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All Journal Medical Journal of Indonesia Jurnal Kesehatan Andalas Indonesian Journal of Cardiology Medical and Health Science Journal J-Kesmas: Jurnal Kesehatan Masyarakat (Indonesian Journal of Public Health) Scientific Journal
Masrul Syafri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Association of endothelial nitric oxyde synthase (eNOS) levels and modifiable risk factors for acute myocardial infarction with ST-segment elevation (AMI-STE) Leona, Denada Florencia; Syafri, Masrul
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 01 (2024): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i01.5672

Abstract

Background. The pathological process underlying myocardial infarction is atherosclerotic thrombosis that causes endothelial dysfunction. In the AMI-STE process, eNOS has functions as the body's defense mechanism to prevent more severe damage to the endothelium. Decreased eNOS levels were found in modifiable AMI risk factors. This study aimed to determine the association of eNOS levels based on modifiable risk factors for AMI-STE patients. Method. This study was an analytical observational study with a historical cohort design. The samples were patients with AMI-STE diagnosis who had undergone PPCI at M. Djamil Hospital Padang from March to June 2022. The eNOS levels were taken from the blood samples. Modifiable AMI risk factors were taken from patient’s medical record. The T test was carried out to determine statistical analysis. Results. The average age of the 38 subjects was 62.53 ± 8.2 years, and 92.1% among them were male, and 52.6% subjects were diagnosed with anterior AMI-STE. The average eNOS level in subjects was 47.47 ± 23.88 (normal level is 48.16 pg/mL). More than half (73.5%) of the subjects in low eNOS group had diabetes mellitus as risk factor (P<0.0001) and most subjects (78.9%) in group with low eNOS had hypertension (p=0.022). Other risk factors, namely dyslipidemia and smoking, were also more common in group with low eNOS. However, statistical tests showed that there was no statistically association between eNOS levels with dyslipidemia and smoking. Conclusion. There was statistically significant association between eNOS levels with diabetes mellitus and hypertension as modifiable risk factors for AMI-STE.
Description of ST Segments Elevation of Myocardial Infarction on Patients Undergoing Primary Percutaneous Coronary Intervention in dr. M. Djamil Hospital Padang Permatasari, Pradita Diah; Fadil, Muhammad; Syafri, Masrul
J-Kesmas: Jurnal Fakultas Kesehatan Masyarakat (The Indonesian Journal of Public Health) Vol 7, No 1 (2020): April 2020
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/j-kesmas.v7i1.1817

Abstract

Myocardial infarction is influenced by various risk factors consist of gender, age, family history, smoking, hypertension, dyslipidemia, diabetes mellitus and menopause. The aim of this study was to describe the description of sex, age and risk factors possessed by patients with ST segments Elevation Myocardial Infarction (STEMI) who underwent primary percutaneous coronary intervention (PPCI) procedures at Dr. M. Djamil hospital Padang. Amount of 40 people were obtained specifically for STEMI patients who underwent PPCI and were treated at the integrated heart services installation of RSUP dr. M. Djamil Padang from July-September 2019. The research variables measured were age, sex, risk factors for hypertension, diabetes mellitus, smokers, dyslipidemia, family history and menopause. Data was analyzed in the form of univariate analysis, which explained each research variable according to the proportion and frequency values. The results were found in 40 patients with acute ST segments elevation myocardial infarction, all aged > 40 years, most were male (85%) and the most risk factor was smoking (82,5%). We conclude that STEMI patients who underwent PPCI in dr.M. Djamil hospital Padang from July-September 2019 were all > 40 years old, most were male, with the most risk factors were smokers.
Double set up technique as a bailout of diagonal branch coronary perforation: a case report Syukri, Muhammad; Yanni, Mefri; Syafri, Masrul; Phalguna, Shindu; Firmansyah, Alles; Indah, Merlin Sari Mutma; Mahendra, Ivan; Zulkarnain, Hadi
Medical Journal of Indonesia Vol. 33 No. 1 (2024): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.247266

Abstract

Coronary artery perforation is a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI). A 55-year-old male with a history of implanted stent on the left main ostium to the proximal left circumflex artery (LCX) and distal right coronary artery, and chronic total occlusion (CTO) on ostium left anterior descending (LAD). PCI was performed using a stiff wire to cross the CTO body in LAD. We performed an injection and confirmed the presence of extravasation. We successfully managed to stop the bleeding by placing the tips of floppy wire that were cut into pieces. A drainage pathway was made through thoracotomy for pericardial effusion. Angiography showed persisting extravasation at the wire insertion site. We then made our own covered stent. We implanted on the osteal LAD until proximal LCX. Repeated angiography showed no contrast extravasated from the perforation site, and the patient was stabilized and discharged.
Utilizing the CHA₂DS₂-VASc-HSF Score to Predict Subclinical Acute Kidney Injury from Contrast Agents: A Focus on Neutrophil Gelatinase-Associated Lipocalin Biomarker : SCI-AKI and CHA₂DS₂-VASc-HSF Score Syafri, Masrul; Firmansyah, Alles; Mutma Indah, Merlin Sari; Muya, Yui
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.287

Abstract

Background: Contrast-Induced Acute Kidney Injury (CI-AKI) is a common complication in patients undergoing Percutaneous Coronary Intervention (PCI), with Subclinical Contrast-Induced Acute Kidney Injury (SCI-AKI) detectable via biomarkers like Neutrophil Gelatinase-Associated Lipocalin (NGAL). The CHA₂DS₂-VASc score, developed for stroke risk in atrial fibrillation, has been modified to CHA₂DS₂-VASc-HSF for assessing cardiovascular risk, but its role in predicting SCI-AKI remains unclear. Objectives: This study aimed to evaluate the CHA₂DS₂-VASc-HSF score as an indicator for SCI-AKI risk in PCI patients, using NGAL as a biomarker for early kidney injury. Methods: A cohort study was conducted at Dr. M. Djamil General Hospital, Padang, from May to December 2024. Thirty-four patients with stable and unstable angina undergoing PCI were included. NGAL levels were measured before and after PCI. Statistical analysis examined the relationship between CHA₂DS₂-VASc-HSF score and SCI-AKI. Results: Nine patients (26.5%) were diagnosed with SCI-AKI. NGAL levels showed a significant difference between SCI-AKI positive and negative groups (p < 0.05), but no significant association was found between CHA₂DS₂-VASc-HSF score and SCI-AKI (p > 0.05). Discussion: The CHA₂DS₂-VASc-HSF score is effective for cardiovascular risk assessment but not for SCI-AKI prediction. SCI-AKI was better predicted by NGAL, a sensitive biomarker of early kidney injury. This study highlights the importance of combining multiple risk factors for accurate SCI-AKI risk stratification in PCI patients. Conclusion: The CHA₂DS₂-VASc-HSF score is not a reliable predictor for SCI-AKI. NGAL remains a valuable biomarker for early detection, emphasizing the need for a multifactorial approach in managing renal complications post-PCI.
Co-Authors Afriwardi Afriwardi David Ramli Dia Rofinda, Zelly Dia Efrida Efrida Eti Yerizel Firmansyah, Alles Fitri Zahara Gestina Aliska Hauda El Rasyid Indah, Merlin Sari Mutma Leona, Denada Florencia Mahendra, Ivan Malinda Meinapuri Meidiza Ariandiny Muhammad Fadil Muhammad Lingga Primananda Muhammad Syukri Mutma Indah, Merlin Sari Nindrea, Ricvan Dana Permatasari, Pradita Diah Phalguna, Shindu putri yeantesa Rahmatini . Rendi Dwi Prasetyo Ricvan Nandra Nindrea Willy Valerian Wiza Erlanda Yanni, Mefri Yui Muya, Yui Zulkarnain, Hadi