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Gustini Syahbirin
Departemen Kimia, Fakultas MIPA, Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Physics Veterinary

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Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos Syahbirin, Gustini; Aditianingrum, Kurnia Alysia; Mohamad, Kusdiantoro
Jurnal Medik Veteriner Vol. 7 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss1.2024.7-18

Abstract

Curcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the potential active compounds contained in the extract. The crude ethanol extract showed a 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 224 ppm against zebrafish embryos. Based on the gas chromatography-mass spectrometry analysis, the suspected active compounds that play a role in the toxicity were epicurzerenone, curzerene, and curzerenone, while 2,4,6-trimethylacetophenone was the predominant compound.
Antioxidant Activity, Cytotoxicity, and Identification of Secondary Metabolites of Kigelia africana from Waterpark Platinum Riau Fitri, Iis Yusma; Kurniawanti, Kurniawanti; Syahbirin, Gustini; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 11 No 2 (2023): Edition for September 2023
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.11-iis

Abstract

Antioxidants can prevent reactive oxygen-associated diseases, which trigger carcinogenesis, cardiovascular disease, and premature aging. India and Africa have mostly practiced sausage trees (Kigelia africana) as traditional medicine, whereas Indonesia is still limited. The research aims to determine the phytochemistry and bioactivity of the n-hexane fractions from crude methanol extract of the leaves and bark of the sausage tree as antioxidants and their toxicity. The sausage tree is derived from Waterpark Platinum Riau. The sausage trees were macerated with methanol and fractionated by n-hexane and ethyl acetate. All samples were tested for their antioxidant to 1,1-diphenyl-2-picrylhydrazyl (DPPH) and cytotoxicity to Artemia salina Leach larvae. Phytochemical results of methanol crude extract, n-hexane, and ethyl acetate fractions of leaves and sausage bark showed the presence of all secondary metabolites except alkaloids in the n-hexane fraction. Antioxidant and cytotoxic activity of stem and leaf bark ethyl acetate fraction was stronger than crude methanol extract and n-hexane fraction. Based on LC-MS/MS data, the secondary metabolite components that have contributed strongly antioxidant activity of this study are flavonoid compounds such as kaempferol and the derivatives, lignans (cubebin), and steroids (pregnant).
Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment Azkiyah, Dina; Syahbirin, Gustini; Firdayani, Firdayani; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-din

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease distinguished by disrupted glucose metabolism, causing elevated blood sugar levels. One of the latest therapeutic strategies involves inhibiting dipeptidyl peptidase-4 (DPP-4) to regulate glucose metabolism. Emodin, a bioactive compound, has shown potential as a DPP-4 inhibitor, but its efficacy requires further research. This study aims to identify and assess emodin and its derivatives as potential DPP-4 inhibitors through a comprehensive in silico and in vitro analysis. Molecular docking analysis revealed that 3-ρ-toluoyl emodin (ρTE) had the lowest binding energy (-111.4 kcal/mol) among the tested compounds. Furthermore, in vitro testing showed consistent results in silico, indicating that ρTE had significant inhibitory activity with an IC50 value of 1.37 μM. Pharmacokinetic and physicochemical evaluations confirmed ρTE’s potential as a safe antidiabetic drug candidate. The research findings indicate that ρTE holds potential as a promising drug candidate for further development.
Co-Authors Abdul Aziz Darwis Aditianingrum, Kurnia Alysia Akhiruddin Maddu Ani Suryani Ani Suryani Auliya Ilmiawati Azkiyah, Dina Budi Arifin DADANG DADANG EKA CHANDRA LINA Firdayani, Firdayani Fitri, Iis Yusma Komar Sutriah Kurniawanti, Kurniawanti Kusdiantoro Mohamad LAKSMI AMBARSARI Muhamad Alif Hamimdal Nur Qadri Rasyid Pajri Samsi Nasution Purwantiningsih Sugita Rahmani, Nabiila Rasyid, Nur Qadri Shabrina Shabrina Sri Mulijani Syafrida Manuwoto Tesar Dzikrulloh Wasrin Syafii