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All Journal The Journal of Pure and Applied Chemistry Research Biology, Medicine, & Natural Product Chemistry Care : Jurnal Ilmiah Ilmu Kesehatan JPPS (Jurnal Penelitian Pendidikan Sains) JPPIPA (Jurnal Penelitian Pendidikan IPA) PROFICIO: Jurnal Pengabdian Masyarakat Jurnal Pijar MIPA Jurnal Pendidikan MIPA Jurnal Ilmiah Ilmu Kesehatan
Titik Taufikurohmah
Jurusan Kimia FMIPA Unesa
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PENGARUH PEMBERIAN NANOGOLD-NANOSILVER UNTUK PENINGKATAN IMUN MASYARAKAT TERDAMPAK COVID-19 KLUSTER SIDOARJO Ningtias, Savira Ayu; Rusmini, Rusmini; Taufikurohmah, Titik
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 3 (2021): EDITION NOVEMBER 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i3.2262

Abstract

ABSTRACTSome countries including Indonesia are currently affected by Covid-19 Pandemic. It absolutely causes a health crisis that generally attacks the body's immune system. Efforts are needed not to be affected by coronavirus, one of which can be conducted by providing health water with nanogold-nanosilver with a concentration of 20 ppm in which nanogold plays a role in strengthening the body's immune system at the cellular level while nanosilver acts as a catalyst for the body's immune system to prevent and kill pathogens. This research aimed to determine the effect of giving nanogold-nanosilver on increasing body immunity in healing complaints of serious illness and minor illness in the 230 people affected by the Covid-19 Sidoarjo cluster. The method used in this research was descriptive quantitative by distributing 150 mL of nanogold-nanosilver in a drinking water mixture to the Sidoarjo cluster people for 10 days in April. Data were obtained from the results of interviews every three times a day, the respondent's response had a significant effect by giving nanogold-nanosilver. It could boost body immunity as evidenced by improving body fitness, healing minor ailments (coughs, colds, menstruation, stomach acid, and acne and spots on the face) ) to recover serious diseases (kidney stones and breast pain). Furthermore, data would be processed in the form of bar chart. Thus, nanogold-nanosilver is able to maintain healthy conditions for people during a pandemic. Therefore, nanogold-nanosilver is expected to be a medicine of the future. Keywords: Body immunity; Nanogold; Nansosilver. ABSTRAKSaat ini berbagai negara khususnya Indonesia telah tedampak pandemi Covid-19, tentunya mengakibatkan krisis kesehatan yang pada umumnya menyerang sistem imun tubuh. Perlu adanya upaya agar tidak terserang coronavirus, salah satunya bisa dilakukan dengan pemberian air kesehatan nanogold-nanosilver dengan konsentrasi 20 ppm dimana nanogold berperan memperkuat sistem imun tubuh tingkat sel sedangkan nanosilverberperan sebagai katalisator sistem imun tubuh untuk mencegah serta membunuh patogen. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian nanogold-nanosilver terhadap peningkatan imunitas tubuh dalam penyembuhan keluhan sakit berat maupun sakit ringan terhadap 230 masyarakat terdampak Covid-19 kluster Sidoarjo. Metode yang digunakan dalam penelitian ini yaitu kuantitatif deskriptif dengan membagikan 150 mL nanogold-nanosilver dalam campuran air minum kepada masyarakat kluster Sidoarjo selama 10 hari dalam bulan April. Data diperoleh dari hasil wawancara setiap tiga kali minum, respon responden memberikan pengaruh yang signifikan dengan pemberian nanogold-nanosilver dapat meningkatkan imun tubuh dibuktikan dengan meningkatkan kebugaran tubuh, penyembuhan penyakit ringan (batuk, pilek, menstruasi, asam lambung, serta jerawat dan flek di wajah) hingga memulihkan penyakit berat (batu ginjal dan nyeri payudara). Selanjutnya data akan diolah dalam bentuk diagram batang. Dengan demikian, nanogold-nanosilver mampu mempertahankan kondisi masyarakat tetap sehat di masa pandemi. Sehingga nanogold-nanosilver diharapkan bisa menjadi obat masa depan. Kata kunci: Imun tubuh; Nanogold; Nanosilver
Synthesis of Gold Nanoparticles Using Ascorbic Acid as a Bioreductor and the Effect of Uric Acid Rachmawati, Yulle; Taufikurohmah, Titik
Jurnal Pijar Mipa Vol. 20 No. 7 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i7.10235

Abstract

Gold nanoparticles (AuNPs), ranging in size from 1 to 100 nm, represent one of the most significant advancements in metal-based technologies in recent years. Their application in the medical field, especially as drug delivery agents, is particularly noteworthy and demonstrates their transformative potential. This study aims to synthesize AuNPs using HAuCl4 as a precursor and ascorbic acid as a bioreductant at a concentration of 20 ppm with a bottom-up method. The result of the synthesis process yields a striking burgundy-colored solution, signifying the successful formation of gold nanoparticles. The results of UV-Vis characterization provided insightful data on the transformation of the HAuCl4 solution. Initially recorded at a wavelength of 314.60 nm, the solution underwent a notable shift to 523.50 nm after the synthesis process, demonstrating an absorbance value of 0.323. Furthermore, the transmission electron microscopy (TEM) analysis illuminated the unique characteristics of the synthesized nanoparticles, revealing an average particle size of 6.23 nm with the highest particle frequency in the range of 6-8 nm. Moreover, the result of clinical trials conducted with ten randomly selected volunteers, who received 20 ppm of AuNPs over a five-week period, demonstrated that seven out of ten participants experienced a significant reduction in uric acid levels, underscoring the therapeutic potential of gold nanoparticles. Microscopic observations following the injection revealed that volunteers with normal uric acid levels exhibited fewer leukocytes than those with elevated uric acid levels, who were noted to have leukocyte counts up to three times higher. In conclusion, the synthesis of AuNPs using ascorbic acid is marked by a wine-red solution and a significant absorption wavelength shift to the 500–600 nm range. The positive results of the clinical trial reflect the ability of AuNPs to lower uric acid levels, thereby paving the way for innovative nanotechnology-based therapeutic strategies in the medical field.
PENINGKATAN HIGIENITAS DAN KUALITAS PRODUK OLAHAN SUSU SAPI BAGI KELOMPOK MASYARAKAT DUSUN BRAU, KOTA BATU Wardana, Andika Pramudya; Suyatno; Taufikurohmah, Titik; Wikandari, Prima Retno; Ramadhania, Nurina Rizka; Prasetya, Rahmad Aji
Jurnal Pengabdian Masyarakat FKIP UTP Vol 7 No 1 (2026): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v7i1.5689

Abstract

Dusun Brau di Kota Batu, Jawa Timur, merupakan salah satu sentra produksi susu sapi yang menghadapi tantangan dalam pengolahan produk turunan seperti keju, terutama pada aspek higienitas dan kualitas produk. Permasalahan utama terletak pada keterbatasan pengetahuan masyarakat mengenai sanitasi pangan dan standar mutu berdasarkan Standar Nasional Indonesia (SNI 8896:2020). Untuk itu diberikan pelatihan partisipatif yang dirancang melalui pemaparan teori, praktik langsung pembuatan keju, pengemasan, pelabelan, serta penyusunan rencana bisnis. Evaluasi dilakukan dengan membandingkan nilai prates dan pascates 13 peserta menggunakan analisis statistik (Shapiro-Wilk dan Wilcoxon). Hasil menunjukkan adanya peningkatan skor rata-rata dari 70,77 (prates) menjadi 83,08 (pascates), meskipun secara statistik tidak signifikan (p=0,2656). Meskipun demikian, peserta menunjukkan peningkatan pemahaman dalam penerapan prinsip higienitas, sanitasi produksi, serta pemenuhan standar mutu produk olahan susu. Temuan ini menegaskan bahwa pelatihan aplikatif dan partisipatif mampu meningkatkan keterampilan teknis maupun kesadaran kualitas, sehingga mendukung peningkatan daya saing produk olahan susu sapi di tingkat lokal maupun nasional.
Formulation and Standardization of Face Wash Using Watermelon Rind Extract (Citrullus lanatus) Wijaya, Dika Putra; Rahmawati, Khofifatul; Bachtiar, Achmad Yusuf; Ridhwan, Alverdha Elvarheta Rasseta; Rahmah, Ayu Alfianita; Taufikurohmah, Titik; Danar, Danar
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1569-1578

Abstract

The purpose of this study was to determine the utilization of watermelon rind waste as an active ingredient in the manufacture of liquid soap preparations and to obtain the best formulation of watermelon rind extract liquid soap that is physically stable. Watermelon rind waste contains many nutritious substances, such as antioxidants, that are beneficial for skin health but have not been widely utilized. This study utilizes citrulline compounds in watermelon rind, which act as antioxidants and potential vasodilators, to be used as active ingredients in the manufacture of bath soap preparations with the aim of removing dirt and stimulating blood circulation. Research method includes the preparation of thick watermelon rind extract, the preparation of salt solution, and the preparation of liquid soap preparation formulas with varying concentrations of watermelon rind extract. Evaluation includes an organoleptic test, pH, viscosity, foam height, foam stability, homogeneity, and spreadability to obtain a liquid soap formula with stable physical properties. Result showed that watermelon rind extract has the potential to be an active ingredient in liquid soap preparations in order to utilize waste and provide benefits for skin health.
Synthesis of Gold Nanoparticles Using Ascorbic Acid Bioreductor and Its Effect on Human Blood Pressure Rahmadhani, Aisyah Cici Dwi; Taufikurohmah, Titik
Jurnal Pijar Mipa Vol. 21 No. 2 (2026): in Progress
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.11331

Abstract

Blood pressure is an important factor in the circulatory system and should be within the normal range of 90-140/60-90 mmHg. Blood pressure imbalances, such as hypertension and hypotension, can be caused by an unhealthy lifestyle, poor diet, or chronic illness. These conditions can trigger oxidative stress, which is an imbalance between the production of free radicals and the body's ability to neutralize them. Oxidative stress can damage cells and tissues, including blood vessels. Therefore, antioxidant intake is needed to help prevent further damage and maintain stable blood pressure. One innovative approach in blood pressure management is the use of gold nanoparticles, which have antioxidant activity. This study aims to characterize gold nanoparticles (AuNPs) synthesized using ascorbic acid bioreductors and examine the effect of their injection on human blood pressure. Characterization was performed using UV-Vis and Transmission Electron Microscopy (TEM), showing a maximum wavelength of 523.50 nm and an average particle diameter of 6.45 nm. Gold nanoparticles were injected intravenously at a dose of 200 mL every week. The results of the study indicate that the administration of gold nanoparticles significantly lowers blood pressure, as shown by the Paired T-Test, which shows an average decrease of 12.6 mmHg (95% CI: 5.1–20.1) and a p-value of 0.004. Based on the blood pressure trend graph, it was found that hypertensive volunteers' blood pressure decreased to normal levels, hypotensive volunteers' blood pressure increased to normal levels, and volunteers with normal blood pressure remained stable. Microscopic analysis showed a higher number of white blood cells in hypertensive volunteers compared to volunteers with normal blood pressure.
Co-Authors Bachtiar, Achmad Yusuf Danar, Danar Dewi, Arfinda Mulya Dewi, Mareidha Nanda ENDANG SUSANTINI ERLITA DAMAYANTI, NURMA Farihah, Neni Isna Fernanda, Cintya Dita Imran, Yuliana Anggraini Madlazim Madlazim Nabila, Awiddah Zuhroh Ningtias, Savira Ayu NOVITA SARI, DIA Prasetya, Rahmad Aji Prima Retno Wikandari Puspitasari, Putri Amalia Putri Puspitasari Putri, Raddina Aprilia Rachmawati, Yulle Rahmadhani, Aisyah Cici Dwi Rahmah, Ayu Alfianita Rahmawati, Khofifatul Ramadhania, Nurina Rizka Ratna Indriyani Ridhwan, Alverdha Elvarheta Rasseta Rudiana Agustini Rusmini Rusmini Safitri, Elys SUYATNO Triana, Aan Dimas Wardana, Andika Pramudya Wijaya, Dika Putra Yaumi, Yaumi