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Gustini Syahbirin
Departemen Kimia, Fakultas MIPA, Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Physics Veterinary

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Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment Azkiyah, Dina; Syahbirin, Gustini; Firdayani, Firdayani; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-din

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease distinguished by disrupted glucose metabolism, causing elevated blood sugar levels. One of the latest therapeutic strategies involves inhibiting dipeptidyl peptidase-4 (DPP-4) to regulate glucose metabolism. Emodin, a bioactive compound, has shown potential as a DPP-4 inhibitor, but its efficacy requires further research. This study aims to identify and assess emodin and its derivatives as potential DPP-4 inhibitors through a comprehensive in silico and in vitro analysis. Molecular docking analysis revealed that 3-ρ-toluoyl emodin (ρTE) had the lowest binding energy (-111.4 kcal/mol) among the tested compounds. Furthermore, in vitro testing showed consistent results in silico, indicating that ρTE had significant inhibitory activity with an IC50 value of 1.37 μM. Pharmacokinetic and physicochemical evaluations confirmed ρTE’s potential as a safe antidiabetic drug candidate. The research findings indicate that ρTE holds potential as a promising drug candidate for further development.
Efek Campuran Ekstrak Temulawak (Curcuma xanthorrhiza) dan Temuputih (Curcuma zedoaria) terhadap Toksisitas Akut pada Embrio Ikan Zebra Mohamad, Kusdiantoro; Aryani, Nursela Sofyanti Mirza; Prasetyaningtyas, Wahono Esthi; Syahbirin, Gustini
Jurnal Sain Veteriner Vol 42, No 2 (2024): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.94142

Abstract

Temulawak (Curcuma xanthorrhiza) dan temuputih (Curcuma zedoaria) termasuk tanaman herbal yang mempunyai potensi sebagai antitumor dan antikanker. Beberapa obat antikanker dan ekstrak herbal telah dilaporkan memiliki toksisitas yang tinggi dan menyebabkan malformasi pada embrio ikan zebra (Danio rerio). Penelitian ini bertujuan membandingkan toksisitas ekstrak etanol C. xanthorrhiza, C. zedoaria, dan campurannya (rasio 1:6) terhadap embrio ikan zebra. Rimpang C. xanthorrhiza dan C. zedoaria diekstrak dengan cara maserasi dalam etanol 80%. Ekstrak diuji toksisitas akut dengan embrio ikan zebra menggunakan metode OECD Guidelines for the Testing of Chemicals No. 236 (2013). Nilai lethal concentration 50 (LC50) campuran ekstrak adalah 82.9 ppm, berada di antara nilai LC50 masing-masing ekstrak (16.9 untuk C. xanthorrhiza dan 112.1 untuk C. zedoaria). Tingkat menetas embrio rendah pada ekstrak C. xanthorrhiza tetapi tinggi pada ekstrak C. zedoaria dan ekstrak campuran. Kelainan notokorda dan edema kantong kuning telur tinggi pada ekstrak C. xanthorrhiza tetapi rendah pada ekstrak C. zedoaria dan ekstrak campuran. Kelainan sirkulasi darah rendah pada ekstrak C. zedoaria tetapi tinggi pada ekstrak campuran. Edema perikardium dan koagulasi darah merupakan malformasi mayor pada semua ekstrak. Dapat disimpulkan bahwa campuran ekstrak etanol temulawak dan temuputih menyebabkan malformasi edema perikardium, koagulasi darah, dan secara sinergis menghambat sirkulasi darah, yang berkaitan dengan potensi antikanker. Selain itu, ekstrak campuran dapat menurunkan hambatan menetas, malformasi notokorda, dan edema kantong kuning telur.
The effect of Cerbera odollam leaf and fruit peel extract on subterranean termite Coptotermes curvignathus Mujahidah, Ummahatul; Ilmiawati, Auliya; Arinana, Arinana; Syahbirin, Gustini; Batubara, Irmanida
Jurnal Hama dan Penyakit Tumbuhan Tropika Vol. 26 No. 1 (2026): MARCH, JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA: JOURNAL OF TROPICAL PLANT PE
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jhptt.126100-111

Abstract

Coptotermes curvignathus is a termite pest that attacks buildings, plantations, and forests. Controlling this pest requires environmentally friendly natural materials. The bintaro plant (Cerbera odollam) are known in Indonesia as natural insecticides and traditional medicines because of their strong toxic properties, so they have the potential to be used in termite control. This study evaluated the efficacy of C. odollam leaf and fruit peel extracts as natural termiticides and their effectiveness against subterranean termite C. curvignathus. The extraction process used three solvents with different polarities: n-hexane, acetone, and ethanol. Anti-termite bioactivity tests were conducted following the Japanese Industrial Standard (JIS) 1571-2010 method. Ethanol extract from C. odollam leaves produced the highest yield (9.52%). Phytochemical analysis showed the presence of alkaloids, flavonoids, phenolics, steroids, and saponins in both leaf and fruit peel extracts. The anti-termite bioactivity test showed that the leaf extract with acetone solvent caused 97.33% mortality, while the fruit peel extract with ethanol solvent caused 100% mortality at a 5% concentration. This study demonstrates that C. odollam leaf and fruit peel extracts have strong potential as natural termiticides.
Metabolite Profiling and Bioactivity Assessment of Antioxidant and Antibacterial Properties in Bulb Fractions of Eleutherine bulbosa (Mill.) Urb Komalasari, Nurma Angeliani; Natalia Marbun, Natalia; Syahbirin, Gustini; Ambarsari, Laksmi; Sugita, Purwatiningsih
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.388

Abstract

Eleutherine bulbosa is known to contain diverse secondary metabolites with pharmacological potential. This study aimed to identify the bioactive compounds in the ethanol, n-hexane, and unsaponified n-hexane fractions of E. bulbosa bulbs and evaluate their antioxidant and antibacterial activities. The bulbs were extracted using ethanol, followed by n-hexane fractionation and saponification. Antioxidant activity was determined using the DPPH assay, and antibacterial activity was assessed against Staphylococcus aureus and Escherichia coli using the disc diffusion method. LC-MS/MS and GC-MS analyses identified compounds such as eleutherol, resveratrol, coniferaldehyde, and stigmasterol. The ethanol fraction exhibited the highest antioxidant activity (IC₅₀ = 47.54 ± 0.03 mg/L), while the unsaponified n-hexane fraction showed the strongest antibacterial effect (inhibition zone = 16.12 ± 0.16 mm). These findings confirm the potential of E. bulbosaas a natural source of antioxidant and antibacterial agents.
Performance of Doped Montmorillonite on Photosensitizer Based Natural Dyes Gardenia Jasminoides Mulijani, Sri; Sutriah, Komar; Syahbirin, Gustini; Shabrina, Shabrina
INDONESIAN JOURNAL OF APPLIED PHYSICS Vol 12, No 1 (2022): April
Publisher : Department of Physics, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/ijap.v12i1.54786

Abstract

Dye Sensitized Solar Cell (DSSC) is an electrochemical cell that is able to convert solar energy from light to electrical energy. This technology is needed by the world as a renewable and environment friendly energy. In this study, we evaluate the consideration of modification montmorillonite and Gardenia jasminoides dyes may achieve better performance of DSSC by manufactured DSSC with modified TiO2 semiconductors using montmorillonite (MMT) and Nafion. Performance of DSSC was determined by potentiometer. Atomic force microscope was used to evaluate the characteristic of DSSC. The UV-vis results revealed that the dyes which is extracted from the Gardenia jasminoides content crocin and quercetin compounds. Modification DSSC contains ratio of MMT: nafion (50:50) exhibited highest power conversion efficiency value of 0.8316%. Topography of surface ensured the dyes have occupied surface area and able to promote electron to higher energy.  However, MMT and nafion capable to enhance potential of dyes as photosensitizer in DSSC. 
Optimalisasi Sifat Reologi Hidrogel Kitosan-Hialuronat yang Ditaut-Silang dengan Glutaraldehida Pajri Samsi Nasution; Muhamad Alif Hamimdal; Gustini Syahbirin; Budi Arifin
ALCHEMY Jurnal Penelitian Kimia Vol 15, No 1 (2019): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (461.927 KB) | DOI: 10.20961/alchemy.15.1.22536.24-43

Abstract

Kitosan membentuk hidrogel polikationik dengan penambahan glutaraldehida sebagai penaut-silang. Penambahan hialuronat yang bersifat polianionik diharapkan akan meningkatkan sifat reologis hidrogel tersebut. Penelitian ini mengevaluasi pengaruh konsentrasi glutaraldehida dan hialuronat pada kekuatan gel, titik pecah, dan ketegaran, serta sifat pembengkakan dan pengerutan hidrogel kitosan, dan menentukan konsentrasi optimum keduanya melalui analisis data dengan perangkat lunak Modde 5Ò. Hialuronat meningkatkan kekuatan gel, titik pecah, dan ketegaran hidrogel kitosan pada konsentrasi glutaraldehida yang rendah, tetapi berpengaruh sebaliknya pada konsentrasi glutaraldehida yang tinggi. Sejalan dengan itu, pembengkakan juga menjadi relatif tinggi, sedangkan pengerutan menjadi relatif rendah setelah penambahan hialuronat, tetapi hanya pada konsentrasi glutaraldehida yang rendah. Berdasarkan hasil ini, hialuronat diperkirakan mengisi ruang kosong di antara taut-silang imina yang terbentuk antara glutaraldehida dan kitosan. Pada konsentrasi glutaraldehida yang tinggi, taut-silang ini tidak menyisakan lagi ruang kosong bagi hialuronat. Sebaliknya, air sedikit demi sedikit akan terdesak keluar dari dalam hidrogel dan memicu pengerutan. Komposisi optimum diperoleh pada konsentrasi kitosan 2,0% (b/v), hialuronat 0,3% (v/v) dan glutaraldehida 1,4% (v/v), yang memberikan kekuatan gel, titik pecah, ketegaran, pembengkakan dan pengerutan berturut-turut sebesar 678,4 g cm-2; 1,294 cm; 5,033 g cm-1; 2,634 g dan 0,148 g. Pengukuran sifat reologi hidrogel yang dibuat dengan komposisi optimum tersebut memberikan hasil yang lebih rendah (190,7 g cm-2; 0,767 cm; 1,675 g cm-1) untuk tiga sifat reologi pertama, tetapi lebih tinggi (2,844 g and 0,348 g) untuk dua sifat berikutnya.Optimization of Rheological Property of Chitosan-Hyaluronate Hydrogel Crosslinked by Glutaraldehyde. Chitosan forms a polycationic hydrogel by addition of glutaraldehyde as a crosslinker. The addition of hyaluronate which is polyanionic is expected to improve the rheological properties of the hydrogel. This study evaluated the effects of glutaraldehyde and hyaluronate concentration on the gel strength, breakpoint, and rigidity of the chitosan hydrogel as well as the swelling and shrinking properties. This study determined the optimum concentration of both of glutaraldehyde and hyaluronate by data analysis using Modde 5Ò software. Hyaluronate increased the gel strength, breakpoint, and rigidity at a low glutaraldehyde concentration, but showed the opposite effects at high glutaraldehyde concentration. At a low concentration of glutaraldehyde, relatively high swelling and low shrinking were revealed after hyaluronate addition. From these results, it was suggested that hyaluronate filled the empty spaces between the imine-crosslinks created by glutaraldehyde and chitosan. At high concentration of glutaraldehyde, the crosslinks became so extensive that no more space was left for hyaluronates. Otherwise, water would be squeezed out from the hydrogel and syneresis would happen. The optimum composition was obtained at 2.0% (w/v) chitosan, 0.3% (v/v) hyaluronate and 1.4% (v/v) glutaraldehyde, which achieved the gel strength, breakpoint, rigidity, swelling and shrinking of 678.4 g cm-2, 1.294 cm, 5.033 g cm-1, 2.634 g and 0.148 g, respectively. However, rheological property measurement of hydrogel synthesized by using the optimum composition gave lower results (190.7 g cm-2, 0.767 cm, 1.675 g cm-1) for the first three properties, but higher results (2.844 g and 0.348 g) for the latter two.
Co-Authors Abdul Aziz Darwis Aditianingrum, Kurnia Alysia Akhiruddin Maddu Ani Suryani Ani Suryani Arinana Arinana Aryani, Nursela Sofyanti Mirza Auliya Ilmiawati Azkiyah, Dina Budi Arifin DADANG DADANG EKA CHANDRA LINA Firdayani, Firdayani Fitri, Iis Yusma Irmanida Batubara Komalasari, Nurma Angeliani Komar Sutriah Kurniawanti, Kurniawanti Kusdiantoro Mohamad LAKSMI AMBARSARI Muhamad Alif Hamimdal Mujahidah, Ummahatul Natalia Marbun, Natalia Nur Qadri Rasyid Pajri Samsi Nasution Purwantiningsih Sugita Purwatiningsih Sugita Rahmani, Nabiila Rasyid, Nur Qadri Shabrina Shabrina, Shabrina Sri Mulijani Syafrida Manuwoto Tesar Dzikrulloh Wahono Esthi Prasetyaningtyas Wasrin Syafii