Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

0.888

P-Index

This Author published in this journals

All Journal Jurnal Natur Indonesia Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Kanderang Tingang Molluca Journal of Chemistry Education (MJoCE) Panrannuangku Jurnal Pengabdian Masyarakat Jurnal Abdi Masyarakat Indonesia Makara Journal of Science

Ruslin Hadanu

Universitas Sembilanbelas November Kolaka

Author-ID : 4048991

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 20 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

SYNTHESIS AND ANTIPLASMODIAL ACTIVITY TESTING OF (1)-N-(4-METHOXYBENZYL)-1,10-PHENANTHROLINIUM BROMIDE Ruslin Hadanu; Sabirin Mastjeh; Jumina Jumina; Mustofa Mustofa; Mahardika Agus Widjayanti; Eti Nurwening Sholikhah
Indonesian Journal of Chemistry Vol 7, No 2 (2007)
Publisher : Universitas Gadjah Mada

Synthesis of (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide from 1,10-phenanthroline monohydrate and 4-methoxybenzaldehyde as starting material and evaluation of its antiplasmodial activities have been carried out. The 4-methoxybenzyl alcohol was prepared from 4-methoxy-benzaldehyde using sodium borohydride (NaBH4) reagent and ethanol absolute solution. The mixture was refluxed for 3 h. To yield colorless dilution compound with 90.41 % in efficiency. Furthermore, bromination of 4-methoxybenzyl alcohol with phosphorus bromide (PBr3) was conducted by refluxing for 3 h. The product of this reaction was yellow liquid of 4-methoxybenzyl bromide, 79.03% yield and 95.34 % purity. The final step of reaction was benzylation of 1,10-phenanthroline monohydrate with 4-methoxybenzyl bromide reagent. It was conducted by refluxing in aceton for 8 h at 55 oC. The yield of the reaction was (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide (77.63%). It is pink solid form, and its melting point is 192-193 oC. Identification of the product was carried out by means of GC-MS, IR and 1H-NMR spectrometers. The in vitro antiplasmodial activity on chloroquine-resistant Plasmodium falciparum FCR-3 strain and chloroquine sensitive P. falciparum D10 strain for (1)-N-(4-methoxybenzyl)-1,10-phenanthroline bromide were determined by microscopic method. The result showed that after 72 h incubation, it has IC50 0.93±0.02 µM and 1.21±0.09 µM, respectively.

QUANTITAVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS (QSAR) OF ANTIMALARIAL 1,10-PHENANTHROLINE DERIVATIVES COMPOUNDS Ruslin Hadanu; Sabirin Mastjeh; Mustofa Mustofa; Eti Nurwening Sholikhah; Mahardika Agus Wijayanti; Iqmal Tahir
Indonesian Journal of Chemistry Vol 7, No 1 (2007)
Publisher : Universitas Gadjah Mada

Quantitative Electronic Structure-Activity Relationship (QSAR) analysis of a series of 1,10-phenanthroline derivatives as antiplasmodial compounds have been conducted using atomic net charges (q), dipole moment (μ) ELUMO, EHOMO, polarizability (α) and log P as the descriptors. The descriptors were obtained from computational chemistry method using semi-empirical PM3. Antiplasmodial activities were taken as the activity of the drugs against chloroquine-resistant Plasmodium falciparum FCR3 strain and are presented as the value of ln (1/IC50) where IC50 is an effective concentration inhibiting 50% of the parasite growth. The best model of QSAR model was determine by multiple linear regression method and giving equation of QSAR: ln 1/IC50 = 3.732 + (5.098) qC5 + (7.051) qC7 + (36.696) qC9 + (41.467) qC11 -(135.497) qC12 + (0.332) μ - (0.170) α + (0.757) log P.The equation was significant on the 95% level with statistical parameters: n=16; r=0.987; r2= 0.975; SE=0.317; Fcalc/Ftable = 15.337 and gave the PRESS=0.707. Its means that there were only a relatively few deviations between the experimental and theoretical data of antimalarial activity.

SYNTHESIS OF ANTIMALARIAL 3-(2-HYDROXYETHYL)-2-METHYL-1,10-PHENANTHROLINE-4-OL FROM 8-AMINOQUINOLINE Ruslin Hadanu; Chairil Anwar; Jumina Jumina; Iqmal Tahir; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 4, No 2 (2004)
Publisher : Universitas Gadjah Mada

It has been conducted the synthesis of 3-(2-hydroxyethyl)-2-methyl-1,10-phenanthroline-4-ol was carried out from 8-aminoquinoline which are expected to posses antimalarial activity. The experiment perfomed consisted of two steps i.e (1) reaction of 8-aminoquinoline with 2-acetyl-butyrolactone and (2) cyclization of the resulted 3-[1-(quinolin-8-ylamino)-ethylidene]-4,5-dihydro-furan-2-one. The reaction of 8-aminoquinoline with 2-acetyl-butyrolactone was performed in toluene at reflux for 6 hours in the presence of p-toluensulfonic acid as catalyst. This reaction gave 3-[1-(quinolin-8-ilamino)-etiliden]-4,5-dihidro-furan-2-on in 60.6% yield. The cyclization of 3-[1-(quinoline-8-ylamino)-ethyliden]-4,5-dihydro-furan-2-one was conducted in cloroform at reflux for 4 hours in the presence of H2SO4 as catalyst and also tween 80 as transfer phase catalyst to give 3-(2-hydroxy-ethyl)-2-methyl-1,10-phenanthroline-4-ol in 76.2% yield. Identification of the products were carried out by means of infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy, and mass spectroscopy (MS).

Sharing Introduction (Sosialisasi) Dengan Metode Klasikal Pengenalan Prodi Pendidikan Kimia Secara Milenial Muhammad Fath Azzajjad; Dewi Satria Ahmar; Alimuddin; Edi Ilimu; Ruslin Hadanu; Musdalifatul Adewia; Ayu Kusumawati; Dian Permana; Ayu Rahayu
Panrannuangku Jurnal Pengabdian Masyarakat Vol. 2 No. 2 (2022)
Publisher : Lembaga Penelitian dan Pengembangan Teknologi dan Rekayasa, Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/panrannuangku790

Universitas Sembilanbelas November Kolaka merupakan Perguruan Tinggi Negeri yang berada di Wilayah Kabupaten Kolaka Provinsi Sulawesi tenggara, sebagai Perguruan Tinggi negeri pertama di Kolaka yang berdiri sebagai kampus Negeri pada tahun 2015, sedangkan program studi pendidikan kimia berdiri mulai tahun 2017. Tantangan bagi civitas akademika adalah program studi pendidikan kimia belum dikenal oleh masyarakat di wilayah kolaka, akses informasi lewat sosial media yang terbatas mempengaruhi animo masyarakat untuk mendaftar pada penerimaan mahasiswa baru dalam 2 tahun terakhir. Strategi sharing introduction dilakukan melalui sosialisasi dengan metode klasikal. sasarannya adalah siswa kelas XII yang akan tamat pada tahun pelajaran 2021/2022. Sosialisasi dilakukan melalui metode pendekatan case study dan pelibatan HMPS untuk sosialisasi melalui media sosial.

QSAR Studies of Nitrobenzothiazole Derivatives as Antimalarial Agents Hadanu, Ruslin; Adelin, La; Sutapa, I Wayan
Makara Journal of Science Vol. 22, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Quantitative Structure and Activity Relationship (QSAR) analyses were carried out for a series of 13 nitrobenzothiazole derivatives as antimalarial compounds to find out the structural relationship of their antimalarial activities against the W2 Plasmodium falciparum strain. The electronic descriptors have been determined usingthe atomic net charges (q), dipole moment (μ), ELUMO, EHOMO, polarizability (α) and Log P. Inaddition, the descriptors were calculated through Hyper Chem for Windows 8.0 using the PM3 semi-empirical method. The antimalarial activities (IC50) were taken fromliterature [1]. Furthermore, the QSAR model was determined by multiple linear regression (MLR) approach, giving equation model of QSAR: Log IC50 = 41.483 + 54.812 (qC2) – 50.058 (qS3) + 416.766 (qC4) + 440.734 (qC5) – 754.213 (qC7) – 73.721 (qC8) + 246.715 (qC9) + 0.551 (μ) – 13.269 (EHOMO) – 3.404 (ELUMO) + 0.042 (α) + 0.107 (LogP). The most statistically significant QSAR model with correlation coefficients n = 13, (r) = 1.00, (r2) = 1.00, SE = 0, and PRESS = 3.40 were developed by MLR. Based on the model of the above QSAR equation 43 new nitrobenzothiazole derivatives were modeled and 24 of these compounds showed high antimalarial activity. It isrecommended that these are synthesized for further investigation 4 new compounds (45, 49, 52 and 55) show equivalent activity to that achieved with chloroquine antimalarial drugs.

Volatile Compounds Detected in Coconut Shell Liquid Smoke through Pyrolysis at a Fractioning Temperature of 350-420 C Hadanu, Ruslin; Apituley, Daniel Ambrosius Nicholas
Makara Journal of Science Vol. 20, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

This study evaluated the volatile components of liquid smoke from coconut shells obtained through the pyrolysis process at fraction 350-420 °C. The volatile compounds of liquid smoke from a coconut shell were analyzed using gas chromatography and mass spectrometry (GC-MS). Nineteen peaks were detected by GC-MS in the coconut shell liquid smoke, and 19 compounds also were identified. The volatile compounds were identified as follows based on their function group’s composition percentage: phenol (90.75%), carbonyl (3.71%), alcohol (1.81%), and benzene (3.73%), respectively. The liquid smoke contains a high ratio of phenol derivatives (90.75%) in volatile profile. The phenol derivatives were the major volatile compounds found in the coconut shell liquid smoke.

Identifikasi Struktur Komponen Senyawa Kimia Kulit Batang Ketapang (Terminalia catappa L.) Edi Ilimu; Alimuddin; Ruslin Hadanu; Nurfianti
Jurnal Ilmiah Kanderang Tingang Vol 14 No 2 (2023): Jurnal Ilmiah Kanderang Tingang
Publisher : FKIP Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jikt.v14i2.283

Ketapang (Terminalia catappa L.) is a type of flowering plant that has been widely used by the community, especially in traditional medicine. This research aims to identify the chemical compound components of Ketapang bark using Virgin Coconut Oil (VCO) solvent. Research methods include making VCO, maceration extraction, solubility testing, identification of chemical compound components using FTIR and GC-MS. The mass of VCO is 744.32 grams (14.88% soaking). The mass of Ketapang bark extract weighed 183.88 grams (0.63% soaking). The solubility test shows that VCO and extracts are generally nonpolar. Identification results using FT-IR show that VCO has C-H, C=O and C-O groups, while ketapang bark extract has aliphatic –CH, C=O, C-O, C-OH, C-N and aromatic C-H groups. Identification using GC-MS showed that VCO had 112 peaks, among the 112 peaks that had a similarity index of 80% there were 14 peaks, while the ketapang bark extract had 190 peaks and 11 peaks had a similarity index. Thus, it can be concluded that the components of the VCO compound are decanoic acid, dodecanoic acid, tridecanoic acid, myristic acid, pentadecanoic acid, 2-monocaprin (2TMS derivative), palmitelaidic acid, palmitic acid, and stearic acid. Meanwhile, Ketapang stem bark extract contains heptadecanoic acid, (z) oleic acid, elaidic acid, 1-ethoxy-4'-methoxy-2,2'-binaptyl-1,4-dione, eikosan, 7-methyl-z-tetradeken- 1-ol-acetate, beta-alanine, sarcosine, 1-aminomethyl-cyclododecanol, and dodecanoic acid, 2,3-dihydroxypropyl ester.

Synthesis and Antiplasmodial Activity of 2-(4-Methoxyphenyl)-4-Phenyl-1,10- Phenanthroline Derivative Compounds Hadanu, Ruslin; Mustofa, Mustofa; Nazudin, Nazudin
Makara Journal of Science Vol. 16, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

A unique of synthetic methods was employed to prepare 2-(4-methoxyphenyl)-4-phenyl-1,10-phenanthroline (5) derivatives from 4-methoxy-benzaldehyde (1), acetophenone (2), and 8-aminoquinoline (4) with aldol condensation and cyclization reactions. The derivatives were tested through antiplasmodial test. The synthesis of derivatives compound 5 was conducted in three steps. The 3-(4-methoxyphenyl)-1-phenylpropenone 3 was synthesized through aldol condensation of 1 and 2 which has a yield of 96.42%. The compound 5 was synthesized through cyclization of compound 4 and 3 with 84.55% yield. The derivative of compound 5 was synthesized from compound 5 using DMS and DES reagents which refluxed for 21 and 22 h, to produce (1)-N-methyl-9-(4-methoxyphenyl)-7-phenyl-1,10- phenanthrolinium sulfate (6) and (1)-N-ethyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (7) with 91.42 and 86.36% yields, respectively. Results of in vitro testing of antiplasmodial activity of compound 5 derivatives (i.e., compound 6 and 7) against chloroquine-resistant P. falciparum FCR3 strain showed that compound 7 had higher antimalarial activity than compounds 5 and 6. Whereas, results of in vitro testing against chloroquine-sensitive P. falciparum D10 strain showed that compound 6 has higher antimalarial activity than compounds 5 and 7.

Modeling of Benzimidazole Derivatives as Antimalarial Agents using QSAR Analysis Hadanu, Ruslin; Sitorus, Marham
Makara Journal of Science Vol. 28, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

In this study, quantitative structure–activity relationship (QSAR) analysis was conducted on 20 homologous compounds of benzimidazole derivatives. The structures of the benzimidazole derivatives were optimized using the semiempirical Parameterized Model 3 method of HyperChem for Windows 8.0 to obtain 14 descriptors. Then, multiple linear regression (MLR) analysis was performed using the backward method. The results of the MLR analysis obtained four new QSAR equation models. Based on statistical criteria, model 1 was determined as the best QSAR equation model in predicting the theoretical IC50 values of the new benzimidazole derivatives. As many as 20 new compounds of benzimidazole derivatives were modeled, of which 13 new compounds (23, 24, 25, 26, 27, 28, 29, 30, 31, 37, 38, 39, and 40 compounds) were recommended for synthesis in the laboratory because these compounds of benzimidazole derivatives havethey theoretically had higher antimalarial activity than chloroquine

Penyuluhan dan Transfer Teknologi Pembuatan Pupuk Organik Plus kepada Petani Hortikultura di Kelurahan Sembilanbelas Nopember Kabupaten Kolaka Sulawesi Tenggara Halim, Halim; Muzuni, Muzuni; Basrudin, Basrudin; Hadanu, Ruslin; Amin, Muhtar; Salam, Nur; Samsaifil, Samsaifil
Jurnal Abdi Masyarakat Indonesia Vol 5 No 3 (2025): JAMSI - Mei 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.1880

Petani hortikultura yang ada di Kelurahan Sembilanbelas November Kolaka senantiasa diperhadapkan dengan masalah kelangkaan pupuk, khususnya pupuk kimia. Walaupun pupuk kimia tersebut telah digunakan oleh petani secara terus-menerus, namun seiring dengan perkembangan waktu hasil panen yang diperoleh mengalami penurunan. Oleh karena itu, penggunaan pupuk organik plus fungi mikoriza merupakan alternatif penting guna menjaga kesuburan tanah dan meningkatkan produksi tanaman. Kegiatan ini bertujuan untuk melakukan penyuluhan dan transfer teknologi pembuatan pupuk organik plus kepada petani hortikultura di Kelurahan Sembilanbelas November Kolaka. Metode pelaksanaan kegiatan ini yaitu: (1) Model Participatory Rapid Appraisal (PRA), dilakukan dengan wawancara langsung kepada petani berkaitan dengan permasalahan yang dihadapi selama melakukan kegiatan budidaya tanaman, (2) Model Focus Group Discussion (FGD), membahas pemecahan masalah yang terjadi selama petani melakukan budidaya tanaman melalui tanya jawab dan diskusi, (3) Model Technology Transfer (TT), mendampingi petani secara langsung dalam membuat pupuk organik plus dan cara aplikasinya pada tanaman, (4) Model Enterpreneurship Capacity Building (ECB), memberikan pelatihan kepada petani tentang cara penjualan pupuk organik plus dan produk pertanian lewat online seperti WA dan Facebook. Hasil kegiatan menunjukkan bahwa petani hortikultura di Kelurahan Sembilanbelas November Kolaka memiliki keterampilan dan pengetahuan untuk membuat pupuk organik plus fungi mikoriza dibandingkan dengan sebelum pelaksanaan kegiatan.

Co-Authors Adelin, La Alimuddin Alimuddin Amin, Muhtar Apituley, Daniel Ambrosius Nicholas Ayu Kusumawati Ayu Rahayu Azzajjad, Muhammad Fath Chairil Anwar Daniel Ambrosius Nicholas Apituley Dewi Satria Ahmar Dian Permana Eti Nurwening Sholikhah Halim Halim, Halim I Wayan Sutapa Ilimu, Edi Iqmal Tahir Iqmal Tahir Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina La Adelin Mahardika Agus Widjayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marham Sitorus Musdalifatul Adewia MUSTAFA MUSTAFA Mustafa Mustafa Mustofa . Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Muzuni, Muzuni Nazudin . NAZUDIN NAZUDIN Nazudin, Nazudin Nur Salam Nurfianti Nurwijayanti Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Salim Idris Samsaifil Samsaifil Sitarina Widyarini

Title

Found 20 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 20 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 20 Documents
Search