.05%, and stearate 0.05% encouraged researchers to conduct research by utilizing tengkawang seed fat as the basis in the manufacture of cosmetic preparations, such as lotions. This research was conducted by combining tengkawang seed fat and cocoa fat as the basis of lotion. This combination aims to determine the physical characteristics of lotions resulting from differences in concentration. The physical characteristics of lotions are known through several evaluations, namely organoleptis, homogeneity, viscosity, pH, adhesion, weight shrinkage, and mechanical stability. Based on the evaluation conducted obtained data that shows the influence caused by differences in the concentration of the base to the physical characteristics of lotions. Striking differences in physical characteristics are especially noticeable in viscosity values indicating formulation I 1485.55 cp, formulation II 3408.88 cp, formulation III 2017.77 cp, and formulation IV 3314.44 cp. Viscosity increases over a long period of time and this is directly proportional to the lotion's adhesion capability.
PENGARUH METODE EKSTRAKSI TERHADAP KADAR FLAVONOID EKSTRAK ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia(L.)Merr) DENGAN METODE SPEKTROFOTOMETRI Hayatus Sa`adah; Henny Nurhasnawati; Vivi Permatasari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 1 No 1 (2017): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bawang dayak (Eleutherine palmifolia (L.) Merr) merupakan salah satu tumbuhan berkhasiat yang mempunyai aktifitas sebagai antioksidan. Salah satu senyawa aktif yang terdapat dalam ekstrak etanol umbi bawang dayak yang merupakan senyawa flavonoid. Optimasi pembuatan ekstrak perlu dilakukan untuk mendapatkan kandungan zat aktif yang tinggi. Optimasi pembuatan ekstrak salah satunya adalah metode ekstraksi. Penelitian merupakan penelitian eksperimental dengan objek penelitian adalah kadar flavonoid dari umbi bawang dayak. Penelitian dilakukan untuk membandingkan hasil metode ekstraksi yaitu metode maserasi dan sokletasi dengan menggunakan pelarut yang sama. Kadar flavonoid diuji menggunakan metode spektrofotometri berdasarkan pembentukan senyawa kompleks aluminium klorida, dengan standar baku kuersetin. Data dianalisis dengan uji statistik independent T-Test menggunakan SPSS versi 20. Hasil penelitian menunjukkan kadar flavonoid rata-rata pada metode ekstraksi maserasi sebesar 1,09% lebih besar daripada metode ekstraksi sokletasi sebesar 0,81%. Hasil uji statistik menunjukkan nilai sig 0,005 lebih kecil dari 0,05 dengan taraf kepercayaan 95%, yang berarti bahwa terdapat perbedaan signifikan antara kadar flavonoid metode ekstraksi maserasi dan sokletasi.
FORMULASI ORALLY DISINTEGRATING TABLET (ODT) EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) DENGAN VARIASI KONSENTRASI EXPLOTAB® Hayatus Sa`adah; Reni Anggraini; Sapri Sapri
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.439 KB) | DOI: 10.37090/jfl.v8i1.83

Abstract

Tahongai leaves (Kleinhovia hospita L.) is a medicinal plant that has antioxidant activity which is almost equivalent to vitamin C. The development of the dosage form to improve the utilization of these plants. Therefore Tahongai leaves made in the form Orally Disintegrating Tablets (ODT), which has several advantages such as more practical use because it can be consumed without the use of water and can be used by people who are hard to swallow capsules or tablets as well as having good taste in the mouth. This study was carried out experimentally using four formulas with various concentrations Explotab® ie; formula 1 (2%); formula 2 (4%); Formula 3 (6%) and the formula 4 (8%). The evaluation of ODT are uniformity of weight, hardness, friability and disintegration time.The results showed that the concentration Explotab® influence on the physical properties of ODT ie hardness, friability and disintegration time. Explotab® concentration of 4% is the best concentration that meets the requirements of the physical properties ODT Tahongai leaf extract. Keywords: Formulation, Orally Disintegrating Tablets (ODT), Explotab, Tahongai (Kleinhovia hospita L.)
Uji Aktivitas Antibakteri EkstrakEtanol dan Fraksi Batang Kuning (Fibraurea Tinctoria Lour) terhadap Bakteri Escherichia coli dan Staphylococcus aureus Lusi Mardika Ariyanti; Supomo Supomo; Hayatus Sa’adah; Eka Siswanto Syamsul; Kintoko Kintoko; Hardi Astuti Witasari
JI-KES (Jurnal Ilmu Kesehatan) Vol 5, No 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.323

Abstract

Abstrak Akar kuning (Fibraurea tinctoria Lour) merupakan tumbuhan khas yang dapat dijumpai di Kalimantan serta biasa dimanfaatkan oleh masyarakat setempat sebagai obat gatal, penyakit kuning dan diare. Salah satu senyawa kimia yang terkandung dalam akar kuning adalah berberin yang berpotensi memiliki khasiat sebagai antidiabetes, antivirus, antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk  mengetahui potensi tumbuhan Akar Kuning (Fibraurea tinctoria Lour.) sebagai antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan menggunakan metode disc diffusion. Ekstrak etanol difraksinasi dengan menggunakan pelarut n-heksan dan etilasetat, ekstrak dan fraksi yang telah didapat ditimbang dengan konsentrasi 2,5%, 5% dan 10%. Kontrol positif yang digunakan yaitu amoxicillin dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ektrak etanol dan fraksi akar kuning (Fibraurea tinctoria Lour.) memiliki potensi untuk menghambat pertumbuhan bakteri. Aktivitas zona hambat terbesar yang terbentuk pada ekstrak etanol yaitu pada konsentrasi 10% dengan diameter zona hambat 9,18 mm terhadap bakteri Escherichia coli dan 12,16 mm terhadap bakteri Staphylococcus aureus sedangkan fraksi batang akar kuning yang memiliki aktivitas antibakteri paling kuat terhadap bakteri Escherichia coli dan Staphylococcus aureus yaitu fraksi sisa. Staphylococcus aureus memiliki sensitifitas lebih tinggi terhadap akar kuning (Fibraurea tinctoria Lour) dari pada bakteri Escherichia coli. Kata kunci  : antibakteri, akar kuning, berberin, Fibraurea tinctoria Lour. Abstract Akar kuning (Fibraurea tinctoria Lour.) is typically plant that can be found in Kalimantan usually used by local people as itch medicine, jaundice and diarrhea. Berberin, one of the chemical compounds contained in the akar kuning, berberin has the potential to act as an anti-diabetic, antiviral, antibacterial, and anti-inflammatory. This study aimed to determine the activity of akar kuning as an antibacterial against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Ethanol extract are fractionated using n-Heksan and Etilasetat solvents, the obtained of extract and fraction are weighed to 2,5%, 5% and 10%. Positive control antibacterial used amoxicillin and DMSO as negative control. The results showed that ethanol extracts and fraction of akar kuning (Fibraurea tinctoria Lour.) are have potential to inhibited bacteria growth. The highest antibacterial activity that showed at 10% concentration of ethanol extract with diameter inhibition is 9,18 mm to Escherichia coli and 12,16 mm to Staphylococcus aureus while the fraction of akar kuning which has the stronger antibacterial activity to Escherichia coli and Staphylococcus aureus is the rest fraction. Staphylococcus aureus were more susceptible to akar kuning (Fibraurea tinctoria Lour.) extract and fraction than Escherichia coli.Keywords:           antibacterial, akar kuning, berberin, Fibraurea tinctoria Lour
PEMANFAATAN LIMBAH SAMPAH RUMAH TANGGA SEBAGAI KOMPOS Risa Supriningrum; Hayatus Sa'adah; Henny Nurhasnawati
Jurnal Abdi Masyarakat Kita Vol 1 No 2 (2021): Jurnal Abdi Masyarakat Kita
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1197.704 KB) | DOI: 10.33759/asta.v1i2.163

Abstract

Garbage is a problem that has not been resolved until now. The central and local governments have tried to make regulations on waste management and have disseminated them to the public, but the waste problem still cannot be resolved. Community concern for the environment plays an important role in overcoming this problem. Starting from the smallest scope, namely the family or household to get used to managing waste properly and correctly. Household waste, especially kitchen waste, can be used as compost. The processing of household waste into compost can be done individually or in groups such as at the RT level. This community service aims to provide counseling about the importance of maintaining environmental cleanliness and the use of household kitchen waste as compost. The activity is intended for residents of Jalan Agus Salim RT 18, Sungai Pinang Luar District, Samarinda. The method used is counseling followed by demonstration of composting, pre-test and post-test are also carried out to determine the level of community understanding of this community service activity. This activity was attended by the head of the RT and several residents as representatives of the residents of the RT. The existence of this activity is expected to change people's behavior to be better in managing waste and become a source of income for residents.
PENYULUHAN PENCEGAHAN HIPERTENSI DENGAN CERDIK fara azzahra; Octariana Sofyan; Andi Wijaya; Mexsi Mutia Rissa; Danang Yulianto; Hayatus Sa’adah
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is a condition where the pressure exceeds the normal limit. Uncontrolled high blood pressure can be a risk factor for cardiovascular disease. High blood pressure is still a dominant health problem and requires a good treatment. Counseling to the community of Ledok Timoho village, Muja Muju Umbulharjo Village, Yogyakarta on how to prevent and control hypertension and improve it. The method of activity used in this community service is in the form of counseling on the prevention and control of hypertension, followed by a question and answer discussion, and evaluation of activities using a questionnaire. The results of the implementation of community service showed that there was an increase in the knowledge of PKK mothers about the prevention and control of hypertension in the community from 86.30% to 100%.
Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101 Supomo Supomo; Dayang Bella R.W; Hayatus Sa'adah
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.99

Abstract

Salah satu tanaman Indonesia yang bisa dimanfaatkan adalah buah manggis (Garcinia mangostana L.). Banyak penelitian yang dilakukan dengan ekstrak kulit manggis terhadap aktivitas farmakologi seperti antiinflamasi, antihistamin, antioksidan dan antimikroorganisme. Variasi pengolahan kulit buah manggis pada masyarakat Indonesia masih terbatas sehingga diperlukan pengembangan dalam bentuk sediaan lain seperti dibuat menjadi granul. Penelitian ini bertujuan untuk mengetahui apakah granul ekstrak kulit buah manggis menggunakan aerosil dan avicel PH 101 memenuhi persyaratan fisik granul yang baik dan untuk mengetahui konsentrasi aerosil dan avicel PH 101 yang memenuhi persyaratan fisik granul ekstrak kulit buah manggis. Penelitian diawali dengan proses ekstraksi simplisia kulit buah manggis secara maserasi dengan menggunakan pelarut etanol 70% dan diuapkan hingga diperoleh ekstrak kental. Pembuatan granul dari ekstrak kulit manggis dilakukan dengan menggunakan kombinasi antara aerosil dan avicel 101 yang divariasikan dalam 4 formula yaitu formula 1 aerosil : avicel 101(0% : 20%), formula 2 aerosil : avicel 101% (20% : 20%), formula 3 aerosil : avicel 101 (0% : 60%) dan formula 4 aerosil : avicel 101 (20% : 60%). Tahap selanjutnya granul hasil dari formulasi dievaluasi sifat fisik granul meliputi uji kandungan lembab, densitas massa, ukuran partikel dan sifat alir. Hasil yang diperoleh dianalisis secara statistik menggunakan analisis variasi (ANAVA). Hasil penelitian menunjukkan dengan konsentrasi avicel 101 : aerosil (20% : 0%) dan konsentrasi avicel 101 : aerosil (60% : 0%) granul ekstrak kulit manggis, memenuhi persyaratan, meliputi uji kandungan lembab, densitas massa, ukuran partikel dan sifat alir. Hal ini menunjukkan bahwa avicel 101 mampu berperan sebagai pengikat yang baik dan kuat sekaligus sebagai penyerap cairan pada granul.Kata Kunci: granul, kulit buah manggis, aerosil, avicel pH 101